CN102618222A - Cooling components of aerosol used for cooling human body surface - Google Patents

Cooling components of aerosol used for cooling human body surface Download PDF

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Publication number
CN102618222A
CN102618222A CN2012100741175A CN201210074117A CN102618222A CN 102618222 A CN102618222 A CN 102618222A CN 2012100741175 A CN2012100741175 A CN 2012100741175A CN 201210074117 A CN201210074117 A CN 201210074117A CN 102618222 A CN102618222 A CN 102618222A
Authority
CN
China
Prior art keywords
cooling
body surface
pentafluoropropane
aerosol
tetrafluoroethane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2012100741175A
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Chinese (zh)
Inventor
杨顶建
张彦军
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Hainan Jian Ke Pharmaceutcal Corp Ltd
Original Assignee
Hainan Jian Ke Pharmaceutcal Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hainan Jian Ke Pharmaceutcal Corp Ltd filed Critical Hainan Jian Ke Pharmaceutcal Corp Ltd
Priority to CN2012100741175A priority Critical patent/CN102618222A/en
Publication of CN102618222A publication Critical patent/CN102618222A/en
Pending legal-status Critical Current

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Abstract

The invention relates to cooling components of aerosol used for cooling human body surface, which include 1, 1, 1, 3, 3-perfluoropropane, tetrafluoro ethane, 1, 1, 1, 3-tetrafluoro propylene and 1, 1, 1, 3, 3-perfluoropropane, used for physical therapy including conventional physical cooling, analgesia and detumescence and the like, and belong to the field of medical instrument and medical treatment and healthcare. The cooling components have the advantages of applicability to human body surface, non-toxic effect, no flame and explosion, excellent chemical stability and environment-friendliness and healthy cooling. The cooling components can be proportioned automatically according to temperature required by production, four of the cooling components can be used independently, and two, three or four of the cooling components can be used mixedly according to any proportion, the temperature is controlled within -60.2-20 DEG C, and during use, the physical therapy effects of quick cooling, analgesia and detumescence can be realized.

