CN102552366A - Chinese medicinal extract composition as female livestock uterus cleaning liquid - Google Patents
Chinese medicinal extract composition as female livestock uterus cleaning liquid Download PDFInfo
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Abstract
The invention provides a Chinese medicinal extract composition as female livestock uterus cleaning liquid, consisting of stachydrine hydrochloride, Herba Epimedii extract, Carthamus tinctorius flower extract, berberine sulfate and Cnidium monnieri fruit extract. The preparation of the invention can shorten the renewal and recovery time of uterine tissue after parturition, promote female livestock oestrus and prevent infertility. According to the invention, the overall effective rate of treatment for dairy cow endometritis is 98%, the overall effective rate of treatment for pig endometritis is 98.2%, the overall effective rate of static treatment for dairy cow ovary and pig ovary are 98.35% and 99%, respectively, and the treatment for infertility in dairy cow and pig due to persistent corpus luteum is effective, and 99% of the treated dairy cows conceive and 98% of treated pigs conceive.
Description
Technical field
The invention belongs to field of veterinary, relate to the female animal uterus cleanout fluid that female animal puerperal and breeding back uterine contraction drain the Chinese medicine extract combination of lochia, treatment breeding difficulty property disease.
Background technology
The increase of livestock number depends on female animal and can keep normal reproductive capacity index, and breeding difficulty property disease is having a strong impact on its reproductive capacity.
For control female livestock breed obstacle disease, after people had found the drawback of antibiotic, hormone through practice, the sight that will prevent and treat medication had focused on Chinese medicine.
Along with the raising of Chinese medicine extraction technology, middle pharmaceutically active ingredient synthetic technology,, we have created condition for effectively utilizing Chinese medicine.
The present invention is intended to propose the female animal uterus cleanout fluid of the Chinese medicine extract combination of a kind of good effect, few side effects, is used to prevent and treat female livestock breed obstacle diseases such as common subinvolution in puerperal, endometritis, ovary barrenness.
Summary of the invention
[0006] the female animal uterus cleanout fluid that the object of the present invention is to provide a kind of Chinese medicine extract to make up.
Be treatment female animal pathogen infection in puerperal and breeding difficulty property disease, become common recognition with Chinese medicine.There is complicated component in Chinese medicine, get into too many levels is arranged in the animal body, the mass action of multi-level, multichannel, many target spots, manifold effect.The invention is intended to improve safety, effectiveness, reach quality controllable, have no side effect, the order ground of no drug residue the control of female livestock breed obstacle disease.
The present invention realizes like this; A kind of female animal uterus cleanout fluid of Chinese medicine extract combination is characterized in that: in the cleanout fluid of 1000ml female animal uterus, the stachydrine hydrochloride consumption is 1.25～15 grams; The Herba Epimedii extract consumption is counted 2.5～3.75 grams by icariin; The Flos Carthami extract consumption is counted 1.5～5 grams by S-A Hydroxysafflor yellow A, berberine sulfate 10～20 grams, and the Fructus cnidii extract consumption is by osthole 4～15 grams; Other has tween 80 10ml, propylene glycol cosolvent 300～900ml and an amount of distilled water.
Said stachydrine hydrochloride content>=98%; Icariin content≤98% in the Herba Epimedii extract; Icariin minimum content>=50%, safflower yellow A content>=50% in the Flos Carthami extract, berberine sulfate content>=98%; Osthole content≤98% in the Fructus cnidii extract, osthole minimum content>=50%.
The female animal uterus cleanout fluid of Chinese medicine extract combination at first is to drain lochia according to female animal needs in puerperal to set about, and acts on stachydrine hydrochloride and uterus, makes its excitement, strengthen it tension force, increase it shrinkage amplitude, accelerate its contraction rhythm and pace of moving things, microcirculation improvement; Adding Flos Carthami extract, is to assist stachydrine hydrochloride to get rid of lochia, reaches the effect in clean uterus.The second, female animal inevitably can be caused damage and by pathogenic bacterial infection, add the berberine sulfate with broad-spectrum antibacterial action in process of production or after being joined clock uterus, vagina, is to strengthen antibacterial and antiinflammation.The 3rd, add icariin, be to utilize it that the effect of direct stimulation follicular cell secretion estradiol is arranged; It is collaborative to have added " selective estrogen receptor modulators " Carthamus yellow, osthole, combines with the estrogen receptor of different target cells, starts various signals transduction pathway in the cell; The trimming body internal hormone; Influence multiple target organ, especially growth, differentiation and the function thereof of the mammary gland of female repro ductive system, uterus, ovary etc. are to promote genital development inside and outside the female animal; The immobilized ovary of activation dissolves corpus luteum and induces female animal to oestrus.
