CN102631714A - Titanium nail - Google Patents
Titanium nail Download PDFInfo
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- CN102631714A CN102631714A CN2012101168528A CN201210116852A CN102631714A CN 102631714 A CN102631714 A CN 102631714A CN 2012101168528 A CN2012101168528 A CN 2012101168528A CN 201210116852 A CN201210116852 A CN 201210116852A CN 102631714 A CN102631714 A CN 102631714A
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- titanium nail
- titanium
- inflammation drugs
- coating
- nail
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Abstract
The invention relates to a medical titanium nail, and aims to provide a titanium nail with an anti-inflammatory drug coating. The titanium nail comprises a titanium body (1) and the anti-inflammatory drug coating (2), wherein the anti-inflammatory drug coating (2) is covered on the surface of the titanium body (1). According to the invention, when the titanium nail is connected with a tissue, the titanium nail can release an anti-inflammatory drug, prevent the tissue from inflammation, and effectively promote healing of the tissue, and is broadly used for various anastomosis and suturing operative instruments.
Description
Technical field
The present invention relates to medical instruments field, follow closely more specifically to medical titanium.
Background technology
The titanium nail is widely used in medical apparatus and instruments; In straight cuts, titanium clamp pincers (vascular forceps) apparatus product etc. under various anastomats, stiching instrument, straight cuts, the chamber mirror, these medical apparatus and instruments are usually used in the operations such as the coincideing of tissue such as surgery stomach, lung and operation on digestive tract tissue, stitching.But, because the biologically inert of titanium can cause sewing up failure under situation such as seam area oozing of blood, inflammation.When titanium nail and the organization healing around it, titanium nail surface nature is to organizing pivotal role.In operation, also will be when needing conjunctive tissue to antiinflammatory around the tissue, but still do not have at present the titanium nail of inflammation-diminishing function.
Summary of the invention
The present invention aims to provide a kind of titanium nail with anti-inflammation drugs coating.
For realizing above-mentioned purpose, the technical scheme that the present invention adopted is: a kind of titanium nail, comprise the titanium body, and it is characterized in that it also comprises the anti-inflammation drugs coating, said anti-inflammation drugs coating is coated in the surface of said titanium body.
Preferably, said anti-inflammation drugs coating contains one or more of following medicine: rifampicin, minocycline hydrochloride, silver sulfadiazine, hibitane, triclosan, gentamycin, berberine hydrochloride.
Preferably, said anti-inflammation drugs coating also contains the copolymer coated carrier.
Preferably, said copolymer coated carrier be following copolymer one or more: medical polyurethane, medical silicone, Biodegradable polylactic acids.
Preferably, the thickness of above-mentioned anti-inflammation drugs coating is 0.001-10mm.
The surfaces coated of titanium nail of the present invention is covered with the anti-inflammation drugs coating, can in conjunctive tissue, discharge anti-inflammation drugs, prevents tissue inflammation, can promote the healing of organizing effectively.
Description of drawings
Fig. 1 is the profile of the titanium nail of embodiments of the invention.
The specific embodiment
Titanium nail of the present invention is used for cutting assembly, disposable stiching instrument, single-use skin anastomat, the anus-expanding unit anastomat of being with light source, disjunctor anastomat, pocket anastomat, clamp anastomat, closing of cutting anastomat, perforator, arc-shaped cutting anastomat etc. under tube type anastomat, straight line stiching instrument, disposable suturing assembly, the following cutting of chamber mirror, the chamber mirror.
Fig. 1 is the profile of the titanium nail of embodiments of the invention.
As shown in Figure 1, the scheme that embodiments of the invention adopt is the titanium body 1 surface-coated anti-inflammation drugs coating 2 at the titanium nail.
The anti-inflammation drugs that is adopted can be following one or more: rifampicin, minocycline hydrochloride, silver sulfadiazine, hibitane, triclosan, gentamycin, berberine hydrochloride.
The painting method of anti-inflammation drugs coating 2 is: the mixed liquor of preparation anti-inflammation drugs and solvent, the titanium nail is immersed in the mixed liquor, and soak time confirms that according to coating layer thickness requiring coating layer thickness is 0.001-10mm, takes out the titanium nail and carries out dried.
The copolymer coated carrier can be one or more of following copolymer: medical polyurethane, medical silicone, Biodegradable polylactic acids.The painting method that is adopted is: the mixed liquor of preparation anti-inflammation drugs and solvent; The preparation copolymer solution; Anti-inflammation drugs is mixed with the mixed liquor and the copolymer solution of solvent, titanium nail is immersed in the mixed liquor of mixed liquor and copolymer solution of blended anti-inflammation drugs and solvent, soak time is definite according to coating layer thickness; The requirement coating layer thickness is 0.001-10mm, takes out the titanium nail and carries out dried.
