CN102656463B - Automatic analysis device - Google Patents
Automatic analysis device Download PDFInfo
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- CN102656463B CN102656463B CN201080057284.8A CN201080057284A CN102656463B CN 102656463 B CN102656463 B CN 102656463B CN 201080057284 A CN201080057284 A CN 201080057284A CN 102656463 B CN102656463 B CN 102656463B
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- detection bodies
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00603—Reinspection of samples
Abstract
Disclosed is an automatic analysis device provided with a pretreatment mechanism, wherein rapid automatic retesting is possible and consumption of a source specimen and treatment liquid can be suppressed. The automatic analysis device is provided with: a source specimen container for accommodating a source specimen; a pretreatment container for pretreating the source specimen dispensed from the source specimen container; a source specimen dispensing mechanism for dispensing the source specimen to the pretreatment container; a reaction container for analyzing a pretreated specimen dispensed from the pretreatment container; a pretreated specimen dispensing mechanism for dispensing the pretreated specimen to the reaction container; and a control unit for controlling the dispensing of the source specimen from the source specimen container to the pretreatment container performed by the source specimen dispensing mechanism, in accordance with information about the type of specimen and/or whether or not automatic retesting has been set.
Description
Technical field
The present invention relates to the automatic analysing apparatus of the constituent analysis of carrying out the biosome samples such as blood, urine, relate in particular to and possess the automatic analysing apparatus that detection bodies is diluted etc. to the pre-treatment mechanism of pre-treatment.
Background technology
In the automatic analysing apparatus of automatically analyzing at the contained composition of biosome sample to blood, urine etc., have and come the variation of color of assaying reaction liquid biological chemistry (colorimetric) analytical equipment that carries out constituent analysis with photometer, and with photodetectors such as photomultiplier tubes to immunoassay device that is additional to the mark body of the material of being combined singularly with analytic target composition (directly or indirectly) and measures etc.Any analytical equipment all limits at detecting device the concentration range (dynamic range) that can measure.Therefore, have in the concentration of determination object composition and exceed the concentration range that can measure, even if operating personnel do not indicate " automatically examining again " function that yet can automatically measure again, and have as required and will automatically examine again the device that is set as effective or invalid mensuration of carrying out detection bodies.
In this situation, from former detection bodies (female detection bodies) directly the automatic analysing apparatus of the mode of dispensing sample, if from former detection bodies container again dispensing sample can automatically examine again, but in the automatic analysing apparatus of the mechanism with pre-treatments such as diluting as described in Patent Document 1, suppose that the detection bodies not had or only implemented pre-treatment remains in the situation on device after the analytical equipment that former detection bodies is carried to other.In the case of the amount of the complete detection bodies of pre-treatment is abundant, while automatically inspection again, in the past container handling again before dispensing be disposed detection bodies and examine again.
Prior art document
Patent documentation
Patent documentation 1: Japanese kokai publication hei 8-194004 communique
Summary of the invention
Invent problem to be solved
But, in the time examining again, the detection bodies deficiency of pre-treatment, cannot carry out automatically examining again of this detection bodies, thereby device needs again the former detection bodies of container handling dispensing forward, via pretreatment procedure, and examines again.In the case of producing such state of affairs, owing to carrying out secondary pretreatment procedure, thereby there is the output of examining again result of the detection bodies of pre-treatment to become problem slowly.
On the other hand, in first pretreatment procedure, if modulate in advance the complete detection bodies of excessive pre-treatment, eliminate the deficiency of the complete detection bodies of pre-treatment while inspection again, but the consumption of former detection bodies, pretreatment liquid increases, burden for patient increases, and causes operating cost to increase, and there is no practicality.
The object of the present invention is to provide following automatic analysing apparatus, that is, possessing in the automatic analysing apparatus of pre-treatment mechanism, can carry out automatically examining again rapidly, and can suppress the consumption of former detection bodies and pretreatment liquid.
