CN102579156A - Simulated muscle prosthesis capable of being implanted into human body and elastically fixing joint - Google Patents
Simulated muscle prosthesis capable of being implanted into human body and elastically fixing joint Download PDFInfo
- Publication number
- CN102579156A CN102579156A CN2011100087105A CN201110008710A CN102579156A CN 102579156 A CN102579156 A CN 102579156A CN 2011100087105 A CN2011100087105 A CN 2011100087105A CN 201110008710 A CN201110008710 A CN 201110008710A CN 102579156 A CN102579156 A CN 102579156A
- Authority
- CN
- China
- Prior art keywords
- muscle
- pull
- line
- prothesis
- implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Prostheses (AREA)
Abstract
The invention relates to a simulated muscle prosthesis capable of being implanted into a human body and elastically fixing a joint. The simulated muscle prosthesis comprises a silicon outer sac, a filling material and a suspension fixing system. The suspension fixing system consists of at least two tensile lines and at least two anchors. Compared with an existing implanting prosthesis, the simulated muscle prosthesis has the advantages that the suspension fixing system of the prosthesis is designed, the tensile lines running in an S shape are woven in the silicon outer sac, and the thickness and the appearance of the prosthesis can be changed according to a tensile direction and tensile strength, so that requirements of muscles with different thickness on different portions are met. The prosthesis can be elastically fixed on upper and lower start points and an end point of muscle of a patient, has an effect of stabilizing a joint, resolves the problem that the prosthesis shifts and is broken due to frequent movement of limbs of the patient, accordingly, is favorable for being implanted in the human body for a long time, can be used for repairing paralyzed quadriceps femoris muscle, atrophic temporalis, intrinsic muscles of hands and soft tissues, muscles and bone defects of the total human body, and is quite practical.
Description
Technical field
Product is used in the shaping that the present invention relates generally to a kind of medical field, relates in particular to a kind of muscle prothesis of implant into body.This muscle prothesis can be used for increasing of filling soft tissue defects, modest limbs thick (just filling), and this prosthese has better elastic and can be some arthrodesises on some POF, and the muscle that replaces paralysis is to exercise partial function; Muscle prothesis of the present invention in addition can also swell damaged with the depression soft tissue, play effect attractive in appearance.
Background technology
Abroad; Prosthese is inserted and is become a kind of comparatively ideal limbs and increase thick operation method; But in existing technology; Different with the female breast prosthese is (the female breast prosthese can keep relative stability by clothing such as medicated bras), the muscle prothesis that is used for positions such as human limb insert the back not the outer additional suspention fixed system of health stablize, along with the frequent activities of limbs often causes prostheses migration; Change thereby make prosthese insert the position profile, severe patient will cause prosthese to be torn owing to strenuous exercise and prosthese self gravitation reason.Prostheses migration: in the prosthese implant into body, the human body natural is organized in Periprosthetic and forms peplos, and along with time lengthening, prosthese peplos capsule possibly become roomy, causes prostheses migration.Prosthesis ruptures: prosthese is easy to break under extruding and shearing action.Though used the high viscosity gel rubber material at present, taking place under the disruptive situation, the silicon gel can not scatter, but still can damage natural fabric around the muscle prothesis, so that lead to complications.
Summary of the invention
The emulation muscle prothesis that the purpose of this invention is to provide a kind of implant into body and ability flexible fastening joint; Through holdfast and line of pull muscle prothesis is fixed on the skeleton with this and solves problems such as prostheses migration that frequent activities and prosthese own wt because of limbs cause, prosthesis ruptures, thereby help the prosthese long-term existence in human body.
The object of the invention can be realized through following technical scheme.
The emulation muscle prothesis in implant into body and ability flexible fastening joint comprises silicon external capsule, implant and suspention fixed system.The suspention fixed system is made up of at least two line of pull and two holdfasts at least.Implant is filled in the silicon external capsule and is integrally formed with the silicon external capsule; Line of pull is embedded in the silicon external capsule on horizontal and vertical both direction and fuses together formation string bag shape structure (can be through placing line of pull on the initial silicon external capsule surface; Spraying and the outer capsule material identical materials of silicon repeatedly above that then; Thereby line of pull is embedded in the silicon external capsule and fuses together; Specifically use according to muscle prothesis, the thickness of spraying also is different, and is thinner because of range of activity and the less then spraying of intensity like the lumbricales muscle prothesis; Quadriceps femoris muscle prosthese range of movement and intensity more then spray thicker), and all S-shaped trend of the line of pull on the vertical and horizontal direction; Holdfast is fastened on line of pull, can be with the muscle prothesis flexible fastening on skeleton by the suspention fixed system that holdfast and line of pull are formed.
