CN111888077A - Flame-retardant analgesic and soothing freezing aerosol and preparation method thereof - Google Patents
Flame-retardant analgesic and soothing freezing aerosol and preparation method thereof Download PDFInfo
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- CN111888077A CN111888077A CN202010933617.4A CN202010933617A CN111888077A CN 111888077 A CN111888077 A CN 111888077A CN 202010933617 A CN202010933617 A CN 202010933617A CN 111888077 A CN111888077 A CN 111888077A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
The invention discloses a flame-retardant analgesic and soothing freezing aerosol and a preparation method thereof, wherein the flame-retardant analgesic and soothing freezing aerosol comprises the following components in parts by mass: 20 to 60 parts of refrigerant (R-134a or HFC134a), 39 to 79 parts of stabilizer (HCFC-141b) and 0.1 to 1 part of auxiliary agent (mint extract); the package is made by using tinplate can or aluminium can, and special aerosol valve and matched button are adopted. The invention can meet the requirement of incombustibility of the aerosol type refrigerant, can ensure good use effect, has controllable instant refrigeration temperature, can avoid adverse reactions such as cold burn and the like, can better permeate the fabric, can maintain the cooling effect for a longer time at a target part, and has better cooling cold compress treatment effect than similar products on the market.
Description
Technical Field
The invention relates to the technical field of aerosol type refrigerants, in particular to a flame-retardant analgesic and soothing freezing aerosol and a preparation method thereof.
Background
It is known in the art that a frozen aerosol, also known as a frozen spray, is used for rapid emergency treatment of athletic injuries. Most of the currently available freezing sprays use a mixture of propane and butane as the main refrigerant component, which has a high potential risk of improper use in enclosed spaces and high-temperature outdoor environments. With the improvement of the requirements of people on safety and environmental protection, the invention uses R-134a or HFC134a (which are isomers and have the same property and performance) and HCFC-141b as main components, avoids using the mixture of propane and butane with extremely strong flammability, prepares a novel flame-retardant type freezing spray by filling non-flammable refrigerant and stabilizer with extremely good compatibility, and meets the requirements of flame retardance and environmental protection of the analgesic freezing spray.
Disclosure of Invention
The invention aims to overcome the defects and shortcomings of the prior art, and provides a flame-retardant analgesic and soothing freezing aerosol and a preparation method thereof, which can meet the requirement of incombustibility of an aerosol type freezing agent, ensure good use effect, control instantaneous refrigerating temperature, avoid adverse reactions such as cold burn and the like, better permeate fabrics, maintain a long-time cooling effect on a target part, and have a cooling cold compress treatment effect superior to that of similar products on the market.
In order to achieve the purpose, the technical scheme provided by the invention is as follows: the flame-retardant analgesic and soothing freezing aerosol comprises the following components in parts by weight:
20 to 60 percent of refrigerant
39-79% of stabilizer
0.1-1% of an auxiliary agent.
Furthermore, the refrigerant is R-134a or HFC134a (tetrafluoroethane), is a medium-low temperature environment-friendly refrigerant, has good safety and comprehensive performance, is nonflammable, non-explosive, nontoxic, nonirritant and noncorrosive, has the safety category of A1, and can control the instantaneous refrigeration temperature to be any temperature section within the range of-5 ℃ to-35 ℃ by changing the proportion of the refrigerant, and the deviation is not more than 5 ℃.
Further, the stabilizer is HCFC-141b (monofluorodichloroethane), which is a high-purity liquid, has excellent compatibility with R-134a and HFC134a, can reduce the air pressure in the aerosol tank and enhance the stability, ensures that the spraying pressure of the aerosol is constant in the whole using period and the atomization effect is kept, and avoids the phenomenon that the spraying port is blocked due to icing when continuously spraying.
Furthermore, the auxiliary agent is a mint extracting solution, so that the spray has mint fragrance and cool feeling.
Further, the peppermint extracting solution is peppermint oil or menthol.
The invention also provides a preparation method of the flame-retardant analgesic and soothing freezing aerosol, which comprises the following steps:
1) respectively weighing 0.1-1% of an auxiliary agent and 39-79% of a stabilizer solution according to the mass percentage, adding the auxiliary agent into the stabilizer solution, uniformly stirring to prepare a base material liquid, and sealing and storing;
2) canning 39.1-80% of base feed liquid into an aerosol can according to the mass percentage, then installing a specific aerosol valve, and sealing;
3) the aerosol is manufactured by filling 20-60% of refrigerant into the aerosol tank by a precision metering instrument according to a preset value, and finally adding a specific actuator, a safety cover and an outer cover.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the invention adopts safe, low-toxicity, environment-friendly and stable formula components, adjusts the dosage proportion of the refrigerant in the formula, and adopts the precise aerosol filling system process, the refrigerant which is incombustible in the air and the stabilizer which can enable the target surface to continuously maintain the cooling effect, so that the product can be uniformly distributed on the target surface when in use, achieves good cooling and cold compress effect, continuously generates the cooling effect, sprays the feed liquid which is safe, environment-friendly and incombustible, has wider use scenes, meets the use and carrying requirements in different space environments, is not possessed by most of the existing products, has practical application value, and is worthy of popularization.