Description

A kind of refrigeration composition that is used for the aerosol of body surface cooling
Technical field
The present invention relates to a kind of refrigeration composition that is used for the aerosol of body surface cooling, belong to medicine equipment and medical health field, particularly with 1,1,1; 3,3-pentafluoropropane, Tetrafluoroethane, 1,1,1,3-tetrafluoeopropene, 1; 1,1,3, the 3-pentafluoropropane is as the refrigeration composition.
Background technology
For a long time, the high R12 of fluorine chlorine is used as refrigeration agent, and it has made very big contribution for human aspect refrigeration, also brought disaster to the mankind but in the process of using, shine into the destruction of ozonosphere.1985, under the promotion of UNEP, formulated " Vienna Convention " of protection ozonosphere.1987, UNEP organized to set up Montreal Protocol on Substances that Deplete the Ozone Layer, and 8 kinds of materials that damage the ozone layer (abbreviation controlled substance) have been proposed to cut down the time requirement of using.Nineteen ninety, 1992 and nineteen ninety-five; In the protocol Meeting of States Parties of holding in London, Copenhagen, vienna; Protocol has been done 3 times again respectively to be revised; Enlarged the scope of controlled substance, comprised freonll-11 (also claiming cfc CFC), Ha Lun (CFCB), tetracol phenixin (CCL4), trichloroethane (CH3CCl3), fluorochlorohydrocarbon (HCFC) and monobromomethane (CH3Br) etc. at present, and shifted to an earlier date the withdraw from service time.According to the regulation of amended protocol, developed country to 1994 stops using Ha Lun year January, stops using freonll-11, tetracol phenixin, trichloroethane in January, 1996; Developing country to 2010 year all stops using freonll-11, Ha Lun, tetracol phenixin, trichloroethane.China has added Montreal protocol in 1992.Fluorine chlorine high 12 can not burn, and also can not explode, and when contacting with naked light or temperature when reaching more than 400 ℃, can be decomposed into harmful hydrogen fluoride, hydrogenchloride photoreactive gas (COCL 2).Fluorine chlorine high 22 does not burn and does not explode, and its toxicity is than R12, and the solubleness of water is bigger than R12, but can form " ice is stifled " phenomenon.
Summary of the invention
For avoiding the use of the composition that Montreal Protocol on Substances that Deplete the Ozone Layer provides against use, can be applicable to people's body surface again, have nontoxic, do not fire cooling substance not quick-fried, that chemicalstability is good.The present invention has used 1,1,1,3 in the refrigeration composition of the aerosol of body surface cooling, 3-pentafluoropropane, Tetrafluoroethane, 1,1,1, and 3-tetrafluoeopropene, 1,1,1,3, the 3-pentafluoropropane provides a kind of green, healthy refrigeration composition.The present invention is achieved in that the cooling scope according to the aerosol of body surface cooling :-60.2 ~ 20 ℃, selectable scheme is: one, with 1,1, and 1; 3,3-pentafluoropropane, Tetrafluoroethane, 1,1,1; 3-tetrafluoeopropene, 1,1,1; 3, the single constituent element in the 3-pentafluoropropane is as the refrigeration composition of the aerosol of body surface cooling, and its consumption is confirmed according to the specification of product.Two, with 1,1,1,3,3-pentafluoropropane, Tetrafluoroethane, 1,1,1,3-tetrafluoeopropene, 1,1,1,3, any two constituent elements in the 3-pentafluoropropane mix, as the refrigeration composition.Can select the arbitrary proportion of any two constituent elements according to demand, the refrigerating consumption is confirmed according to the specification of product.Three, with 1,1,1,3,3-pentafluoropropane, Tetrafluoroethane, 1,1,1,3-tetrafluoeopropene, 1,1,1,3, any three constituent elements in the 3-pentafluoropropane mix, as the refrigeration composition.Can select the arbitrary proportion of wantonly three constituent elements according to demand, the refrigerating consumption is confirmed according to the specification of product.Four, with 1,1,1,3,3-pentafluoropropane, Tetrafluoroethane, 1,1,1,3-tetrafluoeopropene, 1,1,1,3, the 3-pentafluoropropane, in ratio arbitrarily as the refrigeration composition.Can select the arbitrary proportion of four constituent elements according to demand, the refrigerating consumption is confirmed according to product specification.Preparation and use: according to demand, select four single constituent element or mixed assemblages in the refrigeration composition constituent element, confirm consumption; Mix with other compositions in the aerosol of body surface cooling; Place pressure vessel,, make the aerosol ejection during use through valve system control.The contact surface that aerosol sprays is lowered the temperature rapidly, thereby takes away the heat of contact surface, reaches physiotheraping effects such as cooling.
Embodiment
Embodiment 1
With the refrigeration composition of single constituent element Tetrafluoroethane as the aerosol of body surface cooling; The refrigeration composition is 100% Tetrafluoroethane, and other compositions in the aerosol of Tetrafluoroethane and body surface cooling are mixed, and places pressure vessel; Through valve system control, make the aerosol ejection during use.The position that aerosol sprays can be selected voluntarily, and the contact surface that aerosol sprays is lowered the temperature rapidly, and the contact surface temperature can reach :-26.1 ~ 20 ℃, thus reach physiotheraping effect such as external cooling.
Embodiment 2
With 15% 1,1,1,3; 3-pentafluoropropane and 85% Tetrafluoroethane be as the refrigeration composition of the aerosol of body surface cooling, with 15% 1,1; 1,3, other compositions in the aerosol of 3-pentafluoropropane and 85% Tetrafluoroethane and body surface cooling mix; Place pressure vessel,, make the aerosol ejection during use through valve system control.The position that aerosol sprays can be selected voluntarily, and the contact surface that aerosol sprays is lowered the temperature rapidly, and the contact surface temperature can reach :-41.7 ~ 20 ℃, thus reach physiotheraping effect such as external cooling.
Embodiment 3
Tetrafluoroethane with 25%, 30% 1,1,1, the 3-tetrafluoeopropene and 45% 1,1; 1,3, the 3-pentafluoropropane is as the refrigeration composition of the aerosol of body surface cooling, the Tetrafluoroethane with 25%, 30% 1,1; 1, the 3-tetrafluoeopropene and 45% 1,1,1,3; Other compositions in the aerosol of 3-pentafluoropropane and body surface cooling mix, and place pressure vessel, through valve system control, make the aerosol ejection during use.The position that aerosol sprays can be selected voluntarily, and the contact surface that aerosol sprays is lowered the temperature rapidly, and the contact surface temperature can reach :-60.2 ~ 20 ℃, thus reach physiotheraping effect such as external cooling.
Embodiment 4
With 15% 1,1,1,3,3-pentafluoropropane, 20% Tetrafluoroethane, 15% 1,1; 1,3 tetrafluoeopropene, 50% 1,1,1,3, the 3-pentafluoropropane is as the refrigeration composition of the aerosol of body surface cooling; With 15% 1,1,1,3,3-pentafluoropropane, 20% Tetrafluoroethane, 15% 1; 1,1, the 3-tetrafluoeopropene, 50% 1,1,1; 3, other compositions in the aerosol of 3-pentafluoropropane composition and body surface cooling mix, and place pressure vessel, through valve system control, make the aerosol ejection during use.The position that aerosol sprays can be selected voluntarily, and the contact surface that aerosol sprays is lowered the temperature rapidly, and the contact surface temperature can reach :-45.2 ~ 20 ℃, thus reach physiotheraping effect such as external cooling.

