CN102656462B - Automatic analyzer - Google Patents
Automatic analyzer Download PDFInfo
- Publication number
- CN102656462B CN102656462B CN201080053574.5A CN201080053574A CN102656462B CN 102656462 B CN102656462 B CN 102656462B CN 201080053574 A CN201080053574 A CN 201080053574A CN 102656462 B CN102656462 B CN 102656462B
- Authority
- CN
- China
- Prior art keywords
- sample
- reagent
- photometric
- photometric parameter
- measurement result
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00613—Quality control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
- G01N2021/825—Agglutination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
Abstract
Using a microplate having wells for the dispensing and reaction of a sample including blood and a reagent, an automatic analyzer captures an image of whether reactions have occurred inside the wells and performs analysis, the automatic analyzer comprising: a section for, with captured images obtained by capturing images of the inside of the wells corresponding to categories, calculating photometric parameters of the images, evaluating whether a measurement result based on the images is negative for each test, and analyzing characteristic information of the sample; a section for matching and storing characteristic information of samples and measurement results; a section for extracting a photometric parameter of a measurement result judged as negative; and a section for calculating a difference between maximum and minimum values of an extracted photometric parameter, determining whether a measurement is valid using the difference, and adding a result of the determination to characteristic information.
Description
Technical field
The present invention relates to the autoanalyzer for implementing immunology agglutinating reaction.
Background technology
Traditionally, microwell plate has been used to the analysis of the composition of such as blood and body fluid, and each this microwell plate comprises the multiple reaction vessels being called hole being arranged to matrix.Comprise and want the sample of analyzed material and comprise to cause antigen-antibody to be assigned in each hole of microwell plate with the reaction reagent of the material wanting analyzed substance reaction.Then, to after predetermined a period of time from distribution, catch agglutinating reaction by the image capture means of such as CCD camera whether to appear in hole, and be used to by the view data that this image capture obtains the composition analyzing sample.
In as above analysis, obtain catch view data (catching image) based on the image by capture reaction thing, carries out the judgement of feminine gender or the positive, and the pollution impact analysis result to a great extent of foreign matter.In order to confirm reaction result exactly, importantly, analyzing and processing is not being implemented containing on the reactant of foreign matter.About this needs, in order to prevent the pollution of foreign matter, disclose a kind of confirmation method, for detected by pressure transducer the pressure distributed in test tube, by the image of CCD camera container for capturing and confirm soakage and sendout (see, such as, patent documentation 1).
Patent documentation 1: Japanese Unexamined Patent Publication 2000-193670 publication
Summary of the invention
[means of technology]
The invention provides a kind of autoanalyzer, comprising: comprising the sample of blood and the dispenser of reagent for distributing; Comprise the reacting part of substrate, described substrate has multiple reaction vessel, and described multiple reaction vessel reacts wherein for the described sample and described reagent allowing to comprise blood; Photometric measurer, for catching the image within reaction vessel described in each; Analysis portion, this sample is analyzed for whether having appeared within reaction vessel based on reaction, wherein, utilize the multiple images of catching obtained by the image of catching within multiple reaction vessels corresponding with multiple inspection item respectively, analysis portion calculates the photometric parameter of each image, and based on photometric parameter, and by negative for the situation definition not occurring reacting in reaction vessel, judge whether the measurement result based on catching image is negative for each test, and analyze the characteristic information of sample; Storage part, for mating and storing the described characteristic information of described sample and described measurement result; Extraction unit, for extracting the described photometric parameter being judged as negative described measurement result by described analysis portion; And determination processing unit, for calculating the difference between the maximal value of the described photometric parameter extracted by described extraction unit and minimum value, whether described measurement result is effective to use the difference calculated to judge, and the result of described judgement added to the described characteristic information of corresponding sample.
As selection, in the present invention, in autoanalyzer, use the substrate with multiple reaction vessel, described multiple reaction vessel is for distributing the sample and reagent that comprise blood, and allow described sample and described reagent to react wherein, catch the image within reaction vessel described in each, and analyze described sample based on reacting whether to have appeared within described reaction vessel, comprise: analysis portion, wherein, utilize the multiple images of catching obtained by the image of catching within the multiple reaction vessels corresponding respectively to multiple test, analysis portion calculates the photometric parameter of each image, and based on this photometric parameter, and will not occur that in reaction vessel the situation of reacting is defined as feminine gender, judge whether the measurement result based on catching image is negative for each inspection item, with the characteristic information analyzing sample, storage part, for mating and storing the described characteristic information of described sample and described measurement result, extraction unit, for extracting the described photometric parameter being judged as negative described measurement result by described analysis portion, and determination processing unit, for calculating the difference between the maximal value of the described photometric parameter extracted by described extraction unit and minimum value, whether described measurement result is effective to use the difference calculated to judge, and the result of described judgement added to the described characteristic information of corresponding sample.
In one embodiment, in the present invention as above, and in autoanalyzer according to the present invention, from the group comprising P/C, SPC and LIA, select at least two described photometric parameters; And if the described difference of photometric parameter described at least one is outside preset range, so described determination processing unit judges that described measurement result is invalid.
In another embodiment, in the present invention as above, and in autoanalyzer according to the present invention, from the group comprising P/C, SPC and LIA, select photometric parameter described at least one; And if the described difference of all described photometric parameters is outside preset range, so described determination processing unit judges that described measurement result is invalid.
Also having in another embodiment, in the present invention as above, and in autoanalyzer according to the present invention, be always show negative standard reagent according to the reagent that described multiple test uses.
Also having in another embodiment, in the present invention as above, autoanalyzer according to the present invention comprises efferent further, if described measurement result is judged as invalid by described determination processing unit, so described efferent exports the information that described measurement result is invalid to the effect that.
