CN102627663A - Preparation method of fluorine-containing pyridine boric acid - Google Patents
Preparation method of fluorine-containing pyridine boric acid Download PDFInfo
- Publication number
- CN102627663A CN102627663A CN2012100817070A CN201210081707A CN102627663A CN 102627663 A CN102627663 A CN 102627663A CN 2012100817070 A CN2012100817070 A CN 2012100817070A CN 201210081707 A CN201210081707 A CN 201210081707A CN 102627663 A CN102627663 A CN 102627663A
- Authority
- CN
- China
- Prior art keywords
- fluorine
- boric acid
- organic solvent
- preparation
- containing pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention relates to the synthesis of pharmaceutical intermediates, and discloses a preparation method of fluorine-containing pyridine boric acid. The method comprises the steps of: mixing fluorine-containing bromine substituted pyridine and trialkyl boric acid ester; dripping alkyl lithium under nitrogen or inert gas protection; reacting the fluorine-containing bromine substituted pyridine with lithium alkyl under low temperature to generate fluorine-containing pyridine lithium salt; and then reacting the fluorine-containing pyridine lithium salt with trialkyl boric acid ester; carrying out hydrolysis by dilute acid or alkali and extraction on the mixture to obtain corresponding fluorine-containing pyridine boric acid. The method can be used for the synthesis of a variety of fluorine-containing pyridine boric acid, with high yield and broad market prospects.
Description
Technical field
The present invention relates to the field of chemical synthesis, relate in particular to the synthetic of medicine intermediate, be specially the preparation method of fluorine-containing pyridine boric acid.
Background technology
Pyridine derivate is one type of important medicine intermediate, can be used as the synthesis material of medicines such as steroide, sulfamido, anti-resistance amine and volution amides.According to the mechanism of Suzuki aryl linked reaction, utilize the pyridine boric acid compound can under mild conditions, realize the fragrant heterocyclic butt joint of pyridine ring and other.
Fluorine-containing pyridine boric acid is fluorine-containing substituted pyridines boric acid derivatives, is a kind of important organic synthesis intermediate, and is quite extensive in organic synthesis and the synthetic application of pharmaceutical intermediate.Because the atomic radius of fluorine atom and Wasserstoffatoms is quite approaching, so after the Wasserstoffatoms in the molecule is replaced by fluorine atom, can't cause the noticeable change of this molecule steric configuration.But because fluorine atom has very strong electron-withdrawing power; Tend to make the electronic property of original molecule to change a lot; Thereby make fluorine-containing pyridine boric acid have satisfactory stability property and big dielectric anisotropy, therefore fluorine-containing in recent years pyridine boric acid all has important effect in the synthetic and materialogy of medicine especially PTS.
2-fluoro-3-pyridine boric acid, 2-fluoro-5-pyridine boric acid, 2; 6-difluoro pyridine-3-boric acid, 2-chloro-5-fluorine pyridine-4-boric acid and 2-fluoro-3-picoline-5-boric acid are that several kinds of fluorine-containing pyridine boric acid midbodys commonly used (see: Organic letters 2004, vol 6#2P.277-280 by its application; Organic letters 2007, vol 9#25 is P.5175-5178; WO2007/113232A1; US2009/54434A1; Announce in the document such as WO2008/63287 and EP2036907), can be used for further synthetic cancer therapy drug or light active material.But the synthetic difficulty of these several kinds fluorine-containing pyridine boric acid is big, and yield is low, therefore need improve existing method.
Summary of the invention
The present invention aims to provide a kind of preparation method of fluorine-containing pyridine boric acid.
After fluorine-containing bromine substituted pyridines and the mixing of trialkylboron acid esters; Under nitrogen or protection of inert gas, drip lithium alkylide; Fluorine-containing bromine substituted pyridines reacts fluorine-containing pyridine lithium salts with lithium alkylide at low temperatures; With the reaction of trialkylboron acid esters, after diluted acid or diluted alkaline hydrolysis and extraction, obtain corresponding fluorine-containing pyridine boric acid then.
