CN102554250A - Rhombic dodecahedron gold particle as well as preparation method and application thereof - Google Patents
Rhombic dodecahedron gold particle as well as preparation method and application thereof Download PDFInfo
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- CN102554250A CN102554250A CN2010105839274A CN201010583927A CN102554250A CN 102554250 A CN102554250 A CN 102554250A CN 2010105839274 A CN2010105839274 A CN 2010105839274A CN 201010583927 A CN201010583927 A CN 201010583927A CN 102554250 A CN102554250 A CN 102554250A
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Abstract
The invention discloses a rhombic dodecahedron gold particle. The size of the gold particle is in a nanometer level to a submicron level, and a dozen of diamond surfaces are formed by (110)-type crystal faces. The dozen of the diamond surfaces of the gold particle can be further sunk, and the lateral surfaces of the protruding edges of the gold particle are trapezoidal and are formed by the (110)-type crystal faces. The invention also provides a preparation method of the rhombic dodecahedron gold particle, and applications of the rhombic dodecahedron gold particle in a high-sensitivity biosensor and preparations of anti-tumor drugs and drug carriers.
Description
Technical field
The present invention relates to golden granatohedron material of a kind of golden granatohedron and surface depression and preparation method thereof, particularly relate to dodecahedron of a kind of surface depression and preparation method thereof.
Background technology
Noble metal nano particles has good performance, all has important effect such as fields such as optics, photoelectronics, catalysis, bio-sensings.Especially the size of gold nano grain, shape and structure control and corresponding physical property are the forward position focuses of material science and association area always.With regard to gold nano grain, the resonance of surface plasma primitive is its maximum characteristics with strong delustring strong scattering.The Precious Metals-Gold nano material receives researcher's common concern owing to having the surface plasma body resonant vibration effect.This specific character can be used to the structure of SERS research and high sensitivity biology sensor and fiber waveguide device.Because the shape of gold surface plasma resonance effect and its nano material is closely related, therefore, people have been developed the new method of the gold nano-material of many preparation different-shapes (for example: line, rod, band, dish, cube etc.).Yet how through selecting felicity condition, when control generated the gold nano-material of required special appearance, further controlling and keeping this kind pattern was the huge challenge that the material scholar is faced to macro-size evolution and growth.
In recent years, { { nucleation of the regular octahedron of 111} face and growth course have had very big progress for the cube of 100} face and exposure in exposure.{ report of the gold nano-crystal of 110} face does not but almost have, because { the 110} face belongs to unstable face, and its face energy is very high, in growth course, is easy to disappear but about exposing.DMF can dissolve each other with aqueous solution of chloraurate as solvent, and DMF has very big relatedly as its reproducibility of reducing agent and temperature, also can precious metal ion not reduced under the condition of other reducing agents having.1999; People such as Isabel (Isabel Pastoriza-Santos and Luis M.Liz-Marz á n.Formationand Stabilization of Silver Nanoparticles through Reduction byN; N-Dimethylformamide.Langmuir; 1999,15 (4): 948-951) synthesized silver nano-grain with DMF first.Though; Existing people uses this DMF reducing process to prepare silver nano-grain; But,, the method for other reducing agents and DMF coupling is come controllably to prepare to have the golden granatohedron particular recess characters and appearances, that monodispersity is good does not occur as yet through control response parameter and condition.
Summary of the invention
To the deficiency of prior art, the purpose of this paper provides a kind of the have nanometer of 12 structures of granatohedron structure and surface depression rhombus or the monocrystalline gold grain of submicron-scale.Another purpose of this paper provides a kind ofly has the cave in method of monocrystalline gold grain of nanometer or submicron-scale of granatohedron structure of granatohedron structure and surface through the preparation of control response parameter and condition.In addition, another purpose of the present invention provides the purposes of monocrystalline gold grain of nanometer or the submicron-scale of 12 structures of this said granatohedron structure and surface depression rhombus.