For solving the method for problem
In order to suppress the consumption of former detection bodies and pretreatment liquid, and, reduce the generation of the complete detection bodies deficiency of pre-treatment while automatically inspection again, and make automatic analysing apparatus there is following function.
1. based on automatic at least any information without the kind of, detection bodies that is set with of inspection again, to utilize that former detection bodies dispensing mechanism carries out from detection bodies container forward the former detection bodies dispensing of container handling control.
In 2.1,
A) for having automatically again the detection bodies of the possibility of inspection, the effective dose that can use in the dispensing to reaction vessel based in the complete detection bodies of pre-treatment, analyze the complete detection scale of construction of pre-treatment that uses and analyze the premeasuring of the complete detection bodies of pre-treatment being used with the complete detection scale of construction of pre-treatment that above-mentioned first analysis was used and the inspection again that automatically to examine preparation rate be basic calculation again that predetermines for the first time, control former detection bodies dispensing.
B), for there is no automatically the detection bodies of the possibility of inspection, the effective dose that can use in the dispensing to reaction vessel based in the complete detection bodies of pre-treatment, the first complete detection scale of construction of pre-treatment using of analyzing, control former detection bodies dispensing again.
In 3.1 ~ 2, in the situation that being set with automatically inspection again, when the kind of detection bodies is while once analyzing the general detection bodies (primary detection body) of also not carrying out, control point fluence of former detection bodies based on (formula 1) described later, when being while manually examining again any in detection bodies, titer, accuracy control sample, control point fluence of former detection bodies based on (formula 2).
In 4.1 ~ 3, according to the dispensing order of the complete detection bodies of this pre-treatment of utilizing the complete detection bodies dispensing of pre-treatment mechanism to carry out, to each dispensing of the complete detection bodies of pre-treatment, determine whether the effective dose that can use exceeding in the complete detection bodies of pre-treatment in the dispensing to reaction vessel, in the situation that exceeding effective dose, utilize above-mentioned former detection bodies dispensing mechanism, replenish the mode of adjusting the complete detection bodies of pre-treatment with container handling forward, control the former detection bodies dispensing of utilizing former detection bodies dispensing mechanism to carry out.
5. the above-mentioned preparation rate of automatically examining is again the value that uses actual achievement to amount to according to the device in past, or uses the value of input arbitrarily.
Effect of the present invention is as follows.
Possessing in the automatic analysing apparatus of pre-treatment mechanism, can suppress the consumption of former detection bodies and pretreatment liquid, and, can reduce the generation of the complete detection bodies deficiency of pre-treatment while automatically inspection again.
Brief description of the drawings
Fig. 1 is the pie graph of the related automatic analysing apparatus of embodiments of the present invention.
Fig. 2 be related according to the embodiment of the present invention automatic analysing apparatus automatically again the having or not of inspection, select flow process with the corresponding determine type of kind of detection bodies.
Fig. 3 is the determination flow of the related automatic analysing apparatus of embodiments of the present invention.
Fig. 4 is the preparation rate of automatically examining the again input picture of the related automatic analysing apparatus of embodiments of the present invention.
Fig. 5 is device behaviour in service during past certain of related according to the embodiment of the present invention automatic analysing apparatus, amounts to the picture of automatically examining preparation rate again and showing.
Fig. 6 be related according to the embodiment of the present invention automatic analysing apparatus past specific what day device behaviour in service, amount to the picture of automatically examining again preparation rate and showing.
Fig. 7 be the special time period in the past of related according to the embodiment of the present invention automatic analysing apparatus device behaviour in service, amount to the picture of automatically examining again preparation rate and showing.
Fig. 8 be related according to the embodiment of the present invention automatic analysing apparatus pre-treatment kind and input the picture of automatically examining again preparation rate.
Fig. 9 be related according to the embodiment of the present invention automatic analysing apparatus detection bodies classification and input the picture of automatically examining again preparation rate.
Embodiment
Below, based on accompanying drawing, embodiments of the invention are described.
First, use Fig. 1, the summary of automatic analysing apparatus is described.
