CN1026207C - Compound preparation of novel liuyangmeisu (Macro tetrolide ) - Google Patents
Compound preparation of novel liuyangmeisu (Macro tetrolide ) Download PDFInfo
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- CN1026207C CN1026207C CN 88105541 CN88105541A CN1026207C CN 1026207 C CN1026207 C CN 1026207C CN 88105541 CN88105541 CN 88105541 CN 88105541 A CN88105541 A CN 88105541A CN 1026207 C CN1026207 C CN 1026207C
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- macro tetrolide
- macro
- tetrolide
- triphenyl
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Abstract
The present invention provides a composition preparation agriculturally used for killing acarids and insects, which takes macrotetrolide antibiotics and triphenyl phosphate or triphenyl phosphite as effective components. The preparation has safe effect on people, livestock and natural enemy insects, and has the function of no environmental pollution. The present invention has the advantages of low cost and excellent effect, and provides a favorable model for using public nuisance-free agricultural chemicals.
Description
The present invention is for having following chemical structural formula
(R in the formula
1, R
2, R
3And R
4Be low alkyl group) macro tetrolide (maerotetrolide) class antibiotic and a kind of complex preparation of non-chemical pesticide.
Antibiotic shown in the said structure formula can produce the slightly variant stereoisomers in some resonable chemical property aspect because of the difference of its manufacture method, extraction process for purification.But because these isomeric compounds are killing mite, the insecticidal activity aspect there is no very big-difference, so generally can be considered same substance.In the present invention, also above-mentioned isomeric compound is considered as same substance.
In the past, with agricultural chemicals mixing uses different more than two kinds, majority was in order to reduce the medication number of times, to save the labour.Developed complex preparation increasing, that have synergistic effect afterwards gradually, but mostly still be confined to composite between the agricultural chemicals, being re-dubbed the preparation with certain synergistic effect with liuyangmycin antibiotics (being designated hereinafter simply as macro tetrolide) and multiple organophosphorous pesticide (clear 45-71417), organo-chlorine pesticide (clear 48-24726), carbamate chemicals for agriculture (clear 48-25488) also once had repeatedly report, still belonged to the first time but be re-dubbed the preparation with notable synergistic effect with non-chemical pesticide and macro tetrolide as described in the present invention.
The object of the present invention is to provide a kind of farm killing mite, disinsection compound preparation that does not contain chemical pesticide,, reduce environmental pollution with the progressively use of substituting chemical pesticide.
Below just the present invention be elaborated.
Macro tetrolide is almost non-toxic to warm blooded animal, also do not have the teratogenesis carcinogenesis, and triphenyl phosphate and triphenyl phosphite is also lower than macro tetrolide to the toxicity of warm blooded animal, and non-stimulated to skin, and The book of Changes skin does not absorb.
Macro tetrolide and triphenyl phosphate or triphenyl phosphite are carried out composite respectively with 1: 1 to 1: 7 Different Weight ratio, the result all has synergistic effect in various degree, is the best with 1: 3 especially wherein.
(table 1 is seen the literary composition back)
With macro tetrolide (industrial goods, content are 88.7%) and triphenyl phosphate (chemical pure) is reagent agent, two spotted spider mite is carried out coefficient of synergism measure, and the result is as shown in table 2.
(table 2 is seen the literary composition back)
Coefficient of synergism=(macro tetrolide LC
50)/(macro tetrolide+triphenyl phosphate LC
50)=14.07
Compound formulation of the present invention can be used purpose and needs are mixed with various preparations according to different, and is wherein comparatively commonly used with emulsion especially.
Used solvent can be benzene, toluene or dimethylbenzene during preparation emulsion.Emulsifier can select to use 0201,0203 or 0204.
Complex preparation of the present invention is described in the following tabulation of test of pesticide effectiveness effect of killing on mite, the desinsection, and makes comparisons with medicaments such as the compound macro tetrolide that contains chemical pesticide (complex preparation of macro tetrolide and Rogor) commonly used, dicofols.
(table 3, table 4, table 5, table 6, table 7, table 8 are seen the literary composition back)
In sum, the new complex preparation of liuyangmycin antibiotics provided by the present invention does not only contain chemical pesticide, to people and animals and natural enemy insect safety, non-environmental-pollution danger, can be widely used in edible and medicinal crop, and kill mite insecticidal effect brilliance, residual effect is long, is difficult for bringing out resistance, low price.Complex preparation of the present invention provides a good model for using public nuisance-free agricultural chemicals.
