CN102636658B - Automatic sample feeding tray for temperature-controllable type microreactor with magnetic stirring function - Google Patents
Automatic sample feeding tray for temperature-controllable type microreactor with magnetic stirring function Download PDFInfo
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- CN102636658B CN102636658B CN 201210101275 CN201210101275A CN102636658B CN 102636658 B CN102636658 B CN 102636658B CN 201210101275 CN201210101275 CN 201210101275 CN 201210101275 A CN201210101275 A CN 201210101275A CN 102636658 B CN102636658 B CN 102636658B
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Abstract
The invention discloses an automatic sample feeding tray for a temperature-controllable type microreactor with a magnetic stirring function, which comprises a tray, wherein a middle water bath solution cavity is arranged in the tray; a plurality of sample bottle slots used for holding sample bottles are formed in an insertion mode on the middle water bath solution cavity; the outer circumferential surfaces of the sample bottle slots are provided with four-phase stepping coils electrically connected with a circuit outside the tray and are provided with shielding layers for shield; and magnetic force stirrers for electro-magnetic induction with the four-phase stepping coils are arranged in the sample bottles inserted into the sample bottle slots. The automatic sample introduction tray has the advantages that a sample which does not react can be put into the tray and measurement time is set, thereby reaching a purpose of automatically detecting the sample; no manual operation is involved in the sample feeding process, and the advantage of automatic sample feeding is brought into full play. The seamless connection of the test is realized, and transferring sample measurement does not need manual intervention. The stirring modes based on multiple schemes meet the sample detection requirements of different groups, the problem of uneven stirring of the traditional stirrer is solved, and the problem that mutual influence of rotors in a multi-position stirrer is also solved.
Description
Technical field
The present invention relates to a kind of auto injection pallet that has the microreactor function.Particularly relate to a kind of integrated degree height, have the auto injection pallet of the controlled warm type microreactor of magnetic agitation function.
Background technology
In general analytical chemistry, in order to realize robotization, high throughput analysis, adopt automatic sampler to carry sample tray more.It is often to use in a kind of analytical instrument that injector carries pallet, have a plurality of positions (being generally more than tens or 100) and the container that fills analytic sample to be determined can be put into the position that indicates fixed number of pallet, in the workstation program, configure sample introduction site and sample introduction order, automatic sampler is with the setting of automatic operating software end, realized that sample introduction robotization, high pass quantize, under the situation that guarantees instrument stabilizer, can realize running in 24 hours, reduce staff's workload.
This injector carries pallet its shortcoming.It must put into pallet with the testing sample of collecting or preparing could realize auto injection, but need timing sampling as sample (chemical reaction or other need to stir such as carrying out, the situation of heating etc.), during situation that the on-line monitoring sample changes, can only manually take a sample and pack in the sample bottle, putting into pallet again measures, need the artificial sample introduction process that participates in, be tantamount to hand sampling, can't bring into play the advantage of auto injection.
The integrated degree that this injector carries pallet is low, the last sample introduction process that has only related to whole mensuration process, need multiple other equipment to finish the processes such as sample preparation in early stage, be mated and finish whole mensuration jointly, in this process, can not seamless link, intervention that must be artificial is shifted sample and is measured.
Summary of the invention
Technical matters to be solved by this invention is, provides a kind of integrated, unreacted sample also can be put into pallet, sets minute, realizes the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function of automatic test sample purpose.
The technical solution adopted in the present invention is: a kind of auto injection pallet that has the controlled warm type microreactor of magnetic agitation function, include pallet, be provided with water-bath sap cavity in middle part in the described pallet, on the described middle part water-bath sap cavity plug-type be formed with a plurality of for the sample bottle grooves of placing sample bottle, the outer peripheral face of described sample bottle groove is provided with the four phase stepping coils that are electrically connected with the pallet circuit external, and screen layer is set shields, be provided with the magnetic stir bar of carrying out electromagnetic induction with described four phase stepping coils in the sample bottle in inserting the sample bottle groove.
Be formed with on the upper periphery of described pallet tilt to pallet middle part be used for preventing the baffle plate that liquid spills.