Technical scheme of the present invention is that the preparation method of fluorine-containing pyridine boric acid may further comprise the steps:
(1) fluorine-containing bromine substituted pyridines (suc as formula I) and trialkylboron acid esters mix with organic solvent I, and agitation condition adds organic solvent II down and is cooled to-30 ℃～-50 ℃;
The structure of fluorine-containing bromine substituted pyridines goes up the substituted fluorine-containing pyridine bromide of bromine for 3,4 or 5 suc as formula shown in (I), and fluoro substituents is at least one; Also comprise chlorine substituent or alkyl substituent;
Described organic solvent I and organic solvent II are aprotic solvent;
R2=H, Cl, F or C1～C6 alkyl;
Have one to be bromine among R3, R4, R5 and the R6, all the other are H, Cl, F or alkyl substituent;
～-50 ℃ (2)-30 drip lithium alkylide under, under nitrogen or protection of inert gas, dropwised afterreaction 3～6 hours;
(3) be warming up to-15 ℃～-20 ℃, in reaction solution, drip acid solution and temperature is remained between-15 ℃～-0 ℃; After dropwising reaction solution is stirred to layering under 15 ℃～20 ℃;
(4) use the alkali lye extracted organic phase, and merge water, regulate pH to 7～8;
(5) water extracts with organic solvent II I, and resulting organic phase is dry.
The preferred situation of structural formula (I) is:
(1)R2＝F，R3＝Br，R4、R5、R6＝H；
(2)R2＝F，R3、R4、R6＝H，R5＝Br；
(3)R2、R6＝F，R3、R4＝H，R5＝Br；
(4)R2＝Cl，R3、R6＝H，R4＝Br，R5＝Br；
(5)R2＝F，R3＝CH
3，R4、R6＝H，R5＝Br。
Obtain formula (II) compound through above-mentioned reaction, the Br substituting group is R wherein
2'=H, Cl, F or C1～C6 alkyl; R
3', R
4', R
5' and R
6' in one be boronate, all the other are H, Cl, F or alkyl substituent.
The mol ratio of fluorine-containing bromine substituted pyridines and trialkylboron acid esters and lithium alkylide is 1: (1～2): (1～1.5).
Acid solution in the step (3) is hydrochloric acid or sulphuric acid soln, fluorine-containing bromine substituted pyridines and H
+Mol ratio for being 1: 4～1: 6.
Alkali lye in the step (4) is NaOH or KOH solution, and concentration is 4～6mol/L.
Lithium alkylide is preferably n-Butyl Lithium.
Organic solvent I, organic solvent II and organic solvent II I are selected from THF, normal hexane or toluene.Preferably, solvent I is a toluene, and organic solvent II and organic solvent II I are THF; The volume ratio of organic solvent I and organic solvent II is 1: 3～1: 5, more preferably 1: 4.The amount ratio of fluorine-containing bromine substituted pyridines and organic solvent I is 0.2～0.4mol/L.
Said organic solvent I is a toluene, and organic solvent II is a THF.
The present invention utilizes fluorine-containing pyridine bromide to make fluorine-containing pyridine lithium salts with the lithium alkylide effect at low temperatures, with the reaction of trialkylboron acid esters, obtains corresponding fluorine-containing pyridine boric acid through diluted acid or diluted alkaline hydrolysis then.
Method provided by the present invention can prepare the bigger fluorine-containing pyridine boric acid of multiple synthetic difficulty, and improves yield, has filled up domestic blank, has wide market outlook.
Description of drawings
Fig. 1 is the nuclear magnetic spectrum of embodiment 1 product 2-fluoro-3-pyridine boric acid.
Fig. 2 is the nuclear magnetic spectrum of embodiment 2 product 2-fluoro-5-pyridine boric acid.
Fig. 3 is embodiment 3 products 2, the nuclear magnetic spectrum of 6-difluoro pyridine-3-boric acid.
Fig. 4 is the nuclear magnetic spectrum of embodiment 4 product 2-chloro-5-fluorine pyridine-4-boric acid.