Automatic analysing apparatus is divided into detection bodies bridging portion, pre-treatment portion, reacting part.In detection bodies bridging portion, will be in detection bodies container 1 point detection bodies such as serum, urine of getting be set up in sample disk 2, utilize former detection bodies dispensing mechanism 7 from detection bodies container 1 container handling 8 dispensing detection bodies forward.Pre-treatment container 8 is configured on the circumference of pre-treatment portion 3 that is positioned at pre-treatment portion, utilize former detection bodies dispensing mechanism 7 dispensings the pre-treatment container 8 of detection bodies rotate and move to pretreatment liquid dispensing position by pre-treatment portion 3, utilize pretreatment liquid dispensing mechanism 9 to discharge pretreatment liquid.And, rotating by pre-treatment portion 3, the pre-treatment container 8 of having discharged pretreatment liquid moves to mixing position, and is stirred by the stirring rod rotation of the complete detection bodies rabbling mechanism 10 of pre-treatment.By the rotation of pre-treatment portion 3, the complete detection bodies of pre-treatment after stirring moves to the complete detection bodies dispensing of pre-treatment position, and discharges to reaction vessel 12 by the complete detection bodies dispensing of pre-treatment mechanism 11.Reaction vessel 12 is configured on the circumference of reaction tray 6 that is positioned at reacting part, rotate by reaction tray 6, divide the reaction vessel 12 that is marked with the complete detection bodies of pre-treatment to move to reagent point of addition, utilize reagent dispensing mechanism 13 to add reagent from the reagent container 4 being arranged at reagent disc 5.The reaction vessel 12 that has added reagent is rotated and is moved to mixing position by reaction tray 6, and uses rabbling mechanism 16 to rotate by reaction vessel to be stirred.The reaction vessel 12 of putting into the liquid that responds passes through at certain intervals due to the rotation of reaction tray 6 on the optical axis of photometer 14, measures absorbance at every turn.According to the absorbance of measuring, calculate the concentration of the target component in reactant liquor, and Output rusults.In addition, the pre-treatment container 8 after use and reaction vessel 12 are cleaned with wiper mechanism 15 and reaction vessel wiper mechanism 17 by pre-treatment container, and once measure and use upper.
When utilizing former detection bodies dispensing mechanism 7 by 1 point of detection bodies of getting of detection bodies container forward when container handling 8 dispensing, according to the kind of the having or not of inspection, detection bodies more automatically, and former detection bodies dispensing mechanism 7 is controlled.
The effective dose that can use in the dispensing to reaction vessel (being made as ≡ A) among the complete detection bodies of pre-treatment in pre-treatment container 8 is the value that the complete detection scale of construction of pre-treatment deducts the dead band capacity of pre-treatment container.In addition,
A) for thering is again the detection bodies of the possibility of inspection, the complete detection scale of construction of pre-treatment (being made as ≡ B) using when known first analysis and due to unknown and go out taking the complete detection scale of construction of pre-treatment using when first analysis the and the preparation rate of automatically examining again predetermining as basic calculation inspection is analyzed again time the complete detection scale of construction of pre-treatment that uses predicted value (being made as ≡ C) and, be the predicted value of the amount that uses as the complete detection bodies of pre-treatment.
B), for not having the detection bodies of possibility of inspection, the complete detection scale of construction of the pre-treatment B using when known first analysis is the amount using as the complete detection bodies of pre-treatment again.
For the detection bodies of the possibility again with inspection a), automatically when more first analysiss of patient's detection bodies of the effective situation of checking functions, in this situation, consider that the preparation amount for examining again makes the complete detection bodies of pre-treatment.For the detection bodies again without the possibility of inspection b),, automatically the first analysis of patient's detection bodies of the situation that checking functions is invalid again, manually examine again in the analysis of detection bodies, titer, accuracy control sample, can not consider the preparation amount of examining for again.The complete detection scale of construction of the pre-treatment B using when first analysis, except reality by the complete detection bodies dispensing of pre-treatment mechanism 11 to the complete detection bodies of pre-treatment of reaction vessel 12 dispensings, in the time of this dispensing, in the case of attracting redundantly the automatic analysing apparatus of the illusory complete detection bodies of pre-treatment in order to prevent the thin out of the complete detection bodies of pre-treatment, comprise the illusory amount of the complete detection bodies of pre-treatment (ダ ミ mono-amount).