The upper periphery that joins with pallet of described middle part water-bath sap cavity is formed with the intake chute of the liquid that spills for discharge, is formed with on the described pallet for the outage of discharging liquid in the described intake chute.
Be provided with heater strip and many pieces of temperature-sensitive chips of being electrically connected with the pallet circuit external in the described middle part water-bath sap cavity.
Described screen layer is aluminum or graphite screen layer processed.
A kind of auto injection pallet that has the controlled warm type microreactor of magnetic agitation function, include pallet, be provided with water-bath sap cavity in middle part in the described pallet, on the described middle part water-bath sap cavity plug-type be formed with a plurality of for the sample bottle grooves of placing sample bottle, the array that described a plurality of sample bottle groove formation line and file are arranged, the outer peripheral face of described sample bottle groove is provided with screen layer and shields, described pallet exterior bottom is provided with a plurality of rotatable magnetic bars that are parallel to each other, described each rotatable magnetic bar is to provide power by the motor that is connected with external electric, the corresponding two adjacent files that are made of a plurality of sample bottle grooves of described each rotatable magnetic bar or the gap between the line are provided with the magnetic stir bar corresponding with described rotatable magnetic bar in the described sample bottle groove.
Be formed with on the upper periphery of described pallet tilt to pallet middle part be used for preventing the baffle plate that liquid spills.
The upper periphery that joins with pallet of described middle part water-bath sap cavity is formed with the intake chute of the liquid that spills for discharge, is formed with on the described pallet for the outage of discharging liquid in the described intake chute.
Be provided with heater strip and many pieces of temperature-sensitive chips of being electrically connected with the pallet circuit external in the described middle part water-bath sap cavity.
Described screen layer is aluminum or graphite screen layer processed.
The auto injection pallet that has the controlled warm type microreactor of magnetic agitation function of the present invention, solved the shortcoming that old-fashioned pallet can not on-line analysis, the sample of going back unreacted (or other processes are as permeating extraction etc.) can be put into pallet, set minute, realize the purpose of automatic test sample, do not need manually to participate in the sample introduction process, the advantage of performance auto injection.Simultaneously, the integrated degree height of auto injection pallet of the present invention has related to most of METHOD FOR CONTINUOUS DETERMINATION process, does not need equipment agitating heating etc. to finish the processes such as sample preparation in early stage, has realized the seamless link of test, does not need artificial intervention to shift sample determination.And the alr mode of multiple scheme adapted to the demand of different groups to sample detection, solved the uneven problem of stirring of conventional agitator and the issuable rotor of the multidigit stirrer problem that influences each other.
Description of drawings
Fig. 1 is the plan structure synoptic diagram of the first embodiment of the present invention;
Fig. 2 is the A-A section structure synoptic diagram of Fig. 1;
Fig. 3 is the plan structure synoptic diagram of the second embodiment of the present invention;
Fig. 4 is the B-B section structure synoptic diagram of Fig. 3;
Fig. 5 is the excitation mode synoptic diagram of four phase stepping coils and magnetic stir bar among Fig. 1
Wherein, (a) (b) (c) (d) be the synoptic diagram of four kinds of different exciting modes of magnetic stir bar;
Fig. 6 be among Fig. 5 when power supply magnetic stir bar time phasor
Wherein, (f) being the time phasor of (a) among Fig. 5, (c), (g) is the time phasor of (b) among Fig. 5, (d);
Fig. 7 is the structural representation of magnetic stir bar;
Fig. 8 is the synoptic diagram of the sense of rotation of magnetic stir bar;
Fig. 9 is the structural representation of rotatable magnetic bar;
Figure 10 is the synoptic diagram of the sense of rotation of rotatable magnetic bar.
Among the figure:
1: pallet 2: the sample bottle groove
3: intake chute 4: baffle plate
5: four phase stepping coils 6: screen layer
7: middle part water-bath sap cavity 8: rotatable magnetic bar
9: magnetic stir bar 10: sample bottle
Embodiment
Below in conjunction with embodiment and accompanying drawing the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function of the present invention is made a detailed description.
