CN102641283B - Medicine for treating scurf and preparing method thereof - Google Patents
Medicine for treating scurf and preparing method thereof Download PDFInfo
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- CN102641283B CN102641283B CN 201210099163 CN201210099163A CN102641283B CN 102641283 B CN102641283 B CN 102641283B CN 201210099163 CN201210099163 CN 201210099163 CN 201210099163 A CN201210099163 A CN 201210099163A CN 102641283 B CN102641283 B CN 102641283B
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- medicine
- vitamin
- scurf
- treating
- dandruff
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Abstract
The invention discloses a medicine for treating scurf and a preparing method thereof. The medicine for treating the scurf is mainly formed by preparing pyrithionc zinc, ketoconazole and clobetasol propionate according to a certain mixture ratio by weight. The medicine for treating the scurf has the actions of resisting inflammation, sterilizing and resisting pruritus, is used for treating the scurf and has quick curative effect and high cure rate.
Description
Technical field
The present invention relates to a kind of dermopathic medicine for the treatment of, especially a kind of medicine for the treatment of the dandruff and preparation method thereof.
Background technology
Dandruff is one of a kind of common multiple cutaneous disease, and general winter-spring season sickness rate is higher, and white squamous chip appears in initial stage patient scalp, and when serious, dandruff thickens, scalp itch, the normal life of impact and sleep.At present, the medicine for the treatment of dandruff is mostly selected the Western medicine of anti-inflammation class to take orally and is used water preparation to put on the skin outward, but these medicines can only be also symptomatic treatments, only play antipruritic effect, can't cure and effect a radical cure at all.
Summary of the invention
Therefore there is great demand in people to the medicine that can effect a radical cure dandruff, up to now, also do not find the relevant report about medicine of the present invention, the inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, finally work out the medicine that the treatment of better curative effect dandruff is arranged, thereby completed the present invention.
Purpose of the present invention just is to provide a kind of medicine for the treatment of dandruff of better curative effect.
Another object of the present invention just has been to provide the preparation method of this medicine.
Medicine of the present invention selects Zinc Pyrithione, ketoconazole, clobetasol propionate, glycerol, vitamin E, vitamin B and ethanol to make up, these medicines are made up, make each efficacy of drugs produce synergism, thereby can effectively treat the recurrence of dandruff, wherein select Zinc Pyrithione, English name: Pyrithionc Zinc, ZPT, molecular formula: C10H8N2O2S2Zn can suppress the growth of Gram-positive, negative bacteria and mycete.Hair conditioning, delay the aging of hair effectively, controls the generation of poliosis and alopecia.Select ketoconazole, English name: Ketoconazole Capsules, molecular formula: C26H28Cl2N4O4 is the imidazoles antifungal agent, its mechanism of action is the biosynthesis of Antifungi cell membrane ergosterol, affects membrane passage, suppresses its growth.Can be used for treating shallow table and deep mycosis, as skin and fingernail tinea, vagina candidiasis, gastrointestinal fungal infection etc., and the systemic infection that is caused by Candida albicans, class coccidioides immitis, histoplasma capsulatum etc.Select clobetasol propionate, chemical name: 21-Chloro-9-fluoro-11b, 17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate, molecular formula: C25H32ClFO5, clobetasol propionate are the efficient local topical glucocorticoid medicine of synthetic.Have stronger antiinflammatory, antipruritic and blood capillary contraction, its antiinflammatory action is about 112.5 times of hydrocortisone, 2.3 times of betamethasone sodium phosphate, 18.7 times of fluocinolone acetonide.Have simultaneously the effect that suppresses cell mitogen, can effectively penetrate into keratodermatitis.Select glycerol, Chinese name: glycerol, outer literary fame: Glycerin, molecular formula: C3H8O3 is aspect medical science, in order to produce various preparations, solvent, hygroscopic agent, antifreezing agent and sweeting agent, ingredients externally-applied ointment or suppository etc.Select vitamin E, English name: vitamin E is a kind of fatsoluble vitamin, claims again tocopherol, is one of topmost antioxidant, and the protection body cell is avoided the murder by poisoning of free radical, gives full play to the particular physiological function of material to be protected.Select vitamin B, vitamin B (Vitamin B) is also made vitamin B, is the general name of some vitamin, is also referred to as sometimes the assorted or compound group of vitamin B of vitamin B complex, vitamin B.Vitamin B is all water soluble vitamins, and they are synergism, regulates metabolism, keeps the health of skin and muscle, promotes immune system and neural function, Promote cell's growth and division.Select ethanol, the skeleton symbol of ethanol is CH3CH2OH, is commonly called as ethanol, and it is a kind of inflammable, volatile colourless transparent liquid under room temperature, normal pressure, and its aqueous solution has special, pleasant fragrance, and slightly with irritating.Ethanol is a kind of good solvent, can dissolve many inorganic matters, can dissolve many Organic substances again, so ethanol commonly used dissolves plant pigment or medicinal ingredient wherein, also ethanol commonly used is as the solvent of reaction, Organic substance and the inorganic matter of participating in reaction all can be dissolved, and enlarge active surface improves reaction rate.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and the consumption of each component all has curative effect preferably in the following weight scope.