Be used to realize that the technical scheme of above-mentioned purpose is following:
On the one hand, the present invention provides a kind of granatohedron gold grain, and said gold grain is of a size of nanoscale to submicron order, and its 12 lozenges are by { crystal face of 110} type constitutes.
Preferably, 12 lozenges of said granatohedron gold grain are for what cave in, and its outstanding seamed edge side is trapezoidal, and by { crystal face of 110} type constitutes.
The surface of above-mentioned granatohedron gold grain is preferably by nitrogen dimethylformamide and/or its oxide parcel, thus formation monocrystalline gold grain.
On the other hand, the present invention provides the preparation method of above-mentioned granatohedron gold grain, and said method comprises that nitrogen dimethylformamide and gold chloride are 90-100 ℃ of step of reacting down;
Wherein, said purity is that the reaction volume ratio of 99.5%～99.8% nitrogen dimethylformamide and the concentration chlorauric acid solution that is 10mM is 10: 1～12: 1, preferred 90～96 ℃ of reaction temperature.
Preferably,, purity comprises that further concentration is the ascorbic acid solution of 10mM in being the reaction system of 99.5%～99.8% nitrogen dimethylformamide and the concentration gold chloride that is 10mM; The reaction volume ratio of said nitrogen dimethylformamide, chlorauric acid solution and ascorbic acid solution is preferably 10: 1: 0.01～and 12: 1: 0.05.
Above-mentioned preparation method can specifically may further comprise the steps:
1) be that to add 1ml concentration in 99.5%～99.8% the nitrogen dimethylformamide be the aqueous solution of chloraurate of 10mM to 10～12ml purity, 30-35 ℃ is fully mixed;
2) mixture of step 1) is under 90-100 ℃, and preferred 90～96 ℃ were reacted 15～20 hours down.
And in the said method, step 1) comprises that also in reaction system, adding 10～50 μ L concentration is the ascorbic acid solution of 10mM, fully mixes, and preferably adopts ultrasonic mixing; Step 2) reaction is 18～20 hours.
In addition, above-mentioned preparation method also comprises:
3) after the reaction system cooling, remove the liquid in the reaction system, add an amount of ethanol, ultrasonic cleaning is after 20 minutes, and centrifugal 20 minutes of 12000rpm continued with 10000rpm ultrasonic cleaning centrifugal 10 minutes;
Preferably, repeat 10000rpm centrifugal at least 10 minutes at least 1 time, ultrasonic cleaning.
Again on the one hand, the present invention provides the purposes of above-mentioned granatohedron gold grain in preparation high sensitivity biology sensor.In addition, the present invention also provides the purposes of above-mentioned granatohedron gold grain in preparation antineoplastic and pharmaceutical carrier.
Below be detailed description of the present invention:
The gold grain of nanometer provided by the invention or submicron-scale; It is characterized in that: described gold grain profile assumes diamond in shape or the shape characteristic of the rhombus that caves in; Described granatohedron particle surface is made up of 12 rhombuses, and 12 faces are by { crystal face of 110} type constitutes.
The granatohedron particle of said surface depression is { the rhombus crystal face of 110} type, and 24 outstanding seamed edges formations by 12.
This particle full-size with granatohedron structure is near micron order.The pattern of the gold grain that obtains and the information of structure aspects can pass through SEM (SEM) (referring to Fig. 2 a, 2b, 2c, 2d, 2e, 2f) and transmission electron microscope (TEM) (referring to Fig. 3 a, 3b, 3c, 3d, 4a, 4b, 4c, 4d) characterizes acquisition.Sample is prepared in respectively on the copper mesh of n-Si (100) substrate and carbon film covering.Can obtain the information of product crystal structure aspect through X-ray powder diffraction (XRD), see Fig. 5.X-ray photoelectron power spectrum (XPS) characterize obtain the information of the surperficial composition of the gold grain that obtains and chemical state aspect.
The method for preparing nanometer or submicron-scale gold grain provided by the invention according to the specific embodiment of the present invention, said method comprising the steps of:
A) reaction system is selected: concentration is 10mM gold chloride (HuAuCl
44H
2O) aqueous solution, concentration are that ascorbic acid solution (L-Ascorbic acid), the purity of 10mM are the nitrogen dimethylformamide of 99.5%-99.8%;
B) preparation reactant mixed solution:
(1) get in the nitrogen dimethylformamide that 10-12ml purity is 99.5%-99.8% (DMF) polytetrafluoroethylcontainer container of packing into, adding 1ml concentration again is 10mM gold chloride (HuAuCl
44H
2O) aqueous solution.
(2) 10-12ml purity is that the nitrogen dimethylformamide (DMF) of 99.5%-99.8% is packed in the polytetrafluoroethylcontainer container, and the ascorbic acid solution of getting 10-50 μ L concentration again and be 10mM adds container, and then to add 1ml concentration be 10mM gold chloride (HuAuCl
44H
2O) aqueous solution fully mixes.
C) step b) gained (1), (2) polytetrafluoroethylcontainer container are sealed in the metal high-pressure hydrothermal reaction kettle; Then, whole reactor is put into heater, heating is 15-17 hour under 90-96 ℃ of temperature conditions; After waiting to naturally cool to room temperature, take out polytetrafluoroethylcontainer container, obtain filbert liquid and solids precipitation.
D) get step c) gained (1), (2) polytetrafluoroethylcontainer container; Sucking-off liquid adds an amount of alcohol again; Put into ultrasonic washing instrument then ultrasonic 20 minutes, and, continued and continued centrifugal 10 minutes with 10000rpm with gained solution centrifugal 20 minutes with 12000rpm; Take out the centrifuge tube ultrasonic cleaning, centrifugal again up to the flush away excess liquid.
Finally (1) obtains the nanometer of DMF parcel and the granatohedron gold grain deposition of submicron-scale, the granatohedron gold grain deposition of the nanometer of (2) acquisition DMF parcel and the surface depression of submicron-scale.
In above-mentioned technical scheme, also comprise in the described step b) and adopt ultrasonic mixing.
In above-mentioned technical scheme, centrifugal sedimentation more than twice at least in the described step d), second to spread all over its later centrifugal rotational speed be 10000rpm; Said ultrasonic time at least 10 minutes.
The method for preparing nanometer or micron-scale gold grain provided by the invention, its preparating mechanism is:
Generally speaking, gold chloride (HuAuCl
44H
2O) water-soluble fluid power easily dissolves each other with the DMF solvent.In the preparation of granatohedron; Under certain reaction temperature; DMF can be reduced to the simple substance gold with chlorauric acid solution as weak reductant; And the oxidation product of DMF or DMF can be stablized as surface stabilizer, and { the 110} crystal face can guarantee the formation of the granatohedron monocrystalline gold grain of discrete nanometer and submicron-scale.DMF or its oxide molecule play the effect that formed gold nano grain is assembled each other, the phase counterdiffusion is merged that stops.Its formation mechanism is: at first, DMF is reduced to gold atom with gold chloride at a certain temperature, and gold atom is assembled formation gold nuclear, and is wrapped up rapidly by DMF or its oxide molecule.Gold utensil has face-centered cubic crystal structure; Formed in this course DMF or its oxide molecule trend towards being wrapped in higher { the 110} crystal face of energy more; The 110} crystal face is unstable crystal face in the dynamics growth, why can occur, and has made following two kinds of explanations for this reason:
1) since the spacing between the 110} crystal face gold atom is relatively large, and the effect key between the surface atom relatively a little less than, { surface atom of 110} crystal face just is more prone to surfactant Cheng Jian, comes to stablize { 110} crystal face thus so;
2) consider the physisorption of surfactant; Because { atom of 110} crystal face has specific atomic distance; And DMF or its oxide just are complementary with this atomic distance; Make this kind surfactant more easily " inlaying " in that { in the intermittence of 110} surface atom, { growth rate of 110} face has finally formed this special appearance of granatohedron thereby slowed down.