Fig. 5 is the nuclear magnetic spectrum of embodiment 5 product 2-fluoro-3-picoline-5-boric acid.
Embodiment
Below in conjunction with embodiment the present invention is done further in detail, intactly explains:
Synthesizing of embodiment 1 2-fluoro-3-pyridine boric acid (CAS 174669-73-9)
With 3-bromo-2-fluorine pyridine (6.8 grams, 38.6mmol, Mw=175.99) with triisopropyl borate ester (9.5 grams, 50.5mmol Mw=188.1) joins in the toluene (120mL), agitation condition down adding THF (30ml) also is cooled to-30 ℃～-50 ℃.Between temperature keeps-35 ℃～-45 ℃, and dropping n-Butyl Lithium under nitrogen or argon shield (18.5mL, 2.5mol/L).After dropwising, keep temperature-35 ℃～-45 ℃ down reaction be warming up to-15 ℃～-20 ℃ after 4 hours.In reaction solution, drip 2M hydrochloric acid (80ml) and keep between the temperature-15 ℃～0 ℃.Reaction solution is stirred to layering under 15 ℃～20 ℃.Organic phase is extracted 3 times with 6M sodium hydroxide (20ml*3), and all waters are merged, regulate PH to 7.5 with 6M hydrochloric acid again.The gained water is with three times (90ml*3) of THF extraction.The gained organic phase with anhydrous magnesium sulfate (15 gram) drying, is revolved dried target compound 2-fluoro-3-pyridine boric acid 4.3 grams (yield 79%) that obtain.
Synthesizing of embodiment 2 2-fluoro-5-pyridine boric acid (CAS 351019-18-6)
(Mw=175.99) (17.5 grams 93mmol) join in the toluene (200mL), and agitation condition down adding THF (50ml) also is cooled to-30 ℃～-50 ℃ with triisopropyl borate ester for 12.6 grams, 71.6mmol with 5-bromo-2-fluorine pyridine.Between temperature keeps-35 ℃～-45 ℃, and dropping n-Butyl Lithium under nitrogen or argon shield (34.0mL, 2.5mol/L).After dropwising, keep temperature-35 ℃～-45 ℃ down reaction be warming up to-15 ℃～-20 ℃ after 4 hours.In reaction solution, drip 2M hydrochloric acid (150ml) and keep between the temperature-15 ℃～-0 ℃.Reaction solution is stirred to layering under 15 ℃～20 ℃.Organic phase is extracted 3 times with 6M sodium hydroxide (35ml*3), and all waters are merged, regulate PH to 7.5 with 6M hydrochloric acid again.The gained water is with three times (150ml*3) of THF extraction.The gained organic phase with anhydrous magnesium sulfate (25 gram) drying, is revolved dried target compound 2-fluoro-5-pyridine boric acid 7.9 grams (yield 78%) that obtain.
Embodiment 32,6-difluoro pyridine-3-boric acid (CAS 136466-94-9) synthetic
With 3-bromo-2, (Mw=194.98) (6.3 grams 33.5mmol) join in the toluene (100mL) the 6-difluoro pyridine, and agitation condition down adding THF (25ml) also is cooled to-30 ℃～-50 ℃ with triisopropyl borate ester for 5.0 grams, 25.6mmol.Between temperature keeps-35 ℃～-45 ℃, and dropping n-Butyl Lithium under nitrogen or argon shield (12.2mL, 2.5mol/L).After dropwising, keep temperature-35 ℃～-45 ℃ down reaction be warming up to-15 ℃～-20 ℃ after 4 hours.In reaction solution, drip 2M hydrochloric acid (60ml) and keep between the temperature-15 ℃～0 ℃.Reaction solution is stirred to layering under 15 ℃～20 ℃.Organic phase is extracted 3 times with 6M sodium hydroxide (25ml*3), and all waters are merged, regulate PH to 7.5 with 6M hydrochloric acid again.The gained water is with three times (60ml*3) of THF extraction.The gained organic phase with anhydrous magnesium sulfate (10 gram) drying, is revolved the dried target compound 2 that obtains, 6-difluoro pyridine-3-boric acid 3 grams (yield 75%).
