CN102631397B - Traditional Chinese medicine composition for improving cerebral blood circulation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for improving cerebral blood circulation and preparation method thereof Download PDFInfo
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- CN102631397B CN102631397B CN201110036952.5A CN201110036952A CN102631397B CN 102631397 B CN102631397 B CN 102631397B CN 201110036952 A CN201110036952 A CN 201110036952A CN 102631397 B CN102631397 B CN 102631397B
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Abstract
The invention provides a traditional Chinese medicine composition for improving cerebral blood circulation and a preparation method thereof; the traditional Chinese medicine composition mainly comprises 10-40 parts by weight of rhodiola rosea extract and 10-20 parts by weight of fish oil; the preparation method comprises well mixing the rhodiola rosea extract and the fish oil with auxiliary materials; the traditional Chinese medicine composition for improving cerebral blood circulation aims at multiple targets; various components are coordinated to be consistent and have synergistic interaction; the traditional Chinese medicine composition can dredge cerebral vessels comprehensively, improve cerebral hypoxia, improve blood circulation, regulate cerebral vessels, and prevent cerebral arteriosclerosis.
Description
Technical field
The present invention relates to a kind of medicine that improves brain blood circulation and preparation method thereof, especially a kind of Chinese medicine composition that improves brain blood circulation and preparation method thereof.
Background technology
Modern medicine is thought the lipid peroxidation and arteriosclerotic in close relations that free radical causes.When hypoxic-ischemic, body produces a large amount of oxygen-derived free radicals, the lipid of free radical and cell biological film produces lipid peroxidation, cellulation toxicant lipid peroxide also produces chain reaction thus, make that protein molecular is crosslinked, nucleic acid crosslinked, DNA damage variation, cause cellular morphology and changes of function.There are some researches show, a large amount of lipid peroxide and catabolite can damage arterial wall and cause atherosclerosis as MDA.And SOD in body can remove oxygen-derived free radicals and catabolite thereof, cell biological film is shielded, thereby prevent and treat atherosclerosis.Nitric oxide (NO) is relevant with development with the generation of many cardiovascular and cerebrovascular diseases.Study and show recently, NOS has 2 kinds at least, i.e. primary enzyme and induced enzyme, each own different releasing position and biological activitys.NOS deficiency, directly affects the synthetic of NO.Research in recent years shows, NO can vasodilator, suppress platelet adhesion reaction assembles, removes oxygen-derived free radicals, maintains normal cardiac output, cytoprotection.NO is not enough accelerates atherosclerosis.Therefore, research and develop a kind of Chinese medicine composition, make its dredging cerebrovascular in all directions, improve large cerebral anoxia, effectively prevent cerebral arteriosclerosis, there is very important using value.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition that improves brain blood circulation.
Another technical problem to be solved by this invention is to provide the preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation.
For solving the problems of the technologies described above, technical scheme of the present invention is:
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Radix Rhodiolae extractum and fish oil, by its parts by weight Radix Rhodiolae extractum 10-40 part, fish oil 10-20 part.
Preferably, the above-mentioned Chinese medicine composition that improves brain blood circulation, is mainly made up of Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum and fish oil, by its parts by weight Rhizoma Chuanxiong extractum 40-50 part, Radix Rhodiolae extractum 10-40 part, fish oil 10-20 part.
Preferably, the above-mentioned Chinese medicine composition that improves brain blood circulation, is mainly made up of Radix Rhodiolae extractum, extract and fish oil, by its parts by weight Radix Rhodiolae extractum 10-40 part, extract 10-30 part, fish oil 10-20 part.
Preferably, the above-mentioned Chinese medicine composition that improves brain blood circulation, mainly formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum, extract and fish oil, by its parts by weight Rhizoma Chuanxiong extractum 40-50 part, Radix Rhodiolae extractum 10-40 part, extract 10-30 part, fish oil 10-20 part.
Preferably, the above-mentioned Chinese medicine composition that improves brain blood circulation, also comprises the acceptable adjuvant of optional pharmacy.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30%-95% (V/V) ethanol 6000-8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material, in concentrated solution, adding while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000-4000 rev/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) gained Radix Rhodiolae extractum and fish oil are mixed homogeneously with adjuvant, wherein count by weight Radix Rhodiolae extractum 10-40 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times.
The above-mentioned Chinese medicine composition that improves brain blood circulation can be acceptable dosage form on any pharmaceutics.
Preferably, the preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, described dosage form is drops, and it is shaped as reddish brown/brownish black ball shape, and evenly, concrete preparation method is size:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30%-95% (V/V) ethanol 6000-8000ml, filter, merging filtrate, and filtrate is suitably concentrated, being concentrated into every 1g extractum is equivalent to 1-6g medical material in concentrated solution, to add while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, place 24 hours, centrifugal (1000-4000 rev/min), gets supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) gained Radix Rhodiolae extractum and fish oil are mixed homogeneously with adjuvant, wherein count by weight Radix Rhodiolae extractum 10-40 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times;
(3) under 60-100 DEG C of condition, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 0-10 DEG C of liquid paraffin, removes liquid paraffin, selects ball.
Preferably, the preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30%-95% (V/V) ethanol 6000-8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material, in concentrated solution, adding while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000-4000 rev/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 30%-95% (V/V) ethanol 6000-8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material;
(3) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum and fish oil are mixed homogeneously with adjuvant, wherein count by weight Rhizoma Chuanxiong extractum 40-50 part, Radix Rhodiolae extractum 10-40 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times.
