CN102552721A - Method for solving color change of VC Yinqiao tablet coating - Google Patents
Method for solving color change of VC Yinqiao tablet coating Download PDFInfo
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- CN102552721A CN102552721A CN201110210588XA CN201110210588A CN102552721A CN 102552721 A CN102552721 A CN 102552721A CN 201110210588X A CN201110210588X A CN 201110210588XA CN 201110210588 A CN201110210588 A CN 201110210588A CN 102552721 A CN102552721 A CN 102552721A
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- polyvinyl alcohol
- macrogol
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Abstract
The invention provided a method for solving color change of a VC Yinqiao tablet coating and belongs to the medicine production field. By the adoption of the method, the defect that Chinese medical extract tablets of VC Yinqiao tablets in the prior art are easy to absorb moisture, green pigment is easy to dissolve in water, and table core after moisture absorption and water absorption of the free green pigment cause color offset and color change is solved. The method mainly contains the following steps of: firstly coating a layer of obstructing formula on the table core so as to obstruct the contact of VC with a color coating layer, and coating the color coating layer to finally solve the color change of the VC Yinqiao coated tablet. Raw materials of the coating in the obstructing formula contains: Pullulan, polyvinyl alcohol and polyethylene glycol 4000 at the weight ratio of 1:1:0.5. The invention is mainly used for the production of the VC Yinqiao coated tablet.
Description
Technical field
The present invention relates to the pharmaceutical production field, specifically, relate in particular to a kind of method that solves the variable color of Vitaminc lonicera and forsythia coated tablet.
Background technology
WEI C YINQIAO PIAN is generally green coated tablet; Green is a kind of green colourant---the green lake in the film-coat; Green lake is meant on the substrate of aluminium oxide additional a kind of salt of being processed by marennin and basic group aluminum or the direct pigment of the bonded water solublity of calcium, and it is water insoluble, and is not easy to change.But in WEI C YINQIAO PIAN; Because acidity and the strong reducing property of dimension c have been destroyed aluminium oxide and basic group aluminum; Cause marennin from green lake, to wander about as a refugee out; Because the Chinese medical concrete sheet moisture absorption very easily during WEI C YINQIAO PIAN, marennin is very easily water-soluble, and suction causes color displacement and variable color to the label after the moisture absorption with the marennin that dissociates out.The production of always perplexing WEI C YINQIAO PIAN can't solve.
Summary of the invention
The Chinese medical concrete sheet moisture absorption very easily when the present invention is directed in the prior art WEI C YINQIAO PIAN; Marennin is very easily water-soluble; Label after the moisture absorption absorbs water with the marennin that dissociates out and causes the defective of color displacement and variable color, the invention provides a kind of method that solves the variable color of Vitaminc lonicera and forsythia coated tablet.
The present invention realizes through following technical scheme:
A kind of method that solves the variable color of Vitaminc lonicera and forsythia coated tablet is at first wrapped one deck for label and is intercepted prescription, and obstruct dimension C contacts with the color coatings, wraps the color coatings then, finally solves the variable color of Vitaminc lonicera and forsythia coated tablet.
The raw material of coating comprises pulullan polysaccharide, polyvinyl alcohol and Macrogol 4000 in the said obstruct prescription, and three's weight ratio is: pulullan polysaccharide: polyvinyl alcohol: Macrogol 4000=1: 1: 0.5.
Pulullan polysaccharide is a kind of water solublity cement polysaccharide, and finished product is the white solid powder.It has characteristics such as good film forming, one-tenth fiber, choke, bonding, easy processing, avirulence, can be used as the water-soluble material of anti-oxidation.Polyvinyl alcohol is a kind of hydrophobic filmogen, has good film property, and the mechanical performance of film is good, has good tensile and pliability, and the film moisture effect behind the coating is splendid.Nontoxic, the nonirritant of Macrogol 4000 product has good water-solubility, has excellent lubrication property, moisture retention, dispersibility, bonding agent, antistatic additive and softening agent etc. simultaneously.