Synthesizing of embodiment 4 2-chloro-5-fluorine pyridine-4-boric acid (CAS 951677-47-7)
(Mw=211.44) (7.0 grams 37.2mmol) join in the toluene (120mL), and agitation condition down adding THF (30ml) also is cooled to-30 ℃～-50 ℃ with triisopropyl borate ester for 6.2 grams, 29.3mmol with 4-bromo-2-chloro-5-fluoro-pyridine.Between temperature keeps-35 ℃～-45 ℃, and dropping n-Butyl Lithium under nitrogen or argon shield (13.7mL, 2.5mol/L).After dropwising, keep temperature-35 ℃～-45 ℃ down reaction be warming up to-15 ℃～-20 ℃ after 4 hours.In reaction solution, drip 2M hydrochloric acid (60ml) and keep between the temperature-15 ℃～0 ℃.Reaction solution is stirred to layering under 15 ℃～20 ℃.Organic phase is extracted 3 times with 6M sodium hydroxide (25ml*3), and all waters are merged, regulate PH to 7.5 with 6M hydrochloric acid again.The gained water is with three times (60ml*3) of THF extraction.The gained organic phase with anhydrous magnesium sulfate (10 gram) drying, is revolved dried target compound 2-chloro-5-fluorine pyridine-4-boric acid 2.8 grams (yield 57%) that obtain.
Synthesizing of embodiment 5 2-fluoro-3-picolines-5-boric acid (CAS 904326-92-7)
(4.4 grams 23.4mmol) join in the toluene (80mL), and agitation condition adding THF (20ml) down also is cooled to-30 ℃～-50 ℃ with triisopropyl borate ester with 5-bromo-2-fluoro-3-methyl-pyridine (3.4 gram 17mmol Mw=194.99).Between temperature keeps-35 ℃～-45 ℃, and dropping n-Butyl Lithium under nitrogen or argon shield (8.5mL, 2.5mol/L).After dropwising, keep temperature-35 ℃～-45 ℃ down reaction be warming up to-15 ℃～-20 ℃ after 4 hours.In reaction solution, drip 2M hydrochloric acid (40ml) and keep between the temperature-15 ℃～0 ℃.Reaction solution is stirred to layering under 15 ℃～20 ℃.Organic phase is extracted 3 times with 6M sodium hydroxide (20ml*3), and all waters are merged, regulate PH to 7.5 with 6M hydrochloric acid again.The gained water is with three times (30ml*3) of THF extraction.The gained organic phase with anhydrous magnesium sulfate (5 gram) drying, is revolved dried target compound 2-fluoro-3-picoline-5-boric acid 2.1 grams (yield 76%) that obtain.
Raw material C1 and 2-fluoro-5-pyridine boric acid obtain Compound C 2 through the Suzuki coupling.Compound C 2 has good optical activity (EP2036907).
Claims (9)
1. the preparation method of fluorine-containing pyridine boric acid is characterized in that, may further comprise the steps:
(1) fluorine-containing bromine substituted pyridines and trialkylboron acid esters mix with organic solvent I, and agitation condition adds organic solvent II down and is cooled to-30 ℃～-50 ℃;
Said fluorine-containing bromine substituted pyridines be that 3,4 or 5 go up the substituted fluorine-containing bromine substituted pyridines of bromine, fluoro substituents is at least one; Also comprise chlorine substituent or alkyl substituent;
Described organic solvent I and organic solvent II are aprotic solvent;
～-50 ℃ (2)-30 drip lithium alkylide under, under nitrogen or protection of inert gas, dropwised afterreaction 3～6 hours;
(3) be warming up to-15 ℃～-20 ℃, in reaction solution, drip acid solution and temperature is remained between-15 ℃～-0 ℃; After dropwising reaction solution is stirred to layering under 15 ℃～20 ℃;
(4) use the alkali lye extracted organic phase, and merge water, regulate pH to 7～8;
(5) water extracts with organic solvent II I, and resulting organic phase is dry.