In in different, a kind of automatic analysis method is provided, use the substrate with multiple reaction vessel, described multiple reaction vessel is assigned with for the sample and reagent allowing to comprise blood, and allow described sample and described reagent to react wherein, the method for catching the image within reaction vessel described in each, and analyzes described sample based on reacting whether to have appeared within described reaction vessel.The method comprises: analytical procedure, utilize the multiple images of catching obtained by the image of catching within multiple reaction vessels corresponding with multiple inspection item respectively, calculate the photometric parameter of each image, and based on this photometric parameter, and will not occur that in reaction vessel the situation of reacting is defined as feminine gender, judge whether the measurement result based on catching image is negative for each test, and analyze the characteristic information of sample; Storing step, mates and stores the described characteristic information of described sample and described measurement result; Extraction step, extracts the described photometric parameter being judged as negative described measurement result by described analysis portion; And determination processing step, calculate the difference between the maximal value of the described photometric parameter extracted by described extraction unit and minimum value, whether described measurement result is effective to use the difference calculated to judge, and the result of described judgement added to the described characteristic information of corresponding sample.
In various embodiments, method according to the present invention comprises any one or the multiple feature according to autoanalyzer of the present invention.
In in different, a kind of control program used in autoanalyzer is provided, autoanalyzer uses the substrate with multiple reaction vessel, described multiple reaction vessel is assigned with for the sample and reagent allowing to comprise blood, and allow described sample and described reagent to react wherein, autoanalyzer for catching the image within reaction vessel described in each, and analyzes described sample based on reacting whether to have appeared within described reaction vessel.This control program is for carrying out the process performed by autoanalyzer according to the instruction of operator, this process comprises: analytic process, utilize the multiple images of catching obtained by the image of catching within multiple reaction vessels corresponding with multiple test respectively, calculate the photometric parameter of each image, and based on this photometric parameter, and will not occur that in reaction vessel the situation of reacting is defined as feminine gender, judge whether the measurement result based on catching image is negative for each test, and analyze the characteristic information of sample; Storing process, mates and stores the described characteristic information of described sample and described measurement result; Leaching process, extracts the described photometric parameter being judged as negative described measurement result by described analysis portion; And determinating treatment course, calculate the difference between the maximal value of the described photometric parameter extracted by described extraction unit and minimum value, whether described measurement result is effective to use the difference calculated to judge, and the result of described judgement added to the described characteristic information of corresponding sample.
In various embodiments, program according to the present invention comprises any one or the multiple feature according to autoanalyzer of the present invention and method.
In in different, a kind of computer readable recording medium storing program for performing is provided, record the control program used in autoanalyzer on a computer readable recording medium, autoanalyzer uses the substrate with multiple reaction vessel, described multiple reaction vessel is assigned with for the sample and reagent allowing to comprise blood, and allow described sample and described reagent to react wherein, autoanalyzer for catching the image within reaction vessel described in each, and analyzes described sample based on reacting whether to have appeared within described reaction vessel.This control program is for carrying out the process performed by autoanalyzer according to the instruction of operator, this process comprises: analytic process, utilize the multiple images of catching obtained by the image of catching within multiple reaction vessels corresponding with multiple test respectively, calculate the photometric parameter of each image, and based on this photometric parameter, and will not occur that in reaction vessel the situation of reacting is defined as feminine gender, judge whether the measurement result based on catching image is negative for each test, and analyze the characteristic information of sample; Storing process, mates and stores the described characteristic information of described sample and described measurement result; Leaching process, extracts the described photometric parameter being judged as negative described measurement result by described analysis portion; And determinating treatment course, calculate the difference between the maximal value of the described photometric parameter extracted by described extraction unit and minimum value, whether described measurement result is effective to use the difference calculated to judge, and the result of described judgement added to the described characteristic information of corresponding sample.
In various embodiments, recording medium according to the present invention comprises any one or the multiple feature according to autoanalyzer of the present invention, method and program.
[the favourable effect of invention]
According to the present invention, threshold value with make it possible to from comparing between the difference of catching between the maximal value of the photometric parameter that view data obtains and minimum value judge that whether measurement result effective.This has played the effect obtaining reliable measurements.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of diagram according to the schematic configuration of the autoanalyzer of the present embodiment of the present invention.
Fig. 2 being negative (-) relative to abo blood group and the table of combination of reagent of positive (+) according to the present embodiment of the present invention that be diagram.
To be diagram according to Rho (D) blood group of the present embodiment of the present invention be negative Fig. 3 and the table of positive combination.
Fig. 4 is the table of diagram according to the example of the threshold value of each photometric parameter of SPC, P/C and LIA of the present embodiment of the present invention.
Fig. 5 is the threshold value of each photometric parameter of diagram SPC, P/C and LIA illustrated in fig. 4 and is negative and the figure of relation between the qualification of the positive.
Fig. 6 be diagram according to the present embodiment of the present invention, the measured value of each photometric parameter when fibrin is mixed into and qualification; And also illustrate during normal time, the measured value of photometric parameter and the table of qualification.
Fig. 7 is the photometric range of diagram according to the present embodiment of the present invention and the table of threshold value.
Fig. 8 is the process flow diagram of the analyzing and processing that diagram is implemented by autoanalyzer 1.
Fig. 9 is the process flow diagram of diagram according to the distortion of the analyzing and processing of the present embodiment of the present invention.
Figure 10 is the figure of diagram according to the example of the Pop-up screen of the present embodiment of the present invention.
Embodiment
Below, by reference to the accompanying drawings embodiments of the invention will be described, analyzer.Note, the present invention is not limited to the present embodiment, and identical Reference numeral is provided for the identical part in the description of accompanying drawing.
Fig. 1 is the schematic diagram of diagram according to the structure of the analyzer of the present embodiment.As graphic in Fig. 1, measuring mechanism 2 and control gear 3 is comprised according to the autoanalyzer 1 of the present embodiment, measuring mechanism 2 for will be analyzed sample and reagent be assigned in the predetermined hole W of microwell plate 20, with the reaction caused in measured hole W, control gear 3 for implement the whole autoanalyzer 1 comprising measuring mechanism 2 control and for implementing the analysis about the measurement result from measuring mechanism 2.Liang Ge mechanism combines the immune analysis allowing autoanalyzer 1 automatically to implement multiple sample.Microwell plate 20 is the plates be made up of the transparent material of such as acrylic acid, and has the many apertures being called as hole W of opening on the surface of microwell plate 20.Each hole W is the reaction vessel for the sample and reagent holding interreaction, and is the aperture being formed with dip plane wherein.Hole W is with on the rectangular surface being disposed in microwell plate 20.