As shown in Figure 1 and Figure 2, the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function of the present invention, include pallet 1, be provided with middle part water-bath sap cavity 7 in the described pallet 1, be provided with heater strip and many pieces of temperature-sensitive chips of being electrically connected with pallet 1 circuit external in the described middle part water-bath sap cavity 7.On the described middle part water-bath sap cavity 7 plug-type be formed with a plurality of for the sample bottle grooves 2 of placing sample bottle 10, the outer peripheral face of described sample bottle groove 2 is provided with the four phase stepping coils 5 that are electrically connected with pallet 1 circuit external, and screen layer 6 is set shields, described screen layer 6 is aluminum or graphite screen layer processed.Be provided with the magnetic stir bar 9 of carrying out electromagnetic induction with described four phase stepping coils 5 in the sample bottle 10 in inserting sample bottle groove 2.Be formed with on the upper periphery of described pallet 1 tilt to pallet middle part be used for preventing the baffle plate 4 that liquid spills.The upper periphery that joins with pallet 1 of described middle part water-bath sap cavity 7 is formed with for the intake chute 3 of discharging the liquid that spills accidentally, is formed with on the described pallet 1 for the outage of discharging liquid in the described intake chute 3.
As shown in Figure 5, Fig. 1, the excitation mode that has the auto injection pallet of the controlled warm type microreactor of magnetic agitation function of the present invention shown in Figure 2, four phase stepping coils 5 are the electromagnet that adopt four different directions, pass to the electric current of different directions constantly at each, make magnetic stir bar 9 rotations that are positioned at wherein, can change rotating speed by changing excitation frequency, play the effect of speed governing.As shown in Figure 6, be the time phasor of four pieces of electromagnet shown in Figure 5, can export the signal of phasor at this moment by control circuit, drive the magnetic stir bar rotation through amplifying.Because each sample bottle groove 2 is independently, so corresponding stirring site is independently, can control parameters such as mixing time, stirring site number in several ways.
As shown in Figure 3, Figure 4, the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function of the present invention, can also adopt following structure: include pallet 1, be provided with middle part water-bath sap cavity 7 in the described pallet 1, be provided with heater strip and many pieces of temperature-sensitive chips of being electrically connected with pallet 1 circuit external in the described middle part water-bath sap cavity 7.On the described middle part water-bath sap cavity 7 plug-type be formed with a plurality of for the sample bottle grooves 2 of placing sample bottle 10, the array that described a plurality of sample bottle groove 2 formation lines and file are arranged, the outer peripheral face of described sample bottle groove 2 is provided with screen layer 6 and shields, and described screen layer 6 is aluminum or graphite screen layer processed.Described pallet 1 exterior bottom is provided with a plurality of rotatable magnetic bars that are parallel to each other, magnetic bar is the motor that is connected with the pallet external electric to be arranged as power, 8, the corresponding two adjacent files that are made of a plurality of sample bottle grooves 2 of described each rotatable magnetic bar 8 or the gap between the line are provided with the magnetic stir bar 9 corresponding with described rotatable magnetic bar 8 in the described sample bottle groove 2.Be formed with on the upper periphery of described pallet 1 tilt to pallet middle part be used for preventing the baffle plate 4 that liquid spills.The upper periphery that joins with pallet 1 of described middle part water-bath sap cavity 7 is formed with for the intake chute 3 of discharging the liquid that spills accidentally, is formed with on the described pallet 1 for the outage of discharging liquid in the described intake chute 3.
Equally, the pallet 1 in this structure also is to design according to the automatic sampler that mates, and automatic sampler pallet size, thickness, pattern, how many design outline of sample sites according to different can be applied to the high flux testing; Because each sample bottle groove 2 is independently, can control mixing time (can according to means such as software set or hardware timers); Aluminum or graphite screen layer 6 processed can be eliminated the phase mutual interference of 9 of magnetic stir bars; For preventing that acutely rocking the water bath shampoo that causes spills, designed baffle plate 4 and intake chute 3, it imports external pipe with the liquid that flows out, and feeds in the waste liquid bottle; In middle part water-bath sap cavity 7, adopt numeric type temperature-sensitive chip to carry out temperature control (can use as Dallas DS18B20 series digit temperature sensor etc.).