Preferably, the preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, described dosage form is drops, and it is shaped as reddish brown/brownish black ball shape, and evenly, concrete preparation method is size:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30%-95% (V/V) ethanol 6000-8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material, in concentrated solution, adding while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000-4000 rev/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 30%-95% (V/V) ethanol 6000-8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material;
(3) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum and fish oil are mixed homogeneously with adjuvant, wherein count by weight Rhizoma Chuanxiong extractum 40-50 part, Radix Rhodiolae extractum 10-40 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times;
(4) under 60-100 DEG C of condition, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 0-10 DEG C of liquid paraffin, removes liquid paraffin, selects ball.
Preferably, the preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30%-95% (V/V) ethanol 6000-8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material, in concentrated solution, adding while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000-4000 rev/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 30%-95% (V/V) ethanol 6000-8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material;
(3) gained Radix Rhodiolae extractum, extract and fish oil are mixed homogeneously with adjuvant, wherein count by weight Radix Rhodiolae extractum 10-40 part, extract 10-30 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times.
Preferably, the preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, described dosage form is drops, and it is shaped as reddish brown/brownish black ball shape, and evenly, concrete preparation method is size:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30%-95% (V/V) ethanol 6000-8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material, in concentrated solution, adding while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000-4000 rev/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 30%-95% (V/V) ethanol 6000-8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material;
(3) gained Radix Rhodiolae extractum, extract and fish oil are mixed homogeneously with adjuvant, wherein count by weight Radix Rhodiolae extractum 10-40 part, extract 10-30 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times;
(4) under 60-100 DEG C of condition, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 0-10 DEG C of liquid paraffin, removes liquid paraffin, selects ball.
Preferably, the preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30%-95% (V/V) ethanol 6000-8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material, in concentrated solution, adding while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000-4000 rev/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 30%-95% (V/V) ethanol 6000-8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material;
(3) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 30%-95% (V/V) ethanol 6000-8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material;
(4) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum, extract and fish oil are mixed homogeneously with adjuvant, wherein count by weight Rhizoma Chuanxiong extractum 40-50 part, Radix Rhodiolae extractum 10-40 part, extract 10-30 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times.
Preferably, the preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, described dosage form is drops, and it is shaped as reddish brown/brownish black ball shape, and evenly, concrete preparation method is size:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30%-95% (V/V) ethanol 6000-8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material, in concentrated solution, adding while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000-4000 rev/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 30%-95% (V/V) ethanol 6000-8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material;
(3) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 30%-95% (V/V) ethanol 6000-8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1-6g medical material;
(4) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum, extract and fish oil are mixed homogeneously with adjuvant, wherein count by weight Rhizoma Chuanxiong extractum 40-50 part, Radix Rhodiolae extractum 10-40 part, extract 10-30 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times;
(5) under 60-100 DEG C of condition, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 0-10 DEG C of liquid paraffin, removes liquid paraffin, selects ball.
Preferably, the preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, described adjuvant is polyethylene glycol 6000, the one of Macrogol 4000 or PEG400 or combination in any.
Preferably, the preparation method of above-mentioned drops, the ball that makes drop pill is heavily 5-50mg/ grain, diameter is 1.95-5.00mm.
The invention has the beneficial effects as follows:
The above-mentioned Chinese medicine composition that improves brain blood circulation is for multiple target spots, and Multiple components is harmonious, Synergistic, and dredging cerebrovascular in all directions, improves large cerebral anoxia, and blood circulation regulates cerebrovascular, prevention cerebral arteriosclerosis; Each component raw material all comes from natural extractum, and Chinese medicine has been carried out to brand-new elaboration, scientific strong; Raw material is medicinal and edible food, there is no obvious toxic-side effects, between each composition, there is no incompatibility, without ill effect mutually; Its preparation method is simple, and drops effective ingredient content is high, absorbs fast taking convenience in body.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Radix Rhodiolae extractum and fish oil, by its 40 parts of parts by weight Radix Rhodiolae extractum, 10 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30% (V/V) ethanol 8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1g medical material, in concentrated solution, adding while hot concentration is 3% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (4000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2g medical material;
(2) gained Radix Rhodiolae extractum and fish oil are mixed homogeneously with polyethylene glycol 6000, wherein count by weight 40 parts of Radix Rhodiolae extractum, 10 parts, fish oil, polyethylene glycol 6000 addition is extractum and fish oil gross weight 1 times.
Embodiment 2
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Radix Rhodiolae extractum and fish oil, by its 10 parts of parts by weight Radix Rhodiolae extractum, 20 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 95% (V/V) ethanol 6000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 6g medical material, in concentrated solution, adding while hot concentration is 10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 7g medical material;
(2) gained Radix Rhodiolae extractum and fish oil are mixed homogeneously with polyethylene glycol 6000 and PEG400, wherein count by weight 10 parts of Radix Rhodiolae extractum, 20 parts, fish oil, polyethylene glycol 6000 addition is extractum and fish oil gross weight 2 times, and PEG400 addition is extractum and fish oil gross weight 4 times.
Embodiment 3
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Radix Rhodiolae extractum and fish oil, by its 25 parts of parts by weight Radix Rhodiolae extractum, 15 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 60% (V/V) ethanol 7000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 4g medical material, in concentrated solution, adding while hot concentration is 6% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (3000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 5g medical material;
(2) gained Radix Rhodiolae extractum and fish oil are mixed homogeneously with Macrogol 4000, wherein count by weight 25 parts of Radix Rhodiolae extractum, 15 parts, fish oil, Macrogol 4000 addition is extractum and fish oil gross weight 4 times;
(3) under 80 DEG C of conditions, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 5 DEG C of liquid paraffin, removes liquid paraffin, select ball, resulting dosage forms is drops, and it is shaped as rufous ball shape, evenly, the ball of drop pill is heavily 15mg/ grain to size, and diameter is 2.55mm.