A kind of method that solves the variable color of Vitaminc lonicera and forsythia coated tablet may further comprise the steps:
(1) in the retort high-speed shearing machine, add pulullan polysaccharide, polyvinyl alcohol and Macrogol 4000, pulullan polysaccharide: polyvinyl alcohol: Macrogol 4000=1: 1: 0.5 high-speed stirred is sheared after 5 minutes and is processed pre-mixing agent;
(2) take by weighing above-mentioned pre-mixing agent by the coating consumption for 2% of bag tablet product weight, the aqueous solution by 10% calculates the weight of used process water, and blunging with technology adds pre-mixing agent in the process and be made into 10% aqueous solution; Take out behind the mix homogeneously and process coating liquid, for use;
(3) adopt high-efficiency coating machine to carry out coating; Should adjust in the coating process discharge rate, degree of atomization, spray gun and unilateral distance, add the parameters such as temperature of hot blast; Make spray gun ejection coating liquid mist good uniformity, be fan-like pattern, arrives unilateral coating drop exquisiteness, be evenly distributed; Hot air drying is timely, wind speed is reasonable; The tablet that wraps behind this layer clothing gets final product by the common green moistureproof coating of ordinary production technology bag 2% again.
Compared with prior art, the invention has the beneficial effects as follows: possess very strong gas barrier property, at first wrap one deck and isolate prescription for label; Obstruct dimension C contacts with the color coatings; Wrap the color coatings then,, solved the problem of WEI C YINQIAO PIAN variable color through detecting proof.
The specific embodiment
Be described further in the face of the present invention down:
A kind of method that solves the variable color of Vitaminc lonicera and forsythia coated tablet is at first wrapped one deck for label and is intercepted prescription, and obstruct dimension C contacts with the color coatings, wraps the color coatings then, finally solves the variable color of Vitaminc lonicera and forsythia coated tablet; The raw material of coating comprises pulullan polysaccharide, polyvinyl alcohol and Macrogol 4000 in the said obstruct prescription, and three's weight ratio is: pulullan polysaccharide: polyvinyl alcohol: Macrogol 4000=1: 1: 0.5; Pulullan polysaccharide is a kind of water solublity cement polysaccharide, and finished product is the white solid powder.It has characteristics such as good film forming, one-tenth fiber, choke, bonding, easy processing, avirulence, can be used as the water-soluble material of anti-oxidation.Polyvinyl alcohol is a kind of hydrophobic filmogen, has good film property, and the mechanical performance of film is good, has good tensile and pliability, and the film moisture effect behind the coating is splendid.Nontoxic, the nonirritant of Macrogol 4000 product has good water-solubility, has excellent lubrication property, moisture retention, dispersibility, bonding agent, antistatic additive and softening agent etc. simultaneously.
A kind of method that solves the variable color of Vitaminc lonicera and forsythia coated tablet may further comprise the steps:
(1) in the retort high-speed shearing machine, add pulullan polysaccharide, polyvinyl alcohol and Macrogol 4000, pulullan polysaccharide: polyvinyl alcohol: Macrogol 4000=1: 1: 0.5 high-speed stirred is sheared after 5 minutes and is processed pre-mixing agent;
(2) take by weighing above-mentioned pre-mixing agent by the coating consumption for 2% of bag tablet product weight, the aqueous solution by 10% calculates the weight of used process water, and blunging with technology adds pre-mixing agent in the process and be made into 10% aqueous solution; Take out behind the mix homogeneously and process coating liquid, for use;
(3) adopt high-efficiency coating machine to carry out coating; Should adjust in the coating process discharge rate, degree of atomization, spray gun and unilateral distance, add the parameters such as temperature of hot blast; Make spray gun ejection coating liquid mist good uniformity, be fan-like pattern, arrives unilateral coating drop exquisiteness, be evenly distributed; Hot air drying is timely, wind speed is reasonable; The tablet that wraps behind this layer clothing gets final product by the common green moistureproof coating of ordinary production technology bag 2% again.