Described silicon external capsule shape is according to the damaged three-dimensional reconstruction model customization of patient's muscle; Increasing thick patient with modest limbs is example: spiral CT carries out thin-layer CT scanning to the two lower limb of patient; Respectively two-dimensional ct is scanned Dicom view data input service station and carry out three-dimensional soft tissue reconstruction, with the Survey Software on the work station threedimensional model of rebuilding is carried out three-dimensional measurement then, to confirm the difference of patient's left lower extremity and right lower extremity; Thereby confirm the general shape and the volume of required prosthese, the grand lower limb prosthese of customization.
Described silicon external capsule is a silica gel organic synthesis thing; Has good elasticity; But its elasticity tensile elongation is one times of natural length; If just the natural length of silicon external capsule is 10cm then can be stretched to 20cm, but line of pull tensile elongation (initial time, the length of S shape line of pull is the air line distance of line of pull starting point) but less than 3/5ths of silicon external capsule tensile elongation; Thus from different directions, (line of pull and silicon external capsule fuse together with the convenient shape that changes muscle prothesis neatly of varying strength through holdfast stretching line of pull; The line of pull that stretches from different directions can change the shape of silicon external capsule), thus be complementary with space to be implanted, farthest realize the original function of damaged muscle.And do not need accurately to customize muscle prothesis, that is to say that general shape and the volume according to aforementioned prosthese can its shape of fine change mate space to be implanted.Accomplish stretching through U.S. BOSS mechanics stretching-machine with per second and once test, this silicon external capsule can bear the stretching more than 5,000,000 times, and is indeformable, do not break not damaged.
The S-shaped trend of described line of pull; The S shape trend of preferably forming by the identical semicircle of radius; So not only can calculate the extending length of every line of pull easily, can also make muscle prothesis when stretching stressed evenly, and then according to the size of muscle prothesis, space size to be implanted and on every side the anatomical structure in joint be fixed on prosthese on the joint suitably; Greatly reduced the preparation before implanting thus, convenient follow-up implant procedure.If adopt irregular S shape to walk always to arrange line of pull, extending length that then not only can't the budget line of pull, and muscle prothesis unbalance stress, this will cause follow-up implant procedure complicated unusually.In addition, laterally with longitudinal direction on line of pull tie a knot formation string bag shape fabric in the intersection.The line of pull fabric be embedded under the contraction state in the silicon external capsule form whole; Because the silicon external capsule has elasticity line of pull be S out of shape with the silicon external capsule form integral body; Just can realize the elastic telescopic of whole prosthese through the stretching line of pull; The line of pull that exposes outside the silicon external capsule plays the effect that replaces tendon; And after will exposing line of pull outside the silicon external capsule and suitably stretch through holdfast, be fixed in the starting point up and down and the stop of human body natural's muscle of prosthese institute alternate sites, just be fixed on the skeleton.The complexity that reduces operation need to prove, in order also to guarantee with the prosthese suitable stationary on the joint, to have holdfast on a part of line of pull simultaneously; Another part line of pull does not then have, and perhaps many line of pull are fastened in a grappling.The line of pull material can be used ultra-high molecular weight polyethylene and nylon recombination line.Through the experiment of U.S. BOSS mechanics stretching-machine, every line of pull can bear 25 pounds pulling force, and the resisting fatigue experiment can reach 45 years its service life.If every semicircle formation S shape trend that line of pull is 2.5mm with the radius is by vertical and transverse intersection place knotting, vertical and vertically non-intersect; Laterally with horizontal non-intersect principle; (annotate: semicircular radius can lack the muscle parts size according to the patient and decide, but the standard extending length that is line of pull less than silicon external capsule elasticity tensile elongation 3/5ths) according to R/180 ° of arc length formula I=n π, wherein n is the angle radian; R is a radius, then 2.5/180 °=7.85mm of I=180 ° of * π *.Line of pull is stretched fully, and it presents the net of being made up of a plurality of rectangles.Each rectangle wherein, its length equates that with wide its length of side equals arc length H=7.85mm, its girth is Z=31.42mm, the extending length value TXZ=H-2R=7.85mm-5mm=2.85mm of its each semicircular elasticity.