Claims (6)

1. refrigeration composition that is used for the aerosol of body surface cooling is characterized in that: use 1,1,1,3, and 3-pentafluoropropane, Tetrafluoroethane, 1,1,1,3-tetrafluoeopropene, 1,1,1,3, the 3-pentafluoropropane is as the refrigerating composition.
2. refrigeration composition according to claim 1 is characterized in that: the refrigerating TR is :-60.2 ~ 20 ℃.
3. refrigeration composition according to claim 1 is characterized in that: can select 1,1,1,3, and 3-pentafluoropropane, Tetrafluoroethane, 1,1,1,3-tetrafluoeopropene, 1,1,1,3, the single constituent element in the 3-pentafluoropropane is as the refrigeration composition.
4. refrigeration composition according to claim 1 is characterized in that: 1,1,1,3; 3-pentafluoropropane, Tetrafluoroethane, 1,1,1,3-tetrafluoeopropene, 1,1; 1,3, with ratio arbitrarily, mix as the composition that freezes in four constituent elements of 3-pentafluoropropane with two constituent elements, three constituent elements or four constituent elements.
5. refrigeration composition according to claim 1 is characterized in that: the refrigeration composition be applicable to the cooling of body surface, its character be nontoxic, do not fire not quick-fried, chemicalstability is good, is a kind of refrigeration composition of green health.
6. TR according to claim 2 is characterized in that: TR that can be as required, and select different single constituent element or combination to be used as the composition that freezes.
CN2012100741175A 2012-03-20 2012-03-20 Cooling components of aerosol used for cooling human body surface Pending CN102618222A (en)

Priority Applications (1)

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CN2012100741175A CN102618222A (en) 2012-03-20 2012-03-20 Cooling components of aerosol used for cooling human body surface

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CN102618222A true CN102618222A (en) 2012-08-01

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888077A (en) * 2020-09-08 2020-11-06 中山蓓盾运动科技有限公司 Flame-retardant analgesic and soothing freezing aerosol and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235265B1 (en) * 1998-10-28 2001-05-22 Alliedsignal Inc. Evaporative coolant for topical anesthesia comprising hydrofluorocarbons and/or hydrochlorofluorocarbons
CN102015050A (en) * 2008-01-10 2011-04-13 霍尼韦尔国际公司 Compositions and methods containing fluorine substituted olefins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235265B1 (en) * 1998-10-28 2001-05-22 Alliedsignal Inc. Evaporative coolant for topical anesthesia comprising hydrofluorocarbons and/or hydrochlorofluorocarbons
CN102015050A (en) * 2008-01-10 2011-04-13 霍尼韦尔国际公司 Compositions and methods containing fluorine substituted olefins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111888077A (en) * 2020-09-08 2020-11-06 中山蓓盾运动科技有限公司 Flame-retardant analgesic and soothing freezing aerosol and preparation method thereof

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Application publication date: 20120801