Measuring mechanism 2 generally comprises plate transfer passage 10; Sample transport unit 11; Sample dispense mechanism 12; Reagent transport unit 13; Reagent distributor gear 14; Reaction promotion division 15; Photometric measurer 16; And plate collection unit 17.In addition, control gear 3 comprises: control part 31; Efferent 32; Analysis portion 33; Extraction unit 34; Transmission/reception unit 35; Input part 36; And storage part 37.Each portion that measuring mechanism 2 and control gear 3 comprise is electrically connected with control part 31.Sample dispense mechanism and reagent distributor gear can be generically and collectively referred to as dispenser.Plate transfer passage 10, reaction promotion division 15, photometric measurer 16 and plate collection unit 17 and microwell plate 20 can be understood to form reacting part.
Microwell plate 20 is transported to precalculated position by plate transfer passage 10, sample and reagent to be assigned in each hole W, and implements reaction promotion and light-metering to the liquid in the W of hole.Under the control of control part 31 and by the driving of driving mechanism (not shown), such as, as graphic in the arrow in Fig. 1, plate transfer passage 10 carries microwell plate 20 in left direction.
Sample transport unit 11 comprises the multiple specimen holder 11b for keeping multiple sampling receptacle 11a, and multiple sampling receptacle 11a, for holding sample, is continuously transferred in the specimen holder 11b direction of arrow in the drawings.The sample be contained in each sampling receptacle 11a is blood plasma or sediment, blood plasma is that sediment comprises the haemocyte (red blood cell) separated by centrifuging by be added to by anticoagulant the blood sample that gathers from blood donor and to make this centrifugal blood be separated and the supernatant that obtains.Be sent to sample in each sampling receptacle 11a in the precalculated position in sample transport unit 11 to be assigned to by sample dispense mechanism 12 and to be arranged on plate transfer passage 10 and in the predetermined hole W of the microwell plate 20 be transferred by plate transfer passage 10.
Recording medium is attached to the side surface part of sampling receptacle 11a.Sample message about the sample be contained in sampling receptacle 11a is recorded on the recording medium.This recording medium shows the various types of coded messages be optically readable.This sample message comprises, such as, and the name of the patient of donated blood, sex and age, project of analysis etc.
Sample message reading mechanism 11c for reading & recording medium is optically arranged on the appropriate section of sample transport unit 11.Sample message reading mechanism 11c is by infrared ray or VISIBLE LIGHT EMISSION on recording medium, and the reflected light of recording medium is left in process, with the information of reading & recording medium.Sample message reading mechanism 11c can also catch image and the process understood by catching image and the image information that obtains by process recording medium, obtains the sample message from recording medium.When sampling receptacle 11a before sample message reading mechanism 11c through out-of-date, sample message reading mechanism 11c reads the information be attached on the recording medium of sampling receptacle 11a.
Sample dispense mechanism 12 comprises: arm 12a, has the probe 12b and the probe 12c that are respectively used to suck and discharge sample of the terminal part being attached to it; And suck and exhaustjet device or the use suction of piezoelectric element and output mechanism (not shown).Sample dispense mechanism 12 sucks sample by probe 12b and 12c from the sampling receptacle 11a in the precalculated position be sent to sample transport unit 11 as above, and mobile arm 12a in above-below direction in the drawings, to distribute this sample by being discharged to by sample in each hole W.Note, probe 12b sucks and discharges the blood plasma in sampling receptacle 11a, and probe 12c sucks and discharges the haemocyte particle in sampling receptacle 11a.
The reagent that reagent set 13a is sent to for reagent distributor gear 14 by reagent transport unit 13 sucks position, and reagent set 13a is distributed in the reagent in each hole W on microwell plate 20 in reagent suction position collecting.In reagent set 13a, according to various types of test, hold the required reagent of scheduled volume, and each reagent be included in a reagent set 13a may be used for distributing pre-determined number, or may be used for distributing once.Reagent transport unit 13 collects the reagent set 13a of the allocation process experiencing pre-determined number, and another reagent set 13a that next will be assigned with is sent to reagent suction position.
Recording medium is attached to the side surface part of reagent set 13a.This recording medium shows the various types of coded messages be optically readable.Reagent reading mechanism 13b for reading & recording medium is optically arranged on the appropriate section of reagent transport unit 13.Reagent reading mechanism 13b is by infrared ray or VISIBLE LIGHT EMISSION on recording medium, and the reflected light of recording medium is left in process, with the information on reading & recording medium.Reagent reading mechanism 13b can also catch image and the process understood by catching image and the image information that obtains by process recording medium, obtains the information from recording medium.
Reagent distributor gear 14 comprises arm 14a, and arm 14a has the probe for sucking and discharge reagent of the terminal part being attached to it.Arm 14a rises freely in vertical direction and declines, and freely rotates around the perpendicular line of the base end part through arm as central shaft.Reagent distributor gear 14 comprises suction and the output mechanism (not shown) of suction and exhaustjet device or use piezoelectric element.Reagent distributor gear 14 sucks the reagent in the reagent set 13a in the precalculated position be moved in reagent transport unit 13 by each corresponding probe, counterclockwise rotate arm 14a in the drawings, and by each corresponding hole W of the microwell plate 20 that each reagent is discharged to the precalculated position be transported on plate transfer passage 10, distribute each reagent.
Reaction promotion division 15 promotes the reaction between the sample that is distributed in microwell plate 20 and reagent, causes antigen-antibody reaction, and form aggegation pattern on the basal surface of each hole W of microwell plate 20.Reaction promotion division 15 such as comes sample in poke hole W and reagent by vibrations microwell plate 20.In addition, such as, microwell plate 20 is left standstill predetermined a period of time by reaction promotion division 15, and predetermined a period of time corresponds to the content of analytical approach, to promote natural sedimentation of haemocyte particle etc.In addition, such as, react promotion division 15 and apply predetermined magnetic field, to operate the magnetic-particle be present in the W of hole.
Photometric measurer 16 light-metering ground detects the aggegation pattern formed by reaction promotion division 15.Photometric measurer 16 is such as made up of CCD camera, and catches the image of each hole W of microwell plate 20 from top, and exports the image information of catching the image of the aggegation pattern be formed in each hole W.Photometric measurer 16 also comprises: for the light of predefined type being transmitted into the light emission part on each hole W of microwell plate 20; And for receiving the light receiver of the light produced from the sample liquids each hole W, and can be output as photometry result from the briliancy of the light of sample liquids generation.