For the control of former detection bodies dispensing mechanism 7, there are following two implementation methods herein.First, utilize according to the method that is made the complete detection bodies quantitative change of pre-treatment making by above-mentioned amount of a), b) trying to achieve, and controls point fluence of the former detection scale of construction and pre-treatment liquid measure according to the complete detection scale of construction of necessary pre-treatment.Second, utilize according to by above-mentioned a), the method that the amount of b) trying to achieve changes the number of the complete detection bodies of pre-treatment making, according to according to the dispensing order of the complete detection bodies of this pre-treatment of the complete detection bodies dispensing of pre-treatment mechanism 11, carrying out one by one project judges whether exceeding the effective dose A that can use in the dispensing to reaction vessel, in the situation that having exceeded this effective dose A, replenish the mode of the complete detection bodies of modulation pre-treatment with container handling 8 forward, to utilize former detection bodies dispensing mechanism 7 from detection bodies container 1 forward the former detection bodies dispensing of container handling 8 control.
Below, mainly an example that makes the method that the number of the complete detection bodies of pre-treatment changes is described, but according to automatically again the kind of the having or not of inspection, detection bodies to become situation a) or become the logic of situation b), automatically examine in the method that being set in of preparation rate make the complete detection bodies quantitative change of pre-treatment be again also identical.With Fig. 2 represent according to automatically again the kind of the having or not of inspection, detection bodies be chosen in the flow process of the determine type using while controlling.Automatically examine again when effective, the kind of detection bodies is (formula 1) while being primary detection body, for manually examining again detection bodies, titer, when accuracy control sample, be (formula 2), automatically examine again when invalid, according to according to the dispensing order of the complete detection bodies of this pre-treatment of the complete detection bodies dispensing of pre-treatment mechanism 11, whether meeting (formula 2) no matter carry out kind to detection bodies of project one by one judges, in the situation that not meeting (formula 1) or (formula 2), replenish the mode of the complete detection bodies of modulation pre-treatment with container handling 8 forward, to utilize former detection bodies dispensing mechanism 7 from detection bodies container 1 forward the former detection bodies dispensing of container handling 8 control.
(formula 1)
The complete detection bodies Shi Yong of pre-treatment Liang≤(complete inspection of the complete detection bodies effective dose-2 × pre-treatment of pre-treatment
Survey the illusory amount of body)/1+(examines preparation rate/100 automatically again) }
The complete detection bodies use amount of pre-treatment=total complete detection bodies of pre-treatment divides fluence+pre-treatment complete detection
The illusory amount of body × illusory detection bodies switching times
Pre-treatment complete detection bodies effective dose=former detection bodies point fluence+pretreatment liquid divides fluence-pre-treatment container
Dead band capacity
(formula 2)
The complete detection bodies of the complete detection bodies effective dose-pre-treatment of the complete detection bodies Shi Yong of pre-treatment Liang≤pre-treatment
Illusory amount
Here, " the complete detection bodies effective dose of pre-treatment " is suitable with above-mentioned A, " the illusory amount of the pre-treatment complete detection bodies of complete detection bodies use amount+pre-treatment " is suitable with above-mentioned B, and " (automatically examining again preparation rate/100) × (the illusory amount of the pre-treatment complete detection bodies of complete detection bodies use amount+pre-treatment) " is suitable with above-mentioned C.In addition, below, to the term in (formula 1) and (formula 2), describe.
Total complete detection bodies of pre-treatment is divided fluence: in the judgement of the project of n test, n test
Before utilize the complete detection bodies dispensing of pre-treatment mechanism 11
The complete detection bodies of pre-treatment is divided the summation of fluence.