Embodiment 4
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Radix Rhodiolae extractum and fish oil, by its 30 parts of parts by weight Radix Rhodiolae extractum, 17 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 50% (V/V) ethanol 8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 3g medical material, in concentrated solution, adding while hot concentration is 7% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (2000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 4g medical material;
(2) gained Radix Rhodiolae extractum and fish oil are mixed homogeneously with polyethylene glycol 6000, wherein count by weight 30 parts of Radix Rhodiolae extractum, 17 parts, fish oil, polyethylene glycol 6000 addition is extractum and fish oil gross weight 3 times;
(3) under 90 DEG C of conditions, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 4 DEG C of liquid paraffin, removes liquid paraffin, select ball, resulting dosage forms is drops, and it is shaped as brownish black ball shape, evenly, the ball of drop pill is heavily 30mg/ grain to size, and diameter is 3.50mm.
Embodiment 5
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum and fish oil, by 50 parts of its parts by weight Rhizoma Chuanxiong extractums, 40 parts of Radix Rhodiolae extractum, 10 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30% (V/V) ethanol 8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1g medical material, in concentrated solution, adding while hot concentration is 10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 95% (V/V) ethanol 6000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1g medical material;
(3) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum and fish oil are mixed homogeneously with PEG400, wherein count by weight 50 parts of Rhizoma Chuanxiong extractums, 40 parts of Radix Rhodiolae extractum, 10 parts, fish oil, PEG400 addition is extractum and fish oil gross weight 1 times.
Embodiment 6
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum and fish oil, by 40 parts of its parts by weight Rhizoma Chuanxiong extractums, 10 parts of Radix Rhodiolae extractum, 20 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 95% (V/V) ethanol 6000, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 6g medical material, in concentrated solution, adding while hot concentration is 3% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (4000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 7g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 30% (V/V) ethanol 8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 6g medical material;
(3) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum and fish oil are mixed homogeneously with polyethylene glycol 6000, wherein count by weight 40 parts of Rhizoma Chuanxiong extractums, 10 parts of Radix Rhodiolae extractum, 20 parts, fish oil, polyethylene glycol 6000 addition is extractum and fish oil gross weight 6 times;
(4) under 100 DEG C of conditions, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 10 DEG C of liquid paraffin, removes liquid paraffin, select ball, resulting dosage forms is drops, and it is shaped as brownish black ball shape, evenly, the ball of drop pill is heavily 50mg/ grain to size, and diameter is 5.00mm.
Embodiment 7
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum and fish oil, by 45 parts of its parts by weight Rhizoma Chuanxiong extractums, 25 parts of Radix Rhodiolae extractum, 15 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 55% (V/V) ethanol 7000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 4g medical material, in concentrated solution, adding while hot concentration is 7% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (3000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 5g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 60% (V/V) ethanol 7000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 4g medical material;
(3) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum and fish oil are mixed homogeneously with polyethylene glycol 6000 and Macrogol 4000, wherein count by weight 45 parts of Rhizoma Chuanxiong extractums, 25 parts of Radix Rhodiolae extractum, 15 parts, fish oil, Macrogol 4000 addition is extractum and fish oil gross weight 1 times, and Macrogol 4000 addition is extractum and fish oil gross weight 2 times;
(4) under 80 DEG C of conditions, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 0 DEG C of liquid paraffin, removes liquid paraffin, select ball, resulting dosage forms is drops, and it is shaped as rufous ball shape, evenly, the ball of drop pill is heavily 25mg/ grain to size, and diameter is 2.75mm.
Embodiment 8
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Radix Rhodiolae extractum, extract and fish oil, by its 40 parts of parts by weight Radix Rhodiolae extractum, 10 parts of extracts, 20 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 95% (V/V) ethanol 8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 6g medical material, in concentrated solution, adding while hot concentration is 3% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 7g medical material;
(2) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 30% (V/V) ethanol 6000, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1g medical material;
(3) gained Radix Rhodiolae extractum, extract and fish oil are mixed homogeneously with Macrogol 4000 and PEG400, wherein count by weight 40 parts of Radix Rhodiolae extractum, 10 parts of extracts, 20 parts, fish oil, Macrogol 4000 addition is extractum and fish oil gross weight 3 times, and PEG400 addition is extractum and fish oil gross weight 3 times.
Embodiment 9
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Radix Rhodiolae extractum, extract and fish oil, by its 10 parts of parts by weight Radix Rhodiolae extractum, 30 parts of extracts, 10 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30% (V/V) ethanol 6000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1g medical material, in concentrated solution, adding while hot concentration is 10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (4000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2g medical material;
(2) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 95% (V/V) ethanol 8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 6g medical material;
(3) gained Radix Rhodiolae extractum, extract and fish oil are mixed homogeneously with polyethylene glycol 6000, wherein count by weight 10 parts of Radix Rhodiolae extractum, 30 parts of extracts, 10 parts, fish oil, polyethylene glycol 6000 addition is extractum and fish oil gross weight 1-6 times;
(4) under 60 DEG C of conditions, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 0 DEG C of liquid paraffin, removes liquid paraffin, select ball, resulting dosage forms is drops, and it is shaped as rufous ball shape, evenly, the ball of drop pill is heavily 5mg/ grain to size, and diameter is 1.95mm.