Can adopt one or more of following solvents with the solvent of blended solvent of anti-inflammation drugs and dissolving copolymer: acetic acid, methyl acetate, ethyl acetate, hexane, N-N-dimethyl acetylamide, oxolane (THF), ethanol, water, N-ethyl-2-pyrrolidone (NEP), n-(2-hydroxyl-ethyl)-2-Pyrrolidone, n-cyclohexyl-2-Pyrrolidone.
The composition of embodiment of the present invention and anti-inflammation drugs coating 2 can be known through following embodiment.
According to the weight ratio anti-inflammation drugs: solvent be 1: 5 ratio with anti-inflammation drugs and solvent and stir, process the solution or the suspension of homogeneous, anti-inflammation drugs is selected from one or more of aforementioned anti-inflammation drugs, solvent is selected from one or more of aforementioned solvents; The titanium nail is immersed in the solution of making or suspension, and soak time coating layer thickness is as requested selected, and making the gained coating layer thickness is 0.001-10mm; Soak the back and take out the titanium nail, carry out natural drying or in drying oven dry 10-24 hour, obtain the titanium nail of surface-coated anti-inflammation drugs coating 2.
According to the weight ratio silver sulfadiazine: oxolane is that 1: 50 ratio is mixed silver sulfadiazine and stirred with oxolane, processes the suspension of homogeneous; According to the medical polyurethane of weight ratio: oxolane is that 1: 20 ratio is mixed medical polyurethane and stirred with oxolane, processes the solution of homogeneous; Above-mentioned suspension is mixed with solution; The titanium nail is immersed in the aforementioned mixed liquor, and soaked 3 minutes; Taking-up titanium nail, natural drying or in drying oven dry 10-24 hour obtain the titanium nail of the coating 2 of surface-coated silver sulfadiazine and medical polyurethane.
Embodiment 3
(1) 1 milligram of chlorhexidine acetate is added in the N-ethyl-2-pyrrolidone of 5cc, be heated to 50-60 ℃ and stirring, chlorhexidine acetate is dissolved in the N-ethyl-2-pyrrolidone fully.
(2) oxolane with 10cc joins in the solution of gained in (1), fully stirs, and obtains the solution of homogeneous.
(3) 3 milligrams of medical polyurethanes are joined in the oxolane of 50cc, be heated to 65-70 ℃ and stirring, medical polyurethane is dissolved in the oxolane fully.
(4) join 1 milligram sulfadiazine silver powder in the oxolane of 35cc and stir, process suspension.
(5) suspension that makes in the solution that makes in the solution that makes in (2), (3) and (4) is mixed; Obtain containing as the silver sulfadiazine of 1% chlorhexidine acetate of anti-inflammation drugs and 1% and as the mixed liquor of 3% medical polyurethane of copolymer, solvent wherein is 5% N-ethyl-2-pyrrolidone and 95% oxolane.
(6) the titanium nail is immersed in the mixed liquor of gained in (5), soaked 1 minute.
(7) from mixed liquor, take out the titanium nail, and dry, obtain the titanium nail that surfaces coated is covered with the coating 2 that contains silver sulfadiazine, hibitane and medical polyurethane.
Embodiment 4
3 milligrams of gentamycins are dissolved in the 20cc N-ethyl-2-pyrrolidone; 1 milligram of chlorhexidine acetate is dissolved in the 5ccN-ethyl-2-pyrrolidone; 1 milligram of medical polyurethane is dissolved in the 50cc oxolane; 1 milligram of polylactic acid is dissolved in the 25cc oxolane; Aforementioned solution is mixed, obtain mixed solution; The titanium nail is immersed in the mixed solution, soaked 1 minute; Take out titanium nail and dried, obtain the titanium nail that surfaces coated is covered with the coating 2 that contains gentamycin, hibitane, medical polyurethane and polylactic acid.
The foregoing description is with the formal specification of the example specific embodiment of the present invention; Those skilled in the art can make the scheme of various variations according to the foregoing description; Such as the combination of medicine and/or copolymer is made change, perhaps the component ratio of soak is made change, the scheme of these variations all will obtain the titanium nail that surface-coated contains the coating of anti-inflammation drugs; All do not break away from spirit of the present invention and flesh and blood, all fall within protection scope of the present invention.
Claims (5)
1. a titanium nail comprises titanium body (1), it is characterized in that it also comprises anti-inflammation drugs coating (2), and said anti-inflammation drugs coating (2) is coated in the surface of said titanium body (1).