The prescription of embodiment 1 20% macro tetrolide, triphenyl phosphate emulsion
Macro tetrolide 5%
Triphenyl phosphate 15%
Dimethylbenzene 70%
0201 emulsifier 10%
The prescription of embodiment 2 40% macro tetrolides, triphenyl phosphite emulsion
Macro tetrolide 10%
Triphenyl phosphite 30%
Dimethylbenzene 50%
0201 emulsifier 10%
The selection of table 1 macro tetrolide and the different proportionings of triphenyl phosphate
The concentration death rate (%)
（ppm） 1∶1 1∶3 1∶5 1∶7
6.25 15.70 16.88 5.18 3.22
12.50 30.41 32.61 14.18 13.76
25.00 52.01 58.03 48.89 32.85
Table 2 macro tetrolide and compound formulation thereof are to the toxicity test of Vermilion spider
Medicament regression equation coefficient correlation
（Y＝a+bX）
Macro tetrolide+triphenyl phosphate Y=2.0107+2.2919X 0.9937
（1∶3）
Macro tetrolide Y=3.0204+0.8072X 0.9631
Medicament LC＊ 50(ppm) 95% confidence limit
Macro tetrolide+triphenyl phosphate 20.1513 22.5600～17.9747
（1∶3）
Macro tetrolide 283.4204 406.9812～196.9816
*LC
50It is 50% lethal concentration
The small plot experiment of table 3 control watermelon two spotted spider mite
The borer population insect population rate (%) that goes down before the drug concentration medicine
(doubly) (head) 2 days 4 days
20% macro tetrolide phosphatase 11 000 1,844 94.67 84.45
Composite dose of (1: 3) 2,000 1,741 94.02 75.23 of triphenylmethyl methacrylate
Contrast-1,329 47.98+12.00
The test of table 4 control greenhouse watermelon two spotted spider mite
Borer population before the drug concentration medicine
(doubly) (head)
20% Liuyang sun mycin tricresyl phosphate 1,000 316
Phenyl ester complexing agent (1: 3)
20% compound macro tetrolide 1,000 415
Contrast clear water 333
The medicament insect population rate (%) that goes down is proofreaied and correct
1 day 2 days 3 days 4 days 5 days preventive effects
20% macro tetrolide phosphoric acid 80.1 78.5 81.3 78.8 78.2 81.2
Triphenylmethyl methacrylate complexing agent (1: 3)
20% compound macro tetrolide 66.3 66.7 70.6 72.0 69.9 74.1
Contrast+0.9+2.1+1.8+5.4+16.21-
Table 5 control European red mite indoor measurement
The drug concentration examination borer population insect population rate that goes down
(ppm) (head) (%)
20% macro tetrolide tricresyl phosphate 200 199 86.9
Phenyl ester complexing agent (1: 3)
20% compound macro tetrolide 200 199 91.5
Contrast clear water 196 0.6
The withered two spotted spider mite small plot experiment of table 6 control mandarin orange
Worm is proofreaied and correct the rate (%) that goes down before the drug concentration medicine
(doubly) number (head) 1 day 3 days 5 days 7 days
20% macro tetrolide phosphatase 11 000 704 78.0 84.0 71.4 12.1
Composite dose of triphenylmethyl methacrylate (1: 3)
20% dicofol 1,000 875 64.1 72.3 11.2-32.19
Contrast clear water 1035 insect populations propagation
The synergistic effect that table 7 macro tetrolide and triphenyl phosphite are composite
Drug concentration (ppm) lethality (%)
Macro tetrolide, tricresyl phosphite 100 97.99
Composite dose of (1: 3) 50 100 of phenyl ester
25 97.30
Macro tetrolide 25 29.55
Triphenyl phosphite 75 1.21
1000 0
Contrast clear water 0
Composite dose of table 8 triphenyl phosphate and composite dose of comparison of triphenyl phosphite
Drug concentration (ppm) lethality (%)
Macro tetrolide, tricresyl phosphite 100 99.16
Composite dose of (1: 3) 50 99.28 of phenyl ester
25 90.52
Macro tetrolide, phosphoric acid triphen 100 100
Composite dose of ester (1: 3)
Contrast clear water 1.60
Claims (2)
1, a kind of general expression that contains is:
(R in the formula
1, R
2, R
3And R
4Be low alkyl group) macro tetrolide (macro tetrolide) class insecticide acaricide composition, the active ingredient that it is characterized in that described composition is liuyangmycin antibiotics and triphenyl phosphate or triphenyl phosphite, its weight ratio is between 1: 1 to 1: 7.
2, by the composition of the described liuyangmycin antibiotics of claim 1 and triphenyl phosphate or triphenyl phosphite, its weight ratio was the best with 1: 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88105541 CN1026207C (en) | 1988-07-02 | 1988-07-02 | Compound preparation of novel liuyangmeisu (Macro tetrolide ) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88105541 CN1026207C (en) | 1988-07-02 | 1988-07-02 | Compound preparation of novel liuyangmeisu (Macro tetrolide ) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1038919A CN1038919A (en) | 1990-01-24 |
| CN1026207C true CN1026207C (en) | 1994-10-19 |
Family
ID=4833722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88105541 Expired - Fee Related CN1026207C (en) | 1988-07-02 | 1988-07-02 | Compound preparation of novel liuyangmeisu (Macro tetrolide ) |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1026207C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102911227B (en) * | 2008-09-27 | 2015-08-12 | 上海市农药研究所 | A kind of streptomyces diastatochromogenes, its tunning and application |
| CN104351240B (en) * | 2014-11-14 | 2016-08-24 | 青岛青知企业管理咨询有限公司 | A kind of composition containing cyfloxylate and application |
| CN104351220B (en) * | 2014-11-14 | 2016-04-13 | 济南新起点医药科技有限公司 | A kind of composition and application containing brofluthrinate |
| CN104322518B (en) * | 2014-11-14 | 2016-02-24 | 徐桂香 | A kind of wetting powder and application containing flucythrinate |
| CN104322517B (en) * | 2014-11-14 | 2016-04-13 | 济南新起点医药科技有限公司 | A kind of wetting powder and application containing ether chrysanthemum ester |
-
1988
- 1988-07-02 CN CN 88105541 patent/CN1026207C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1038919A (en) | 1990-01-24 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |