CN102597225B - 重组草酸盐降解酶的纯化和分离以及含有草酸盐降解酶的喷雾干燥粒子 - Google Patents

重组草酸盐降解酶的纯化和分离以及含有草酸盐降解酶的喷雾干燥粒子 Download PDF

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Publication number
CN102597225B
CN102597225B CN201080029636.9A CN201080029636A CN102597225B CN 102597225 B CN102597225 B CN 102597225B CN 201080029636 A CN201080029636 A CN 201080029636A CN 102597225 B CN102597225 B CN 102597225B
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oxalate
seq
enzyme
oxdc
particles
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CN102597225A (zh
Inventor
哈密特·司杜
李青山
阿隆·布莱克·科里
卡尔-古斯塔夫·格兰德
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Oxthera Intellectual Property AB
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Priority claimed from US12/497,275 external-priority patent/US8431122B2/en
Priority claimed from EP09164430.2A external-priority patent/EP2270138B1/en
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Priority to CN201510140451.XA priority Critical patent/CN104805067A/zh
Publication of CN102597225A publication Critical patent/CN102597225A/zh
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Priority to HK15111425.5A priority patent/HK1210805A1/xx
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201080029636.9A 2009-07-02 2010-07-01 重组草酸盐降解酶的纯化和分离以及含有草酸盐降解酶的喷雾干燥粒子 Expired - Fee Related CN102597225B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510140451.XA CN104805067A (zh) 2009-07-02 2010-07-01 重组草酸盐降解酶的纯化和分离以及含有草酸盐降解酶的喷雾干燥粒子
HK15111425.5A HK1210805A1 (en) 2009-07-02 2015-11-19 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/497,275 US8431122B2 (en) 2009-07-02 2009-07-02 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes
EP09164430.2A EP2270138B1 (en) 2009-07-02 2009-07-02 Purification and isolation of recombinant oxalate degrading enzymes
EP09164430.2 2009-07-02
US12/497,275 2009-07-02
PCT/EP2010/003864 WO2011000523A1 (en) 2009-07-02 2010-07-01 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes

Related Child Applications (1)

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CN201510140451.XA Division CN104805067A (zh) 2009-07-02 2010-07-01 重组草酸盐降解酶的纯化和分离以及含有草酸盐降解酶的喷雾干燥粒子

Publications (2)

Publication Number Publication Date
CN102597225A CN102597225A (zh) 2012-07-18
CN102597225B true CN102597225B (zh) 2015-04-29

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CN201080029636.9A Expired - Fee Related CN102597225B (zh) 2009-07-02 2010-07-01 重组草酸盐降解酶的纯化和分离以及含有草酸盐降解酶的喷雾干燥粒子
CN201510140451.XA Pending CN104805067A (zh) 2009-07-02 2010-07-01 重组草酸盐降解酶的纯化和分离以及含有草酸盐降解酶的喷雾干燥粒子

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CN201510140451.XA Pending CN104805067A (zh) 2009-07-02 2010-07-01 重组草酸盐降解酶的纯化和分离以及含有草酸盐降解酶的喷雾干燥粒子

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US (1) US20120189604A1 (https=)
EP (1) EP2449098B1 (https=)
JP (2) JP2012531186A (https=)
CN (2) CN102597225B (https=)
BR (1) BRPI1013956B8 (https=)
CA (2) CA3012811A1 (https=)
DK (1) DK2449098T3 (https=)
ES (1) ES2617917T3 (https=)
HK (1) HK1210805A1 (https=)
HU (1) HUE030905T2 (https=)
IL (1) IL216873A (https=)
IN (1) IN2012DN00592A (https=)
LT (1) LT2449098T (https=)
PL (1) PL2449098T3 (https=)
PT (1) PT2449098T (https=)
WO (1) WO2011000523A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8431122B2 (en) 2009-07-02 2013-04-30 Oxthera Intellectual Property Ab Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes
US9714456B2 (en) 2013-01-18 2017-07-25 Allena Pharmaceuticals, Inc. Crystallized oxalate decarboxylase and methods of use
CN103540569A (zh) * 2013-06-05 2014-01-29 黄虹寓 结石酶及其制备方法
WO2014197806A2 (en) * 2013-06-07 2014-12-11 Allena Pharmaceuticals, Inc. Compositions, methods, and devices for dialysis
CN107299089B (zh) * 2014-12-22 2019-09-17 武汉康复得生物科技股份有限公司 一种在生理pH条件下有活力的草酸氧化酶及其应用
CN114903985A (zh) * 2021-02-10 2022-08-16 宁波倍益嘉生物科技有限公司 一种组合物及其在防治高草酸尿症方面的应用
CN116124853B (zh) * 2022-11-07 2024-01-16 东北农业大学 一种检测草酸的电化学生物传感器、制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8486389B2 (en) * 1997-05-23 2013-07-16 Oxthera, Inc. Compositions and methods for treating or preventing oxalate-related disease
AU2003274918A1 (en) * 2002-08-20 2004-03-11 University Of Florida Polynucleotide encoding oxalate decarboxylase from aspergillus niger and methods of use
US6929940B1 (en) * 2002-08-20 2005-08-16 University Of Florida Research Foundation, Inc. Polynucleotides encoding oxalate decarboxylase from Aspergillus niger and methods of use
WO2007070052A2 (en) * 2005-12-14 2007-06-21 Oxthera, Inc. Pharmaceutical compositions and methods for treating or preventing oxalate-related disease
JP5558002B2 (ja) * 2005-12-16 2014-07-23 オクセラ インコーポレイテッド シュウ酸塩低減化のための組成物および方法
WO2008105911A2 (en) * 2006-08-02 2008-09-04 Altus Pharmaceuticals Inc. Crystallized oxalate decarboxylase and methods of use

Also Published As

Publication number Publication date
BRPI1013956B8 (pt) 2021-05-25
PT2449098T (pt) 2017-03-10
BRPI1013956A2 (pt) 2019-04-09
CA2767039C (en) 2018-09-04
JP2016121138A (ja) 2016-07-07
LT2449098T (lt) 2017-05-25
IL216873A (en) 2017-07-31
PL2449098T3 (pl) 2017-06-30
WO2011000523A1 (en) 2011-01-06
EP2449098A1 (en) 2012-05-09
BRPI1013956B1 (pt) 2021-04-06
ES2617917T3 (es) 2017-06-20
IL216873A0 (en) 2012-02-29
US20120189604A1 (en) 2012-07-26
CA3012811A1 (en) 2011-01-06
JP6220845B2 (ja) 2017-10-25
CN104805067A (zh) 2015-07-29
DK2449098T3 (en) 2017-03-06
JP2012531186A (ja) 2012-12-10
CN102597225A (zh) 2012-07-18
IN2012DN00592A (https=) 2015-06-12
HUE030905T2 (en) 2017-06-28
CA2767039A1 (en) 2011-01-06
EP2449098B1 (en) 2016-12-07
HK1210805A1 (en) 2016-05-06

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