CN102603774A - Addition technology for tetramisole hydrochloride - Google Patents
Addition technology for tetramisole hydrochloride Download PDFInfo
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- CN102603774A CN102603774A CN2012100289154A CN201210028915A CN102603774A CN 102603774 A CN102603774 A CN 102603774A CN 2012100289154 A CN2012100289154 A CN 2012100289154A CN 201210028915 A CN201210028915 A CN 201210028915A CN 102603774 A CN102603774 A CN 102603774A
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Abstract
The invention discloses an addition technology for tetramisole hydrochloride. The technology is characterized in that the technology comprises the following steps: weighing 230-240 parts by mass of styrene oxide with the mass concentration of 96-99%, pumping styrene oxide into a metering tank, weighing 695-705 parts by mass of ethanolamine with the mass concentration of 96-99%, pumping ethanolamine into an addition kettle, adding 4-6 parts by mass of sodium hydrogen carbonate to the addition kettle, starting stirring, heating until the temperature in the addition kettle is 58-60DEG C, adding styrene oxide to the addition kettle from the metering tank drop by drop, maintaining the temperature of a reaction liquid in the addition kettle at 58-60DEG C, adjusting the temperature after ending the 3-3.5h styrene oxide addition to make the temperature of the reaction liquid in the addition kettle rise to 61-63DEG C, ending an addition reaction after maintaining the temperature for 120-130min, and discharging the obtained material. The technology of the invention, which has the advantages of yield improvement, and reduction of the raw material consumption and the production cost of an enterprise, plays an effect in energy saving, emission reduction and environmental protection.
Description
Technical field
The present invention relates to a kind of additive process of tetramisole hydrochloride.
Background technology
Tetramisole hydrochloride is a kind of white crystalline powder, odorless, and the bitter band is puckery.Soluble in water, methyl alcohol slightly are dissolved in ethanol, and the atomic chloroform that is dissolved in is insoluble to acetone.Its main application is as the R-12564 midbody, anthelmintic, vermifuge.Be used for roundworm, angle worm and retrofection.Current, chemical products output such as the medicine of China, dyestuff continue steady-state growth always, and then drive the also lasting steady-state growth of demand of tetramisole hydrochloride, and the midbody market demand further enlarges.The additive process that tetramisole hydrochloride is produced in existing employing Styrene oxide 98min., thanomin addition reaction does not add any catalyzer, causes the danger low, that produce of whole process recovery ratio many.Therefore, should provide a kind of new technical scheme to address the above problem.
Summary of the invention
The objective of the invention is:, the additive process of the tetramisole hydrochloride that a kind of product yield is high, the Hazardous wastes generation is low, environmentally friendly, raw material consumption is low, production cost is few is provided to above-mentioned deficiency.
Be to realize above-mentioned purpose, the technical scheme that the present invention adopts is: a kind of additive process of tetramisole hydrochloride comprises the steps: to take by weighing 230-240 mass parts mass concentrations and is 96-99% Styryl oxide; Styryl oxide is pumped in the test tank, takes by weighing 695-705 mass parts mass concentrations then and be 96-99% thanomin, thanomin is pumped in the addition still; In the addition still, drop into the sodium hydrogencarbonate of 4-6 mass parts again, open and stir, and heating; Make the addition temperature in the kettle be increased to 58-60 ℃, from test tank, in the addition still, drip Styryl oxide then, control addition still internal reaction liquid temp remains on 58-60 ℃; The Styryl oxide adding finishes behind 3-3.5h, and attemperation makes addition still internal reaction liquid temp be increased to 61-63 ℃; Addition reaction finishes blowing behind insulation 120-130min.
The additive process of a kind of tetramisole hydrochloride of the present invention; With existing starting material Styryl oxide, thanomin is raw material, as catalyzer, organic raw material is reacted with sodium hydrogencarbonate in suitable reaction system; Reduce the generation of isomer in the reaction process; Thereby the raising product yield has simultaneously also reduced the generation of Hazardous wastes such as resin in the reaction process, and is environmentally friendly.
Advantage of the present invention is: the technology that the present invention adopts has improved yield, has reduced the production cost of raw material consumption and enterprise, has improved enterprise competitiveness, has filled up domestic blank again simultaneously, has played energy-saving and emission-reduction, has protected the effect of environment.
Embodiment
Embodiment 1
A kind of additive process of tetramisole hydrochloride comprises the steps: to take by weighing 230 mass parts mass concentrations and is 96% Styryl oxide, and Styryl oxide is pumped in the test tank; Take by weighing 695 mass parts mass concentrations then and be 96% thanomin, thanomin is pumped in the addition still, in the addition still, drop into the sodium hydrogencarbonate of 4 mass parts again; Open and stir, and heating, make the addition temperature in the kettle be increased to 58 ℃; From test tank, in the addition still, drip Styryl oxide then, control addition still internal reaction liquid temp remains on 58 ℃, and the Styryl oxide adding finishes behind the 3h; Attemperation; Make addition still internal reaction liquid temp be increased to 61 ℃, addition reaction finishes blowing behind the insulation 120min.