Embodiment 10
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Radix Rhodiolae extractum, extract and fish oil, by its 30 parts of parts by weight Radix Rhodiolae extractum, 20 parts of extracts, 15 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 60% (V/V) ethanol 7000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 3g medical material, in concentrated solution, adding while hot concentration is 5% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (3000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 4g medical material;
(2) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 65% (V/V) ethanol 7000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 4g medical material;
(3) gained Radix Rhodiolae extractum, extract and fish oil are mixed homogeneously with Macrogol 4000, wherein count by weight 30 parts of Radix Rhodiolae extractum, 20 parts of extracts, 15 parts, fish oil, Macrogol 4000 addition is extractum and fish oil gross weight 4 times;
(4) under 90 DEG C of conditions, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 8 DEG C of liquid paraffin, removes liquid paraffin, select ball, resulting dosage forms is drops, and it is shaped as brownish black ball shape, evenly, the ball of drop pill is heavily 20mg/ grain to size, and diameter is 2.33mm.
Embodiment 11
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum, extract and fish oil, by 40 parts of its parts by weight Rhizoma Chuanxiong extractums, 40 parts of Radix Rhodiolae extractum, 10 parts of extracts, 20 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 30% (V/V) ethanol 8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1g medical material, in concentrated solution, adding while hot concentration is 3% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (3000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 95% (V/V) ethanol 8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 6g medical material;
(3) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 30% (V/V) ethanol 8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 6g medical material;
(4) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum, extract and fish oil are mixed homogeneously with polyethylene glycol 6000, wherein count by weight 40 parts of Rhizoma Chuanxiong extractums, 40 parts of Radix Rhodiolae extractum, 10 parts of extracts, 20 parts, fish oil, polyethylene glycol 6000 addition is extractum and fish oil gross weight 6 times.
Embodiment 12
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum, extract and fish oil, by 50 parts of its parts by weight Rhizoma Chuanxiong extractums, 10 parts of Radix Rhodiolae extractum, 30 parts of extracts, 10 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 95% (V/V) ethanol 6000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 6g medical material, in concentrated solution, adding while hot concentration is 10% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (1000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 7g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 30% (V/V) ethanol 6000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1g medical material;
(3) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 95% (V/V) ethanol 6000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 1g medical material;
(4) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum, extract and fish oil are mixed homogeneously with PEG400, wherein count by weight 50 parts of Rhizoma Chuanxiong extractums, 10 parts of Radix Rhodiolae extractum, 30 parts of extracts, 10 parts, fish oil, PEG400 addition is extractum and fish oil gross weight 1 times.
Embodiment 13
Preferably, the above-mentioned Chinese medicine composition that improves brain blood circulation, is mainly made up of Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum, extract and fish oil, by 45 parts of its parts by weight Rhizoma Chuanxiong extractums, 25 parts of Radix Rhodiolae extractum, 20 parts of extracts, 15 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 60% (V/V) ethanol 7000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 3g medical material, in concentrated solution, adding while hot concentration is 6% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (3000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 4g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 55% (V/V) ethanol 7000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 3g medical material;
(3) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 55% (V/V) ethanol 7000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 4g medical material;
(4) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum, extract and fish oil are mixed homogeneously with Macrogol 4000, wherein count by weight 45 parts of Rhizoma Chuanxiong extractums, 25 parts of Radix Rhodiolae extractum, 20 parts of extracts, 15 parts, fish oil, Macrogol 4000 addition is extractum and fish oil gross weight 4 times;
(5) under 80 DEG C of conditions, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 4 DEG C of liquid paraffin, removes liquid paraffin, select ball, resulting dosage forms is drops, and it is shaped as brownish black ball shape, evenly, the ball of drop pill is heavily 25mg/ grain to size, and diameter is 3.00mm.
Embodiment 14
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum, extract and fish oil, by 42 parts of its parts by weight Rhizoma Chuanxiong extractums, 30 parts of Radix Rhodiolae extractum, 25 parts of extracts, 13 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 40% (V/V) ethanol 8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 5g medical material, in concentrated solution, adding while hot concentration is 7% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (2000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 6g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 70% (V/V) ethanol 6000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 2g medical material;
(3) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 35% (V/V) ethanol 8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 5g medical material;
(4) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum, extract and fish oil are mixed homogeneously with polyethylene glycol 6000, Macrogol 4000 and PEG400 and wherein count by weight 42 parts of Rhizoma Chuanxiong extractums, 30 parts of Radix Rhodiolae extractum, 25 parts of extracts, 13 parts, fish oil, polyethylene glycol 6000 addition is extractum and fish oil gross weight 2 times, Macrogol 4000 addition is extractum and fish oil gross weight 1 times, and PEG400 addition is extractum and fish oil gross weight 2 times;
(5) under 70 DEG C of conditions, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 2 DEG C of liquid paraffin, removes liquid paraffin, select ball, resulting dosage forms is drops, and it is shaped as brownish black ball shape, evenly, the ball of drop pill is heavily 40mg/ grain to size, and diameter is 4.21mm.
Embodiment 15
Improve a Chinese medicine composition for brain blood circulation, mainly formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum, extract and fish oil, by 47 parts of its parts by weight Rhizoma Chuanxiong extractums, 15 parts of Radix Rhodiolae extractum, 15 parts of extracts, 18 parts, fish oil.