2. the preparation method of the said fluorine-containing pyridine boric acid of claim 1 is characterized in that, described fluorine-containing bromine substituted pyridines structural formula is suc as formula (I);
R2=H, Cl, F or C1～C6 alkyl wherein;
Have one to be bromine among R3, R4, R5 and the R6, all the other are H, Cl, F or alkyl substituent.
3. the preparation method of the said fluorine-containing pyridine boric acid of claim 2 is characterized in that, R2～R6 substituting group is:
(1)R2＝F，R3＝Br，R4、R5、R6＝H；
(2)R2＝F，R3、R4、R6＝H，R5＝Br；
(3)R2、R6＝F，R3、R4＝H，R5＝Br；
(4) R2=Cl, R3, R6=H, R4=Br, R5=Br; Or
(5)R2＝F，R3＝CH
3，R4、R6＝H，R5＝Br。
4. the preparation method of the said fluorine-containing pyridine boric acid of claim 1 is characterized in that, the mol ratio of fluorine-containing bromine substituted pyridines and trialkylboron acid esters and lithium alkylide is 1: (1～2): (1～1.5).
5. the preparation method of the said fluorine-containing pyridine boric acid of claim 1 is characterized in that, the acid solution in the step (3) is hydrochloric acid or sulphuric acid soln, and the mol ratio of fluorine-containing bromine substituted pyridines and H+ is for being 1: 4～1: 6.
6. the preparation method of the said fluorine-containing pyridine boric acid of claim 1 is characterized in that, the alkali lye in the step (4) is NaOH or KOH solution, and concentration is 4～6mol/L.
7. the preparation method of the said fluorine-containing pyridine boric acid of claim 1 is characterized in that, said lithium alkylide is a n-Butyl Lithium.
8. the preparation method of the said fluorine-containing pyridine boric acid of claim 1 is characterized in that, said organic solvent I, organic solvent II and organic solvent II I are selected from THF, normal hexane or toluene; And the volume ratio of organic solvent I and organic solvent II is 1: 3～1: 5; The amount ratio of fluorine-containing bromine substituted pyridines and organic solvent I is 0.2～0.4mol/L.
9. the preparation method of the said fluorine-containing pyridine boric acid of claim 1 is characterized in that, said solvent I is a toluene, and solvent II and organic solvent II I are THF.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100817070A CN102627663A (en) | 2012-03-23 | 2012-03-23 | Preparation method of fluorine-containing pyridine boric acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100817070A CN102627663A (en) | 2012-03-23 | 2012-03-23 | Preparation method of fluorine-containing pyridine boric acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102627663A true CN102627663A (en) | 2012-08-08 |
Family
ID=46586078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100817070A Pending CN102627663A (en) | 2012-03-23 | 2012-03-23 | Preparation method of fluorine-containing pyridine boric acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102627663A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103030660A (en) * | 2012-12-20 | 2013-04-10 | 大连联化化学有限公司 | Technological method for synthesizing methylboronic acid |
| CN107936048A (en) * | 2018-01-17 | 2018-04-20 | 珠海奥博凯生物医药技术有限公司 | A kind of preparation method of 2 fluorine, 4 methyl, 3 pyridine boronic acid |
| CN112159421A (en) * | 2020-10-10 | 2021-01-01 | 珠海奥博凯生物医药技术有限公司 | Preparation method of 2-fluoro-4-methyl-3-pyridineboronic acid |
| CN112820940A (en) * | 2019-11-15 | 2021-05-18 | 华南师范大学 | Non-aqueous electrolyte containing 2-fluoro-3-pyridineboronic acid, and lithium metal battery containing same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101616915A (en) * | 2006-12-28 | 2009-12-30 | 金克斯医药品有限公司 | The composition and the method for regulation and control kinase cascade |