Because the size of this kind particle is bigger,, in its dynamics growth course, just have more destabilizing factor compared with the preparation of the granatohedron of reduced size through particle.But observe the formed particle of this method; Complete shape and appearance and have sharp keen rib and summit mostly; The effect of stabilization in whole process that DMF can be described thus is all bigger; And if with first kind of explanation, 111} with { in crystal growth course gradually, also can participate in the bond energy combination though the 100} energy is low.
In the granatohedron preparation of surface depression, owing to added ascorbic acid, the reducing power of ascorbic acid is strong than DMF, can reduce gold chloride rapidly, improves the output of golden simple substance.In ultrasonic mixing, reactant is mixed fully, a side can provide the certain energy nucleation, and depression does not all have sharp keen rib and summit mostly in particle on the most of above-mentioned surface of preparation, proposes following possible explanation thus yet:
Because the reducing power of ascorbic acid is stronger, it can quicken the growth of limit, angle, rib, has caused the generation of concave surface.The summit that per three faces intersect and the line at center are totally 8 in < 111>direction, and the summit that per four faces intersect and the line at center are totally six in < 100>direction.Thereby { speed of growth of the crystal face of 110} type does not match (relatively perfectly granatohedron), has finally formed the face structure of depression to make the speed of growth and 12 of summit and rib.
Through the gold grain of method of the present invention preparation, its 12 faces are rhombus and for { 110} type crystal face, the depression side on its 12 is trapezoidal, and also is { 110} type crystal face.Compared with prior art, invention has following advantage:
1, the simple and easy operating of the inventive method only adopts wet chemistry method to synthesize this monocrystalline gold grain, and required step is less.
2, the nanometer of 12 structures of the surface of the present invention preparation depression rhombus or the monocrystalline gold grain of submicron-scale, increased the area of 110} high energy face, and reduced volume with respect to other polyhedron particles of same size, have higher specific surface area.
3, the nanometer of 12 structures of surface depression rhombus of the present invention's preparation or the monocrystalline gold grain of submicron-scale; Other noble metal can be modified on its surface or its recess, this characteristics such as gold grain catalytic that are modified with noble metal can be further studied.
4, the gold grain of this kind micron-scale can be used as the manufacturing materials of high sensitivity biology sensor.
5, the gold grain of this kind nano-scale can be directly as the medicine of oncotherapy or as pharmaceutical carrier.
Description of drawings
Describe the present invention below in conjunction with accompanying drawing and specific embodiment, but not as to qualification of the present invention.
Among Fig. 1,1a is the structural representation of granatohedron gold grain of the present invention; 1b is the structural representation of the granatohedron gold grain of surface of the present invention depression.
Among Fig. 2,2a, 2b are the scanning electron microscope image of granatohedron gold grain of the present invention; 2c, 2d, 2e, 2f are the scanning electron microscope image of surface of the present invention depression granatohedron gold grain.
Among Fig. 3,3a is the transmission electron microscopy figure of the slick and sly granatohedron gold grain of surface of the present invention depression, corner angle, and 3b is the SEAD figure in the 3a circle; 3c is a high resolution picture, and 3d is the enlarged drawing in the 3c frame.
Among Fig. 4,4a is the transmission electron microscopy figure of surface of the present invention depression, sharp-featured granatohedron gold grain, and 4b is the SEAD figure in the 4a circle; 4c is a high resolution picture, and 4d is the enlarged drawing in the 4c frame.
Fig. 5 is the XRD figure picture of the granatohedron gold grain of surface of the present invention depression.
The specific embodiment
Below in conjunction with accompanying drawing and specific embodiment the present invention is described in further detail.It will be appreciated by those skilled in the art that these embodiment only are used to explain the present invention, the scope that it does not limit the present invention in any way.
Gold chloride that adopts among the embodiment and nitrogen dimethylformamide are all bought from Alfa Aesar, and chemical reagent factory buys alcohol from Beijing, and deionized water is all used in all embodiment solution preparations.
In following embodiment, various processes and the method do not described in detail are conventional methods as known in the art.
In addition, the last centrifugal product that obtains adds the 1ml deionized water among the embodiment, fully mixes, and gets the mixed drips of solution of 100 μ l on the silicon chip of a 5mm * 5mm, in the insulating box of 60 degree, takes out the data characterization that is used for SEM and XRD behind the placement 1h; Get the mixed drips of solution of 20 μ l on the special-purpose common little grid copper mesh of TEM, after insulating box 60 degree are placed one hour, carry out TEM and characterize.In these characterize, adopt this area routine techniques, equipment and sign condition.SEM adopts hitachS-4800 awkward silence at a meeting emission scan Electronic Speculum to characterize, and TEM adopts Tecnai G2 F20 U-TWIN transmission electron microscope to characterize, and XRD adopts Bruker D8 Focus x-ray powder diffraction instrument to characterize.
The crystal data of the gold grain of the surface depression that obtains among the embodiment comprises:
Structure cell is the face-centered cubic structure cell, and each structure cell contains 4 gold atoms.Cell parameter: a=407.82pm, b=407.82pm, c=407.82pm, α=90 °, β=90 °, γ=90.
Embodiment 1:
The present embodiment preparation has the gold grain of the granatohedron of rule, and rib is long generally at 200-500nm, shown in Fig. 1 a, Fig. 2 a and Fig. 2 b.(length of side is: the 100-500 nanometer) also to have a small amount of irregular spherical particle in the product.Fig. 3 b is its SEAD pattern design.Described gold grain is made up of complete monocrystalline; Altogether by 12 { crystal face formations (Fig. 1 a, 2a, 2b) of 110} type; The gold grain surface is by DMF or its oxide parcel.
Concrete preparation method may further comprise the steps:
A) reaction system is selected: in volume is the polytetrafluoroethylcontainer container of 25ml, adding 12ml purity is nitrogen dimethylformamide (DMF) liquid of 99.5+%; Adding 1ml concentration then is the gold chloride (HuAuCl of 10mM
44H
2O) aqueous solution obtains the reactant mixed solution after fully mixing;
B) polytetrafluoroethylcontainer container with step a) is sealed in the metal high pressure autoclave simultaneously; Then, whole reactor is put into heater, heating is 16 hours under 94 ℃ of conditions; After waiting to naturally cool to room temperature, take out polytetrafluoroethylcontainer container, obtain filbert liquid and particle;
C) get step b) gained polytetrafluoroethylcontainer container sucking-off liquid, add a certain amount of alcohol and put into ultrasonic washing instrument ultrasonic 20 minutes, then with gained solution centrifugal 10 minutes with 12000rpm; The sucking-off supernatant; Obtain brown deposition, continue with alcohol eccentric cleaning multipass (10000rpm, 10min); For example: 2 times, up to the unnecessary DMF solvent of flush away.
Embodiment 2
The present embodiment preparation has the slick and sly relatively granatohedron gold grain of surface depression corner angle; Shown in Fig. 1 b, Fig. 2 c and Fig. 2 d; Its each face is { the crystal face formation of 110} type; The gold grain surface is by DMF or its oxide parcel, and gold grain rib length is at 200-500nm, and is { the crystal face of 110} type (seeing SEAD 3a, 3b).(length of side is: the 100-500 nanometer) also to have the irregular polyhedrons nanogold particle of remaining surface depression in the product.Fig. 3 a, 3b are its SEAD pattern design, and Fig. 3 c, 3d are high resolution picture.