The preparation method of the above-mentioned Chinese medicine composition that improves brain blood circulation, concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, extract by every kilogram of Radix Rhodiolae 75% (V/V) ethanol 8000ml, filter merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 3g medical material, in concentrated solution, adding while hot concentration is 4% gelatin solution, in 5 DEG C of refrigerators, places 24 hours, centrifugal (4000 revs/min), get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 3g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Chuanxiong 45% (V/V) ethanol 7000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 5g medical material;
(3) Rhizoma Gastrodiae of learning from else's experience and pulverizing, extracts by every kilogram of Rhizoma Gastrodiae 70% (V/V) ethanol 8000ml, filters, and merging filtrate, and filtrate is suitably concentrated, be concentrated into every 1g extractum and be equivalent to 3g medical material;
(4) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum, extract and fish oil are mixed homogeneously with Macrogol 4000, wherein count by weight 47 parts of Rhizoma Chuanxiong extractums, 15 parts of Radix Rhodiolae extractum, 15 parts of extracts, 18 parts, fish oil, Macrogol 4000 addition is extractum and fish oil gross weight 3 times;
(5) under 90 DEG C of conditions, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 7 DEG C of liquid paraffin, removes liquid paraffin, select ball, resulting dosage forms is drops, and it is shaped as brownish black ball shape, evenly, the ball of drop pill is heavily 35mg/ grain to size, and diameter is 3.87mm.
Rhizoma Chuanxiong extractum, the traditional Chinese medicine of Radix Rhodiolae extractum and extract Jun Shi China in the above-mentioned Chinese medicine composition that improves brain blood circulation, integration of edible and medicinal herbs, wherein:
(1) Rhizoma Chuanxiong extractum: Rhizoma Chuanxiong is the key medicine of traditional treatment headache, has blood-activating and qi-promoting, effect of wind-expelling pain-stopping.Modern pharmacological research shows that Rhizoma Chuanxiong has effect and the sedation of blood circulation promoting and blood stasis dispelling, dredging collateral, alleviating vascular spasm.The expansible cerebrovascular of main component ligustrazine in Rhizoma Chuanxiong, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation.
(2) Radix Rhodiolae extractum: the applicating history of Radix Rhodiolae is long, the people of Tibet plateau is often used as medicine with it, with building body, the impact of opposing poor environment.Radix Rhodiolae has invigorating the spleen and benefiting QI, blood circulation invigorating efficacies.18 seed amino acids of its main active rhodioside, multiple flavone and needed by human, the vitamin A. D. E of various trace elements etc.Studies have shown that rhodioside can make drug-induced irritability or inhibition type brain wave recover normal; There is the effect of the microcirculation disturbance of improvement, anti-hypoxia, can strengthen the irritability of brain stem reticular system, stimulates the spontaneous potential activity of neuronal survival, visual area and cortex primary structure, the level that lowers 5-HT, has adaptation and synchronization effect to mice spontaneous brain electricity.Can effectively lower platelet aggregation function and blood viscosity.
(3) extract: Rhizoma Gastrodiae has endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.Rhizoma Gastrodiae breath liver-wind, suppressing the hyperactive liver sun, the key medicine of, headache dizzy for controlling.Effective ingredient gastrodine in Rhizoma Gastrodiae can reduce blood pressure, and blood vessel dilating improves brain cell anti-anoxia ability, increases cerebral blood flow, reduces cerebral vascular resistance, slightly shrinks cerebrovascular; Especially the improving blood flow of vertebra one basilar artery is had to good effect, make vertebra one basilar artery insufficiency patient's cerebral blood supply be improved significantly, thereby remove the symptoms such as the disequilibrium being brought by blood supply insufficiency, dizzy, tinnitus and nystagmus.
(4) in fish oil fish oil, mainly contain DHA and EPA.DHA and EPA are unsaturated fatty acid (ω-3), and their chemical name is respectively docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).The two is unsaturated fatty acid, and molecular structure is very approaching, and therefore EPA is very easily converted into high density lipoprotein (HDL) performance physiological function in human body.Unsaturated fatty acid (ω-3), is the street cleaner of human vas, can also prevention of arterial sclerosis, apoplexy and heart disease.
By each component reasonable formula, effectively anoxia enduring, resist myocardial ischemia and improve memory ability, the head vasospasm of releiving, improve brain blood circulation, alleviate headache, treatment is due to diseases caused by exogenous pathogenic factor wind, cold, wet, heat, or wound tumbling down, qi depression to blood stasis due to pathogen usually intruding into collateral in protracted disease, dizzy, dizzy, headache that venation block causes, definite effect is remarkable.
Application test example:
Test example 1
1 material and method
120 of the clean level of 1.1 animal healths Kunming mouses, body weight (22.1 ± 2.7) g, male and female half and half.Animal housing's temperature is controlled at 20 DEG C-25 DEG C, and relative humidity is 45%-55%, is 12h/12h round the clock, freely takes the photograph water and diet.
Chinese medicine composition described in 1.2 medicine embodiment 3;
Nuodikang capsule Tibet Nuodikang Pharmaceutical Co., Ltd. produces, product batch number 20100404, specification 0.28g/ grain, 6 of adult's maximum dose levels every day;
3A never forgets soft capsule Yuwang Pharmaceutical Co., Ltd., Shandong Prov. and produces, product batch number 20100201, specification 0.15g/ grain, 9 of adult's maximum dose levels every day;
Scopolamine hydrobromide injection Shanghai Hefeng Pharmaceutical Co., Ltd. produces, lot number 20090403.
The pure sodium nitrite of 1.3 reagent analysis (Tianjin good fortune chemical reagent factory in morning, lot number 20070827).
2 experimental techniques
2.1 keep away dark test: experimental provision divides camera-lucida and camera bellows two parts, have a duck eye to pass through for mice between two casees, and case bottom is provided with the copper grid animal of can shocking by electricity.When experiment, mice is placed in to camera-lucida in hole dorsad, in the time that mice enters camera bellows, with the 36V 3S that shocks by electricity, mice can escape to camera-lucida again.The errors number recording in 5min is the number of times that mice enters camera bellows, using this as school grade.After 24h, survey again, using its errors number and incubation period (entering the time of camera bellows the 1st time) as Memory result.