The auto injection pallet that has the controlled warm type microreactor of magnetic agitation function of present embodiment, after the pallet 1 of top removed, sample introduction demand that can adaptive multiple 96 orifice plates.
As Fig. 7～shown in Figure 10, the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function of present embodiment, under each row's stirring site, settle a rotatable magnetic bar 8, the rotation of rotatable magnetic bar drives the circular magnetic stir bar of top, is specially adapted to detections such as suspension, cell suspending liquid to prevent sedimentation.
The control system that has the auto injection pallet of the controlled warm type microreactor of magnetic agitation function of the present invention can adopt circuit common control or digital control, realize motor speed adjusting, the data of temperature sensor receive, the realization of temperature-adjusting circuit, the convenient computer that connects carries out operated from a distance (based on the single-chip microcomputer function).
Claims (9)
1. auto injection pallet that has the controlled warm type microreactor of magnetic agitation function, include pallet (1), it is characterized in that, be provided with middle part water-bath sap cavity (7) in the described pallet (1), described middle part water-bath sap cavity (7) is gone up plug-type a plurality of sample bottle grooves (2) for placement sample bottle (10) that are formed with, the outer peripheral face of described sample bottle groove (2) is provided with the four phase stepping coils (5) that are electrically connected with pallet (1) circuit external, and screen layer (6) is set shields, be provided with the magnetic stir bar (9) of carrying out electromagnetic induction with described four phase stepping coils (5) in the sample bottle (10) in inserting sample bottle groove (2), the upper periphery that joins with pallet (1) of described middle part water-bath sap cavity (7) is formed with the intake chute (3) of the liquid that spills for discharge, is formed with on the described pallet (1) for the outage of discharging the interior liquid of described intake chute (3).
2. the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function according to claim 1 is characterized in that, be formed with on the upper periphery of described pallet (1) tilt to pallet middle part be used for preventing the baffle plate (4) that liquid spills.
3. the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function according to claim 1, it is characterized in that, be provided with heater strip and many pieces of temperature-sensitive chips of being electrically connected with pallet (1) circuit external in the described middle part water-bath sap cavity (7).
4. the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function according to claim 1 is characterized in that, described screen layer (6) is aluminum or graphite screen layer processed.
5. auto injection pallet that has the controlled warm type microreactor of magnetic agitation function, include pallet (1), it is characterized in that, be provided with middle part water-bath sap cavity (7) in the described pallet (1), described middle part water-bath sap cavity (7) is gone up plug-type a plurality of sample bottle grooves (2) for placement sample bottle (10) that are formed with, the array that described a plurality of sample bottle grooves (2) formation line and file are arranged, the outer peripheral face of described sample bottle groove (2) is provided with screen layer (6) and shields, described pallet (1) exterior bottom is provided with a plurality of rotatable magnetic bars (8) that are parallel to each other, described each rotatable magnetic bar (8) is to provide power by the motor that is connected with external electric, the corresponding two adjacent files that are made of a plurality of sample bottle grooves (2) of described each rotatable magnetic bar (8) or the gap between the line are provided with the magnetic stir bar (9) corresponding with described rotatable magnetic bar (8) in the described sample bottle groove (2).
6. the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function according to claim 5 is characterized in that, be formed with on the upper periphery of described pallet (1) tilt to pallet middle part be used for preventing the baffle plate (4) that liquid spills.
7. the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function according to claim 5, it is characterized in that, the upper periphery that joins with pallet (1) of described middle part water-bath sap cavity (7) is formed with the intake chute (3) of the liquid that spills for discharge, is formed with on the described pallet (1) for the outage of discharging the interior liquid of described intake chute (3).
8. the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function according to claim 5, it is characterized in that, be provided with heater strip and many pieces of temperature-sensitive chips of being electrically connected with pallet (1) circuit external in the described middle part water-bath sap cavity (7).