Illusory amount: be held in the complete detection bodies dispensing of pre-treatment mechanism 11
The complete detection bodies of pre-treatment, what in mensuration, do not use is unnecessary
Amount.
Illusory detection bodies switching times: in the dispensing of the complete detection bodies of this pre-treatment midway, will
Be held in the complete detection bodies dispensing of pre-treatment mechanism 11
Illusory detection bodies is discarded, and again keeps illusory detection bodies
Number of times.
Former detection bodies point fluence: utilize former detection bodies dispensing mechanism 7, from detection bodies container 1
The former detection scale of construction of container handling 8 dispensings forward.
Pretreatment liquid point fluence: utilize pretreatment liquid dispensing mechanism 9, forward container handling 8
The pre-treatment liquid measure of dispensing.
Dead band capacity: the unnecessary amount not using in the mensuration in pre-treatment container 8.
Automatically examine again preparation rate: complete with respect to the pre-treatment using in initial examination is measured
Detect the scale of construction, in the time examining again use with expect pre-treatment
The ratio (%) of the complete detection scale of construction.
Use Fig. 3, the flow process of judging is described.About the complete detection bodies of pre-treatment that each detection bodies is required to N test, judge since the 1st test.In the judgement of I test, calculate the total amount that 1st ~ I the complete detection bodies of pre-treatment till test divided fluence, use (formula 1) or (formula 2) selected according to the flow process of Fig. 2 to judge.In the situation that result of determination is I < N and establishment (OK), move to the judgement of I+1 test.In the situation that being false (NG) for one, be the state of the complete detection bodies deficiency of pre-treatment of initial modulation, to be judged as pre-treatment container 8 be an amount, need to replenish the modulation of the complete detection bodies of pre-treatment.In addition, I is resetted in 1, M the test of be false from becoming (NG) starts residue project to start to judge again.This flow process repeatedly, finally in the moment of I=N and establishment (OK), finishes to judge.According to above flow process, the pre-treatment container 8 of the number from detection bodies container 1 to needs, utilizes the former detection bodies dispensing of former detection bodies dispensing mechanism 7.
Next, use Fig. 4, the input of automatically examining again preparation rate is described.Operating personnel are for general detection bodies, urgent detection bodies, and preparation rate (%) is examined in input automatically again, presses login button.For device, use the preparation rate of automatically examining again after login, carry out the judgement according to (formula 1).
Next, use Fig. 5, to according to the device behaviour in service during past certain, amount to the function of automatically examining again preparation rate and show and describe.Operating personnel press total start button during specifying wish to amount to.For device, first, during specifying, extract out and become automatically the detection bodies of the object of inspection again, and be divided into 2 groups of general detection bodies and urgent detection bodies.Next, with respect to each detection bodies group, when checking again total detection scale of construction of dispensing during with respect to initial examination in the past container handling 8 calculate to the ratio of total detection scale of construction of reaction vessel 12 dispensings, and in its mean value of picture disply, maximal value, minimum value.Operating personnel confirm the each value showing, to general detection bodies, urgent detection bodies, select the value of employing, and press login button respectively.By this series of operation, according to the device behaviour in service during past certain, amount to and automatically examine again preparation rate, operating personnel use the preparation rate of automatically examining again of specifying from aggregate values, and can be applied to the judgement of (formula 1).
Next, use Fig. 6, to determined according to the past what day device behaviour in service, amount to and automatically examine again the function that preparation rate shows and describe.Operating personnel specify wish amount to during and what day, press total start button.For device, first, during specifying and in what day, extract out and become automatically the detection bodies of the object of inspection again, be divided into 2 groups of general detection bodies and urgent detection bodies.Next, with respect to each detection bodies group, when checking again total detection scale of construction of dispensing during with respect to initial examination in the past container handling 8 calculate to the ratio of total detection scale of construction of reaction vessel 12 dispensings, and in its mean value of picture disply, maximal value, minimum value.Operating personnel confirm the each value showing, to general detection bodies, urgent detection bodies, select the value of employing, and press login button respectively.By this series of operation, according to during past certain and what day the device behaviour in service of determining, amount to and automatically examine again preparation rate, operating personnel use the preparation rate of automatically examining again of specifying from aggregate values, and can be applied to the judgement of (formula 1).