Described implant is filled in the silicon external capsule.The implant material can be used high viscoelasticity silicon gel or boron body.Final silicon external capsule and packing material are integrally formed.
Described holdfast is with exposing line of pull outside the silicon external capsule suitably the stretch starting point up and down and the stop of human body natural's muscle of being fixed in prosthese institute alternate sites, just being fixed on the skeleton.The holdfast number decides at least 2 according to the size of muscle with alternate position.
Emulation muscle prothesis through technical scheme of the present invention; The damaged shape of the complete simulated patient of this prosthese profile; Make patient's form conform to the Human Physiology curve more; Why be under the contraction state braiding to the line of pull fabric with the silicon external capsule and be bundled together, and the associating holdfast forming the suspention fixed system of prosthese, is in order better prosthese to be fixed in the human body.Some patients are arranged because the muscle in joint disappearance or paralysis make this joint can not fulfil its effect; What at this moment we just can implantable artificial muscle trans-articular is fixing; And make artificial-muscle keep certain force of strain through line of pull; Thereby make this arthrodesis on certain functional position, realize that function that the patient wants most.
This prosthese advantage is: 1, one of key of the present invention is to have designed the suspention fixed system of prosthese (this system is made up of line of pull and holdfast), has solved that prosthese is sagging, the displacement problem.Existing both at home and abroad prosthese does not suspend fixed system in midair, often occurs sagging and displacement, makes troubles and has increased the complication that prosthese is implanted to clinical practice.2, the effect in this prosthese flexible fastening joint is to have designed the line of pull fabric with S traveling of being bundled together with the braiding of silicon external capsule, extends lumbricales prosthese line of pull longitudinally like adjustment, can metacarpophalangeal joints be fixed on the hands functional position.Reduced and implanted preceding preparation and can change the shape of muscle prothesis effectively, thereby greatly simplified follow-up implant procedure process through holdfast stretching line of pull.3, extend line of pull on the vertical and horizontal direction of prosthese, the thickness and the profile that can change prosthese according to the direction and the tension intensity of pulling force.Satisfy the requirement of different parts, different-thickness muscle.As: when repairing temporalis, can process circular muscle prothesis, the line of pull through around stretching is adjusted to suitable shape.Repair gluteus maximus, mesogluteal the time, can extend the line of pull of prosthese, be adjusted to fan-shaped or leaf etc. through stretching.4, we can emulation make each position muscle of whole body.As: the lumbricales of hand, interosseus etc.5, can swell damaged and the depression soft tissue, play effect attractive in appearance.
Description of drawings
Fig. 1 is the front view according to muscle prothesis of the present invention;
Fig. 2 is the cross section structural representation according to muscle prothesis of the present invention;
Fig. 3 is according to line of pull layout drawing of the present invention;
Fig. 4 is the rough schematic that is used to repair the muscle prothesis of temporalis according to of the present invention;
Fig. 5 is the rough schematic that is used for the crown muscle prothesis that the muscle prothesis implantation is increased outside the skull according to of the present invention;
Fig. 6 is the rough schematic that is used to correct the muscle prothesis of light moderate O shape lower limb according to of the present invention;
Fig. 7 is the rough schematic that is used to repair clawhand's muscle prothesis after the injury of radial nerve according to of the present invention.
The specific embodiment
1-7 with reference to the accompanying drawings; The specific embodiment of the invention is described in detail; Fig. 1 is the front view according to muscle prothesis of the present invention, and Fig. 2 is the cross section structural representation according to muscle prothesis of the present invention, and wherein 1 is holdfast, the 2nd, silicon external capsule, the 3rd, line of pull, the 4th, implant.In Fig. 1-7, identical parts are represented with identical reference number.