Zinc Pyrithione 40-60mg ketoconazole 800-1200mg
Clobetasol propionate 40-60mg glycerol 0.01-0.02mg
Vitamin E 450-550mg vitamin B 200-300mg
Ethanol 300-450ml
Preparation method of the present invention
1, Zinc Pyrithione, ketoconazole, clobetasol propionate, vitamin E, the vitamin B mix and blend with described weight is ground into superfine powder;
2, glycerol, the ethanol of described weight is added be mixed into ointment in powder.
Medicine of the present invention has stronger antiinflammatory, antifungal, antipruritic and blood capillary contraction, is used for the treatment of the dandruff curative effect fast, and cure rate is high.
Further set forth the beneficial effect of medicine of the present invention below by test example.
The toxicity test report of [test example 1] medicine of the present invention
1, get 20 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5kg is divided into two groups, and wherein one group is the normal amount test group, and another group is the excess test group.
2, the normal amount test group abdominal part rabbit hair is pulled out the cadre, the rabbit hair around excess test group abdominal part and anus is pulled out only.
3, every day with ointment smear the abdominal part that pulls out the clean rabbit hair and anus around epilation place, every day, secondary, be used in conjunction 7 days.
4, observe the medication reaction every day, two groups of rabbit diet activities are normal, and result shows that the medicine external has no side effect.
[test example 2] clinical observation material
1, physical data
Accept out-patient's 120 examples for medical treatment, age 10-20 year 25 examples, 21-30 year 27 examples, 31-40 year 21 examples, 41-50 year 18 examples, 29 examples more than 50 years old.
2, diagnostic criteria
Light-duty dandruff: morbidity 1-2, patient's scalp surface irregular chip that comes off, and with slight pruritus.
Heavy dandruff: medical history is more than 2 years, and large tracts of land phosphorus shape dandruff appears in patient's scalp, and pruritus is hard to bear, affects work and sleep, the postemphasis of drinking.
3, Therapeutic Method
Smearing ointment after cleaning, light-duty every twice-daily, heavy every day three times, 10 days is a course for the treatment of, is used in conjunction 2-3 the course for the treatment of.
4, efficacy assessment standard
Produce effects: degree type dandruff disease is after treatment, and the head dandruff disappears, and recovers normal, follows up a case by regular visits to 1-2 without recurrence.
Take a turn for the better: patient's symptom progressively takes a turn for the better, and dandruff disappears substantially, and pruritus alleviates, and feels good.
Invalid: as not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In the treatment of two courses for the treatment of, with light-duty dandruff patient 69 examples of Drug therapy of the present invention, produce effects 64 examples, 4 examples that take a turn for the better, total effective rate is 98.55%; With the heavy dandruff patient of Drug therapy of the present invention 51 examples, produce effects 45 examples, 4 examples that take a turn for the better, total effective rate is 96.08%.
Claims (2)
1. medicine for the treatment of dandruff, it is characterized in that: it is to be made by the crude drug in following weight range:
Zinc Pyrithione 40-60mg, ketoconazole 800-1200mg,
Clobetasol propionate 40-60mg, glycerol 0.01-0.02mg,
Vitamin E 450-550mg, vitamin B 200-300mg,
Ethanol 300-450ml.
2. the preparation method of medicine according to claim 1, it comprises the following steps:
(1) Zinc Pyrithione, ketoconazole, clobetasol propionate, vitamin E, the vitamin B mix and blend with described weight is ground into superfine powder;
(2) glycerol, the ethanol of described weight is added be mixed into ointment in powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210099163 CN102641283B (en) | 2012-04-07 | 2012-04-07 | Medicine for treating scurf and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210099163 CN102641283B (en) | 2012-04-07 | 2012-04-07 | Medicine for treating scurf and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102641283A CN102641283A (en) | 2012-08-22 |
| CN102641283B true CN102641283B (en) | 2013-05-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 201210099163 Expired - Fee Related CN102641283B (en) | 2012-04-07 | 2012-04-07 | Medicine for treating scurf and preparing method thereof |
Country Status (1)
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1165181A (en) * | 1996-05-10 | 1997-11-19 | 殷国健 | Washing free shampoo for nourishing and growing hair |
| FR2761600B1 (en) * | 1998-06-19 | 2000-03-31 | Oreal | FOAMING COMPOSITION FOR THE WASHING AND TREATMENT OF HAIR AND / OR SCALP BASED ON AN ACTIVE INGREDIENT, AN ANIONIC SURFACTANT, AN AMPHOTERIC SURFACTANT AND A PROPENETANT |
| US7186416B2 (en) * | 2003-05-28 | 2007-03-06 | Stiefel Laboratories, Inc. | Foamable pharmaceutical compositions and methods for treating a disorder |
| CN101112349B (en) * | 2007-08-16 | 2011-05-18 | 峰胜集团有限公司 | Shampoo composition provided with anti-dandruff and opsonize efficacy |
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2012
- 2012-04-07 CN CN 201210099163 patent/CN102641283B/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN102641283A (en) | 2012-08-22 |
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Granted publication date: 20130508 Termination date: 20140407 |