Statistical data analysis represents with x ± SD, adopts SPSS11.5 software to carry out statistical procedures to data, carries out t inspection.
2.1.1 dosage setting: experiment is established 6 groups: 1 blank, 2 positive controls, positive drug 1 is for 3A never forgets soft capsule, and positive drug 2 is Nuodikang capsule, and 3 experimental grouies.10 of every group of mices.Described in 3 test group embodiment 3, the dosage of Chinese medicine composition is respectively 0.35g/kg, 0.6g/kg and 1.2g/kg; Positive drug 1 dosage is 0.25g/kg, and positive drug 2 is 0.028g/kg, and negative and matched group gives distilled water.Each group of gavage of 6 experiments is to sample, and every day 1 time, continuous 15 days, gavage volume was 0.1ml/10g body weight.
2.1.2 test method
2.1.2.1 normal mouse is kept away dark test: underproof animal is rejected in preliminary election.When formal test, animal was first trained in the 14th day, after 24h, make memory and keep test, record mice and enter the incubation period (being greater than 5min calculates with 300S) in darkroom and the number of animals that the interior mice of 5min suffers number of shocks and enters darkroom, calculate the animal percentage rate that occurs wrong reaction.The results are shown in Table 1.
2.1.2.2 memory acquisition disturbance model mice is kept away dark test: grouping keeps away dark test with normal mouse, increase by 1 model group, before mice training, 10min is except blank group, and all the other respectively organize lumbar injection scopolamine 5mg/kg, and test operation method is kept away dark test with normal mouse.The results are shown in Table 2.
The poisoning survival experiment of 2.2 sodium nitrite
Dosage setting and feed same 2.1.1, after last gives sample 1 hour, each treated animal was pressed 240mg/kg body weight dosage lumbar injection sodium nitrite, observes the animals survived time.
2.3 impacts that asphyxiating hypoxia mice electrocardio is disappeared: dosage setting and feed same 2.1.1, after last gives sample, after 30min, with urethane 1.2g/kg anesthesia, back of the body position is fixing, separates trachea, and folder is held one's breath after pipe and is recorded electrocardio extinction time.The results are shown in Table 3.
Table 1 normal mouse memory test result (n=10)
Table 2 scopolamine model mice memory test result (n=10)
The poisoning survival test of table 3 sodium nitrite and asphyxiating hypoxia test (
n=10)
＊p＜0.05，
＊＊p＜0.01，#p＜0.05
Result: (1) keeps away dark test: no matter be that normal mouse is kept away dark test or memory acquisition disturbance model mice is kept away 3 dosage groups of dark test and 2 positive drug groups are all better than matched group, and there were significant differences, 1 group of positive drug is slightly lower than 3 dosage groups, positive drug 2 is higher than low dose group, suitable with middle dosage group, but lower than high dose group.Illustrate that compound rhodiola root has the effect of memory reinforcing.
(2) the poisoning survival test of mice sodium nitrite is compared with matched group, 3 dosage groups and 2 positive drug groups are all better than matched group, and there were significant differences, and 1 group of effect of positive drug is best, positive drug 2 is higher than low dose group and middle dosage group, but lower than high dose group.Illustrate that Chinese medicine composition of the present invention has resisting oxygen lack.
(3) mice asphyxiating hypoxia test is compared with blank group, 3 dosage groups all can obviously extend the mice mice asphyxiating anoxia electrocardio persistent period, there is dose-effect relationship, 3 dosage groups and 2 positive drug groups are all better than matched group, and there were significant differences, and positive drug 1 is higher than low dosage and middle dosage group, slightly lower than high dose group, positive drug 2 is higher than low dose group, suitable with middle dosage group, but lower than high dose group.Illustrate that Chinese medicine composition of the present invention has function of resisting myocardial ischemia.
Test example 2
Materials and methods
Subjects is observed case totally 100 examples, treatment group 50 examples, male 28 examples, female's 22 examples, age 25-46 year; 1 week in February ,-1 of the course of disease; Wherein Therapy on Episode Tension-type Headache 23 examples, chronic tension headache 27 examples.Matched group 50 examples, male 24 examples, female's 26 examples; Age 22-40 year; 15 days in June ,-1 of the course of disease; Wherein Therapy on Episode Tension-type Headache 20 examples, chronic tension headache 30 examples.Treat row transcranial doppler (TCD) inspection of advancing for two groups, treatment group has 196 vascular flows abnormal, and wherein 160 blood flows slow down, and 36 blood flows speed; Matched group has 192 vascular flows abnormal, and wherein 166 blood flows slow down, and 26 blood flows speed.
Inclusive criteria is cured: headache, anxiety, dizziness, dizzy transference cure, and it is normal that cerebral blood flow recovers;
Effective: above symptom is clearly better, blood flow anomalies blood vessel number reduces more than 50%;
Effective: above symptom is improved, blood flow anomalies blood vessel number reduces, but less than more than 50%;
Invalid: above symptom is without improvement, and blood flow anomalies blood vessel number is without minimizing.
Test method: whole objects are divided into treatment group and matched group at random, test group 50 examples, matched group 50 examples, between two groups without significant difference.
Medication: adopt single-blind randomized administration, test group is taken Chinese medicine composition described in embodiment 7, and matched group is taken and Chinese medicine composition dosage form, outward appearance, the identical placebo of packaging described in embodiment 7.Usage is every day 1 time, and each 1,30 days courses for the treatment of.
Result treatment group is cured 25 examples, effective 7 examples, and effective 13 examples, invalid 5 examples, total effective rate 90.0%, average month attack times slip 78.0%, transcranial doppler (TCD) checks improving blood flow rate 83.2%; Matched group is cured 7 examples, effective 9 examples, and effective 12 examples, invalid 22 examples, total effective rate 56.0%, average month attack times slip 36.7%, TCD checks improving blood flow rate 36.0%.Two groups of total effective rate comparisons, difference is very significant (P < 0.01), and average month attack times, improving blood flow degree are all better than matched group (P < 0.01).The results are shown in Table 4.
Table 4 liang group curative effect comparison
With matched group comparison
*p < 0.01
Test example 3
Materials and methods
Subjects is observed case totally 120 examples, treatment group 60 examples, male 37 examples, female's 23 examples, age 22-45 year; 1 week in February ,-1 of the course of disease; Matched group 60 examples, male 34 examples, female's 26 examples; Age 20-39 year; 15 days in June ,-1 of the course of disease; Treat row transcranial doppler (TCD) inspection of advancing for two groups, treatment group has 213 vascular flows abnormal, and wherein 173 blood flows slow down, and 40 blood flows speed; Matched group has 226 vascular flows abnormal, and wherein 195 blood flows slow down, and 31 blood flows speed.
Inclusive criteria is cured: headache, anxiety, dizziness, dizzy transference cure, and it is normal that cerebral blood flow recovers;
Effective: above symptom is clearly better, blood flow anomalies blood vessel number reduces more than 50%;
Effective: above symptom is improved, blood flow anomalies blood vessel number reduces, but less than more than 50%;
Invalid: above symptom is without improvement, and blood flow anomalies blood vessel number is without minimizing.
Test method: whole objects are divided into treatment group and matched group at random, test group 50 examples, matched group 50 examples, between two groups without significant difference.
Medication: adopt single-blind randomized administration, test group is taken Chinese medicine composition described in embodiment 10, and matched group is taken and Chinese medicine composition dosage form, outward appearance, the identical placebo of packaging described in embodiment 10.Usage is every day 1 time, and each 1,30 days courses for the treatment of.
Result treatment group is cured 38 examples, effective 7 examples, and effective 10 examples, invalid 5 examples, total effective rate 91.6%, average month attack times slip 73.0%, transcranial doppler (TCD) checks improving blood flow rate 81.7%; Matched group is cured 10 examples, effective 11 examples, and effective 12 examples, invalid 27 examples, total effective rate 53.1.0%, average month attack times slip 35.7%, TCD checks improving blood flow rate 32.1%.2 groups of total effective rate comparisons, difference is very significant (P < 0.01), and average month attack times, improving blood flow degree are all better than matched group (P < 0.01).The results are shown in Table 5.
Table 5 liang group curative effect comparison
Test example 4
Materials and methods
Subjects is observed case totally 135 examples, treatment group 80 examples, male 36 examples, female's 44 examples, age 20-40 year; 1 week in February ,-1 of the course of disease; Wherein Therapy on Episode Tension-type Headache 57 examples, chronic tension headache 23 examples.Matched group 55 examples, male 26 examples, female's 29 examples; Age 21-38 year; 15 days in June ,-1 of the course of disease; Wherein Therapy on Episode Tension-type Headache 37 examples, chronic tension headache 19 examples.Treat row transcranial doppler (TCD) inspection of advancing for two groups, treatment group has 392 vascular flows abnormal, and wherein 331 blood flows slow down, and 61 blood flows speed; Matched group has 279 vascular flows abnormal, and wherein 234 blood flows slow down, and 45 blood flows speed.
Inclusive criteria is cured: headache, anxiety, dizziness, dizzy transference cure, and it is normal that cerebral blood flow recovers;
Effective: above symptom is clearly better, blood flow anomalies blood vessel number reduces more than 50%;
Effective: above symptom is improved, blood flow anomalies blood vessel number reduces, but less than more than 50%;
Invalid: above symptom is without improvement, and blood flow anomalies blood vessel number is without minimizing.
Test method: whole objects are divided into treatment group and matched group at random, test group 78 examples, matched group 56 examples, between two groups without significant difference.
Medication: adopt single-blind randomized administration, test group is taken Chinese medicine composition described in embodiment 13, and matched group is taken and Chinese medicine composition dosage form, outward appearance, the identical placebo of packaging described in embodiment 13.Usage is every day 1 time, and each 1,30 days courses for the treatment of.
Result treatment group is cured 38 examples, effective 12 examples, effective 21 examples, invalid 7 examples, total effective rate 91.2%, average month attack times slip 74.0%, transcranial doppler (TCD) inspection improving blood flow rate 82.1% matched group is cured 7 examples, effective 10 examples, effective 14 examples, invalid 25 examples, total effective rate 55.4%, average month attack times slip 37.9%, TCD checks improving blood flow rate 43.0%.2 groups of total effective rate comparisons, difference is very significant (P < 0.01), and average month attack times, improving blood flow degree are all better than matched group (P < 0.01).The results are shown in Table 6.
Table 6 liang group curative effect comparison
With matched group comparison
*p < 0.01
Visible, headache is one of the most common clinically clinical symptoms, is the subjective sensation that human body produces various induced pain factors, belongs to the category of pain.Induced pain factor can be physics, chemistry, biochemical or mechanical, etc.These factors have stimulated the sensory nerve ending that is arranged in the outer organizational structure of intracranial, pass to brain and perception by corresponding pathway.