According to an aspect of the present invention, muscle prothesis of the present invention can be used for quadriceps femoris.1 couple of this embodiment is elaborated with reference to accompanying drawing.At first the two lower limb of patient are carried out thin-layer CT scanning with spiral CT; Respectively two-dimensional ct is scanned Dicom view data input service station and carry out three-dimensional soft tissue reconstruction; With the Survey Software on the work station threedimensional model of rebuilding is carried out three-dimensional measurement then; Confirming the difference of patient's left lower extremity and right lower extremity, thus the shape and the volume of definite required prosthese, and the longitudinal length of the quadriceps femoris that need fill through this patient of ratiometric conversion approximates L=400mm; Lateral length approximates K=200mm, and thickness approximates the likeness in form cuboid of G=20mm.Line of pull 3 is the fabric that the semicircle of R=2.5mm constitutes S shape trend with the radius; This fabric is by silicon external capsule 2 braiding parcels; Be filled into integral body of formation in the silicon external capsule 2 to implant 4; The line of pull 3 that will extend silicon external capsule 2 outsides through holdfast 1 is individually fixed in starting point: anterior inferior iliac spine, shaft of femur front, external lip of linea aspera of femur, labium mediale lineae asperae femoris, and stop: terminate in tibial tuberosity.(annotate: quadriceps femoris is by four sarcous integral body in the human dissection, is respectively rectus femoris and rises from anterior inferior iliac spine; Flesh rises from the shaft of femur front in strand; Vastus lateralis rises from external lip of linea aspera of femur; Vastus medialis rises from labium mediale lineae asperae femoris.The head of last four muscle is merged into a tendon, holds patella, forms patellar ligament downwards and terminates in tibial tuberosity.) vertically connect up 79, laterally connect up 87, but vertical tensile elongation maximum 228mm minima 0mm.But horizontal tensile elongation maximum 125.4mm minima 0mm.Need ten of holdfasts, the position of holdfast anchor: 2 of anterior inferior iliac spine, 2 of shaft of femur fronts, 2 of external lip of linea aspera of femur, 2 of labium mediale lineae asperae femoris, terminate in 2 of tibial tuberosity.Being disjoint between the lateral pull line 3-1 wherein, also is disjoint between the longitudinal pulling force line 3-2, but lateral pull line 3-1 and longitudinal pulling force line 3-2 are crossing and have node 3-3, as shown in Figure 3.Certainly, also be inequality for needed line of pull of different patients and holdfast number, numerical value such as length L also can change.
According to another embodiment of the present invention, available hands temporalis is repaired, and is as shown in Figure 4.Design the muscle prothesis of temporalis shape; The shape of size thickness shape approximation three-dimensional reconstruction behind patient's CT scan; Be implanted to after patient's temples; Line of pull 3 through will being woven in silicon external capsule 2 from different perspectives, with the stretching of varying strength, the thickness and the profile of the whole muscle prothesis of a nearly step, reach after the degree similar with damaged natural muscle will around line of pull be fixed in skull with holdfast 1.When temporalis was repaired, common two line of pull and two holdfasts just can be realized the function of damaged muscle with the muscle prothesis fix in position, wherein on a line of pull holdfast is arranged, and another root do not have.Certainly also to confirm the quantity of line of pull and holdfast according to patient's actual demand.
According to another embodiment of the present invention, muscle prothesis of the present invention is used for the outer muscle prothesis implantation of skull and increases, and is as shown in Figure 5.Demand Design according to the patient goes out crown muscle prothesis shape, and the line of pull 3 through crown muscle Periprosthetic is adjusted to the thickness of patient demand with it, and reuse holdfast 1 is fixed on line of pull 3 on the skull, to reach the purpose that increases.Set the quantity of holdfast and line of pull according to the anatomical structure of the outer muscle of skull, common holdfast number is six to eight, four to six of line of pull.