Plate collection unit 17 collects the microwell plate 20 of the light-metering process experienced by means of photometric measurer 16.By means of cleaning part (not shown), the injection of the suction of the mixing material of passing hole W and discharge and cleaning liquid and suction, the microwell plate 20 that cleaning is collected.Cleaned microwell plate 20 is reused.Note, according to the content of test, this microwell plate 20 can be discarded after one-shot measurement completes.
Next, control gear 3 will be described.Control part 31 is made up of CPU etc., and controls process and the operation of the various piece of autoanalyzer 1.Control part 31 controls being input to these elements and implementing predetermined input and output from the information that these elements export, and implements predetermined information processing to this information.Control part 31 also comprises determination processing unit 311.Determination processing unit 311 judges the validity of the measurement result extracted according to the photometric parameter of measurement result.
Efferent 32 is made up of display, printer, loudspeaker etc., and exports various types of information, and various types of information comprises the analytical information produced by analysis portion 33.Efferent 32 also exports the view data extracted by extraction unit 34 on screen.
Analysis portion 33 analyzes antigen-antibody reaction based on the photometry result measured by photometric measurer 16.When photometric measurer 16 output image information, analysis portion 33 processes the image information exported by photometric measurer 16, and obtains the light value of the briliancy corresponding to sample.Analysis portion 33 also uses for judging that agglutinating reaction is positive or negative SPC (sharpness at the edge of the image at center), P (brightness of outer peripheral areas), C (brightness of central area), LIA (size of low brightness area) etc. calculate photometric parameter, and the threshold value of this photometric parameter with each photometric parameter being stored in SPC, P/C and LIA in storage part 37 is compared.Note, the photometric parameter of SPC and P/C obtains from the value between 0 and 99, and the photometric parameter of LIA obtains from the value between 0 and 999.By the numerical value of the photometric parameter of calculating compared with the threshold value of photometric parameter, and for each test can be judged to be+(positive) ,-(feminine gender) or? (undetermined; Comparative result between positive and feminine gender, and can not judge it is which situation).Note, for the photometric parameter of P/C, P is divided by C, and the value being then multiplied by ten is used as the photometric parameter of P/C.
When existence is judged as negative measurement result by analysis portion 33, extraction unit 34 extracts from storage part 37 or scratchpad area (SPA) (not shown) the photometric parameter corresponding to measurement result.The photometric parameter extracted is output to determination processing unit 311.
Transmission/reception unit 35 has the function as interface, and this interface is used for sending and receiving information according to predetermined format via communication network (not shown).Input part 36 is made up of keyboard, mouse, microphone etc., and obtains the command information etc. of the various types of information needed for sample analyzed, analysis operation from outside.The extraction project that transmission/reception unit 35 also will be displayed on screen exports to control part 31.
Storage part 37 is made up of hard disk and storer, and hard disk is used for magnetically storing information; Storer is used for when analyzer 1 performs this process, loads and the various programs that electricity stores and process associates from hard disk.Storage part 37, for each sample, is also stored as the test result of characteristic information and the photometric parameter associated with each other for this test result.Note, storage part 37 can comprise the auxiliary memory element that can read the information be stored on medium, all cards of CD-ROM, DVD-ROM, PC in this way of storage medium etc.
In the autoanalyzer 1 of configuration as mentioned above, sample is assigned to the microwell plate 20 of multiple continus convergence from sampling receptacle 11a by sample dispense mechanism 12, and each reagent in reagent set 13a is assigned in the microwell plate 20 of multiple continus convergence by reagent distributor gear 14; Then, photometric measurer 16 sample with capture reaction image under the state of reagent reacting; And the view data that analysis portion 33 analysis is caught, automatically to implement analysis of the agglutinating reaction of sample etc.
Below, the judgement in logic of the test about abo blood group and Rho (D) blood group that analysis portion 33 is implemented is described through with reference to Fig. 2 and 3.Fig. 2 being negative (-) and the combination of positive (+) according to each reagent relative to abo blood group of the present embodiment of the present invention that be diagram.Fig. 3 being negative and the table of combination of positive Rho (D) blood group according to the present embodiment of the present invention that be diagram.Graphicly in analysis portion 33 constitutional diagram 2 and 3 to be negative and the result of each positive reagent, to judge the test result of abo blood group as the characteristic information of sample and Rho (D) blood group.In the test result of the present embodiment, judge abo blood group according to relation graphic in Fig. 2 and by the agglutinating reaction of combining for anti-A antibody (anti-A), anti-B antibody (anti-B), A haemocyte (A cell) and B haemocyte (B cell); And according to relation graphic in Fig. 3 and by combination, Rho (D) blood group is judged for anti-D (anti-D) and benchmark (Ref).Here, the judgement of abo blood group can only utilize anti-A antibody and anti-B antibody to carry out.
In the result of reagent be negative and positive judgement derives from and the comparing of the threshold value of each photometric parameter of SPC, P/C and LIA as above.Fig. 4 is the table of diagram according to the example of the threshold value of each photometric parameter of SPC, P/C and LIA of the present embodiment of the present invention.Fig. 5 is the threshold value of each photometric parameter that SPC, P/C and LIA illustrated in fig. 4 are described and is negative and the figure of relation between the judgement of the positive.
In the example of the graphic threshold value for qualitatively judging in the diagram, each measurement parameter of SPC, P/C and LIA has and corresponds to the positive threshold value that judges and correspond to the negative threshold value judged.SPC is set to 10, and as the threshold value judged for the positive (low), and SPC is set to 20, as the threshold value judged for feminine gender (height).P/C is set to 20, and as the threshold value judged for feminine gender ((-) limit), and P/C is set to 30, as the threshold value judged for the positive ((+) limit).LIA is set to 100, and as the threshold value judged for feminine gender ((-) limit), and LIA is set to 400, as the threshold value judged for the positive ((+) limit)." benchmark " refers to standard reagent; And the physiological salt solution not comprising reactive ingredients is as reagent and sample mix, to confirm response diagram picture.Standard reagent always forms negative response diagram picture, and negative response diagram picture may be used for and the comparing of the measurement result of various test equally.
According to the setting of the threshold value for qualitatively judging, based on the calculated value of photometric parameter, and with reference to being used for the regional of graphic judgement in Fig. 5, analysis portion 33 judges whether the photometric parameter of each reagent in each reagent is negative.Particularly, about photometric parameter SPC, if the value of the photometric parameter SPC obtained is less than the threshold value (low) judged for the positive, that is, 10, so analysis portion 33 judges that this result is as positive.If the value of the photometric parameter SPC obtained is greater than the threshold value (height) judged for feminine gender, that is, 20, so analysis portion 33 judges that this result is as negative.In addition, if the value of photometric parameter SPC is some values between 10 to 20, so analysis portion 33 judge this judgement be impossible (Fig. 5:?).
On the other hand, about photometric parameter P/C, if the value of the photometric parameter P/C obtained is less than the threshold value judged for the positive, that is, 30, so analysis portion 33 judges that this result is as positive.If the value of the photometric parameter P/C obtained is greater than the threshold value judged for feminine gender, that is, 20, so analysis portion 33 judges that this result is as negative.In addition, if the value of photometric parameter P/C is some values between two threshold values, that is, between 20 to 30, so this result can be judged as positive or negative (Fig. 5 :+or-).In this case, the result based on other photometric parameter judges reagent result.For photometric parameter LIA, be similar to the situation of P/C, if value is less than the threshold value judged for the positive, that is, 400, so the result of photometric parameter LIA is judged as the positive; If value is greater than the threshold value judged for feminine gender, that is, 100, so this result is judged as feminine gender; And if the value of photometric parameter LIA is between two threshold values, that is, some values between 100 to 400, so this result is determined to be positive or negative (Fig. 5 :+or-).In this case, the result based on other photometric parameter judges reagent identification result.Note, for the setting of the threshold value of the qualitative judgement of each photometric parameter and the decision method of reagent result be not limited to as above those.
Judging to correspond to each photometric parameter of reagent in analysis portion 33 is negative or after the positive, and if the result of determination of each photometric parameter of SPC, P/C and LIA be identical, so the result of determination of photometric parameter is determined as reagent result.Here, if a result of determination in the middle of the result of determination of lucky SPC, P/C and LIA is different from remaining, so reagent identification result is judged as undetermined.Priority can be set for each photometric parameter in each photometric parameter, and the result of determination of a photometric parameter with higher priority can be used as reagent result, judge reagent result.
Use the reagent identification result that obtained by flow process as above and according to combination graphic in Fig. 2 and 3, judge the result of each project of qualification.Note, can judge that other reagent of such as irregular antibody is negative or positive with similar flow process.
Subsequently, be described in foreign matter with reference to Fig. 6,7 and 8 and distribute in the situation of sample mix, such as, when fibrine precipitation in the sample to which the validity of test result.Fibrin, in blood plasma and associates with blood clotting because the effect of proteinase and calcium forms fibrin polymer as fibrinogenolysis.For blood analysis, in order to solidifying of the blood that prevents from causing due to fibrin, anticoagulant is added; But, there are the fibrinous precipitation caused owing to changing in time or the situation occurring clot due to insufficient mixing of anticoagulant, and the fibrin of precipitation or clot are mixed to and will be captured as in the reaction vessel of image, cause the mistake of check result to be identified.
Fig. 6 illustrates according to the present embodiment of the present invention, the measured value of each photometric parameter when fibrin is mixed into and result; And illustrate by the measured value of the photometric parameter of normal allocation and the table of result.For sample, use identical sample, and the condition mixed with fibrin at a sample (abnormal distributes) is middle implements reaction treatment and analyzing and processing.As graphic in Fig. 6, calculate the numerical value of photometric parameter about each reagent respectively, and carry out being negative based on this numerical value or the judgement of the positive.
At this, about anti-A (anti-A antibody), the result sucking fibrinous sample is different from the result by normal allocation.So, A type sample is misjudged is decided to be O type, and this can cause the accident during blood transfusion.This mistake occurs it being because the fibrinous image of this clot or precipitation is captured, and in computing interval of each photometric parameter, it is non-agglutination image that the fibrinous image of this clot or precipitation is mistakenly considered, and supposes that this result is judged as the positive simultaneously.In the present embodiment, know the result of this mistake, then the validity of measurement result is determined.
By photometric range graphic in calculating chart 6 threshold value graphic in it and Fig. 7 compared the judgement carrying out validity.Fig. 7 is the photometric range of diagram according to the present embodiment of the present invention and the table of threshold value.Each photometric range is the value being judged as the difference between the maximal value of the numerical value of each photometric parameter of negative reagent and minimum value by calculating in the middle of each reagent for analyzing identical sample and obtaining.Such as, when the LIA of abnormal distribution (fibrin is inhaled into), maximal value is 869 of anti-A, and minimum value is 390 of anti-B, and the difference calculated, that is, 479 be defined as light value scope.In addition, when LIA during normal allocation, maximal value is 689 of anti-B and minimum value is 679 of benchmark, and light value scope is defined as 10.By arranging graphic threshold value in Fig. 7 for the light value scope so obtained, judge for the identification of parameters whether reliable, and judge that whether this qualification effective.
In the figure 7, when fibrin is inhaled into, the light value scope of P/C and SPC is 11 and 6 respectively, but when sample is normally allocated, P/C scope and SPC scope both 1.In addition, when fibrin is inhaled into, LIA scope is 479, is scope wide in the middle of each reagent.But when sample is normally allocated, this scope is 10, it is little value.By arranging the threshold value of this difference be used between photometric range, the validity of discriminating test result.Note, any threshold values can be set, and threshold value for invalid judgement can be changed according to the project checked or the type of sample.
Next, the flow process of analyzing and processing as above is described with reference to Fig. 8.Fig. 8 is the process flow diagram of the analyzing and processing that diagram is implemented by autoanalyzer 1.If control part 31 obtains from photometric measurer 16 and catches view data (step S102), so control part 31 indicates analysis portion 33 to calculate photometric parameter (step S104) from the view data of catching obtained; Instruction analysis portion 33 judges that each reagent is negative or positive (step S106); And indicate analysis portion 33 to come discriminating test result (characteristic information) (step S108) based on the result of determination of step S106.
After the judgement of test result (characteristic information), control part 31 is confirmed whether to be judged as relative to the reagent except benchmark any reagent identification (step S110) be negative.Here, if there is any reagent to be determined to be negative (step S110: yes), so control part 31 indicates extraction unit 34 to extract object photometric parameter (step S112).After the extraction of photometric parameter, the photometric parameter of extraction is outputted to determination processing unit 311 by control part 31, can calculate light value scope (step S114).
After the calculating of photometric range, determination processing unit 311 judges whether the light value scope of each photometric parameter is less than threshold value (step S116 to S120).First, determination processing unit 311 judges whether the light value scope (LIA scope) of photometric parameter LIA is less than threshold value (step S116).Here, if LIA scope is less than threshold value (step S116: yes), so determination processing unit 311 moves to step S118, and judges whether the light value scope (P/C scope) of photometric parameter P/C is less than threshold value.If P/C scope is also less than threshold value (step S118: yes), so determination processing unit 311 moves to step S120, and judges whether the light value scope (SPC scope) of photometric parameter SPC is less than threshold value.If SPC scope is less than threshold value (step S120: yes), so because each scope of photometric parameter is less than each threshold values, so determination processing unit 311 discriminating test result is effective, and determination processing unit 311 will identify it is that effective information outputs to control part 31 to the effect that.Be say that qualification is the input of effective information because of carelessness, control part 31 moves to step S124.In step S124, if there is the measurement result (step S124: yes) for the next object analyzed, so control part 31 moves back to step S102 to repeat process as above.If there is no measurement result (step S124: no), so operate end.
On the other hand, if at any step S116 to S120, any light value scope is more than or equal to corresponding threshold value (step S116, S118, S120: no), so determination processing unit 311 judges the numerical exception of photometric parameter, and the qualification result information this numerical value being to the effect that accredited as exceptional value is added to test result (characteristic information) (step S122).Once the information that the qualification result information to the effect that receives has been added, control part 31 just moves to step S124.
In addition, if be not judged as negative reagent identification (step S110: no) in step S110, so control part 31 moves to step S124.
By process as above, identify that whether the photometric parameter obtained from view data is effective, thus the validity of discriminating test result (characteristic information), so make it can improve the reliability of the data of acquisition.
Should note, although in fig. 8 in graphic process flow diagram, if a parameter exceedes corresponding threshold value, so three parameter LIA, P/C and SPC are judged as and have exceptional value, if but all three parameters all exceed threshold values, also can judge that this parameter has exceptional value.Fig. 9 is the process flow diagram of the distortion of the analyzing and processing illustrated according to the present embodiment of the present invention.
Be similar to graphic process flow diagram in Fig. 8, if control part 31 obtains from photometric measurer 16 catch view data (step S202), so control part 31 indicates analysis portion 33 to calculate photometric parameter (step S204) from the view data of catching obtained; Instruction analysis portion 33 judges that each reagent is negative or positive (step S206); And indicate analysis portion 33 to come discriminating test result (characteristic information) (step S208) based on the qualification result of step S206.
After the judgement of test result (characteristic information), control part 31 is confirmed whether to be judged as relative to the reagent except benchmark any reagent identification (step S210) be negative.Here, if there is any reagent to be determined to be negative (step S210: yes), so control part 31 indicates extraction unit 34 to extract object photometric parameter (step S212).After the extraction of photometric parameter, the photometric parameter of extraction is outputted to determination processing unit 311 by control part 31, can calculate light value scope (step S214).
After the calculating of photometric range, determination processing unit 311 judges whether the light value scope of each photometric parameter is more than or equal to threshold value (step S216 to S220).First, determination processing unit 311 judges whether the light value scope (LIA scope) of photometric parameter LIA is less than threshold value (step S216).Here, if LIA scope is more than or equal to threshold value (step S216: yes), so determination processing unit 311 moves to step S218, and judges whether the light value scope (P/C scope) of photometric parameter P/C is more than or equal to threshold value.If P/C scope is also more than or equal to threshold value (step S218: yes), so determination processing unit 311 moves to step S220, and judges whether the light value scope (SPC scope) of photometric parameter SPC is more than or equal to threshold value.If SPC scope is more than or equal to threshold value (step S220: yes), so because each scope of photometric parameter is more than or equal to each threshold values, so determination processing unit 311 judges that photometric parameter has exceptional value and test result is invalid, and the information that photometric parameter is to the effect that had an exceptional value by determination processing unit 311 adds test result (characteristic information) to, and information photometric parameter to the effect that with exceptional value outputs to control part 31 (step S222).Once receiving test result is to the effect that invalid information, control part 31 just moves to step S224.In step S224, if there is the measurement result (step S224: yes) for the next object analyzed, so control part 31 moves back to step S202 to repeat process as above.If there is no measurement result (step S224: no), so operate end.
On the other hand, if at any step S216 to S220, any light value scope is less than corresponding threshold value (step S216, S218, S220: no), so determination processing unit 311 judges that the numerical value of photometric parameter is effective, and will photometric parameter be that effective information outputs to control part 31 to the effect that.Once the information that the qualification result information to the effect that receives has been added, control part 31 just moves to step S224.In addition, in step S210, if be not judged as negative reagent identification (step S210: no) in step S210, so control part 31 moves to step S224.
By process as above, when all light value scopes of each photometric parameter all exceed each threshold value, the judgement of this exceptional value can be carried out.
In the present embodiment, although in step S110 and S210, except benchmark, find out negative findings, also can find out the multiple negative findingses whether having and comprise this benchmark.In fact, the result of benchmark always turns out to be feminine gender.So, if be judged as the positive relative to benchmark, so reason is caused by the factor of other except fibrinous precipitation or clot.In that case, the confirmation of separate kind will be needed.
In addition, the order of photometric parameter compared with threshold value can be any order.According to the characteristic of parameters relative to the type of sample or reagent, this order can be changed to any order.
Here, photometric parameter is accredited as has exceptional value and the information that photometric parameter has an exceptional value is to the effect that added to the display of the result of the test result of test result (characteristic information), can so be carried out, namely, when the result that efferent 32 shows test results, the shade of corresponding test result and/or reagent identification and/or photometric parameter part utilization interpolation is shown; Or the word associated from qualification and numerical value can be shown with different colors.