Detailed Description
The present invention will be further described with reference to the following specific examples.
The flame-retardant analgesic and soothing refrigeration aerosol provided by the embodiment comprises the following components in parts by weight:
20 to 60 portions of refrigerant (R-134a or HFC134a), 39 to 79 portions of stabilizer (HCFC-141b) and 0.1 to 1 portion of auxiliary agent (mint extract).
Wherein, the R-134a and the HFC134a are both tetrafluoroethane which is a medium-low temperature environment-friendly refrigerant with good safety performance; the HCFC-141b is a non-perhalogenated chlorofluorocarbon monofluorodichloroethane having excellent thermal stability; the auxiliary agent is herba Menthae extractive solution prepared by natural herba Menthae synthesis method, and can be oleum Menthae Dementholatum or menthol.
The flame-retardant analgesic and soothing freezing aerosol is packaged by using a tinplate can or an aluminum can, and a special aerosol valve and a matched button are adopted.
Through repeated tests, the optimal component ratios of the groups of the flame-retardant analgesic and soothing freezing aerosol are provided:
a first group: r-134 a: 20 parts, HCFC-141 b: 79 parts, menthol: 1 part.
The instantaneous refrigeration temperature of the components is higher, the spraying effect is wetter, and a certain cooling effect can be maintained on the target surface for a longer time.
Second group: r-134 a: 30 parts, HCFC-141 b: 69.9 parts, menthol: 0.1 part.
The instantaneous refrigeration temperature of the components is moderate, the spraying effect is moderate in dryness and humidity, and the target surface can maintain a good cooling effect for a long time.
Third group: r-134 a: 60 parts, HCFC-141 b: 39 parts, menthol: 1 part.
The instantaneous refrigeration temperature of the components is lower, the spraying effect is drier, and the target surface can be recovered to the normal temperature in a shorter time.
The following is a preparation method of the flame-retardant analgesic and soothing refrigeration aerosol of the embodiment, which comprises the following steps:
1) respectively weighing 0.1-1% of an auxiliary agent (mint extract) and 39-79% of a stabilizer (HCFC-141b) solution according to the mass percentage, adding the auxiliary agent (mint extract) into the stabilizer (HCFC-141b) solution, uniformly stirring to prepare a base material liquid, and sealing and storing;
2) canning 39.1-80% of base feed liquid into an aerosol can according to the mass percentage, then installing a specific aerosol valve, and sealing;
3) the aerosol can is filled with 20% -60% of refrigerant (R-134a or HFC134a) according to a predetermined value by a precision metering instrument, and finally a specific actuator, a safety cover and an outer cover are added to complete the manufacture of the aerosol.
In summary, compared with the prior art, the invention adjusts the dosage proportion of the refrigerant and the stabilizer in the formula, uses the solvents such as R-134a or HFC134a and HCFC-141b which are safe, environment-friendly, stable, nonflammable and excellent in compatibility, adjusts the dosage proportion of the refrigerant in the formula, adopts the precise aerosol filling system process, adopts the refrigerant which is nonflammable in the air and the stabilizer which can enable the target surface to continuously maintain the cooling effect, enables the product of the invention to be uniformly distributed on the target surface when in use, achieves the good cooling cold compress effect, continuously generates the cooling effect, sprays the liquid material which is safe, environment-friendly and nonflammable, has wider use scenes, meets the use and carrying requirements in different space environments, and is not possessed by most of the existing products.
In conclusion, the invention adopts the refrigerant R-134a or HFC134a which has good comprehensive performance, safety, no toxicity and non-flammability to replace the existing refrigeration aerosol which is mainly produced by using LPG (liquefied petroleum gas: a mixture of propane and butane and accompanied by a small amount of propylene and butylene) as the refrigerant in the market. The process is simple and reliable, the manufacturing efficiency is high, the stability is strong, the requirements of flame retardance and safety and environmental protection are met, the potential risks of using and carrying the frozen aerosol are greatly reduced, the use scene is wider, and the requirements of using and carrying in different space environments are met. Is worthy of popularization.
The above-mentioned embodiments are merely preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, so that the changes in the shape and principle of the present invention should be covered within the protection scope of the present invention.
Claims (6)
1. The flame-retardant analgesic and soothing freezing aerosol is characterized by comprising the following components in parts by mass:
20 to 60 percent of refrigerant
39-79% of stabilizer
0.1-1% of an auxiliary agent.
2. The flame-retardant analgesic and soothing refrigeration aerosol as claimed in claim 1, wherein: the refrigerant is R-134a or HFC134a, is a medium-low temperature environment-friendly refrigerant, has good safety and comprehensive performance, is nonflammable, non-explosive, nontoxic, nonirritant and noncorrosive, has the safety category of A1, and can control the instant refrigeration temperature to be any temperature section within the range of-5 ℃ to-35 ℃ by changing the refrigerant proportion, and the deviation is not more than 5 ℃.
3. The flame-retardant analgesic and soothing refrigeration aerosol as claimed in claim 1, wherein: the stabilizer is HCFC-141b which is a high-purity liquid, has excellent compatibility with R-134a and HFC134a, can reduce the air pressure in the aerosol tank and enhance the stability, ensures that the spraying pressure of the aerosol in the whole using period is constant and the atomizing effect is kept, and avoids the phenomenon that a spraying port is blocked due to icing when continuously spraying.
4. The flame-retardant analgesic and soothing refrigeration aerosol as claimed in claim 1, wherein: the auxiliary agent is a mint extracting solution, so that the spray has mint fragrance and cool feeling.
5. The flame-retardant analgesic and soothing refrigeration aerosol as claimed in claim 4, wherein: the herba Menthae extract is oleum Menthae Dementholatum or menthol.
6. A process for preparing the flame-retardant analgesic and soothing aerosol formulation according to any one of claims 1 to 5, comprising the steps of:
1) respectively weighing 0.1-1% of an auxiliary agent and 39-79% of a stabilizer solution according to the mass percentage, adding the auxiliary agent into the stabilizer solution, uniformly stirring to prepare a base material liquid, and sealing and storing;
2) canning 39.1-80% of base feed liquid into an aerosol can according to the mass percentage, then installing a specific aerosol valve, and sealing;
3) the aerosol is manufactured by filling 20-60% of refrigerant into the aerosol tank by a precision metering instrument according to a preset value, and finally adding a specific actuator, a safety cover and an outer cover.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010933617.4A CN111888077A (en) | 2020-09-08 | 2020-09-08 | Flame-retardant analgesic and soothing freezing aerosol and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010933617.4A CN111888077A (en) | 2020-09-08 | 2020-09-08 | Flame-retardant analgesic and soothing freezing aerosol and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN111888077A true CN111888077A (en) | 2020-11-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010933617.4A Pending CN111888077A (en) | 2020-09-08 | 2020-09-08 | Flame-retardant analgesic and soothing freezing aerosol and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018592A (en) * | 2009-09-11 | 2011-04-20 | 李炳连 | External-use refrigeration equipment for human body |
| CN102618222A (en) * | 2012-03-20 | 2012-08-01 | 海南建科药业有限公司 | Cooling components of aerosol used for cooling human body surface |
| CN106821588A (en) * | 2017-02-24 | 2017-06-13 | 中山威习日化科技有限公司 | A kind of analgesia cryospray agent with specific aerosol valve Yu actuator |
| CN109568267A (en) * | 2018-12-28 | 2019-04-05 | 中山市天图精细化工有限公司 | A kind of frost pain-stopping aerosol and preparation method thereof |
| CN110522721A (en) * | 2019-09-23 | 2019-12-03 | 重庆玩趣体育文化传播有限公司 | A kind of quickly cooling is spraying and preparation method thereof |
-
2020
- 2020-09-08 CN CN202010933617.4A patent/CN111888077A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018592A (en) * | 2009-09-11 | 2011-04-20 | 李炳连 | External-use refrigeration equipment for human body |
| CN102618222A (en) * | 2012-03-20 | 2012-08-01 | 海南建科药业有限公司 | Cooling components of aerosol used for cooling human body surface |
| CN106821588A (en) * | 2017-02-24 | 2017-06-13 | 中山威习日化科技有限公司 | A kind of analgesia cryospray agent with specific aerosol valve Yu actuator |
| CN109568267A (en) * | 2018-12-28 | 2019-04-05 | 中山市天图精细化工有限公司 | A kind of frost pain-stopping aerosol and preparation method thereof |
| CN110522721A (en) * | 2019-09-23 | 2019-12-03 | 重庆玩趣体育文化传播有限公司 | A kind of quickly cooling is spraying and preparation method thereof |
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Application publication date: 20201106 |
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