CN102614520A - Composite matrix of water-soluble film coating agent - Google Patents
Composite matrix of water-soluble film coating agent Download PDFInfo
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- CN102614520A CN102614520A CN2012101207838A CN201210120783A CN102614520A CN 102614520 A CN102614520 A CN 102614520A CN 2012101207838 A CN2012101207838 A CN 2012101207838A CN 201210120783 A CN201210120783 A CN 201210120783A CN 102614520 A CN102614520 A CN 102614520A
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- water
- liniment
- coating agent
- film coating
- soluble film
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a composite matrix of a water-soluble film coating agent based on salt of casein. The composite matrix is mainly characterized by comprising the following raw materials in percentage by weight: 5-25 percent of salt of casein, 0.1-3 percent of thickening agent, 1-5 percent of plasticizer and the balance of purified water, wherein the raw materials are mixed and stirred. The water-soluble film coating agent prepared by the invention has a good filming effect and strong film adhesion, medicinal infiltration can be promoted, and evaporation of water can be reduced.
Description
Technical field
The present invention relates to a kind of water solublity liniment composite interstitial substance, is a kind of water solublity liniment composite interstitial substance based on caseic salt.
Background technology
Liniment is used for that medicine and macromolecule filming material are dissolved in solvent and is prepared into external use liquid.Liniment not only preparation technology is simple, need not mount the backing material, does not need special plant equipment; Low cost of manufacture, and after being applied to the affected part, can form medicine film protection wound surface; And reduce the moisture of skin evaporation, and promoted the effect of hydration with the dissolving cutin, make medicine be easy to see through horny layer; Discharge medicine gradually, bring into play therapeutical effect better, so be a kind of rising dosage form.
Prior art filmogen commonly used is polyvinyl formal-acetal, polyvinyl alcohol contract first butyraldehyde, collodion, zein, polyvinyl alcohol, sodium carboxymethyl cellulose etc.Contract first butyraldehyde, collodion, zein of polyvinyl formal-acetal, polyvinyl alcohol all need use high concentration ethanol to make solvent, and like this to skin, particularly wound surface has strong and stimulating, has increased patient's misery.Though polyvinyl alcohol, sodium carboxymethyl cellulose are water soluble film-forming materials, adhesive force is general, after the film forming slightly one the friction promptly come off.Therefore, it is necessary to develop the stronger water solublity varnish of a kind of adhesive force.
Summary of the invention
Technical problem to be solved by this invention provides a kind of water solublity liniment that can make has the composite interstitial substance than strong adhesive force.
For solving the problems of the technologies described above, the technical scheme that the present invention taked is that the water solublity liniment composite interstitial substance that is designed is processed by following percentage by weight raw material:
Caseic salt 5～25%, thickening agent 0.1～3%, plasticizer 1～5%, all the other are purified water.
Said thickening agent is a kind of in hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose or the carbomer or their combination.
Said plasticizer is glycerol or PEG400.
The present invention is a kind of water solublity liniment composite interstitial substance based on caseic salt, and caseic salt (like sodium caseinate) is caseic a kind of derivant, has good emulsifying, thermally-stabilised, thickening, bubbles, preserves moisture, characteristic such as film forming.
Manufacture method of the present invention is to take by weighing caseic salt according to the above ratio, thickening agent, and plasticizer, purified water is mixed then, and stirring gets final product.
The present invention can be used as the substrate of medicine, skin degerming product etc., the substrate of the facial film that can also in cosmetics, be used to sleep.
The present invention utilizes that caseic salt has good emulsifying, thermally-stabilised, thickening, bubbles, preserves moisture, film forming characteristic; A certain amount of caseic salt and a certain amount of thickening agent, plasticizer, purified water are configured; Prepared water solublity liniment film-formation result is good; Film adhesive force is stronger, can promote drug osmotic, reduces water evaporates.
The specific embodiment
A kind of water solublity liniment of the present invention composite interstitial substance disposes all effective in following percentage by weight raw material range:
Caseic salt 5～25%, thickening agent 0.1～3%, plasticizer 1～5%, all the other are purified water.
Embodiment 1
Water solublity liniment composite interstitial substance of the present invention is processed by following percentage by weight raw material:
Sodium caseinate 10%, hydroxypropyl emthylcellulose 0.3%, glycerol 2%, deionized water 87.7%.
Embodiment 2
Water solublity liniment composite interstitial substance of the present invention is processed by following percentage by weight raw material:
Sodium caseinate 25%, hydroxypropyl cellulose 1%, glycerol 3.5%, deionized water 70.5%.
Embodiment 3
Water solublity liniment composite interstitial substance of the present invention is processed by following percentage by weight raw material:
Sodium caseinate 5%, sodium carboxymethyl cellulose 2.5%, PEG400 3%, deionized water 89.5%.
Embodiment 4
Water solublity liniment composite interstitial substance of the present invention is processed by following percentage by weight raw material:
Sodium caseinate 20%, carbomer 3%, PEG400 4.5%, deionized water 72.5%.
Claims (3)
1. water solublity liniment composite interstitial substance is characterized in that being processed by following percentage by weight raw material:
Caseic salt 5～25%, thickening agent 0.1～3%, plasticizer 1～5%, all the other are purified water.
2. water solublity liniment composite interstitial substance according to claim 1 is characterized in that said thickening agent is a kind of in hydroxypropyl cellulose, hydroxypropyl emthylcellulose, sodium carboxymethyl cellulose or the carbomer or their combination.
3. water solublity liniment composite interstitial substance according to claim 1 is characterized in that said plasticizer is glycerol or PEG400.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101207838A CN102614520A (en) | 2012-04-24 | 2012-04-24 | Composite matrix of water-soluble film coating agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101207838A CN102614520A (en) | 2012-04-24 | 2012-04-24 | Composite matrix of water-soluble film coating agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102614520A true CN102614520A (en) | 2012-08-01 |
Family
ID=46554964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101207838A Pending CN102614520A (en) | 2012-04-24 | 2012-04-24 | Composite matrix of water-soluble film coating agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102614520A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02308760A (en) * | 1989-05-23 | 1990-12-21 | Mitsubishi Rayon Co Ltd | Edible film and preparation thereof |
| CN1148485A (en) * | 1995-10-26 | 1997-04-30 | 魏东 | Hair shaping, beutifying and conditioning composition |
| WO2003043659A1 (en) * | 2001-11-16 | 2003-05-30 | Givaudan Sa | Edible film |
| CN1480128A (en) * | 2003-08-06 | 2004-03-10 | 北京扬新科技有限公司 | Preparation of transparent, cryptomorphic external remedy |
-
2012
- 2012-04-24 CN CN2012101207838A patent/CN102614520A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02308760A (en) * | 1989-05-23 | 1990-12-21 | Mitsubishi Rayon Co Ltd | Edible film and preparation thereof |
| CN1148485A (en) * | 1995-10-26 | 1997-04-30 | 魏东 | Hair shaping, beutifying and conditioning composition |
| WO2003043659A1 (en) * | 2001-11-16 | 2003-05-30 | Givaudan Sa | Edible film |
| CN1480128A (en) * | 2003-08-06 | 2004-03-10 | 北京扬新科技有限公司 | Preparation of transparent, cryptomorphic external remedy |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120801 |