Next, use Fig. 7, to according to the device behaviour in service of definite time period in past, amount to and automatically examine again the function that preparation rate shows and describe.Operating personnel specify wish amount to during and the time period, press total start button.For device, first, during specifying and in the time period, extract out and become automatically the detection bodies of the object of inspection again, be divided into 2 groups of general detection bodies and urgent detection bodies.Next, with respect to each detection bodies group, when checking again total detection scale of construction of dispensing during with respect to initial examination in the past container handling 8 calculate to the ratio of total detection scale of construction of reaction vessel 12 dispensings, and its mean value of picture disply, maximal value, minimum value.Operating personnel confirm the each value showing, to general detection bodies, urgent detection bodies, select the value of employing, and press login button respectively.By this series of operation, according to during past certain and the device behaviour in service of definite time period, amount to and automatically examine again preparation rate, operating personnel use the preparation rate of automatically examining again of specifying from aggregate values, and can be applied to the judgement of (formula 1).
Next, illustrate and can set to various pretreatment liquids the function of automatically examining again preparation rate.Pretreatment liquid is not limited to a kind, according to purposes, can multiple pretreatment liquids be set at device.Use Fig. 8, illustrate various pretreatment liquids are changed to the function of automatically examining again preparation rate.Operating personnel examine preparation rate automatically again to various pretreatment liquid inputs, and press login button.For device, use the preparation rate of automatically examining again to various pretreatment liquid logins, carry out the judgement according to (formula 1).
Next, describe change the automatic function of examining again preparation rate according to detection bodies classification.Detection bodies classification refers to the origin of the detection bodies such as serum, urine, blood plasma, marrow liquid.Use Fig. 9, illustrate according to detection bodies classification and change the function of automatically examining again preparation rate.Operating personnel examine preparation rate according to general detection bodies, urgent detection bodies automatically again for various detection bodies inputs, and press login button.For device, use the preparation rate of automatically examining again to various detection bodies logins, carry out the judgement according to (formula 1).
Symbol description
1-detection bodies container, 2-sample disk, 3-pre-treatment portion, 4-reagent container, 5-reagent disc, 6-reaction tray, 7-former detection bodies dispensing mechanism, 8-pre-treatment container, 9-pretreatment liquid dispensing mechanism, the complete detection bodies rabbling mechanism of 10-pre-treatment, the complete detection bodies dispensing of 11-pre-treatment mechanism, 12-reaction vessel, 13-reagent dispensing mechanism, 14-photometer, 15-pre-treatment container wiper mechanism, 16-reaction vessel rabbling mechanism, 17-reaction vessel wiper mechanism.
Claims (9)
1. an automatic analysing apparatus, possesses: the former detection bodies container of the former detection bodies of folding and unfolding; Be used for carry out the pre-treatment container of pre-treatment from the former detection bodies of this former detection bodies container dispensing; By former detection bodies dispensing in the former detection bodies dispensing mechanism of this pre-treatment container; For the reaction vessel that the complete detection bodies of pre-treatment from this pre-treatment container dispensing is analyzed; And by complete pre-treatment detection bodies dispensing in the complete detection bodies dispensing of the pre-treatment mechanism of this reaction vessel, this automatic analysing apparatus is characterised in that,
Possesses control gear, the at least information of any of the kind that be set with nothing, detection bodies of this control gear based on automatically examining again, and to utilizing controlling to a point fluence for the former detection bodies of described pre-treatment container dispensing from described former detection bodies container that described former detection bodies dispensing mechanism carries out
For thering is automatically the detection bodies of the possibility of inspection again, the premeasuring of the effective dose that can in dispensing to reaction vessel use of this control gear based among the complete detection bodies of pre-treatment, the complete detection scale of construction of pre-treatment using while analyzing for the first time and the complete detection scale of construction of pre-treatment being used during with described first analysis and the complete detection bodies of pre-treatment that automatically to examine preparation rate be basic calculation again is used when inspection is analyzed again that predetermines, control the dispensing of former detection bodies
Possess and set the described set mechanism of automatically examining again preparation rate,
Possess calculation mechanism, the device behaviour in service of this calculation mechanism based on the past, automatically calculates the described preparation rate of automatically examining again.
