CN102596235A - 显示有效细胞毒活性的包含豹蛙酶(rap)的免疫毒素的组合物和使用方法 - Google Patents

显示有效细胞毒活性的包含豹蛙酶(rap)的免疫毒素的组合物和使用方法 Download PDF

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Publication number
CN102596235A
CN102596235A CN2010800386149A CN201080038614A CN102596235A CN 102596235 A CN102596235 A CN 102596235A CN 2010800386149 A CN2010800386149 A CN 2010800386149A CN 201080038614 A CN201080038614 A CN 201080038614A CN 102596235 A CN102596235 A CN 102596235A
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Prior art keywords
seq
antibody
cancer
rap
antigen
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Pending
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CN2010800386149A
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English (en)
Chinese (zh)
Inventor
C-H·张
D·M·戈登堡
E·A·罗斯
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Immunomedics Inc
IBC Pharmaceuticals Inc
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Immunomedics Inc
IBC Pharmaceuticals Inc
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Priority claimed from US12/644,146 external-priority patent/US7981398B2/en
Priority claimed from US12/731,781 external-priority patent/US8003111B2/en
Priority claimed from US12/752,649 external-priority patent/US8034352B2/en
Priority claimed from US12/754,140 external-priority patent/US8722047B2/en
Priority claimed from US12/754,740 external-priority patent/US8562988B2/en
Application filed by Immunomedics Inc, IBC Pharmaceuticals Inc filed Critical Immunomedics Inc
Publication of CN102596235A publication Critical patent/CN102596235A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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CN2010800386149A 2009-08-31 2010-08-30 显示有效细胞毒活性的包含豹蛙酶(rap)的免疫毒素的组合物和使用方法 Pending CN102596235A (zh)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US23847309P 2009-08-31 2009-08-31
US61/238,473 2009-08-31
US26630509P 2009-12-03 2009-12-03
US61/266,305 2009-12-03
US12/644,146 2009-12-22
US12/644,146 US7981398B2 (en) 2005-04-06 2009-12-22 PEGylation by the dock and lock (DNL) technique
US31699610P 2010-03-24 2010-03-24
US61/316,996 2010-03-24
US12/731,781 2010-03-25
US12/731,781 US8003111B2 (en) 2005-04-06 2010-03-25 Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivo
US12/752,649 2010-04-01
US12/752,649 US8034352B2 (en) 2005-04-06 2010-04-01 Tetrameric cytokines with improved biological activity
US12/754,140 US8722047B2 (en) 2005-03-03 2010-04-05 Humanized anti-HLA-DR antibodies
US12/754,140 2010-04-05
US12/754,740 2010-04-06
US12/754,740 US8562988B2 (en) 2005-10-19 2010-04-06 Strategies for improved cancer vaccines
US32396010P 2010-04-14 2010-04-14
US61/323,960 2010-04-14
PCT/US2010/047132 WO2011026026A1 (en) 2009-08-31 2010-08-30 Compositions and methods of use of immunotoxins comprising ranpirnase (rap) show potent cytotoxic activity

Publications (1)

Publication Number Publication Date
CN102596235A true CN102596235A (zh) 2012-07-18

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CN2010800386149A Pending CN102596235A (zh) 2009-08-31 2010-08-30 显示有效细胞毒活性的包含豹蛙酶(rap)的免疫毒素的组合物和使用方法

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EP (1) EP2473187A4 (enExample)
JP (1) JP6114936B2 (enExample)
CN (1) CN102596235A (enExample)
BR (1) BR112012004274A2 (enExample)
CA (1) CA2770351C (enExample)
IN (1) IN2012DN01662A (enExample)
WO (1) WO2011026026A1 (enExample)

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CN106661112A (zh) * 2014-07-16 2017-05-10 Ucb生物制药私人有限公司 具有针对cd45和cd79的特异性的分子
CN107073135A (zh) * 2014-09-08 2017-08-18 麦考拉·阿恩特 用于将分子递送至细胞的细胞质中的构建体
CN107217068A (zh) * 2017-07-18 2017-09-29 哈尔滨紫霞生物科技有限公司 一种提高重组犬干扰素‑α融合蛋白抗病毒活性的方法
CN108061798A (zh) * 2016-11-07 2018-05-22 国药中生生物技术研究院有限公司 检测HBsAg/anti-HBs复合物体系中有效成分的量的方法和应用

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CN102559636B (zh) * 2011-12-30 2014-03-12 百泰生物药业有限公司 用于白血病和自身免疫疾病的抗体融合蛋白及其制备方法
AU2016220535B2 (en) * 2015-02-16 2021-05-27 Targinta Ab Detection and treatment of malignant tumours in the CNS
TWI614023B (zh) * 2015-05-20 2018-02-11 免疫功坊股份有限公司 具有標的部分及效應部分的胜肽核多臂接合物
KR20190038537A (ko) * 2016-06-17 2019-04-08 마젠타 테라퓨틱스 인코포레이티드 Cd117+ 세포의 고갈을 위한 조성물 및 방법
WO2019222533A1 (en) * 2018-05-18 2019-11-21 Okogen, Inc. Methods of treating ocular melanoma

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CN107073135A (zh) * 2014-09-08 2017-08-18 麦考拉·阿恩特 用于将分子递送至细胞的细胞质中的构建体
CN108061798A (zh) * 2016-11-07 2018-05-22 国药中生生物技术研究院有限公司 检测HBsAg/anti-HBs复合物体系中有效成分的量的方法和应用
CN108061798B (zh) * 2016-11-07 2019-11-08 国药中生生物技术研究院有限公司 检测HBsAg/anti-HBs复合物体系中有效成分的量的方法和应用
CN107217068A (zh) * 2017-07-18 2017-09-29 哈尔滨紫霞生物科技有限公司 一种提高重组犬干扰素‑α融合蛋白抗病毒活性的方法

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AU2010286496A1 (en) 2012-02-16
JP2013503200A (ja) 2013-01-31
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