CN102645419A - Multi-channel wireless cascade surface plasma resonance spectrometer - Google Patents
Multi-channel wireless cascade surface plasma resonance spectrometer Download PDFInfo
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- CN102645419A CN102645419A CN2012101107280A CN201210110728A CN102645419A CN 102645419 A CN102645419 A CN 102645419A CN 2012101107280 A CN2012101107280 A CN 2012101107280A CN 201210110728 A CN201210110728 A CN 201210110728A CN 102645419 A CN102645419 A CN 102645419A
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Abstract
The invention relates to a multi-channel wireless cascade surface plasma resonance spectrometer which is characterized by comprising a plurality of independent 8-channel surface plasma resonance spectrum wireless detection modules (8-channel-SPR (Surface Plasmon Resonance)) and a main control computer for wireless data receiving and data processing and controlling. The number of the 8-channel-SPR modules can be optionally configured to be 1-12; the main control computer can automatically identify the 8-channel-SPR modules in an area; and the surface plasma resonance spectrometer with 96 channels at most can be formed, so that the high-throughput analysis of 96 samples is realized. The multi-channel wireless cascade surface plasma resonance spectrometer has the advantages that the spectrometer adopts a framework structure collected in a distributive manner and managed in a centralizing manner, the space limit is broken through in a wireless cascade manner, the configuration is convenient and flexible, and different scales of application can be satisfied. Meanwhile, each independent 8-channel-SRP module comprises a micro-flow control system, a SPR sensing system, a time division multiplexing optical fiber light spectrum detection system, an automatic control system and a wireless transmission module, and the detection of the massive samples can be quickly finished. The multi-channel wireless cascade surface plasma resonance spectrometer has the characteristics of super sensitivity, high flux, low cost and the like.
Description
Technical field
The present invention relates to a kind of high flux, high sensitivity harm factorial analysis measuring equipment, particularly about a kind of channel wireless radio multi cascade surface plasma resonance spectrometer.
Background technology
Surface plasma resonance spectrometer (Surface Plasmon Resonance; SPR); Also claim the interaction of molecules spectrometer; As a kind of hypersensitive Fast Detection Technique, be widely used in interaction of molecules research in fields such as life science, drug screening, food securities, demonstrate great application prospect.The SPR testing process need not the mark sample, has kept molecular activity, and testing process is convenient and swift, has characteristics such as highly sensitive, high precision, and is generally good by external large-scale instrument company, and begun to research and develop on a large scale.
Existing SPR instrument mainly adopts single channel or binary channels detecting pattern; Can't satisfy the high throughput testing demand; Yet in fields such as food security, inspection and quarantine, consumer goods safety, bio-safeties, sample size is huge and growing, and sample concentration, composition vary; Therefore, press for the rapid screening that to realize sample and hypersensitive and confirm the hyperchannel, hypersensitive, the high-throughout New type of S PR spectrometer that detect.Simultaneously, because the difference of concrete application scenario, the requirement of instrument detecting handling capacity also there is difference; In order to satisfy requirements of different users; Practice thrift cost, should develop the convenient, flexible collocation channel number of a kind of ability, and can distributed capture; The SPR spectrometer of centralized management, the customization flexible customization of realization instrument scale.
The optical sensor system of SPR instrument mainly contains two kinds of prism and optical fiber, respectively has superiority.Wherein the prism class SPR system development time is studied morely the earliest, is that series such as BIAcore is adopted, and major advantage is that precision is very high, but testing expense is higher, the difficulty is integrated; And types of fiber SPR, the coupled apparatus that is about in the SPR sensor will adopt optical fiber instead, though precision decreases, volume is small, specimen is cheap, easy of integration.
Summary of the invention
The technical matters that the present invention will solve is: overcome existing SPR instrument and mainly adopt single channel or binary channels detecting pattern, can't satisfy the high throughput testing demand, proposed a kind of channel wireless radio multi cascade surface plasma resonance spectrometer.This instrument adopts distributed capture, and the framed structure of centralized management adopts wireless cascade system to break through the restriction in space, and convenient configuration is flexible.Can carry out the personalized customization of instrument scale (port number) according to user's real needs.Simultaneously, for each standalone module, each sense channel can be according to wherein one group of concrete application demand apolegamy prism or Fibre Optical Sensor assembly; And the fiber spectrum detection system of using time-sharing multiplex carries out hyperchannel spectral detection simultaneously, when guaranteeing test performance, greatly reduced instrument cost.This instrument has high flux, hypersensitive, characteristics cheaply.
Technical solution of the present invention is: a kind of channel wireless radio multi cascade surface plasma resonance spectrometer; It is characterized in that: comprise the spectrum radio detection module of 8 channel surface plasma resonances independently and be used for the main control computer of wireless data reception, data processing and control; Wherein, According to concrete application need; 8 channel surface plasma resonances spectrum radio detection module can dispose 1 ~ 12 group arbitrarily; Main control computer is discerned the spectrum of 8 channel surface plasma resonances in zone radio detection module automatically, can form the surface plasma resonance spectrometer of 96 passages at most, high throughput analysis when realizing 96 samples; Described 8 channel surface plasma resonances are composed the radio detection module, comprise fiber spectrum detection system, automatic control system and the wireless transport module of microfluidic system, surface plasma sensor-based system, time-sharing multiplex.
Described surface plasma sensor-based system comprises light source, prism sensory package and Fibre Optical Sensor assembly, adopts the wavelength-modulated mode, and each sense channel can be according to wherein one group of concrete application demand apolegamy prism or Fibre Optical Sensor assembly.
The light source of described surface plasma sensor-based system is the halogen tungsten light source; The prism sensory package is the cylindricality prism, and its xsect is an isosceles triangle, and the bottom surface is coated with the metallic reflective coating on plane; The Fibre Optical Sensor assembly connects light source cell, Fibre Optical Sensor unit and optical sensor respectively by one or more optical fiber.
The core of described microfluidic system is micro-fluidic sample cell, is responsible for the transmission of sample and moving phase mixed solution, accurately controls the flow velocity and the stability of sample pool inner fluid.
Described wireless transport module, the Wi-Fi home control network communication protocol of employing IEEE 802.11.
The fiber spectrum detection system of time-sharing multiplex adopts the 8-1 multichannel optical switch to carry out light path to switch, the shared same spectral detection of 8 passages system, and optical sensor is a ccd detector.Automatic control system links to each other with other each sub-systems respectively, according to each assembly synergistic work of requirement control of testing process.Wireless transport module is responsible for the transmission of signal, comprises the transmission that detects data and the reception of Host Command, adopts Wi-Fi (IEEE 802.11) home control network communication protocol.
Compared with prior art; Advantage of the present invention: (1) this instrument adopts distributed capture, and the framed structure of centralized management is an elementary cell with 8 channel surface plasma resonances spectrum radio detection module; Adopt wireless cascade system to break through the restriction in space, convenient configuration is flexible.The personalized customization of instrument scale (port number) can be carried out according to user's real needs, the surface plasma resonance spectrometer of 96 passages can be formed at most, high throughput analysis when can realize 96 samples.(2) adopt the fiber spectrum detection system of time-sharing multiplex, carry out light path through the 8-1 multichannel optical switch and switch, make 8 to measure the shared same spectral detection of passage system, when guaranteeing instrument performance, greatly reduce instrument cost.
Description of drawings
Fig. 1 channel wireless radio multi cascade surface plasma resonance spectrometer connects sketch.
Fig. 28 channel surface plasma resonances spectrum radio detection module frame chart.
Fig. 3 single channel SPR sensing and detecting system connects synoptic diagram.
Label title in the above accompanying drawing: 1.8 channel surface plasma resonances spectrums radio detection module, 2. main control computer, 11. automatic control systems, 12. wireless transport modules, 13.SPR sensor-based system; 14. microfluidic system, 15. time-sharing multiplex fiber spectrum detection systems, 131. prism sensory packages, 132. Fibre Optical Sensor assemblies, 1311. prism sensory package light sources; 1312. lens 1,1313. lens 2,1314. polaroids, 1315. prisms, 1316. metallic reflective coatings; 1317. lens 3,1318. optical fiber, 1321. Fibre Optical Sensor assembly light sources, 1322.P type polaroid; 1323.Y the type fiber coupler, 1324. coupling mechanism joints, 1325. sensor fibres, 1326. end reflection formula optical fiber surface plasmon sensor probes; 151.8-1 photoswitch, 152. slits, 153. gratings, 154.CCD detector.
Embodiment
Below in conjunction with accompanying drawing and embodiment the present invention is further described:
Embodiment 1:
Shown in accompanying drawing 1; A kind of channel wireless radio multi cascade surface plasma resonance spectrometer; By some of the spectrum of 8 channel surface plasma resonances independently radio detection module 1 (8-channel-SPR); Constitute with main control computer 2, adopt Wi-Fi (IEEE 802.11) wireless communication mode to carry out the data double-way transmission.Wherein, 8-channel-SPR radio detection module 1 is responsible for the high throughput testing of hyperchannel sample, and will detect data in real time and be sent to main control computer through wireless network, accepts the steering order of main control computer simultaneously; Main control computer 2 is used for wireless data reception, data processing and centralized control.According to concrete application need; 8-channel-SPR radio detection module can dispose 1 ~ 12 arbitrarily; Main control computer can be discerned the 8-channel-SPR module in the zone automatically, can form the surface plasma resonance spectrometer of 96 passages at most, high throughput analysis when can realize 96 samples.This instrument adopts distributed capture, and the framed structure of centralized management adopts wireless cascade system to break through the restriction in space, and convenient configuration is flexible, can satisfy different scales and use.
Embodiment 2:
Referring to shown in Figure 2; 8 channel surface plasma resonances spectrums radio detection module by 8 independently sense channel constitute; Except automatic control system 11; Wireless transport module 12 and time-sharing multiplex fiber optic detection system 15 be 8 passages shared outside, other microfluidic system 14 are the independent cover of each passage with SPR sensor-based system 13.The core of microfluidic system 14 is micro-fluidic sample cell, is responsible for the transmission of sample and moving phase mixed solution, accurately controls the flow velocity and the stability of sample pool inner fluid.Sample in 13 pairs of sample pools of SPR sensor-based system carries out check and analysis; Adopt the wavelength-modulated mode; According to concrete application demand apolegamy prism sensory package 131 or Fibre Optical Sensor assembly 132; Break the boundary line that prism sensing cell or optical fiber sensing cell use separately, be applicable to the online check and analysis of the big sample of concentration difference.The optical signalling that SPR sensor-based system 13 is obtained gets into time-sharing multiplex fiber optic detection system 15; Time-sharing multiplex fiber optic detection system 15 closes the switching that switch is realized the multi-channel detection signal through the light of a 8-1; Utilize same set of spectrum detection device to realize 8 passages are detected simultaneously, lowering apparatus cost greatly under the situation that does not reduce system performance.Automatic control system 11 links to each other respectively at other each sub-systems, according to each assembly synergistic work of requirement control of testing process.Wireless transport module 12 is responsible for the transmission of signals, comprises the transmission that detects data and the reception of Host Command, employing Wi-Fi (IEEE 802.11) home control network communication protocol.
Embodiment 3:
Referring to shown in Figure 3, single channel SPR sensing and detecting system comprises parts such as prism sensory package 131, Fibre Optical Sensor assembly 132 and time-sharing multiplex fiber optic detection system 15, and wherein, prism sensory package 131 is matched one of which with Fibre Optical Sensor assembly 132 according to user's needs.Prism sensory package light source 1311 and 1321. Fibre Optical Sensor assembly light sources 1321 use the halogen tungsten light source; Prism sensory package 131 adopts cylindricality prism 1315; Its xsect is an isosceles triangle; The bottom surface is coated with the metallic reflective coating 1316 on plane; Central plane is coated with incident highly reflecting films and outgoing highly reflecting films respectively, and the prism emergent ray is coupled into optical fiber 1318 after focusing on through lens 1317, gets into time-sharing multiplex fiber optic detection system 15 then; Fibre Optical Sensor assembly 132 comprises that light source 1321 links to each other with the input end of y-type optical fiber coupling mechanism 1323 through P type polaroid 1322; The output terminal of y-type optical fiber coupling mechanism is connected in sensor fibre 1325 through coupling mechanism joint 1324; These sense line 1325 ends are end reflection formula fiber-optic sensor probe 1326, and the signal of realizing end reflection optical fiber through y-type optical fiber coupling mechanism 1323 is to 15 transmission of time-sharing multiplex fiber optic detection system.Time-sharing multiplex fiber optic detection system 15 comprises 8-1 photoswitch 151, slit 152, grating 153, ccd detector 154.
Claims (5)
1. channel wireless radio multi cascade surface plasma resonance spectrometer is characterized in that: comprise 8 channel surface plasma resonances spectrum radio detection module independently and be used for the main control computer of wireless data reception, data processing and control; Wherein, According to concrete application need; 8 channel surface plasma resonances spectrum radio detection module can dispose 1 ~ 12 group arbitrarily; Main control computer is discerned the spectrum of 8 channel surface plasma resonances in zone radio detection module automatically, can form the surface plasma resonance spectrometer of 96 passages at most, high throughput analysis when realizing 96 samples; Described 8 channel surface plasma resonances are composed the radio detection module, comprise fiber spectrum detection system, automatic control system and the wireless transport module of microfluidic system, surface plasma sensor-based system, time-sharing multiplex.
2. channel wireless radio multi cascade surface plasma resonance spectrometer according to claim 1; It is characterized in that the surface plasma sensor-based system comprises light source, prism sensory package and Fibre Optical Sensor assembly; Adopt the wavelength-modulated mode, each sense channel can be according to wherein one group of concrete application demand apolegamy prism or Fibre Optical Sensor assembly.
3. channel wireless radio multi cascade surface plasma resonance spectrometer according to claim 2, the light source that it is characterized in that the surface plasma sensor-based system is the halogen tungsten light source; The prism sensory package is the cylindricality prism, and its xsect is an isosceles triangle, and the bottom surface is coated with the metallic reflective coating on plane; The Fibre Optical Sensor assembly connects light source cell, Fibre Optical Sensor unit and optical sensor respectively by one or more optical fiber.
4. channel wireless radio multi cascade surface plasma resonance spectrometer according to claim 1; The core that it is characterized in that microfluidic system is micro-fluidic sample cell; Be responsible for the transmission of sample and moving phase mixed solution, accurately control the flow velocity and the stability of sample pool inner fluid.
5. channel wireless radio multi cascade surface plasma resonance spectrometer according to claim 1 is characterized in that described wireless transport module, adopts the Wi-Fi home control network communication protocol of IEEE 802.11.
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| CN103808341A (en) * | 2014-01-26 | 2014-05-21 | 沈阳师范大学 | Distributed microstructure optical fiber sensor |
| CN106814047A (en) * | 2017-01-20 | 2017-06-09 | 天津大学 | A kind of optical fiber multiplex sensor demodulation device and demodulation or method for developing functions |
| CN106918579A (en) * | 2017-03-31 | 2017-07-04 | 王利兵 | Multichannel optical fiber type surface plasma resonance spectrometer |
| CN108120852A (en) * | 2017-11-24 | 2018-06-05 | 清华大学 | A kind of Multi probe time sharing multiplex device, flow rate measuring device and method |
| CN108414453A (en) * | 2018-01-23 | 2018-08-17 | 大连理工大学 | A kind of multichannel optical fiber SPR system of comprehensive time division multiplexing and wavelength-division multiplex technique |
| CN109569749A (en) * | 2018-11-16 | 2019-04-05 | 华南师范大学 | The portable sliceable digital microcurrent-controlled driving circuit of one kind, apparatus and system |
| CN111893038A (en) * | 2019-12-12 | 2020-11-06 | 山东鑫科生物科技股份有限公司 | Bacteria counting device with modularization |
| CN113795783A (en) * | 2021-08-06 | 2021-12-14 | 香港应用科技研究院有限公司 | Display integrated imaging device for head mounted display |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103808341A (en) * | 2014-01-26 | 2014-05-21 | 沈阳师范大学 | Distributed microstructure optical fiber sensor |
| CN106814047A (en) * | 2017-01-20 | 2017-06-09 | 天津大学 | A kind of optical fiber multiplex sensor demodulation device and demodulation or method for developing functions |
| CN106918579A (en) * | 2017-03-31 | 2017-07-04 | 王利兵 | Multichannel optical fiber type surface plasma resonance spectrometer |
| CN106918579B (en) * | 2017-03-31 | 2023-08-25 | 王利兵 | Multi-channel optical fiber type surface plasma resonance spectrometer |
| CN108120852A (en) * | 2017-11-24 | 2018-06-05 | 清华大学 | A kind of Multi probe time sharing multiplex device, flow rate measuring device and method |
| CN108414453A (en) * | 2018-01-23 | 2018-08-17 | 大连理工大学 | A kind of multichannel optical fiber SPR system of comprehensive time division multiplexing and wavelength-division multiplex technique |
| CN108414453B (en) * | 2018-01-23 | 2020-09-11 | 大连理工大学 | Multi-channel optical fiber SPR system integrating time division multiplexing and wavelength division multiplexing technologies |
| CN109569749A (en) * | 2018-11-16 | 2019-04-05 | 华南师范大学 | The portable sliceable digital microcurrent-controlled driving circuit of one kind, apparatus and system |
| CN111893038A (en) * | 2019-12-12 | 2020-11-06 | 山东鑫科生物科技股份有限公司 | Bacteria counting device with modularization |
| CN113795783A (en) * | 2021-08-06 | 2021-12-14 | 香港应用科技研究院有限公司 | Display integrated imaging device for head mounted display |
| CN113795783B (en) * | 2021-08-06 | 2024-02-06 | 香港应用科技研究院有限公司 | Display-integrated imaging device for head-mounted display |
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Application publication date: 20120822 |