According to another embodiment of the present invention, muscle prothesis is used to correct light moderate O shape lower limb, and is as shown in Figure 6.The shape of the void designs muscle prothesis of two shank internodes during according to patient and foot orthostatism; After the muscle prothesis implantation; Line of pull 3 through around the muscle prothesis is adjusted to suitable size, thickness, shape; Reuse holdfast 1 is fixed on line of pull on the tibia, to reach the purpose of correcting light moderate O shape lower limb.Different with the outer muscle prothesis of the muscle prothesis of repairing temporalis and skull, the muscle prothesis of correcting O shape lower limb is in frequent active position, is shifted easily even tears, therefore usually need tens line of pull and tens holdfasts be fixed in place.
According to another embodiment of the present invention, muscle prothesis is used to repair clawhand after the injury of radial nerve, and is as shown in Figure 7.The difform muscle prothesis of size design according to patient's interosseus, lumbricales, muscle of thenar, muscle of hypothenar; Implant corresponding position; Through the line of pull around the muscle prothesis 3 it is adjusted to suitable shape, reuse holdfast 1 is fixed on line of pull on phalanges, metacarpal bone, the carpal bone etc.The adjustment lumbricales is line of pull longitudinally, can metacarpophalangeal joints be fixed on the hands functional position, has effectively corrected the claw hand deformity that metacarpophalangeal joints hyperextension interphalangeal joint is bent excessively.Article two, lateral pull line (wherein on have holdfast), two longitudinal pulling force lines (wherein on have two holdfasts) can be with lumbricales muscle prothesis fix in position.
Muscle prothesis of the present invention can be used for repairing the filling behind whole body any position soft tissue defects and congenital amyotrophy and the tumor resection; According to the damaged size of patient's different parts, thickness, muscle prothesis that shaped design is different; And adjust to suitable size, thickness, shape through the line of pull around the muscle prothesis; The reuse holdfast is fixed on line of pull on the skeleton, to reach the damaged purpose of repair tissue.Need to prove that the number of line of pull and holdfast only is illustrative being not limited thereto in the Figure of description.Under the situation of spirit of the present invention and essence thereof, those skilled in the art can make various corresponding changes and distortion according to the present invention, but these corresponding changes and distortion all should be in the protection domains of claim of the present invention.
Claims (5)
1. implant into body and emulation muscle prothesis that can the flexible fastening joint, this muscle prothesis comprises: silicon external capsule, implant and suspention fixed system; Said suspention fixed system is made up of at least two line of pull and two holdfasts at least; It is characterized in that: said implant is filled in the said silicon external capsule and is integrally formed with said silicon external capsule; Said line of pull is embedded on the vertical and horizontal both direction in the said silicon external capsule and with said silicon external capsule and fuses together formation string bag shape structure, and all S-shaped trend of the line of pull on the vertical and horizontal both direction; Said holdfast is fastened on said line of pull, can be with the muscle prothesis flexible fastening on skeleton by the suspention fixed system that holdfast and line of pull are formed.
2. the emulation muscle prothesis in implant into body according to claim 1 and ability flexible fastening joint; It is characterized in that: said holdfast with said line of pull flexible fastening on skeleton; And through said holdfast from different directions, change the shape of this muscle prothesis with this, with the different dynamics said line of pull that stretches thus this muscle prothesis and space to be implanted are complementary.
3. the emulation muscle prothesis in implant into body according to claim 1 and ability flexible fastening joint is characterized in that; Said implant is high viscoelasticity silicon gel or boron body.
4. the emulation muscle prothesis in implant into body according to claim 1 and ability flexible fastening joint; It is characterized in that: every line of pull constitutes S shape trend with the identical semicircle of radius; And in accordance with vertical and transverse intersection place knotting, vertically with vertically non-intersect, horizontal and horizontal non-intersect principle.