Press Chinese Pharmacopoeia 2010 editions, through 45 ℃ of temperature, the accelerated test comparison and detection of humidity 75%, variable color promptly appearred in 3 months in the normal packet garment piece, and the WEI C YINQIAO PIAN of process this patent coating had no metachromatism to take place in 6 months.Reach the prescription of WEI C YINQIAO PIAN.
| Time | Commercially available VC YINQIAO coated tablet (5) | This patent VC YINQIAO sheet (5) |
| 1 month | No change, unilateral color even | No change |
| 2 months | The unilateral slightly moisture absorption | No change |
| 3 months | The unilateral slightly moisture absorption has few speckle to occur | No change |
| 4 months | The unilateral moisture absorption is quickened, and has 5 speckles to occur | No change |
| 5 months | The unilateral moisture absorption is serious, and speckle is extremely many, and label takes place softening | The unilateral slightly moisture absorption |
| 6 months | Unilateral complete variable color, label is softening serious | The unilateral slightly moisture absorption |
Claims (4)
1. method that solves the variable color of Vitaminc lonicera and forsythia coated tablet is characterized in that: at first wrap one deck for label and intercept prescription, intercept contacting of dimension C and color coatings, wrap the color coatings then, finally solve the variable color of Vitaminc lonicera and forsythia coated tablet.
2. according to right 1 described a kind of method that solves the variable color of Vitaminc lonicera and forsythia coated tablet; It is characterized in that: the raw material of coating comprises pulullan polysaccharide, polyvinyl alcohol and Macrogol 4000 in the said obstruct prescription, and three's weight ratio is: pulullan polysaccharide: polyvinyl alcohol: Macrogol 4000=1: 1: 0.5.
3. a kind of method that solves the variable color of Vitaminc lonicera and forsythia coated tablet according to claim 2 is characterized in that: pulullan polysaccharide is a kind of water solublity cement polysaccharide, and finished product is the white solid powder.It has characteristics such as good film forming, one-tenth fiber, choke, bonding, easy processing, avirulence, can be used as the water-soluble material of anti-oxidation.Polyvinyl alcohol is a kind of hydrophobic filmogen, has good film property, and the mechanical performance of film is good, has good tensile and pliability, and the film moisture effect behind the coating is splendid.Nontoxic, the nonirritant of Macrogol 4000 product has good water-solubility, has excellent lubrication property, moisture retention, dispersibility, bonding agent, antistatic additive and softening agent etc. simultaneously.
4. method that solves the variable color of Vitaminc lonicera and forsythia coated tablet, it is characterized in that: this method may further comprise the steps:
(1) in the retort high-speed shearing machine, add pulullan polysaccharide, polyvinyl alcohol and Macrogol 4000, pulullan polysaccharide: polyvinyl alcohol: Macrogol 4000=1: 1: 0.5 high-speed stirred is sheared after 5 minutes and is processed pre-mixing agent;
(2) take by weighing above-mentioned pre-mixing agent by the coating consumption for 2% of bag tablet product weight, the aqueous solution by 10% calculates the weight of used process water, and blunging with technology adds pre-mixing agent in the process and be made into 10% aqueous solution; Take out behind the mix homogeneously and process coating liquid, for use;
(3) adopt high-efficiency coating machine to carry out coating; Should adjust in the coating process discharge rate, degree of atomization, spray gun and unilateral distance, add the parameters such as temperature of hot blast; Make spray gun ejection coating liquid mist good uniformity, be fan-like pattern, arrives unilateral coating drop exquisiteness, be evenly distributed; Hot air drying is timely, wind speed is reasonable; The tablet that wraps behind this layer clothing gets final product by the common green moistureproof coating of ordinary production technology bag 2% again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110210588XA CN102552721A (en) | 2011-07-26 | 2011-07-26 | Method for solving color change of VC Yinqiao tablet coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110210588XA CN102552721A (en) | 2011-07-26 | 2011-07-26 | Method for solving color change of VC Yinqiao tablet coating |
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| Publication Number | Publication Date |
|---|---|
| CN102552721A true CN102552721A (en) | 2012-07-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110210588XA Pending CN102552721A (en) | 2011-07-26 | 2011-07-26 | Method for solving color change of VC Yinqiao tablet coating |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
-
2011
- 2011-07-26 CN CN201110210588XA patent/CN102552721A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
| US11878079B2 (en) | 2017-04-14 | 2024-01-23 | Capsugel Belgium Nv | Pullulan capsules |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120711 |