Concrete preparation method may further comprise the steps:
A) reaction system is selected: in volume is the polytetrafluoroethylcontainer container of 25ml, adding 11.5ml purity is the nitrogen dimethylformamide (DMF) of 99.5+%; Getting 50 μ L concentration is the ascorbic acid solution adding container of 10mM, and then adding 1ml concentration is 10mM gold chloride (HuAuCl
44H
2O) aqueous solution is put into Ultrasound Instrument after this solution fully mixed, 35 ℃ of ultrasonic mixing 30 minutes;
B) step a) gained polytetrafluoroethylcontainer container is sealed in the metal high-pressure hydrothermal reaction kettle; Then, whole reactor is put into heater, heating is 18 hours under 95 ℃ of temperature conditions; After waiting to naturally cool to room temperature, take out polytetrafluoroethylcontainer container, obtain filbert liquid and particle;
C) get step b) gained polytetrafluoroethylcontainer container and put into ultrasonic washing instrument ultrasonic 20 minutes; With gained solution with 12000rpm centrifugal 10 minutes, the sucking-off supernatant obtained the brown deposition then; Continue to add alcohol eccentric cleaning sedimentation (10000rpm; 10min) multipass, for example: 2 times, up to the unnecessary DMF solvent of flush away.
Embodiment 3
The present embodiment preparation has the mutually clearly demarcated granatohedron gold grain of surface depression corner angle; Shown in Fig. 1 b, Fig. 2 e, Fig. 2 f; Its each face is { the crystal face formation of 110} type; Gold grain surface DMF or its oxide parcel, gold grain rib length be at 200-500nm, and be { the crystal face of 110} type (referring to the diffraction pattern of Fig. 4 a, 4b).(length of side is: the 100-500 nanometer) also to have the irregular polyhedrons nanogold particle of remaining surface depression in the product.Fig. 4 a, 4b are its SEAD pattern design, and Fig. 4 c, 4d are high resolution picture.
Concrete preparation method may further comprise the steps:
A) reaction system is selected: in volume is the polytetrafluoroethylcontainer container of 25ml, adding 11ml purity is the nitrogen dimethylformamide (DMF) of 99.8+%; Getting 10 μ L concentration is the ascorbic acid solution adding container of 10mM, and then adding 1ml concentration is 10mM gold chloride (HuAuCl
44H
2O) aqueous solution is put into Ultrasound Instrument after this solution fully mixed, 30 ℃ of ultrasonic mixing 30 minutes;
B) step a) gained polytetrafluoroethylcontainer container is sealed in the metal high-pressure hydrothermal reaction kettle; Then, whole reactor is put into heater, heating is 20 hours under 95 ℃ of temperature conditions; After waiting to naturally cool to room temperature, take out polytetrafluoroethylcontainer container, obtain filbert liquid and particle;
C) get step b) gained polytetrafluoroethylcontainer container sucking-off liquid; Add a certain amount of alcohol and put into ultrasonic washing instrument ultrasonic 20 minutes, then with gained solution centrifugal 10 minutes with 12000rpm, the sucking-off supernatant; Obtain the brown deposition; Continue with alcohol eccentric cleaning multipass, for example: 2 times, up to the unnecessary DMF solvent of flush away.
Certainly; The present invention also can have other various embodiments; Under the situation that does not deviate from spirit of the present invention and essence thereof; Those of ordinary skill in the art work as can make various corresponding changes and distortion according to the present invention, but these corresponding changes and distortion all should belong to the protection domain of the appended claim of the present invention.
Claims (10)
1. granatohedron gold grain, said gold grain is of a size of nanoscale to submicron order, and its 12 lozenges are by { crystal face of 110} type constitutes.
2. granatohedron gold grain as claimed in claim 1, wherein, 12 lozenges of said gold grain are for depression, and its outstanding seamed edge side is trapezoidal and by { crystal face of 110} type constitutes.
3. according to claim 1 or claim 2 granatohedron gold grain, wherein, the surface of said gold grain is by nitrogen dimethylformamide and/or its oxide parcel.
4. like the preparation method of each described granatohedron gold grain among the claim 1-3, said method comprises that nitrogen dimethylformamide and gold chloride are 90-100 ℃ of step of reacting down;
Preferably, said reaction temperature is 90～96 ℃;
Preferably, adopting purity is that 99.5%～99.8% nitrogen dimethylformamide and concentration are the chlorauric acid solution of 10mM, and the reaction volume of said nitrogen dimethylformamide and chlorauric acid solution is than further being preferably 10: 1～12: 1.