2. titanium nail as claimed in claim 1 is characterized in that said anti-inflammation drugs coating (2) contains rifampicin and/or minocycline hydrochloride and/or silver sulfadiazine and/or hibitane and/or triclosan and/or gentamycin and/or berberine hydrochloride.
3. titanium nail as claimed in claim 2 is characterized in that said anti-inflammation drugs coating (2) also contains the copolymer coated carrier.
4. titanium nail as claimed in claim 3 is characterized in that said copolymer coated carrier is medical polyurethane and/or medical silicone and/or Biodegradable polylactic acids.
5. like each described titanium nail of claim 1 to 4, it is characterized in that the thickness of described anti-inflammation drugs coating (2) is 0.001-10mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101168528A CN102631714A (en) | 2012-04-20 | 2012-04-20 | Titanium nail |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101168528A CN102631714A (en) | 2012-04-20 | 2012-04-20 | Titanium nail |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102631714A true CN102631714A (en) | 2012-08-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101168528A Pending CN102631714A (en) | 2012-04-20 | 2012-04-20 | Titanium nail |
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| Country | Link |
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| CN (1) | CN102631714A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861363A (en) * | 2012-10-09 | 2013-01-09 | 王学凡 | Medical metal wire |
| CN105920683A (en) * | 2016-04-24 | 2016-09-07 | 李蒙 | Titanium nail used for stomach diseases and being capable of preventing bacterial infection |
| CN106377290A (en) * | 2016-08-19 | 2017-02-08 | 北京派尔特医疗科技股份有限公司 | Drug-loaded titanium nail and preparation method thereof |
| CN108348639A (en) * | 2015-08-31 | 2018-07-31 | 伊西康有限责任公司 | Attaching material for providing controlled drug release |
| CN112190772A (en) * | 2020-10-12 | 2021-01-08 | 淮阴工学院 | Anastomosis nail with anti-inflammation function and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642587A (en) * | 2009-08-21 | 2010-02-10 | 中国人民解放军第三军医大学第三附属医院 | Orthopaedic metal implant loaded with slow release antibiotic and preparation method thereof |
| CN102266595A (en) * | 2011-07-14 | 2011-12-07 | 王学凡 | Medicament coating titanium nail using chitosan gelatin as carrier |
-
2012
- 2012-04-20 CN CN2012101168528A patent/CN102631714A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642587A (en) * | 2009-08-21 | 2010-02-10 | 中国人民解放军第三军医大学第三附属医院 | Orthopaedic metal implant loaded with slow release antibiotic and preparation method thereof |
| CN102266595A (en) * | 2011-07-14 | 2011-12-07 | 王学凡 | Medicament coating titanium nail using chitosan gelatin as carrier |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861363A (en) * | 2012-10-09 | 2013-01-09 | 王学凡 | Medical metal wire |
| CN108348639A (en) * | 2015-08-31 | 2018-07-31 | 伊西康有限责任公司 | Attaching material for providing controlled drug release |
| CN105920683A (en) * | 2016-04-24 | 2016-09-07 | 李蒙 | Titanium nail used for stomach diseases and being capable of preventing bacterial infection |
| CN105920683B (en) * | 2016-04-24 | 2019-02-01 | 河北卫崭医疗科技有限公司 | A kind of titanium that can prevent bacterium infection used for gastrointestinal disease is followed closely |
| CN106377290A (en) * | 2016-08-19 | 2017-02-08 | 北京派尔特医疗科技股份有限公司 | Drug-loaded titanium nail and preparation method thereof |
| WO2018032664A1 (en) * | 2016-08-19 | 2018-02-22 | 北京派尔特医疗科技股份有限公司 | Titanium clip with drug-loading feature, drug-loaded titanium clip, and manufacturing method thereof |
| CN106377290B (en) * | 2016-08-19 | 2018-06-22 | 北京派尔特医疗科技股份有限公司 | A kind of medicine-carried titanium nail and load medicine titanium nail and preparation method thereof |
| US10286117B2 (en) | 2016-08-19 | 2019-05-14 | B.J. Zh. F. Panther Medical Equipment Co. Ltd. | Titanium nail capable of loading drug and drug-loaded titanium nail and preparing method of the same |
| CN112190772A (en) * | 2020-10-12 | 2021-01-08 | 淮阴工学院 | Anastomosis nail with anti-inflammation function and preparation method thereof |
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Addressee: Wang Xuefan Document name: Notification of Passing Preliminary Examination of the Application for Invention |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice |
Addressee: Wang Xuefan Document name: Notification of Publication and of Entering the Substantive Examination Stage of the Application for Invention |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120815 |