2. automatic analysing apparatus according to claim 1, is characterized in that,
Possesses control gear, for there is no automatically the detection bodies of the possibility of inspection again, the effective dose that can in dispensing to reaction vessel use of this control gear based among the complete detection bodies of pre-treatment, the complete detection scale of construction of pre-treatment using while analyzing for the first time, control the dispensing of former detection bodies.
3. automatic analysing apparatus according to claim 1, is characterized in that,
Possess control gear, in the situation that being set with automatically inspection again, when the kind of described former detection bodies is while once analyzing the general detection bodies of also not carrying out, this control gear is controlled point fluence of former detection bodies based on (formula 1),
(formula 1)
The complete detection bodies Shi Yong of pre-treatment Liang≤(the illusory amount of the pre-treatment complete detection bodies of complete detection bodies effective dose-2 × pre-treatment)/1+(examines preparation rate/100 automatically again) }
The complete detection bodies use amount of pre-treatment=total complete detection bodies of pre-treatment is divided the illusory amount of the complete detection bodies of fluence+pre-treatment × illusory detection bodies switching times
Pre-treatment complete detection bodies effective dose=former detection bodies point fluence+pretreatment liquid divides the dead band capacity of fluence-pre-treatment container,
The illusory amount of the complete detection bodies of described pre-treatment is for being held in the complete detection bodies of the pre-treatment in-house pre-treatment of complete detection bodies dispensing, the unnecessary amount not using in mensuration,
The complete detection bodies of described total pre-treatment point fluence is in the judgement of project of n test, the summation of the complete detection bodies of the pre-treatment point fluence of utilizing the complete detection bodies dispensing of pre-treatment mechanism before n test,
Described illusory detection bodies switching times is in the dispensing of the complete detection bodies of this pre-treatment midway, will be held in the in-house illusory detection bodies of the complete detection bodies dispensing of pre-treatment discarded, and again keeps the number of times of illusory detection bodies,
The described preparation rate of automatically examining is again the complete detection scale of construction of pre-treatment using with respect in initial examination mensuration, the ratio of the complete detection scale of construction of pre-treatment using in the time examining again and expect,
The dead band capacity of described pre-treatment container is the unnecessary amount not using in the mensuration in pre-treatment container.
4. automatic analysing apparatus according to claim 2, is characterized in that,
Possessing control gear, is that while manually examining any in detection bodies, titer, accuracy control sample, this control gear is controlled point fluence of former detection bodies based on (formula 2) again in the kind of described former detection bodies,
(formula 2)
The illusory amount of the complete detection bodies Shi Yong of pre-treatment Liang≤pre-treatment complete detection bodies of complete detection bodies effective dose-pre-treatment,
The complete detection scale of construction of pre-treatment that the complete detection bodies use amount of described pre-treatment is used while being known first analysis deducts the value of the illusory amount of the complete detection bodies of pre-treatment,
The complete detection bodies effective dose of described pre-treatment is the effective dose that can use in the dispensing to reaction vessel among the complete detection bodies of pre-treatment in pre-treatment container, is the value that the complete detection scale of construction of pre-treatment deducts the dead band capacity of pre-treatment container,
The illusory amount of the complete detection bodies of described pre-treatment is for being held in the complete detection bodies of the pre-treatment in-house pre-treatment of complete detection bodies dispensing, the unnecessary amount not using in mensuration.