Embodiment 2
A kind of additive process of tetramisole hydrochloride comprises the steps: to take by weighing 235 mass parts mass concentrations and is 98% Styryl oxide, and Styryl oxide is pumped in the test tank; Take by weighing 700 mass parts mass concentrations then and be 98% thanomin, thanomin is pumped in the addition still, in the addition still, drop into the sodium hydrogencarbonate of 5 mass parts again; Open and stir, and heating, make the addition temperature in the kettle be increased to 59 ℃; From test tank, in the addition still, drip Styryl oxide then, control addition still internal reaction liquid temp remains on 59 ℃, and the Styryl oxide adding finishes behind the 200min; Attemperation; Make addition still internal reaction liquid temp be increased to 62 ℃, addition reaction finishes blowing behind the insulation 125min.
Embodiment 3
A kind of additive process of tetramisole hydrochloride comprises the steps: to take by weighing 240 mass parts mass concentrations and is 99% Styryl oxide, and Styryl oxide is pumped in the test tank; Take by weighing 705 mass concentrations then and be the thanomin of 99% mass parts, thanomin is pumped in the addition still, in the addition still, drop into the sodium hydrogencarbonate of 6 mass parts again; Open and stir, and heating, make the addition temperature in the kettle be increased to 60 ℃; From test tank, in the addition still, drip Styryl oxide then, control addition still internal reaction liquid temp remains on 60 ℃, and the Styryl oxide adding finishes behind the 3.5h; Attemperation; Make addition still internal reaction liquid temp be increased to 63 ℃, addition reaction finishes blowing behind the insulation 130min.
Claims (1)
1. the additive process of a tetramisole hydrochloride is characterized in that comprising the steps: taking by weighing 230-240 mass parts mass concentrations and is 96-99% Styryl oxide, in Styryl oxide suction test tank; The mass concentration that takes by weighing 695-705 mass parts then is 96-99% thanomin, and thanomin is pumped in the addition still, in the addition still, drops into the sodium hydrogencarbonate of 4-6 mass parts again; Open and stir, and heating, make the addition temperature in the kettle be increased to 58-60 ℃; From test tank, in the addition still, drip Styryl oxide then, control addition still internal reaction liquid temp remains on 58-60 ℃, and the Styryl oxide adding finishes behind 3-3.5h; Attemperation; Make addition still internal reaction liquid temp be increased to 61-63 ℃, addition reaction finishes blowing behind insulation 120-130min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210028915.4A CN102603774B (en) | 2012-02-10 | 2012-02-10 | Addition technology for tetramisole hydrochloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210028915.4A CN102603774B (en) | 2012-02-10 | 2012-02-10 | Addition technology for tetramisole hydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102603774A true CN102603774A (en) | 2012-07-25 |
| CN102603774B CN102603774B (en) | 2014-03-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210028915.4A Active CN102603774B (en) | 2012-02-10 | 2012-02-10 | Addition technology for tetramisole hydrochloride |
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| CN (1) | CN102603774B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103242347A (en) * | 2013-05-20 | 2013-08-14 | 黑龙江大学 | Preparation method of tetramisole hydrochloride |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3855234A (en) * | 1971-07-09 | 1974-12-17 | Ici Ltd | Manufacture of tetramisole |
| US4107170A (en) * | 1975-10-29 | 1978-08-15 | American Cyanamid Company | Method of preparing dl 6-phenyl-2,3,5,6-tetrahydroimidazo-[2,1-b]thiazole and acid addition salts thereof |
-
2012
- 2012-02-10 CN CN201210028915.4A patent/CN102603774B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3855234A (en) * | 1971-07-09 | 1974-12-17 | Ici Ltd | Manufacture of tetramisole |
| US4107170A (en) * | 1975-10-29 | 1978-08-15 | American Cyanamid Company | Method of preparing dl 6-phenyl-2,3,5,6-tetrahydroimidazo-[2,1-b]thiazole and acid addition salts thereof |
Non-Patent Citations (2)
| Title |
|---|
| 郑博等: "盐酸四咪唑合成工艺及后处理技术的研究", 《山东医药工业》, vol. 15, no. 2, 31 December 1996 (1996-12-31), pages 1 - 2 * |
| 陈玉书等: "氧化苯乙烯-乙醇胺加成法合成四咪唑中间试验", 《医药工业》, no. 11, 31 December 1979 (1979-12-31), pages 11 - 14 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103242347A (en) * | 2013-05-20 | 2013-08-14 | 黑龙江大学 | Preparation method of tetramisole hydrochloride |
| CN103242347B (en) * | 2013-05-20 | 2015-04-08 | 黑龙江大学 | Preparation method of tetramisole hydrochloride |
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| Publication number | Publication date |
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| CN102603774B (en) | 2014-03-26 |
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Effective date of registration: 20201027 Address after: No.18, Jinlong Road, Chunjiang Town, Xinbei District, Changzhou City, Jiangsu Province, 213000 Patentee after: CHANGZHOU YABANG-QH PHARMACHEM Co.,Ltd. Patentee after: Inner Mongolia Qihui Pharmaceutical Co., Ltd Patentee after: LIANYUNGANG YAHUI PHARMACHEM Co.,Ltd. Address before: 226100, Jiangsu, Nantong Haimen Ling industrial concentration zone Patentee before: NANTONG HAISHENG PHARMACEUTICAL Co.,Ltd. |
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