CN102573905A - 利用抗脂类抗体晶体结构的抗体设计 - Google Patents

利用抗脂类抗体晶体结构的抗体设计 Download PDF

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Publication number
CN102573905A
CN102573905A CN2009801562855A CN200980156285A CN102573905A CN 102573905 A CN102573905 A CN 102573905A CN 2009801562855 A CN2009801562855 A CN 2009801562855A CN 200980156285 A CN200980156285 A CN 200980156285A CN 102573905 A CN102573905 A CN 102573905A
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CN
China
Prior art keywords
antibody
lipid
site
antibodies
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801562855A
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English (en)
Chinese (zh)
Inventor
罗杰·安·萨巴蒂尼
约翰·米切尔·沃杰斯克
汤姆·哈克斯福德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apollo Endosurgery Inc
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Apollo Endosurgery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apollo Endosurgery Inc filed Critical Apollo Endosurgery Inc
Publication of CN102573905A publication Critical patent/CN102573905A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2009801562855A 2008-12-05 2009-12-04 利用抗脂类抗体晶体结构的抗体设计 Pending CN102573905A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12031808P 2008-12-05 2008-12-05
US61/120,318 2008-12-05
US15589509P 2009-02-26 2009-02-26
US61/155,895 2009-02-26
US23125809P 2009-08-04 2009-08-04
US61/231,258 2009-08-04
PCT/US2009/066862 WO2010065921A2 (en) 2008-12-05 2009-12-04 Antibody design using anti-lipid antibody crystal structures

Publications (1)

Publication Number Publication Date
CN102573905A true CN102573905A (zh) 2012-07-11

Family

ID=42233904

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801562855A Pending CN102573905A (zh) 2008-12-05 2009-12-04 利用抗脂类抗体晶体结构的抗体设计

Country Status (9)

Country Link
US (1) US20110044990A1 (https=)
EP (1) EP2374001A4 (https=)
JP (1) JP2012511026A (https=)
KR (1) KR20110097923A (https=)
CN (1) CN102573905A (https=)
AU (1) AU2009322185A1 (https=)
CA (1) CA2745436A1 (https=)
IL (1) IL213358A0 (https=)
WO (1) WO2010065921A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109837250A (zh) * 2019-01-15 2019-06-04 中国农业科学院兰州兽医研究所 羔羊睾丸支持细胞永生化细胞系及其建立方法和应用
CN110698560A (zh) * 2015-12-24 2020-01-17 凯惠科技发展(上海)有限公司 一种tpbg抗体及其制备方法、其偶联物和应用

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WO2011153416A2 (en) * 2010-06-04 2011-12-08 Lpath, Inc. Novel anti-s1p antibody variants of lt1009
ITRM20100441A1 (it) * 2010-08-05 2012-02-06 Michele Pitaro Procedimento per la produzione di anticorpi monoclonali anti-idiotipo ad uso diagnostico e/o terapeutico
KR102165384B1 (ko) * 2012-08-07 2020-10-16 메사추세츠 인스티튜트 오브 테크놀로지 항-뎅기 바이러스 항체 및 이들의 용도
AU2015217149B2 (en) 2014-02-11 2020-09-10 Massachusetts Institute Of Technology Novel full spectrum anti-dengue antibody
KR20170076756A (ko) 2014-10-30 2017-07-04 텍스타일-베이스드 딜리버리, 인코포레이티드 전달 시스템
US20190214108A1 (en) * 2016-09-16 2019-07-11 Osaka University Immunological entity clustering software
CN117050176A (zh) 2017-07-31 2023-11-14 豪夫迈·罗氏有限公司 基于三维结构的人源化方法
CN107480360B (zh) * 2017-08-03 2020-04-24 中北大学 光束细分和相界面漫反射的激光烧熔的数值计算方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110698560A (zh) * 2015-12-24 2020-01-17 凯惠科技发展(上海)有限公司 一种tpbg抗体及其制备方法、其偶联物和应用
CN109837250A (zh) * 2019-01-15 2019-06-04 中国农业科学院兰州兽医研究所 羔羊睾丸支持细胞永生化细胞系及其建立方法和应用
CN109837250B (zh) * 2019-01-15 2021-10-12 中国农业科学院兰州兽医研究所 羔羊睾丸支持细胞永生化细胞系及其建立方法和应用

Also Published As

Publication number Publication date
KR20110097923A (ko) 2011-08-31
US20110044990A1 (en) 2011-02-24
EP2374001A4 (en) 2013-03-13
IL213358A0 (en) 2011-07-31
WO2010065921A2 (en) 2010-06-10
WO2010065921A3 (en) 2011-12-29
CA2745436A1 (en) 2010-06-10
AU2009322185A1 (en) 2011-07-21
EP2374001A2 (en) 2011-10-12
JP2012511026A (ja) 2012-05-17

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: 4025 Sorrento Valley Avenue, California, Santiago, USA

Applicant after: Lpath Inc.

Address before: American California

Applicant before: Lpath Inc.

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20120711