The treatment of headache will be according to aforementioned different headache type and difference.Such as the headache causing due to the clear and definite disease of some causes of disease, the state of an illness should first be controlled, with alleviating pain.If tension headache or migraine should note respectively avoiding its risk factor, for example light, insomnia, works and rests irregular etc.There is very substantial connection in headache blood platelet disorders in early stage and headache.Obviously increase at headache platelet aggregation in early stage, cause antiotasis contraction thereby discharge 5-HT, cerebral blood flow reduces, and later because platelet aggregation declines, 5-HT exhausts, causes the outer arteriectasia of cranium, and severe headache, appears in blood flow increase.Therefore can think that the change of platelet aggregation causes that Plasma 5-HT Level changes and generation headache.
The Chinese medicine composition being formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum and/or extract and fish oil natural component of the present invention.Its each composition has the mechanism reliably and through confirming, the wherein expansible cerebrovascular of Rhizoma Chuanxiong reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Radix Rhodiolae can lower the level of 5-HT, can effectively lower platelet aggregation function and blood viscosity; Rhizoma Gastrodiae has neuroprotective, eliminates oxygen-derived free radicals, sleeps peacefully and the effect such as analgesia, is also improved vascular compliance simultaneously, reduces vascular resistance, increases the effect of cerebral blood flow; Unsaturated fatty acid (ω-3) in fish oil, is the street cleaner of human vas, can also prevention of arterial sclerosis.Show by clinical test results, each component Synergistic, the headache of obviously releiving, the symptom such as dizzy, dizzy, increase cerebral blood flow, improves microcirculation, and safe, has no adverse reaction.
Above-mentioned detailed description of this kind of Chinese medicine composition that improves brain blood circulation and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (4)
1. one kind is improved the Chinese medicine composition of brain blood circulation, it is characterized in that: formed by Rhizoma Chuanxiong extractum, Radix Rhodiolae extractum, extract and fish oil, by its parts by weight Rhizoma Chuanxiong extractum 40-50 part, Radix Rhodiolae extractum 10-40 part, extract 10-30 part, fish oil 10-20 part.
2. the preparation method of the Chinese medicine composition that improves brain blood circulation claimed in claim 1, is characterized in that: concrete steps are:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, by every kilogram of Radix Rhodiolae 30%-95%(V/V) ethanol 6000-8000ml extraction, filter, merging filtrate, and filtrate is concentrated into every 1g extractum is equivalent to 1-6g medical material, in concentrated solution, adding while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, place 24 hours, centrifugal, get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, by every kilogram of Rhizoma Chuanxiong 30%-95%(V/V) ethanol 6000-8000ml extracts, filtration, merging filtrate, and filtrate is concentrated into every 1g extractum is equivalent to 1-6g medical material;
(3) Rhizoma Gastrodiae of learning from else's experience and pulverizing, by every kilogram of Rhizoma Gastrodiae 30%-95%(V/V) ethanol 6000-8000ml extracts, filtration, merging filtrate, and filtrate is concentrated into every 1g extractum is equivalent to 1-6g medical material;
(4) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum, extract and fish oil are mixed homogeneously with adjuvant, wherein count by weight Rhizoma Chuanxiong extractum 40-50 part, Radix Rhodiolae extractum 10-40 part, extract 10-30 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times.
3. the preparation method of the Chinese medicine composition that improves brain blood circulation according to claim 2, is characterized in that: described dosage form is drops, and concrete preparation method is:
(1) Radix Rhodiolae of learning from else's experience and pulverizing, by every kilogram of Radix Rhodiolae 30%-95%(V/V) ethanol 6000-8000ml extraction, filter, merging filtrate, and filtrate is concentrated into every 1g extractum is equivalent to 1-6g medical material, in concentrated solution, adding while hot concentration is 3%-10% gelatin solution, in 5 DEG C of refrigerators, place 24 hours, centrifugal, get supernatant, concentrated supernatant, is concentrated into every 1g extractum and is equivalent to 2-7g medical material;
(2) Rhizoma Chuanxiong of learning from else's experience and pulverizing, by every kilogram of Rhizoma Chuanxiong 30%-95%(V/V) ethanol 6000-8000ml extracts, filtration, merging filtrate, and filtrate is concentrated into every 1g extractum is equivalent to 1-6g medical material;
(3) Rhizoma Gastrodiae of learning from else's experience and pulverizing, by every kilogram of Rhizoma Gastrodiae 30%-95%(V/V) ethanol 6000-8000ml extracts, filtration, merging filtrate, and filtrate is concentrated into every 1g extractum is equivalent to 1-6g medical material;
(4) gained Radix Rhodiolae extractum, Rhizoma Chuanxiong extractum, extract and fish oil are mixed homogeneously with adjuvant, wherein count by weight Rhizoma Chuanxiong extractum 40-50 part, Radix Rhodiolae extractum 10-40 part, extract 10-30 part, fish oil 10-20 part, adjuvant addition is extractum and fish oil gross weight 1-6 times;
(5) under 60-100 DEG C of condition, heat material, move into the drip irrigation of pill dripping machine, medicinal liquid drops in 0-10 DEG C of liquid paraffin, removes liquid paraffin, selects ball.
4. according to the preparation method of the Chinese medicine composition that improves brain blood circulation described in claim 2 or 3, it is characterized in that: described adjuvant is polyethylene glycol 6000, the one of Macrogol 4000 or PEG400 or combination in any.
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| 陈俊宁等.鳗油精治疗脑血管病与高血脂症的疗效观察.《上海医药》.1995,(第10期),16-18. |
| 鳗油精治疗脑血管病与高血脂症的疗效观察;陈俊宁等;《上海医药》;19951231(第10期);16-18 * |
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