CN102636431A - Electrochemiluminescent (ECL) analysis and detection device with self-cleaning function - Google Patents
Electrochemiluminescent (ECL) analysis and detection device with self-cleaning function Download PDFInfo
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- CN102636431A CN102636431A CN2012100730861A CN201210073086A CN102636431A CN 102636431 A CN102636431 A CN 102636431A CN 2012100730861 A CN2012100730861 A CN 2012100730861A CN 201210073086 A CN201210073086 A CN 201210073086A CN 102636431 A CN102636431 A CN 102636431A
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Abstract
The invention relates to an electrochemiluminescent (ECL) analysis and detection device with a self-cleaning function, and belongs to the field of analysis and test, and the device is used for solving the following problems: working electrodes and counter electrodes of the ECL analysis and detection device can be easily adsorbed and polluted by organic substances generated by electrolysis, especially the adsorption pollutions when glassy carbon electrodes are used as the working electrodes are more serious, and the adsorption pollution causes the performances of the working electrodes and auxiliary electrodes to be weakened quickly. The device comprises an electrolytic cell, and working electrodes, counter electrodes and reference electrodes, which are inserted into the electrolytic cell; and importantly, an ultrasonic transducer is arranged on the bottom or side of the electrolytic cell. According to the scheme, low-powered and above 80 KHz ultrasonic waves are used for cleaning the electrodes in the electrolytic cell in time, accordingly, the electrodes are prevented from being absorbed and polluted by organic electrolysates, so that the electrode performance is prevented from being weakened quickly.
Description
Technical field
The present invention relates to a kind of Electrochemiluminescprocess process pick-up unit, belong to the analytical test field with self-cleaning function.
Background technology
In the applied analysis detection means; Electrogenerated chemiluminescence is a kind of new detection technique that on the chemiluminescence basis, grows up; The system that contains chemiluminescent substance through electrode pair applies certain voltage or electric current; Luminescent substance is stimulated and transition is returned ground state and sent photon, so electrochemiluminescence has good selectivity of galvanochemistry and chemiluminescent highly sensitive advantage.The electrogenerated chemiluminescence technology is in the life analysis; Environmental monitoring; Aspects such as food analysis detection have a wide range of applications; Mainly show as based on its good characteristics: its selectivity of (1) electrogenerated chemiluminescence technology is high, and electrogenerated chemiluminescence is combined with electrochemical and chemiluminescence two parts, because the current potential of the redox reaction that different materials takes place is different; Show on the cyclic voltammetry curve to be exactly that the oxidation reduction peak appears in different potentials, the variation according to spike potential can have response curve to different materials like this.(2) highly sensitive, chemiluminescent high sensitivity is equally applicable to electrogenerated chemiluminescence, and the redox reaction that in the middle of magazine, produces does not have the interference of external light source, through the detection of photomultiplier, realizes highly sensitive detection.(3) experimental instrument and equipment is simple, operates photomultiplier and signal output system that this experimental technique only needs corresponding electrochemical workstation and sensed light signal, and is easy to operate.(4) weak point consuming time, response efficiency is high, and accomplishing a cyclic voltammetry scan only needs 3-5 minute time.
Yet; Working electrode in the related device of this electrochemiluminescdetection detection and be that the absorption that auxiliary electrode very receives the organic type of material that electrolysis produces is easily polluted to electrode; Especially adopting under the situation of glass-carbon electrode as working electrode; Said absorption is polluted even more serious, and said absorption pollution can cause the rapid decay of working electrode and auxiliary electrode performance; Therefore, how when carrying out the electrochemiluminescdetection detection operation, effectively, immediately clean said working electrode and auxiliary electrode, just become a technical matters that needs to be resolved hurrily.
Summary of the invention
Problem to be solved by this invention is, researches and develops a kind ofly can carry out when Electrochemiluminescprocess process detects the novel Electrochemiluminescprocess process pick-up unit that immediately carries out the self-cleaning running of electrode.
This case addresses the above problem through following scheme, and the device that this scheme provides is a kind of Electrochemiluminescprocess process pick-up unit with self-cleaning function, and the structure of this device comprises electrolytic cell; And, be installed in below the electrolytic cell or the photomultiplier of side, said electrolytic cell is installed within the magazine; And, working electrode, and; To electrode, and, contrast electrode; Said is sheet, column or thread platinum electrode or gold electrode to electrode, and said contrast electrode is Ag/AgCl electrode or mercurous chloride electrode, and said working electrode is sheet, column or thread platinum electrode, gold electrode or glass-carbon electrode; Said working electrode and the working end of electrode and contrast electrode goed deep into the inside of said electrolytic cell, this electrolytic cell are that its opening end profile is square, the cup-shaped vessel of rectangle, circle or oval-shaped indent, and emphasis is; The structure of this device comprises ultrasonic transducer, and the installation position of this ultrasonic transducer is at the lateral location of this electrolytic cell or the bottom position of electrolytic cell.