9. the auto injection pallet that has the controlled warm type microreactor of magnetic agitation function according to claim 5 is characterized in that, described screen layer (6) is aluminum or graphite screen layer processed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210101275 CN102636658B (en) | 2012-04-09 | 2012-04-09 | Automatic sample feeding tray for temperature-controllable type microreactor with magnetic stirring function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210101275 CN102636658B (en) | 2012-04-09 | 2012-04-09 | Automatic sample feeding tray for temperature-controllable type microreactor with magnetic stirring function |
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| CN102636658A CN102636658A (en) | 2012-08-15 |
| CN102636658B true CN102636658B (en) | 2013-08-14 |
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| CN 201210101275 Expired - Fee Related CN102636658B (en) | 2012-04-09 | 2012-04-09 | Automatic sample feeding tray for temperature-controllable type microreactor with magnetic stirring function |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106732244B (en) * | 2015-11-24 | 2019-03-29 | 中国科学院过程工程研究所 | A kind of in-situ observation mineral microreactor and its processing method and purposes |
| CN105688724A (en) * | 2016-04-22 | 2016-06-22 | 中国科学院苏州生物医学工程技术研究所 | High-flux magnetic stirring and heating mixing device for reagent |
| CN106085856B (en) * | 2016-08-22 | 2019-01-11 | 中国医学科学院整形外科医院 | A kind of combined type organizational project dynamic cultivation instrument |
| CN106085855B (en) * | 2016-08-22 | 2019-01-15 | 中国医学科学院整形外科医院 | A kind of organizational project dynamic cultivation instrument |
| CN106318868B (en) * | 2016-08-22 | 2019-04-16 | 中国医学科学院整形外科医院 | A kind of organizational project dynamic cultivation instrument stimulated using dynamic mechanical |
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| CN2142752Y (en) * | 1993-01-15 | 1993-09-29 | 航空航天工业部第五研究院第五一四研究所 | Intelligent magnetic stirrer |
| CN201271585Y (en) * | 2008-09-26 | 2009-07-15 | 杭州博日科技有限公司 | Constant temperature trough with magnetic stirring |
| CN101545902A (en) * | 2008-03-24 | 2009-09-30 | 江苏省肿瘤医院 | Automatic sampling distinguishing chemiluminescent multi-component immunological detection system and analysis method of same |
| CN102234610A (en) * | 2010-04-27 | 2011-11-09 | 杭州绿洁水务科技有限公司 | Control system applied to comprehensive toxicity detection |
| CN202512127U (en) * | 2012-04-09 | 2012-10-31 | 天津大学 | Automatic feeding tray for controllable temperature type microreactor with magnetic stirring function |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3426375B2 (en) * | 1994-12-08 | 2003-07-14 | 日清製粉株式会社 | Automatic sample preparation equipment for analysis |
| NO312921B1 (en) * | 1999-07-05 | 2002-07-15 | Sinvent As | Multitest compilation for evaluation, detection and monitoring of processes at elevated pressure |
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2012
- 2012-04-09 CN CN 201210101275 patent/CN102636658B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2142752Y (en) * | 1993-01-15 | 1993-09-29 | 航空航天工业部第五研究院第五一四研究所 | Intelligent magnetic stirrer |
| CN101545902A (en) * | 2008-03-24 | 2009-09-30 | 江苏省肿瘤医院 | Automatic sampling distinguishing chemiluminescent multi-component immunological detection system and analysis method of same |
| CN201271585Y (en) * | 2008-09-26 | 2009-07-15 | 杭州博日科技有限公司 | Constant temperature trough with magnetic stirring |
| CN102234610A (en) * | 2010-04-27 | 2011-11-09 | 杭州绿洁水务科技有限公司 | Control system applied to comprehensive toxicity detection |
| CN202512127U (en) * | 2012-04-09 | 2012-10-31 | 天津大学 | Automatic feeding tray for controllable temperature type microreactor with magnetic stirring function |
Non-Patent Citations (1)
| Title |
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| JP8－160052A 1996.06.21 |
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