5. according to the automatic analysing apparatus described in any one in claim 1～4, it is characterized in that,
Possesses control gear, in each dispensing of the complete detection bodies of pre-treatment of utilizing the complete detection bodies dispensing of described pre-treatment mechanism to carry out, this control gear judges whether to exceed the effective dose that can use in the dispensing to reaction vessel in the complete detection bodies of pre-treatment, in the situation that exceeding effective dose, replenish the mode of adjusting the complete detection bodies of pre-treatment with container handling forward, control the former detection bodies dispensing of utilizing described former detection bodies dispensing mechanism to carry out.
6. automatic analysing apparatus according to claim 1, is characterized in that,
As setting the described mechanism that automatically examines again preparation rate, can set the preparation rate of automatically examining again according to the kind of pretreatment liquid.
7. automatic analysing apparatus according to claim 1, is characterized in that,
As setting the described mechanism that automatically examines again preparation rate, can set the preparation rate of automatically examining again according to detection bodies classification.
8. automatic analysing apparatus according to claim 1, is characterized in that,
Possess indication mechanism, this indication mechanism shows the described preparation rate of automatically examining again being calculated by described calculation mechanism.
9. automatic analysing apparatus according to claim 1, is characterized in that,
Described calculation mechanism has according to individually calculating the described function of automatically examining again preparation rate during certain.
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| JP2009-283572 | 2009-12-15 | ||
| JP2009283572A JP5372723B2 (en) | 2009-12-15 | 2009-12-15 | Automatic analyzer |
| PCT/JP2010/006578 WO2011074173A1 (en) | 2009-12-15 | 2010-11-10 | Automatic analysis device |
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| CN102656463A CN102656463A (en) | 2012-09-05 |
| CN102656463B true CN102656463B (en) | 2014-09-10 |
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| JP7245644B2 (en) * | 2018-12-26 | 2023-03-24 | 日本電子株式会社 | Automatic analyzer and automatic analysis method |
| EP3751284B1 (en) | 2019-06-14 | 2023-02-22 | F. Hoffmann-La Roche AG | Method and laboratory system to provide control samples for validating a diagnostic test |
| WO2023106234A1 (en) * | 2021-12-09 | 2023-06-15 | 積水メディカル株式会社 | Automatic analysis device and reagent amount display method |
| WO2024006041A1 (en) * | 2022-06-28 | 2024-01-04 | Beckman Coulter, Inc. | Method and instrument for drawing a volume of a biological sample for testing |
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| JP3229915B2 (en) * | 1995-01-19 | 2001-11-19 | 日本電子株式会社 | Biochemical automatic analyzer |
| JPH08304416A (en) * | 1995-05-12 | 1996-11-22 | Toshiba Corp | Detector for sample to be measured and automatic chemical analyzer using the same |
| JP3579517B2 (en) * | 1995-07-26 | 2004-10-20 | 株式会社エイアンドティー | Sample transport system |
| JPH1019900A (en) * | 1996-06-28 | 1998-01-23 | Shimadzu Corp | Automatic analyzer |
-
2009
- 2009-12-15 JP JP2009283572A patent/JP5372723B2/en active Active
-
2010
- 2010-11-10 CN CN201080057284.8A patent/CN102656463B/en active Active
- 2010-11-10 WO PCT/JP2010/006578 patent/WO2011074173A1/en active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1621846A (en) * | 2003-11-25 | 2005-06-01 | 株式会社日立高新技术 | Automatic analyzer |
Non-Patent Citations (4)
| Title |
|---|
| JP特开平8-114604A 1996.05.07 |
| JP特开平8-194004A 1996.07.30 |
| JP特开平8-304416A 1996.11.22 |
| JP特开平9-43246A 1997.02.14 |
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| JP2011127900A (en) | 2011-06-30 |
| JP5372723B2 (en) | 2013-12-18 |
| WO2011074173A1 (en) | 2011-06-23 |
| CN102656463A (en) | 2012-09-05 |
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