5. the emulation muscle prothesis in implant into body according to claim 1 and ability flexible fastening joint; It is characterized in that: but said silicon external capsule tensile elongation is a times of its natural length, but but and the line of pull tensile elongation less than 3/5ths of silicon external capsule tensile elongation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100087105A CN102579156A (en) | 2011-01-17 | 2011-01-17 | Simulated muscle prosthesis capable of being implanted into human body and elastically fixing joint |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100087105A CN102579156A (en) | 2011-01-17 | 2011-01-17 | Simulated muscle prosthesis capable of being implanted into human body and elastically fixing joint |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102579156A true CN102579156A (en) | 2012-07-18 |
Family
ID=46468782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100087105A Pending CN102579156A (en) | 2011-01-17 | 2011-01-17 | Simulated muscle prosthesis capable of being implanted into human body and elastically fixing joint |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102579156A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1465744A (en) * | 1974-01-30 | 1977-03-02 | Ethicon Inc | Attaching fibrous connective tissue to bone |
| FR2743294A1 (en) * | 1996-01-05 | 1997-07-11 | Ethnor | Mesh anchor for bone anchorage of a ligamentary transplant especially for repairing ligaments of the knee |
| CN101827563A (en) * | 2007-10-16 | 2010-09-08 | 奥比斯医疗有限公司 | A system and method for reshaping soft tissue |
| CN202036367U (en) * | 2011-01-17 | 2011-11-16 | 王江宁 | Artificial muscle prosthesis implanted into human body and capable of elastically fixing joint |
-
2011
- 2011-01-17 CN CN2011100087105A patent/CN102579156A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1465744A (en) * | 1974-01-30 | 1977-03-02 | Ethicon Inc | Attaching fibrous connective tissue to bone |
| FR2743294A1 (en) * | 1996-01-05 | 1997-07-11 | Ethnor | Mesh anchor for bone anchorage of a ligamentary transplant especially for repairing ligaments of the knee |
| CN101827563A (en) * | 2007-10-16 | 2010-09-08 | 奥比斯医疗有限公司 | A system and method for reshaping soft tissue |
| CN202036367U (en) * | 2011-01-17 | 2011-11-16 | 王江宁 | Artificial muscle prosthesis implanted into human body and capable of elastically fixing joint |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101854886B (en) | Prosthetic devices and methods for using same | |
| CN105615966A (en) | Method and apparatus for force redistributon in articular joints | |
| EP3049003B1 (en) | Prosthetic augments to improve muscle mechanics | |
| CN202036367U (en) | Artificial muscle prosthesis implanted into human body and capable of elastically fixing joint | |
| AU2011288930A1 (en) | Prosthetic menisci and method of implanting in the human knee joint | |
| US20200337848A1 (en) | Method for manufacturing artificial cartilage and artificial cartilage manufactured with the method | |
| CN110215323A (en) | Flat foot lower-limb body-shaping harness | |
| Abidin et al. | Three dimensional finite element modelling and analysis of human knee joint-model verification | |
| Lovegreen et al. | Lower limb amputation and gait | |
| CN102579156A (en) | Simulated muscle prosthesis capable of being implanted into human body and elastically fixing joint | |
| CN107157617A (en) | The direct Suspending fixation device of tissue grafts | |
| CN107028684B (en) | The direct Suspending fixation device of soft material tissue grafts | |
| CHAREF et al. | Effects of dynamic loading on the mechanical behavior of total hip prosthesis | |
| Ali et al. | A preliminary study: Finite element analysis of an artificial knee implant design | |
| CN218279888U (en) | Knee joint prosthesis capable of realizing axial and longitudinal rotation | |
| Fadul et al. | Design of a Multi-axis Prosthetic foot for the amputees in the developing world based on human's foot bones structure for Sudanese environment | |
| RU2655446C1 (en) | Method of plasty of the anterior cruciate ligament | |
| Lee et al. | Finite element modeling to aid in refining the rehabilitation of amputees using osseointegrated prostheses | |
| Hong et al. | Dynamic analysis of transfemoral amputee's musculoskeletal system using muscle activation control parameters measured by FES experiments | |
| CN205359607U (en) | Improvement type hone lamella structure | |
| Preuschoft | Primates: The Group Including Humans | |
| CHEMELLO et al. | Finite element analysis of socket optimization in accordance with the deformation of external surface of the stump | |
| Bogdan et al. | Nitinol artificial anterior cruciate ligament: A finite element study | |
| Noble | The biomechanics of the acetabulum and acetabular replacement | |
| Schultz | Myofascial kinetic lines in horses. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice |
Addressee: Wang Jiangning Document name: the First Notification of an Office Action |
|
| DD01 | Delivery of document by public notice |
Addressee: Wang Jiangning Document name: Notification that Application Deemed to be Withdrawn |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120718 |