In addition, when have be accredited as abnormal photometric parameter time, efferent 32 also can show message.Figure 10 is the figure of diagram according to the example of the Pop-up screen of the present embodiment of the present invention.Efferent 32 can in such as Figure 10 graphic Pop-up screen W1 monitor etc. on show the message of sample ID as analytical information and measurement result exception to the effect that.
For the time of display, when result is judged as abnormal, or when operator confirms this result, can show.When operator confirms this message and presses OK button B1, also Pop-up screen W1 can be set to close, or when OK button B1 is pressed, also can will be used for confirming that the screen of measurement result is set to be displayed automatically.
The misjudged fixed measurement result due to the pollution of foreign matter is allowed suitably to be extracted and confirm according to the autoanalyzer of embodiment as above.Except having fibrinous situation, this autoanalyzer also can deal with this situation as foreign substance pollution sample (catching in image).According to the analyzing and processing of the present embodiment, owing to carrying out whether effectively judging about measurement result based on the change of catching in image, so the comparison of the numerical value of photometric parameter allows invalid measurement result suitably to be extracted.
Here, relative to the process flow diagram in Fig. 8 and 9, about the photometric parameter compared with threshold value, can only by the photometric parameter of measured value most marked change due to the pollution of impurity, such as, the light value scope of LIA, compares with threshold value.Also can by two optional photometric parameters, each light value scope of such as LIA and P/C and threshold value compare.The photometric parameter used in the present invention can be arbitrarily selected according to the character of the characteristic of reagent or sample.
Control program for controlling the process performed by autoanalyzer 1 is mounted the storage part 37 of graphic control gear 3 in FIG.Usually, in the storer of computing machine, install this control program allows computing machine to play the function partly or completely of control gear 3 (Fig. 1).This control program can be mounted on a memory before the delivery of computing machine, or can be mounted on a memory after the delivery of computing machine.By reading record program on the recording medium, program can be installed on the storer of computing machine, or can be mounted on a memory via the program that the network of such as the Internet is downloaded.For computing machine, the computing machine of any type can be used.
Once control program is mounted on computers, computing machine will play the function partly or completely of control gear 3 (Fig. 1).In this case, the control gear 3 (Figure 17) in operation means that the control method corresponding to the control program installed just is performed.This is because this control method corresponds to the method for operating for this control gear.
As mentioned above, by utilizing its preferred embodiment to illustrate the present invention.But the present invention should only be explained based on embodiment as above.Understand, scope of the present invention should only be explained based on claims.Same understanding, those skilled in the art based on the general knowledge of description of the invention and the description from detailed preferred embodiment of the present invention, can realize the scope of the technology of equivalence.In addition, understanding, any patent quoted in current instructions, any patented claim and any document should be bonded in current instructions by reference to the same manner be specifically described wherein.
This application claims the right of priority of No. 2009-269039th, Japanese patent application, and understanding is, full content by reference to being bonded to this, using the same manner as the content described particularly in current instructions, as a part for the current instructions of composition.
Industrial applicibility
As mentioned above, autoanalyzer according to the present invention can be used for extracting the measurement result of misinterpretation, and is particularly suitable for the analyzing and processing made based on image.
[list of reference signs]
1 autoanalyzer
2 measuring mechanisms
3 control gears
10 plate transfer passages
11 sample transport units
11a sampling receptacle
11b specimen holder
11c sample information reading mechanism
12 sample dispense mechanisms
12a, 14a arm
12b, 12c probe
13 reagent transport units
13a reagent set
13b reagent reading mechanism
14 reagent distributor gears
15 reaction promotion divisions
16 photometric measurers
17 plate collection units
20 microwell plates
31 control parts
311 determination processing units
32 efferents
33 analysis portion
34 extraction units
35 transmission/reception units
36 input parts
37 storage parts
Claims (8)
1. an automatic analysis method, it is characterized in that, use the substrate with multiple reaction vessel, described multiple reaction vessel is assigned with for the sample and reagent allowing to comprise blood, and allow described sample and described reagent to react wherein, described method for catching the image within reaction vessel described in each, and analyzes described sample based on reacting whether to have appeared within described reaction vessel, and described method comprises:
Analytical procedure, utilize the multiple images of catching obtained by the image of catching within multiple reaction vessels corresponding with multiple inspection item respectively, calculate the photometric parameter of image described in each, and based on described photometric parameter, and will not occur that in described reaction vessel the situation of reacting is defined as feminine gender, judge based on described measurement result of catching image, whether inspection item described in each to be negative, and analyze the characteristic information of described sample;
Storing step, mates and stores the described characteristic information of described sample and described measurement result;
Extraction step, extracts the described photometric parameter being judged as negative described measurement result by described analytical procedure; And
Determination processing step, calculate the difference between the maximal value of the described photometric parameter extracted by described extraction step and minimum value, use the difference of this calculating to judge that whether described measurement result is effective, and the result of this judgement is added to the described characteristic information of corresponding sample.
2. the method for claim 1, is characterized in that, described method used by autoanalyzer, and described autoanalyzer comprises:
For distributing the dispenser of described sample;
Comprise the reacting part of described substrate, described substrate has multiple reaction vessels that described sample and described reagent for allowing to comprise blood react wherein;
Photometric measurer, for catching the described image within reaction vessel described in each;
Control part;
Wherein, described control part comprises determination processing unit;
Wherein, described control part is connected to analysis portion, extraction unit and storage part; And
Wherein, described control part is configured to carry out the method for claim 1.
3. method as claimed in claim 1 or 2, is characterized in that,
At least two described photometric parameters are selected from the group comprising P/C, SPC and LIA;
If the described difference of photometric parameter described at least one is outside preset range, so described determination processing step judges that described measurement result is invalid; And
Wherein, the P in P/C represents the brightness of outer peripheral areas, and the C in P/C represents the brightness of central area, and P is divided by C, and the value being then multiplied by ten is used as described photometric parameter P/C;
Wherein, SPC is the sharpness at the edge of the image at center, and
Wherein, LIA is the size of low brightness area.
4. method as claimed in claim 1 or 2, is characterized in that,
Photometric parameter described at least one is selected from the group comprising P/C, SPC and LIA; And
If the described difference of all described photometric parameters is outside preset range, so described determination processing step judges that described measurement result is invalid, and
Wherein, the P in P/C represents the brightness of outer peripheral areas, and the C in P/C represents the brightness of central area, and P is divided by C, and the value being then multiplied by ten is used as described photometric parameter P/C;
Wherein, SPC is the sharpness at the edge of the image at center, and
Wherein, LIA is the size of low brightness area.