5. preparation method as claimed in claim 4 further comprises ascorbic acid in the reaction system of said nitrogen dimethylformamide and gold chloride;
Preferably, adopting concentration is the ascorbic acid solution of 10mM; The reaction volume of said nitrogen dimethylformamide, chlorauric acid solution and ascorbic acid solution is than further being preferably 10: 1: 0.01～12: 1: 0.05.
6. like claim 4 or 5 described preparation methods, wherein, said method comprises:
1) be that to add 1ml concentration in 99.5%～99.8% the nitrogen dimethylformamide be the aqueous solution of chloraurate of 10mM to 10～12ml purity, 30-35 ℃ is fully mixed;
2) mixture of step 1) is under 90-100 ℃, and preferred 90～96 ℃ were reacted 15～20 hours down.
7. preparation method as claimed in claim 6, wherein, in the said method, step 1) comprises that also in reaction system, adding 10～50 μ L concentration is the ascorbic acid solution of 10mM, fully mixes, and preferably adopts ultrasonic mixing; Step 2) reaction is 18～20 hours.
8. like claim 6 or 7 described preparation methods, wherein, said method also comprises:
3) remove liquid in the reaction system, add an amount of ethanol, ultrasonic cleaning is after 20 minutes, and centrifugal 20 minutes of 12000rpm continued with 10000rpm ultrasonic cleaning centrifugal 10 minutes;
Preferably, repeat 10000rpm centrifugal at least 10 minutes at least 1 time, ultrasonic cleaning.
9. like the purposes of each described granatohedron gold grain among the claim 1-3 in preparation high sensitivity biology sensor.
10. like the purposes of each described granatohedron gold grain among the claim 1-3 in preparation antineoplastic and pharmaceutical carrier.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110510656A (en) * | 2019-08-29 | 2019-11-29 | 东莞东阳光科研发有限公司 | A kind of Cu2O receive microcrystal and preparation method thereof, application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101775638A (en) * | 2010-03-24 | 2010-07-14 | 中国科学院长春应用化学研究所 | Preparation method of palladium nano crystal |
| CN101775647A (en) * | 2010-02-10 | 2010-07-14 | 中国科学院长春应用化学研究所 | Gold nano-crystal and preparation method thereof |
-
2010
- 2010-12-07 CN CN2010105839274A patent/CN102554250A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101775647A (en) * | 2010-02-10 | 2010-07-14 | 中国科学院长春应用化学研究所 | Gold nano-crystal and preparation method thereof |
| CN101775638A (en) * | 2010-03-24 | 2010-07-14 | 中国科学院长春应用化学研究所 | Preparation method of palladium nano crystal |
Non-Patent Citations (4)
| Title |
|---|
| 《Journal of the American Chemical Society》 20090228 Wenxin Niu Selective Synthesis of single-Crystalline rhombic dodecahedral,octahedral,and cubic gold nanocrystals 第131卷, 第2期 * |
| 《Journal of the American Chemical Society》 20090531 Gyoung wa Polyhedral Au Nanocrystals Exclusively Bound by {110}Facets:The rhomblc Dodecahedron 第131卷, 第5期 * |
| GYOUNG HWA: "Polyhedral Au Nanocrystals Exclusively Bound by {110}Facets:The rhomblc Dodecahedron", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》 * |
| WENXIN NIU: "Selective Synthesis of single-Crystalline rhombic dodecahedral,octahedral,and cubic gold nanocrystals", 《JOURNAL OF THE AMERICAN CHEMICAL SOCIETY》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110510656A (en) * | 2019-08-29 | 2019-11-29 | 东莞东阳光科研发有限公司 | A kind of Cu2O receive microcrystal and preparation method thereof, application |
| CN110510656B (en) * | 2019-08-29 | 2020-06-23 | 东莞东阳光科研发有限公司 | Cu2O-nano microcrystal and preparation method and application thereof |
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Application publication date: 20120711 |