Said glass-carbon electrode one speech, its art-recognized meanings is known in the Electrochemiluminescprocess process field.
Said ultrasonic transducer is the device that higher-order of oscillation electric signal is converted to the high frequency mechanical oscillation, and the art-recognized meanings of said ultrasonic transducer one speech itself is known at the ultrasound wave professional skill field.
This case device can also comprise higher-order of oscillation electric signal generator certainly; This higher-order of oscillation electric signal generator can be connected with said ultrasonic transducer; This higher-order of oscillation electric signal generator constitutes ultrasound emission mechanism together with the said ultrasonic transducer that links together with it, and the ultrasound emission power of this ultrasound emission mechanism is between between 1 milliwatt and 20 watts.Adopt lower power, help avoid the said electrode of damage, and help avoiding interference electrochemiluminescdetection detection.
The art-recognized meanings of said higher-order of oscillation electric signal generator one speech is known at the ultrasound wave professional skill field.
The structure of this case device can also comprise some annexes, said annex for example: the faint light measuring instrument, this faint light measuring instrument can be connected with said photomultiplier; And, registering instrument, this registering instrument can be connected with said faint light measuring instrument.
Said annex is again for example: the electrochemical workstation device, this electrochemical workstation device can be connected with said working electrode and auxiliary electrode and contrast electrode.
Said annex is also for example: the electrode clamping, the fixed support that are used for clamping working electrode and auxiliary electrode and contrast electrode; Or the like.
Expressed in terms such as said faint light measuring instrument and said registering instrument and electrochemical workstation device, for the instrumental analysis chemical field, its art-recognized meanings is known.
Ultrasonic cavitation is the strong effect of a kind of ten minutes, and low-frequency ultrasonic waves is stronger to the surface impacts of object workpiece, the cavitation of this low-frequency ultrasonic waves for meticulous as being not too to be fit to for the pick-up unit of this case; Along with the raising of ultrasonic frequency, cavitation weakens until ignoring to the damage of object workpiece gradually; Therefore, the preferred ultrasonic frequency that is suitable for this case device is not random frequency.
As stated, for avoiding the damage of ultrasonic cavitation to working electrode and auxiliary electrode surface, and avoid bringing out sonoluminescence, the preferred frequency of this institute of ultrasound emission mechanism ultrasonic waves transmitted at least should be more than 40KHz; Its scope of preferred frequency of this institute of ultrasound emission mechanism ultrasonic waves transmitted is between 40KHz and 12MHz.
On more meticulous aspect; For avoiding the surperficial ultrasound injury of said working electrode and auxiliary electrode; And, avoid bringing out sonoluminescence more subtly, the preferred frequency further of this institute of ultrasound emission mechanism ultrasonic waves transmitted at least should be more than 80KHz; Further preferred its scope of frequency of this institute of ultrasound emission mechanism ultrasonic waves transmitted is between 80KHz and 12MHz.
Liquid and different electrochemiluminescdetection detection analytic targets at the bottom of the different electrolytic cells; Hyperacoustic susceptibility to different capacity and frequency is different; For avoiding the interference of ultrasound wave to analyzing; Can progressively adjust, confirm required ultrasonic frequency and power according to liquid at the bottom of the concrete electrolytic cell and concrete check and analysis object.
As stated; To liquid at the bottom of different Electrochemiluminescprocess process detected objects and the electrolytic cell, should carefully adjust, select required ultrasonic frequency and power, yet; Under previous work situation not in place; When selecting for use ultrasonic frequency and power are not enough appropriate,, also be not enough worried to such an extent as to induce the sonoluminescence of certain intensity; As long as the blank comparison value of deduction in analyte detection process is automatically converted to a kind of electrogenerated chemiluminescence, the two excitation of electrochemiluminescence Conjoint Analysis pick-up unit with the instant self-cleaning function of electrode under this situation of this device of this case.
The advantage of this case is; This case device can be when carrying out the Electrochemiluminescprocess process detection; Sound wave transmission through liquid at the bottom of the electrolytic cell; Utilize high-frequency, lower powered ultrasound wave to being placed in working electrode and the operative end surface cleaning action that continue, instant of auxiliary electrode in the electrolytic cell, in this way, the organic impurities of having avoided the electrolytic oxidation reduction reaction to generate immediately pollutes the absorption of said electrode surface; Make said electrode can in whole said analyte detection process, remain the pure and fresh state of electrode surface, stoped the quick decay of electrode performance.Certainly; Design feature based on this case device; Before Electrochemiluminescprocess process detects beginning and after finishing, the said ultrasound emission mechanism that this case device can utilize also that it carries launches cleaning in advance and ending cleaning to electrolytic cell and electrode easily.This device of this case also can convert a kind of electrogenerated chemiluminescence, the two excitation of electrochemiluminescence Conjoint Analysis pick-up unit with the instant self-cleaning function of electrode easily to.