5. method as claimed in claim 1 or 2, is characterized in that, is always show negative standard reagent according to the reagent that described multiple inspection item uses.
6. method as claimed in claim 2, it is characterized in that, described autoanalyzer comprises efferent further, if described measurement result is judged as invalid by described determination processing step, so described efferent exports and shows the information that described measurement result is invalid.
7. method as claimed in claim 2, it is characterized in that, described method is implemented the control program as being undertaken by described control part.
8. method as claimed in claim 7, it is characterized in that, described control program is recorded on a computer readable recording medium.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009269039A JP5274436B2 (en) | 2009-11-26 | 2009-11-26 | Automatic analyzer |
| JP2009-269039 | 2009-11-26 | ||
| PCT/JP2010/006832 WO2011064982A1 (en) | 2009-11-26 | 2010-11-22 | Automatic analysis device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102656462A CN102656462A (en) | 2012-09-05 |
| CN102656462B true CN102656462B (en) | 2014-12-17 |
Family
ID=44066094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080053574.5A Active CN102656462B (en) | 2009-11-26 | 2010-11-22 | Automatic analyzer |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8974733B2 (en) |
| JP (1) | JP5274436B2 (en) |
| CN (1) | CN102656462B (en) |
| WO (1) | WO2011064982A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6276087B2 (en) * | 2014-03-28 | 2018-02-07 | シスメックス株式会社 | Sample analyzer and sample analysis method |
| GB201415329D0 (en) | 2014-07-21 | 2014-10-15 | Ge Healthcare Bio Sciences | Parallel cell processing method and facility |
| WO2016130964A1 (en) | 2015-02-13 | 2016-08-18 | Abbott Laboratories | Decapping and capping apparatus, systems and methods for use in diagnostic analyzers |
| WO2018006050A1 (en) * | 2016-06-30 | 2018-01-04 | Beckman Coulter, Inc. | Substance dispense evaluation system |
| CN107091935A (en) * | 2017-04-20 | 2017-08-25 | 陈凡 | Automate General layout Plan of blood clotting Inhibition test work station and application thereof |
| EP3645166A4 (en) | 2017-06-30 | 2021-04-21 | SRI International | Apparatuses for reaction screening and optimization, and methods thereof |
| EP3701271A1 (en) * | 2017-10-27 | 2020-09-02 | Beckman Coulter, Inc. | Sample container recognition |
| JP7054343B2 (en) * | 2017-12-26 | 2022-04-13 | 川崎重工業株式会社 | Dispensing device and dispensing method |
| WO2024053025A1 (en) * | 2022-09-07 | 2024-03-14 | 株式会社日立ハイテク | Dispenser and analysis device |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07119768B2 (en) * | 1986-07-04 | 1995-12-20 | 株式会社日立製作所 | Dicecrete automatic analysis method |
| JPH10223379A (en) * | 1997-02-07 | 1998-08-21 | Mitsubishi Electric Corp | Luminaire supervising device |
| JPH11142412A (en) * | 1997-11-05 | 1999-05-28 | Hitachi Ltd | Automatic analyzer |
| JP4285171B2 (en) * | 2003-09-26 | 2009-06-24 | 株式会社日立製作所 | Alternator abnormality detection apparatus and method |
| JP4902419B2 (en) * | 2007-04-27 | 2012-03-21 | ベックマン コールター， インコーポレイテッド | Analysis apparatus and analysis method |
| JP2009020059A (en) * | 2007-07-13 | 2009-01-29 | Hitachi High-Technologies Corp | Automatic analyzer and analysis method of the same |
-
2009
- 2009-11-26 JP JP2009269039A patent/JP5274436B2/en active Active
-
2010
- 2010-11-22 CN CN201080053574.5A patent/CN102656462B/en active Active
- 2010-11-22 WO PCT/JP2010/006832 patent/WO2011064982A1/en active Application Filing
-
2012
- 2012-05-16 US US13/473,544 patent/US8974733B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011112501A (en) | 2011-06-09 |
| US20120270336A1 (en) | 2012-10-25 |
| WO2011064982A1 (en) | 2011-06-03 |
| US8974733B2 (en) | 2015-03-10 |
| JP5274436B2 (en) | 2013-08-28 |
| CN102656462A (en) | 2012-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102656462B (en) | Automatic analyzer | |
| US8524153B2 (en) | Quality control system | |
| EP2040081B1 (en) | Sample analyzer and error information displaying method | |
| US9074971B2 (en) | Sample processing apparatus and non-transitory storage medium | |
| KR20190076009A (en) | Material Preparation Evaluation System | |
| EP2237033B1 (en) | Urine sample analyzer | |
| US8871147B2 (en) | Sample analyzer and storage medium | |
| WO2009110583A1 (en) | Analysis apparatus and measurement unit | |
| EP2299276A2 (en) | Sample processing apparatus and sample processing method | |
| EP1837660A1 (en) | Automated analyzer with a self-test reagent cartridge | |
| EP2690443B1 (en) | Specimen analysis device, specimen information processing device, and specimen analysis method | |
| EP2083275B1 (en) | Sample processing apparatus, method of outputting processing result by sample processing apparatus, and computer program product | |
| CN115144603A (en) | Automatic analysis device and automatic analysis method | |
| JP2008058129A (en) | Autoanalyzer | |
| JP4283350B2 (en) | Method for detecting abnormal reactions in cassettes used to classify hemagglutination | |
| JP5869068B2 (en) | Sample processing equipment | |
| CN101965518A (en) | Cleaning equipment and analyzer | |
| JP2005106506A (en) | System and device for clinical examination | |
| EP4130748A1 (en) | Automatic analysis system | |
| JP5346737B2 (en) | Sample testing apparatus and information management apparatus used therefor | |
| JP2008256547A (en) | Automatic analyzer | |
| JP2010266271A (en) | Abnormality cause estimation method, analysis system, and information management server device | |
| JP6696172B2 (en) | Analytical apparatus, analytical method, and analytical system | |
| WO2024057718A1 (en) | Automatic analysis device | |
| JP2013253993A (en) | Sample analyzing device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |