CN102641361A - Chinese herb preparation for treating abnormal menstruation - Google Patents
Chinese herb preparation for treating abnormal menstruation Download PDFInfo
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- CN102641361A CN102641361A CN2012100392174A CN201210039217A CN102641361A CN 102641361 A CN102641361 A CN 102641361A CN 2012100392174 A CN2012100392174 A CN 2012100392174A CN 201210039217 A CN201210039217 A CN 201210039217A CN 102641361 A CN102641361 A CN 102641361A
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Abstract
The invention relates to a Chinese herb preparation for treating abnormal menstruation. The Chinese herb preparation consists of the following Chinese herb raw materials by weight parts: angelica sinensis, ligusticum wallichii, radix paeoniae rubra, radix bupleuri, platycodon grandiflorum, medicinal cyathula root, fructus aurantii, leonurus, herba lycopi, semen boitae, the root of three-nerved spicebush, roasted rhizoma atractylodis macrocephalae, poria cocos, mangnolia officinalis, pericarpium citri reticulatae, astragalus mongholicus, fructus cnidii, elecampane and caulis spatholobi; and then dextrin, potassium sorbate and cane sugar are added as auxiliary material. The Chinese herb preparation has the effects of complementing qi and nourishing blood, removing blood stasis and relieving pain, nourishing yin and generating body fluid and nourishing liver and kidney, is reliable in treating abnormal menstruation, simple and convenient in preparation, wide in medicinal herbs resource, low in cost, moderate in drug properties and does not have any side effects.
Description
Technical field
The application relates to a kind of pharmaceutical preparation, is specifically related to a kind of method for preparing that is used to treat the menoxenia Chinese medicine preparation.
Background technology
Menoxenia, dysmenorrhea are commonly encountered diseases, the frequently-occurring diseases in the gynecological, in daily life, work, bring inconvenience with worried for the women.Etiology and pathogenesis mainly is congenital deficiency of kidney-QI, and fecund is tired, and overstrain makes visceral-qi impaired, and the kidney function of liver and spleen is not normal, and qi and blood disorder causes to appoint and dashes the damage of two arteries and veins and fall ill, and is many with qi depression to blood stasis.The patient is many usually, and troubled thoughts are depressed, and gas is not declared and reached, and blood is the stagnation of QI, and retardance is dashed and appointed, and menses move not smooth, and the sea of blood is spill-over on time, send out to be menoxenia and dysmenorrhea.The makings blood stasis causes menoxenia, and main clinical manifestation is: delay menstrual period, and amount is few, and color is dark red, or clot is arranged, or little petechia is arranged, and thready and hesitant pulse or string are puckery.The common every menstruation of patient is last, two days or menstrual period lower abdominal distention pain, tenderness, or companion's breast side of body, breast expand, or hypomenorrhea, or blockage of menstruation, dark menses has piece, the clot discharge is alleviation of pain afterwards, pain disappeared after menstruation, tongue is dark violet or petechia arranged.
At present, physiotherapy, Drug therapy, operative treatment are often adopted in the western medical treatment menoxenia.Because of physiotherapy, pharmacotherapy can not fundamentally be cured, and it is long to exist treatment cycle, and the treatment cost is high, the unconspicuous deficiency of curative effect.Operative treatment is difficult to accepted by the patient because of the uncertainty of inherent danger, curative effect.
According to theory of Chinese medical science, to the pathogeny of menoxenia, carry out dialectical composition of prescription, to reach the purpose of treating both the principal and secondary aspects of a disease.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical preparation of treating menoxenia, main purpose is to treat menoxenia, dysmenorrhea, has that cost is low, preparation is simple, has no side effect, characteristics evident in efficacy.
Medicament of the present invention is grouped into by following one-tenth:
Major ingredient: Radix Angelicae Sinensis 15-20 part, Rhizoma Chuanxiong 10-15 part, Radix Paeoniae Rubra 10-15 part, Radix Paeoniae Alba 6-10 part, Radix Bupleuri 5-8 part; Radix Platycodonis 12-15 part, Radix Cyathulae 13-18 part, Fructus Aurantii 4-7 part, Herba Leonuri 35-40 part, Herba Lycopi 12-15 part; Semen Platycladi 10-20 part, Radix Linderae 3-8 part, Rhizoma Atractylodis Macrocephalae (parched) 10-15 part, Poria 20-25 part, Cortex Magnoliae Officinalis 5-10 part; Pericarpium Citri Reticulatae 3-8 part, Radix Astragali 30-35 part, Fructus Cnidii 10-15 part, Radix Aucklandiae 7-10 part, Caulis Spatholobi 10-20 part;
Adjuvant: dextrin 3-5 part, sucrose 5-10 part, potassium sorbate 1-2 part;
Medicament processing method of the present invention is carried out as follows:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 50 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the corase meal about 50 orders;
(4) getting the coarse powder of the Radix Aucklandiae after the pulverizing, the Radix Linderae, Rhizoma Atractylodis Macrocephalae (parched), Herba Lycopi, Radix Angelicae Sinensis, is solvent with 75% ethanol, floods 12-15 hour; Carry out percolation, collect percolate, decompression recycling ethanol; Under 65 ℃ of conditions percolate is concentrated into the concentrated solution A of relative density 1.05, subsequent use;
(5) get the coarse powder of Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Radix Platycodonis, Radix Cyathulae, Fructus Aurantii, Herba Leonuri, Semen Platycladi, Poria, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Radix Astragali, Fructus Cnidii and Caulis Spatholobi; The pure water that adds 10 times of powder weight decocted 5-8 hour; Temperature is no more than 100 ℃; Filter medicinal residues, it is subsequent use to obtain medicinal liquid;
(6) water that step (5) gained medicinal residues is added 3 times of weight decocted 1-2 hour once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(7) with twice collected combining medicine that gets, filter once more, concentrate after remaining tiny medicinal residues are removed in the separation of 6000-8000rpm high speed centrifugation; 80 ℃ of thickening temperatures time 30-40 minute, obtain the concentrated solution B of relative density 1.02; Add step (4) gained concentrated solution A again, continue to be concentrated into relative density 1.15 under 68 ℃ of conditions, subsequent use;
(8) in step (7) gained end product (concentrated solution of relative density 1.15), add dextrin, potassium sorbate and sucrose, fully stir;
(9) spray drying forming;
(10) granulate, sieve, packing, sterilization, quality inspection, packing, obtain finished product.
Usage: oral, every day 3 times, each one bag, after washing open, boiling water takes, and 7 days is a course of treatment, and be 3-6 visual effects the course of treatment usually.
The specific embodiment
Composition of the present invention and method for preparing are to the characteristics of various flavour of a drug in the prescription; And, factors considerations such as absorption fast, evident in efficacy, easy to carry, steady quality few from taking dose; Adopt best practice to extract; Effective ingredient is farthest kept, thereby guarantee clinical efficacy.Adopt the electuary form to take, improve bioavailability.Technological process is simple and practical, is suitable for enlarging producing.
Below in conjunction with embodiment the present invention is further specified.
Embodiment 1.
A kind of Chinese medicine preparation of treating menoxenia, form by following materials of weight proportions:
Major ingredient: 15 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 10 parts of Radix Paeoniae Rubra, 6 parts of the Radix Paeoniae Albas, 5 parts of Radix Bupleuri; 12 parts of Radix Platycodoniss, 13 parts of Radix Cyathulaes, 4 parts of Fructus Aurantiis, 35 parts of Herba Leonuris, 12 parts of Herba Lycopi; 10 parts of Semen Platycladi, 3 parts of the Radixs Linderae, 10 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 20 parts in Poria, 5 parts of Cortex Magnoliae Officinalis; 3 parts of Pericarpium Citri Reticulataes, 30 parts of the Radixs Astragali, 10 parts of Fructus Cnidiis, 7 parts of the Radix Aucklandiae, 10 parts of Caulis Spatholobis;
Adjuvant: 3 parts in dextrin, 5 parts of sucrose, 1 part of potassium sorbate;
By following method manufacturing:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 50 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the corase meal about 50 orders;
(4) getting the coarse powder of the Radix Aucklandiae after the pulverizing, the Radix Linderae, Rhizoma Atractylodis Macrocephalae (parched), Herba Lycopi, Radix Angelicae Sinensis, is solvent with 75% ethanol, floods 12 hours; Carry out percolation, collect percolate, decompression recycling ethanol; Under 65 ℃ of conditions percolate is concentrated into the concentrated solution A of relative density 1.05, subsequent use;
(5) get the coarse powder of Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Radix Platycodonis, Radix Cyathulae, Fructus Aurantii, Herba Leonuri, Semen Platycladi, Poria, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Radix Astragali, Fructus Cnidii and Caulis Spatholobi; The pure water that adds 10 times of powder weight decocted 5 hours; Temperature is no more than 100 ℃; Filter medicinal residues, it is subsequent use to obtain medicinal liquid;
(6) water that step (5) gained medicinal residues is added 3 times of weight decocted 1 hour once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(7) with twice collected combining medicine that gets, filter once more, concentrate after remaining tiny medicinal residues are removed in the separation of 8000rpm high speed centrifugation; 80 ℃ of thickening temperatures, obtain the concentrated solution B of relative density 1.02 at 30 minutes time; Add step (4) gained concentrated solution A again, continue to be concentrated into relative density 1.15 under 68 ℃ of conditions, subsequent use;
(8) in step (7) gained end product, add dextrin and sucrose, fully stir;
(9) spray drying forming;
(10) granulate, sieve, packing, sterilization, quality inspection, packing, obtain finished product.
Embodiment 2
A kind of Chinese medicine preparation of treating menoxenia, form by following materials of weight proportions:
Major ingredient: 20 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Radix Paeoniae Rubra, 10 parts of the Radix Paeoniae Albas, 8 parts of Radix Bupleuri; 15 parts of Radix Platycodoniss, 18 parts of Radix Cyathulaes, 7 parts of Fructus Aurantiis, 40 parts of Herba Leonuris, 15 parts of Herba Lycopi; 20 parts of Semen Platycladi, 8 parts of the Radixs Linderae, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 25 parts in Poria, 10 parts of Cortex Magnoliae Officinalis; 8 parts of Pericarpium Citri Reticulataes, 35 parts of the Radixs Astragali, 15 parts of Fructus Cnidiis, 10 parts of the Radix Aucklandiae, 20 parts of Caulis Spatholobis;
Adjuvant: 5 parts in dextrin, 10 parts of sucrose, 2 parts of potassium sorbate;
By following method manufacturing:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 50 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the corase meal about 50 orders;
(4) getting the coarse powder of the Radix Aucklandiae after the pulverizing, the Radix Linderae, Rhizoma Atractylodis Macrocephalae (parched), Herba Lycopi, Radix Angelicae Sinensis, is solvent with 75% ethanol, floods 15 hours; Carry out percolation, collect percolate, decompression recycling ethanol; Under 65 ℃ of conditions percolate is concentrated into the concentrated solution A of relative density 1.05, subsequent use;
(5) get the coarse powder of Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Radix Platycodonis, Radix Cyathulae, Fructus Aurantii, Herba Leonuri, Semen Platycladi, Poria, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Radix Astragali, Fructus Cnidii and Caulis Spatholobi; The pure water that adds 10 times of powder weight decocted 8 hours; Temperature is no more than 100 ℃; Filter medicinal residues, it is subsequent use to obtain medicinal liquid;
(6) water that step (5) gained medicinal residues is added 3 times of weight decocted 2 hours once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(7) with twice collected combining medicine that gets, filter once more, concentrate after remaining tiny medicinal residues are removed in the separation of 7500rpm high speed centrifugation; 80 ℃ of thickening temperatures, obtain the concentrated solution B of relative density 1.02 at 40 minutes time; Add step (4) gained concentrated solution A again, continue to be concentrated into relative density 1.15 under 68 ℃ of conditions, subsequent use;
(8) in step (7) gained end product, add dextrin, potassium sorbate and sucrose, fully stir;
(9) spray drying forming;
(10) granulate, sieve, packing, sterilization, quality inspection, packing, obtain finished product.
Embodiment 3
A kind of Chinese medicine preparation of treating menoxenia, form by following materials of weight proportions:
Major ingredient: 18 parts of Radix Angelicae Sinensis, 11 parts of Rhizoma Chuanxiongs, 13 parts of Radix Paeoniae Rubra, 8 parts of the Radix Paeoniae Albas, 6 parts of Radix Bupleuri; 14 parts of Radix Platycodoniss, 15 parts of Radix Cyathulaes, 5 parts of Fructus Aurantiis, 33 parts of Herba Leonuris, 13 parts of Herba Lycopi; 17 parts of Semen Platycladi, 4 parts of the Radixs Linderae, 11 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 23 parts in Poria, 6 parts of Cortex Magnoliae Officinalis; 5 parts of Pericarpium Citri Reticulataes, 32 parts of the Radixs Astragali, 12 parts of Fructus Cnidiis, 9 parts of the Radix Aucklandiae, 14 parts of Caulis Spatholobis;
Adjuvant: 4 parts in dextrin, 7 parts of sucrose, 1 part of potassium sorbate;
By following method manufacturing:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 50 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the corase meal about 50 orders;
(4) getting the coarse powder of the Radix Aucklandiae after the pulverizing, the Radix Linderae, Rhizoma Atractylodis Macrocephalae (parched), Herba Lycopi, Radix Angelicae Sinensis, is solvent with 75% ethanol, floods 13 hours; Carry out percolation, collect percolate, decompression recycling ethanol; Under 65 ℃ of conditions percolate is concentrated into the concentrated solution A of relative density 1.05, subsequent use;
(5) get the coarse powder of Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Radix Platycodonis, Radix Cyathulae, Fructus Aurantii, Herba Leonuri, Semen Platycladi, Poria, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Radix Astragali, Fructus Cnidii and Caulis Spatholobi; The pure water that adds 10 times of powder weight decocted 6 hours; Temperature is no more than 100 ℃; Filter medicinal residues, it is subsequent use to obtain medicinal liquid;
(6) water that step (5) gained medicinal residues is added 3 times of weight decocted 1 hour once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(7) with twice collected combining medicine that gets, filter once more, concentrate after remaining tiny medicinal residues are removed in the separation of 8000rpm high speed centrifugation; 80 ℃ of thickening temperatures, obtain the concentrated solution B of relative density 1.02 at 40 minutes time; Add step (4) gained concentrated solution A again, continue to be concentrated into relative density 1.15 under 68 ℃ of conditions, subsequent use;
(8) in step (7) gained end product, add dextrin, potassium sorbate and sucrose, fully stir;
(9) spray drying forming;
(10) granulate, sieve, packing, sterilization, quality inspection, packing, obtain finished product.
Embodiment 4
A kind of Chinese medicine preparation of treating menoxenia, form by following materials of weight proportions:
Major ingredient: 16 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiongs, 11 parts of Radix Paeoniae Rubra, 10 parts of the Radix Paeoniae Albas, 8 parts of Radix Bupleuri; 14 parts of Radix Platycodoniss, 13 parts of Radix Cyathulaes, 47 parts of Fructus Aurantiis, 35 parts of Herba Leonuris, 15 parts of Herba Lycopi; 20 parts of Semen Platycladi, 3 parts of the Radixs Linderae, 10 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 25 parts in Poria, 9 parts of Cortex Magnoliae Officinalis; 5 parts of Pericarpium Citri Reticulataes, 35 parts of the Radixs Astragali, 15 parts of Fructus Cnidiis, 10 parts of the Radix Aucklandiae, 15 parts of Caulis Spatholobis;
Adjuvant: 5 parts in dextrin, 5 parts of sucrose, 2 parts of potassium sorbate;
Medicament processing method of the present invention is carried out as follows:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 50 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the corase meal about 50 orders;
(4) getting the coarse powder of the Radix Aucklandiae after the pulverizing, the Radix Linderae, Rhizoma Atractylodis Macrocephalae (parched), Herba Lycopi, Radix Angelicae Sinensis, is solvent with 75% ethanol, floods 13 hours; Carry out percolation, collect percolate, decompression recycling ethanol; Under 65 ℃ of conditions percolate is concentrated into the concentrated solution A of relative density 1.05, subsequent use;
(5) get the coarse powder of Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Radix Platycodonis, Radix Cyathulae, Fructus Aurantii, Herba Leonuri, Semen Platycladi, Poria, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Radix Astragali, Fructus Cnidii and Caulis Spatholobi; The pure water that adds 10 times of powder weight decocted 7 hours; Temperature is no more than 100 ℃; Filter medicinal residues, it is subsequent use to obtain medicinal liquid;
(6) water that step (5) gained medicinal residues is added 3 times of weight decocted 1.5 hours once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(7) with twice collected combining medicine that gets, filter once more, concentrate after remaining tiny medicinal residues are removed in the separation of 8000rpm high speed centrifugation; 80 ℃ of thickening temperatures, obtain the concentrated solution B of relative density 1.02 at 30 minutes time; Add step (4) gained concentrated solution A again, continue to be concentrated into relative density 1.15 under 68 ℃ of conditions, subsequent use;
(8) in step (7) gained end product, add dextrin, potassium sorbate and sucrose, fully stir;
(9) spray drying forming;
(10) granulate, sieve, packing, sterilization, quality inspection, packing, obtain finished product.
Clinical trial: this Chinese medicine preparation is used for clinical case 95 examples, age 18-40 year.
Criterion of cure: the official holiday rule is normal, and the dysmenorrhea phenomenon is slight.
The improvement standard: rule is tending towards normally, and dysmenorrhea alleviates.
Invalid: as to take 6 and do not see any effect more than the course of treatment, symptom such as preceding.
Model case
Case 1: Liu, 29 years old, according to patient's private prosecution, be in the menoxenia state over 4 years always, menstrual cycle is more than 40-45 days, go through 6-7 days clean, many through amount, color is dark red, the time hold clot under the arm.Pale complexion, spiritlessness and weakness, dizziness, the soreness of waist, thin white fur of tongue, deep-thready pulse.With take pharmaceutical preparation of the present invention 14 days continuously through after date, spirit is gradually strong, menstrual period, delay shortened to 35 days, menstruation is clean during official holiday once more, the dysmenorrhea condition improved.Continued to take this medicament afterwards 28 days, menstrual cycle recovers normally basically, and is normal through amount, do not have the sense of obvious dysmenorrhea.
Case 2: journey, 40 years old, polymenorrhea appears the bimester that the patient being near, and 20 days one tides are menstrual onset the 2nd day during prescription on individual diagnosis, and amount is many, and color is dark red, is mingled with a large amount of clots, and companion's lower abdomen pain is uncomfortable in chest, feels sick yellowish fur, wiry and frequent pulse.Take pharmaceutical treatment of the present invention half a year, menstrual cycle is adjusted to 30 days one tides, increases through amount.
Case 3: the week certain, 33 years old, the patient had menstrual cycle to delay phenomenon in 1 year always, about 50 days tides, hypomenorrhea, the light red band mucus of color, build is fat, and expectorant is arranged in the pharynx, white and greasy fur, thready and rolling pulse.Take pharmaceutical treatment of the present invention after 1 month, the menstrual cycle shortening causes a tide about 35 days, continues to take one month, and it is normal that menstrual cycle recovers, and MBV is normal.
The above; Be merely the specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any those of ordinary skill in the art are in the technical scope that the present invention disclosed, and variation or the replacement that can expect without creative work all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain that claims were limited.
Claims (4)
1. Chinese medicine preparation of treating menoxenia is characterized in that: be made up of following materials of weight proportions:
Major ingredient: Radix Angelicae Sinensis 15-20 part, Rhizoma Chuanxiong 10-15 part, Radix Paeoniae Rubra 10-15 part, Radix Paeoniae Alba 6-10 part, Radix Bupleuri 5-8 part; Radix Platycodonis 12-15 part, Radix Cyathulae 13-18 part, Fructus Aurantii 4-7 part, Herba Leonuri 35-40 part, Herba Lycopi 12-15 part; Semen Platycladi 10-20 part, Radix Linderae 3-8 part, Rhizoma Atractylodis Macrocephalae (parched) 10-15 part, Poria 20-25 part, Cortex Magnoliae Officinalis 5-10 part; Pericarpium Citri Reticulatae 3-8 part, Radix Astragali 30-35 part, Fructus Cnidii 10-15 part, Radix Aucklandiae 7-10 part, Caulis Spatholobi 10-20 part;
Adjuvant: dextrin 3-5 part, sucrose 5-10 part, potassium sorbate 1-2 part;
By following method manufacturing:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 50 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the corase meal about 50 orders;
(4) getting the coarse powder of the Radix Aucklandiae after the pulverizing, the Radix Linderae, Rhizoma Atractylodis Macrocephalae (parched), Herba Lycopi, Radix Angelicae Sinensis, is solvent with 75% ethanol, floods 12-15 hour; Carry out percolation, collect percolate, decompression recycling ethanol; Under 65 ℃ of conditions percolate is concentrated into the concentrated solution A of relative density 1.05, subsequent use;
(5) get the coarse powder of Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Radix Platycodonis, Radix Cyathulae, Fructus Aurantii, Herba Leonuri, Semen Platycladi, Poria, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Radix Astragali, Fructus Cnidii and Caulis Spatholobi; The pure water that adds 10 times of powder weight decocted 5-8 hour; Temperature is no more than 100 ℃; Filter medicinal residues, it is subsequent use to obtain medicinal liquid;
(6) water that step (5) gained medicinal residues is added 3 times of weight decocted 1-2 hour once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(7) with twice collected combining medicine that gets, filter once more, concentrate after remaining tiny medicinal residues are removed in the separation of 6000-8000rpm high speed centrifugation; 80 ℃ of thickening temperatures time 30-40 minute, obtain the concentrated solution B of relative density 1.02; Add step (4) gained concentrated solution A again, continue to be concentrated into relative density 1.15 under 68 ℃ of conditions, subsequent use;
(8) add dextrin, potassium sorbate and sucrose, fully stir;
(9) spray drying forming;
(10) granulate, sieve, packing, sterilization, quality inspection, packing, obtain finished product.
2. medicament according to claim 1 is characterized in that, is made up of following materials of weight proportions:
Major ingredient: 15 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 10 parts of Radix Paeoniae Rubra, 6 parts of the Radix Paeoniae Albas, 5 parts of Radix Bupleuri; 12 parts of Radix Platycodoniss, 13 parts of Radix Cyathulaes, 4 parts of Fructus Aurantiis, 35 parts of Herba Leonuris, 12 parts of Herba Lycopi; 10 parts of Semen Platycladi, 3 parts of the Radixs Linderae, 10 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 20 parts in Poria, 5 parts of Cortex Magnoliae Officinalis; 3 parts of Pericarpium Citri Reticulataes, 30 parts of the Radixs Astragali, 10 parts of Fructus Cnidiis, 7 parts of the Radix Aucklandiae, 10 parts of Caulis Spatholobis;
Adjuvant: 3 parts in dextrin, 5 parts of sucrose, 1 part of potassium sorbate;
By following method manufacturing:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 50 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the corase meal about 50 orders;
(4) getting the coarse powder of the Radix Aucklandiae after the pulverizing, the Radix Linderae, Rhizoma Atractylodis Macrocephalae (parched), Herba Lycopi, Radix Angelicae Sinensis, is solvent with 75% ethanol, floods 12 hours; Carry out percolation, collect percolate, decompression recycling ethanol; Under 65 ℃ of conditions percolate is concentrated into the concentrated solution A of relative density 1.05, subsequent use;
(5) get the coarse powder of Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Radix Platycodonis, Radix Cyathulae, Fructus Aurantii, Herba Leonuri, Semen Platycladi, Poria, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Radix Astragali, Fructus Cnidii and Caulis Spatholobi; The pure water that adds 10 times of powder weight decocted 5 hours; Temperature is no more than 100 ℃; Filter medicinal residues, it is subsequent use to obtain medicinal liquid;
(6) water that step (5) gained medicinal residues is added 3 times of weight decocted 1 hour once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(7) with twice collected combining medicine that gets, filter once more, concentrate after remaining tiny medicinal residues are removed in the separation of 8000rpm high speed centrifugation; 80 ℃ of thickening temperatures, obtain the concentrated solution B of relative density 1.02 at 30 minutes time; Add step (4) gained concentrated solution A again, continue to be concentrated into relative density 1.15 under 68 ℃ of conditions, subsequent use;
(8) add dextrin and sucrose, fully stir;
(9) spray drying forming;
(10) granulate, sieve, packing, sterilization, quality inspection, packing, obtain finished product.
3. medicament according to claim 1 is characterized in that, is made up of following materials of weight proportions:
Major ingredient: 20 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Radix Paeoniae Rubra, 10 parts of the Radix Paeoniae Albas, 8 parts of Radix Bupleuri; 15 parts of Radix Platycodoniss, 18 parts of Radix Cyathulaes, 7 parts of Fructus Aurantiis, 40 parts of Herba Leonuris, 15 parts of Herba Lycopi; 20 parts of Semen Platycladi, 8 parts of the Radixs Linderae, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 25 parts in Poria, 10 parts of Cortex Magnoliae Officinalis; 8 parts of Pericarpium Citri Reticulataes, 35 parts of the Radixs Astragali, 15 parts of Fructus Cnidiis, 10 parts of the Radix Aucklandiae, 20 parts of Caulis Spatholobis;
Adjuvant: 5 parts in dextrin, 10 parts of sucrose, 2 parts of potassium sorbate;
By following method manufacturing:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 50 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the corase meal about 50 orders;
(4) getting the coarse powder of the Radix Aucklandiae after the pulverizing, the Radix Linderae, Rhizoma Atractylodis Macrocephalae (parched), Herba Lycopi, Radix Angelicae Sinensis, is solvent with 75% ethanol, floods 15 hours; Carry out percolation, collect percolate, decompression recycling ethanol; Under 65 ℃ of conditions percolate is concentrated into the concentrated solution A of relative density 1.05, subsequent use;
(5) get the coarse powder of Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Radix Platycodonis, Radix Cyathulae, Fructus Aurantii, Herba Leonuri, Semen Platycladi, Poria, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Radix Astragali, Fructus Cnidii and Caulis Spatholobi; The pure water that adds 10 times of powder weight decocted 8 hours; Temperature is no more than 100 ℃; Filter medicinal residues, it is subsequent use to obtain medicinal liquid;
(6) water that step (5) gained medicinal residues is added 3 times of weight decocted 2 hours once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(7) with twice collected combining medicine that gets, filter once more, concentrate after remaining tiny medicinal residues are removed in the separation of 7500rpm high speed centrifugation; 80 ℃ of thickening temperatures, obtain the concentrated solution B of relative density 1.02 at 40 minutes time; Add step (4) gained concentrated solution A again, continue to be concentrated into relative density 1.15 under 68 ℃ of conditions, subsequent use;
(8) add dextrin, potassium sorbate and sucrose, fully stir;
(9) spray drying forming;
(10) granulate, sieve, packing, sterilization, quality inspection, packing, obtain finished product.
4. medicament according to claim 1 is characterized in that, is made up of following materials of weight proportions:
Major ingredient: 18 parts of Radix Angelicae Sinensis, 11 parts of Rhizoma Chuanxiongs, 13 parts of Radix Paeoniae Rubra, 8 parts of the Radix Paeoniae Albas, 6 parts of Radix Bupleuri; 14 parts of Radix Platycodoniss, 15 parts of Radix Cyathulaes, 5 parts of Fructus Aurantiis, 33 parts of Herba Leonuris, 13 parts of Herba Lycopi; 17 parts of Semen Platycladi, 4 parts of the Radixs Linderae, 11 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 23 parts in Poria, 6 parts of Cortex Magnoliae Officinalis; 5 parts of Pericarpium Citri Reticulataes, 32 parts of the Radixs Astragali, 12 parts of Fructus Cnidiis, 9 parts of the Radix Aucklandiae, 14 parts of Caulis Spatholobis;
Adjuvant: 4 parts in dextrin, 7 parts of sucrose, 1 part of potassium sorbate;
By following method manufacturing:
(1) takes by weighing various medicinal raw materials by said ratio, and choose the removal of impurity with manual method;
(2) raw material of select is dried under 50 ℃ of environment, and sterilize with conventional method;
(3) with disintegrating apparatus raw material is broken into the corase meal about 50 orders;
(4) getting the coarse powder of the Radix Aucklandiae after the pulverizing, the Radix Linderae, Rhizoma Atractylodis Macrocephalae (parched), Herba Lycopi, Radix Angelicae Sinensis, is solvent with 75% ethanol, floods 13 hours; Carry out percolation, collect percolate, decompression recycling ethanol; Under 65 ℃ of conditions percolate is concentrated into the concentrated solution A of relative density 1.05, subsequent use;
(5) get the coarse powder of Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Radix Bupleuri, Radix Platycodonis, Radix Cyathulae, Fructus Aurantii, Herba Leonuri, Semen Platycladi, Poria, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, the Radix Astragali, Fructus Cnidii and Caulis Spatholobi; The pure water that adds 10 times of powder weight decocted 6 hours; Temperature is no more than 100 ℃; Filter medicinal residues, it is subsequent use to obtain medicinal liquid;
(6) water that step (5) gained medicinal residues is added 3 times of weight decocted 1 hour once more, and temperature is no more than 100 ℃, filtered medicinal residues, collected medicinal liquid;
(7) with twice collected combining medicine that gets, filter once more, concentrate after remaining tiny medicinal residues are removed in the separation of 8000rpm high speed centrifugation; 80 ℃ of thickening temperatures, obtain the concentrated solution B of relative density 1.02 at 40 minutes time; Add step (4) gained concentrated solution A again, continue to be concentrated into relative density 1.15 under 68 ℃ of conditions, subsequent use;
(8) add dextrin, potassium sorbate and sucrose, fully stir;
(9) spray drying forming;
(10) granulate, sieve, packing, sterilization, quality inspection, packing, obtain finished product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102824611A (en) * | 2012-09-20 | 2012-12-19 | 于广明 | Traditional Chinese medicine for treating menstrual disorder |
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| CN102824611A (en) * | 2012-09-20 | 2012-12-19 | 于广明 | Traditional Chinese medicine for treating menstrual disorder |
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