Description of drawings
Fig. 1 is this case embodiment synoptic diagram, and expressed is the rough form of the core texture part of this device.
Among the figure, the 1st, magazine, the 2nd, electrolytic cell, the 3rd, auxiliary electrode; The 4th, working electrode, the 5th, the cable of connection auxiliary electrode, the 6th, the cable of connection working electrode; The 7th, the cable of connection contrast electrode, the 8th, contrast electrode, the 9th, ultrasonic transducer; The 10th, liquid at the bottom of the electrolytic cell, 11 schematically represent it is photomultiplier, the 12nd, base.
Embodiment
In this case embodiment that Fig. 1 showed, the structure of device comprises electrolytic cell 2, and; Photomultiplier 11, photomultiplier 11 both can be as being installed in the below of electrolytic cell 2 as the legend, and photomultiplier 11 also can be installed in the lateral location of electrolytic cell 2; Electrolytic cell 2 is installed within the magazine 1, and, working electrode 4; And to electrode 3, this claims auxiliary electrode again to electrode 3; And contrast electrode 8 is sheet, column or thread platinum electrode or gold electrode to electrode 3; Contrast electrode 8 is Ag/AgCl electrode or mercurous chloride electrode, and working electrode 4 is sheet, column or thread platinum electrode, gold electrode or glass-carbon electrode, working electrode 4 and the inside of the working end of electrode 3 and contrast electrode 8 being goed deep into electrolytic cell 2; Electrolytic cell 2 is that its opening end profile is square, the cup-shaped vessel of rectangle, circle or oval-shaped indent, and this apparatus structure comprises ultrasonic transducer 9, in this legend; The installation position of ultrasonic transducer 9 is the lateral location at electrolytic cell 2, and the installation position of ultrasonic transducer 9 also can be the bottom position at electrolytic cell 2.
In this legend, do not draw the higher-order of oscillation electric signal generator that is connected with ultrasonic transducer 9; Do not draw the faint light measuring instrument that is connected with photomultiplier 11 yet; And, do not draw the registering instrument that is connected with this faint light measuring instrument; This legend is not drawn via cable 5,6,7 and the electrochemical workstation device that electrode 3 and working electrode 4 and contrast electrode 8 are connected yet; Do not draw electrode clamping, the fixed support that is used for each electrode of clamping in this legend yet, or the like.
Ultrasonic transducer 9 in the legend can be connected with higher-order of oscillation electric signal generator via cable; Do not draw the cable of this connection ultrasonic transducer and higher-order of oscillation electric signal generator in the legend; The ultrasonic transducer that comprises higher-order of oscillation electric signal generator and link together with it 9 constitutes ultrasound emission mechanisms, and its preferable range of ultrasound emission power of this ultrasound emission mechanism is between between 1 milliwatt and 20 watts; Its preferable range of frequency of this institute of ultrasound emission mechanism ultrasonic waves transmitted is between 40KHz and 12MHz; The further preferred range of the frequency of this institute of ultrasound emission mechanism ultrasonic waves transmitted is between 80KHz and 12MHz.Arbitrary value within the above-mentioned preferred value scope all is the operational parameter value that this case device allows selection; Certainly, the concrete operations parameter value of actual selection will be done careful selection according to the concrete condition of concrete analysis object system.
The ultrasonic transducer of being installed in the device certainly is one incessantly, that is to say, the installing quantity of ultrasonic transducer can be more than one, for example: two, three, four, five, six or the like; The quantity of ultrasonic transducer will be selected according to actual needs; Generally speaking, a foot also.
The embodiment of this case device is not limited to this case accompanying drawing legend.
Claims (4)
1. have the Electrochemiluminescprocess process pick-up unit of self-cleaning function, the structure of this device comprises electrolytic cell, and; Be installed in the photomultiplier of electrolytic cell below or side, said electrolytic cell is installed within the magazine, and; Working electrode, and, to electrode; And, contrast electrode, said is sheet, column or thread platinum electrode or gold electrode to electrode; Said contrast electrode is Ag/AgCl electrode or mercurous chloride electrode, and said working electrode is sheet, column or thread platinum electrode, gold electrode or glass-carbon electrode, said working electrode and the inside of the working end of electrode and contrast electrode being goed deep into said electrolytic cell; This electrolytic cell is that its opening end profile is square, the cup-shaped vessel of rectangle, circle or oval-shaped indent; It is characterized in that the structure of this device comprises ultrasonic transducer, the installation position of this ultrasonic transducer is at the lateral location of this electrolytic cell or the bottom position of electrolytic cell.
2. the Electrochemiluminescprocess process pick-up unit with self-cleaning function according to claim 1; It is characterized in that; The structure of this device comprises higher-order of oscillation electric signal generator; This higher-order of oscillation electric signal generator is connected with said ultrasonic transducer, and this higher-order of oscillation electric signal generator constitutes ultrasound emission mechanism together with the said ultrasonic transducer that links together with it, and the ultrasound emission power of this ultrasound emission mechanism is between between 1 milliwatt and 20 watts.
3. the Electrochemiluminescprocess process pick-up unit with self-cleaning function according to claim 2 is characterized in that, the frequency of this institute of ultrasound emission mechanism ultrasonic waves transmitted is between 40KHz and 12MHz.
4. the Electrochemiluminescprocess process pick-up unit with self-cleaning function according to claim 3 is characterized in that, the frequency of this institute of ultrasound emission mechanism ultrasonic waves transmitted is between 80KHz and 12MHz.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2012100730861A CN102636431A (en) | 2012-03-08 | 2012-03-08 | Electrochemiluminescent (ECL) analysis and detection device with self-cleaning function |
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| CN2012100730861A CN102636431A (en) | 2012-03-08 | 2012-03-08 | Electrochemiluminescent (ECL) analysis and detection device with self-cleaning function |
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| CN102636431A true CN102636431A (en) | 2012-08-15 |
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| CN2012100730861A Pending CN102636431A (en) | 2012-03-08 | 2012-03-08 | Electrochemiluminescent (ECL) analysis and detection device with self-cleaning function |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102928539A (en) * | 2012-10-25 | 2013-02-13 | 宁波大学 | Elution device for detection and sample preparation of water trace polychlorinated biphenyl through gas chromatography-mass spectrometer (GC-MS) method |
| CN102937633A (en) * | 2012-10-25 | 2013-02-20 | 宁波大学 | Adsorption and elution method used in gas chromatography-mass spectrometer (GC-MS) analysis and sample preparation of water trace polychlorinated biphenyls |
| CN106959289A (en) * | 2017-03-22 | 2017-07-18 | 东南大学 | A kind of electrogenerated chemiluminescence material, its preparation method and application |
| CN108489964A (en) * | 2017-02-16 | 2018-09-04 | 爱科来株式会社 | Electrolysis unit |
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| CN101029896A (en) * | 2007-03-22 | 2007-09-05 | 南京大学 | Analysis of quantum-point electrogenerated chemiluminescent hydrophobic-based compound |
| CN101162199A (en) * | 2007-11-19 | 2008-04-16 | 福州大学 | Heat controlled electric pole electrogenerated chemiluminescence testing apparatus and testing-pool preparation method |
| CN201740759U (en) * | 2010-07-21 | 2011-02-09 | 宇星科技发展(深圳)有限公司 | All-in-one heavy metal online analyzer |
| CN102070222A (en) * | 2011-03-08 | 2011-05-25 | 广州金川环保设备有限公司 | Method and device for pre-treating oil field sewage by ultrasonic oxidation united with electrochemical oxidation |
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| CN101029896A (en) * | 2007-03-22 | 2007-09-05 | 南京大学 | Analysis of quantum-point electrogenerated chemiluminescent hydrophobic-based compound |
| CN101162199A (en) * | 2007-11-19 | 2008-04-16 | 福州大学 | Heat controlled electric pole electrogenerated chemiluminescence testing apparatus and testing-pool preparation method |
| CN201740759U (en) * | 2010-07-21 | 2011-02-09 | 宇星科技发展(深圳)有限公司 | All-in-one heavy metal online analyzer |
| CN102070222A (en) * | 2011-03-08 | 2011-05-25 | 广州金川环保设备有限公司 | Method and device for pre-treating oil field sewage by ultrasonic oxidation united with electrochemical oxidation |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102928539A (en) * | 2012-10-25 | 2013-02-13 | 宁波大学 | Elution device for detection and sample preparation of water trace polychlorinated biphenyl through gas chromatography-mass spectrometer (GC-MS) method |
| CN102937633A (en) * | 2012-10-25 | 2013-02-20 | 宁波大学 | Adsorption and elution method used in gas chromatography-mass spectrometer (GC-MS) analysis and sample preparation of water trace polychlorinated biphenyls |
| CN108489964A (en) * | 2017-02-16 | 2018-09-04 | 爱科来株式会社 | Electrolysis unit |
| CN106959289A (en) * | 2017-03-22 | 2017-07-18 | 东南大学 | A kind of electrogenerated chemiluminescence material, its preparation method and application |
| CN106959289B (en) * | 2017-03-22 | 2019-07-12 | 东南大学 | A kind of electrogenerated chemiluminescence material, preparation method and application |
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Application publication date: 20120815 |