-
2012
- 2012-03-23 CN CN2012100817070A patent/CN102627663A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101616915A (en) * | 2006-12-28 | 2009-12-30 | 金克斯医药品有限公司 | The composition and the method for regulation and control kinase cascade |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103030660A (en) * | 2012-12-20 | 2013-04-10 | 大连联化化学有限公司 | Technological method for synthesizing methylboronic acid |
| CN107936048A (en) * | 2018-01-17 | 2018-04-20 | 珠海奥博凯生物医药技术有限公司 | A kind of preparation method of 2 fluorine, 4 methyl, 3 pyridine boronic acid |
| CN112820940A (en) * | 2019-11-15 | 2021-05-18 | 华南师范大学 | Non-aqueous electrolyte containing 2-fluoro-3-pyridineboronic acid, and lithium metal battery containing same |
| CN112820940B (en) * | 2019-11-15 | 2022-05-10 | 华南师范大学 | Non-aqueous electrolyte containing 2-fluoro-3-pyridineboronic acid, and lithium metal battery containing same |
| CN112159421A (en) * | 2020-10-10 | 2021-01-01 | 珠海奥博凯生物医药技术有限公司 | Preparation method of 2-fluoro-4-methyl-3-pyridineboronic acid |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102627663A (en) | Preparation method of fluorine-containing pyridine boric acid | |
| CN103420801B (en) | Method for preparing pentafluorophenol | |
| CN102329277A (en) | Method for preparing Parecoxib | |
| CN105330600A (en) | Preparation method for Regorafenib hydrate | |
| CN103554083A (en) | Monocrystal structure of cadmium coordination compound with blue light performance and preparation method thereof | |
| CN101671340A (en) | Carboxyl porphyrin and preparation method thereof | |
| CN102351864A (en) | Organic-functionalized non-aggregated phthalocyanine and preparation method thereof | |
| CN103787968B (en) | The preparation method of compound | |
| CN104725321A (en) | Preparation method of azoxystrobin intermediate | |
| CN104672180B (en) | Chiral preparation method of [(1S)-3-methyl-1-[[(2R)-2-methylepoxyethyl]carbonyl]butyl]tert-butyl carbamate | |
| RU2014142545A (en) | METHOD FOR PRODUCING 5- (DIFFORMETHYL) PYRAZINE-2-CARBOXYLIC ACID AND INTERMEDIATE COMPOUND WHEN ITS PREPARATION | |
| CN102993165A (en) | Synthesis method of 5-chlorothiophene-2-formic acid | |
| CN102617390B (en) | Preparation method of epsilon-N-lauroyl lysine | |
| CN103044339A (en) | Preparation method of rosuvastatin calcium intermediate | |
| CN102432524A (en) | Method for preparing indole-2-carboxylic acid | |
| CN106243018B (en) | A kind of synthetic method of poly-fluorine phenyl pyridine compounds and their | |
| Cheng et al. | A left-handed 21 helix with triple chiral components: Synthesis, luminescence and SHG response | |
| CN102295596B (en) | Synthesis method of 2,2'-bipyridine-4,4'-dicarboxaldehyde | |
| CL2012001528A1 (en) | Process to prepare the crystalline form a of ilaprazole from an inorganic salt of ilaprazole and subsequent neutralization of the salt with an acid in a reaction solvent; and process for preparing the crystalline form b of ilaprazole into the crystalline form a of ilaprazole. | |
| CN103601671A (en) | Preparation method of iodo trifluoro methyl pyridine | |
| CN104447506A (en) | Preparation method of 2-acetyl-9-alkyl carbazole | |
| CN102850244A (en) | Preparation method for 3-(3-phenylsulfamoyl-phenyl)-acrylic acid | |
| CN103980260B (en) | A kind of little molecule of thiocarbamide functionalization is quick adsorbent altogether | |
| CN103435530A (en) | Preparation method of D-tryptophan lower alcohol ester hydrochloride with high optical purity | |
| CN103288097B (en) | Preparation method of caesium decahydrodecaborate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120808 |