Under the fellowship of above-mentioned each Chinese medicine extract, synergism, the intrauterine lochia of emptying female animal, cure static, the retained corpus luteum of endometritis, ovary of breeding difficulty property disease, impel female animal to oestrus and become pregnant.
The female animal uterus cleanout fluid of Chinese medicine extract combination, its production technology has following characteristic:
The female animal uterus cleanout fluid of Chinese medicine extract combination with stachydrine hydrochloride, Herba Epimedii extract, Carthamus yellow extract, berberine sulfate, Fructus cnidii extract combination, is pressed the solution prepared.
The advantage of present technique scheme
1, to reproductive system and disease, with Chinese medicine extract---middle pharmaceutically active ingredient, effective site prescription.
2, the female animal uterus cleanout fluid of Chinese medicine extract combination can be given full play to the effect of each Chinese medicine to the mucosa system, improves curative effect.
3, clear and definite raw material, finished product controlling index is for controllable product quality provides guarantee.
The specific embodiment
Embodiment
Cleanout fluid one
The female animal uterus cleanout fluid of forming the combination of 1000ml Chinese medicine extract
Stachydrine hydrochloride 2.0 grams
Herba Epimedii extract is by icariin 3.0 grams
Flos Carthami extract is by S-A Hydroxysafflor yellow A 4 grams
Berberine sulfate 10 grams
Fructus cnidii extract is by osthole 4 grams
Tween 80 10ml
Propylene glycol cosolvent 300～900ml
Distilled water adds to 1000ml.
Raw material is by following requirement control of quality
Stachydrine hydrochloride content>=98%; Icariin content≤98% in the Herba Epimedii extract, icariin minimum content>=50%; Safflower yellow A content>=50% in the Flos Carthami extract; Berberine sulfate content>=98%; Osthole content≤98% in the Fructus cnidii extract, osthole minimum content>=50%.
Stachydrine hydrochloride, Herba Epimedii extract, Flos Carthami extract, berberine sulfate, Fructus cnidii extract are measured stachydrine hydrochloride, icariin, S-A Hydroxysafflor yellow A, berberine sulfate, osthole content respectively with high performance liquid chromatograph.
Production technology
1, Herba Epimedii extract is with an amount of propylene glycol cosolvent heating for dissolving;
2, Fructus cnidii extract is with an amount of propylene glycol cosolvent heating for dissolving;
3, stachydrine hydrochloride, Flos Carthami extract, berberine sulfate with suitable quantity of water dissolving, mixing, add tween 80 respectively;
4, will go up 1～3 and be mixed in the pill tank, add the nearly 1000ml of water, stir, regulate pH5～7;
5, supply water, stir, filter sampling Detection stachydrine hydrochloride, icariin, S-A Hydroxysafflor yellow A, berberine sulfate, osthole index of correlation;
6, after the assay was approved, sucking filtration, embedding, sterilization are 15 minutes;
7, pack, put in storage for sale.
Cleanout fluid two
The female animal uterus cleanout fluid of forming the combination of 1000ml Chinese medicine extract
Stachydrine hydrochloride 1.25 grams
Herba Epimedii extract is by icariin 3.75 grams
Flos Carthami extract is by S-A Hydroxysafflor yellow A 5 grams
Berberine sulfate 15 grams
Fructus cnidii extract is by osthole 6 grams
Tween 80 10ml
Propylene glycol cosolvent 300～900ml
Distilled water adds to 1000ml
Raw material is by following requirement control of quality
Stachydrine hydrochloride content>=98%; Icariin content≤98% in the Herba Epimedii extract, icariin minimum content>=50%; Safflower yellow A content>=50% in the Flos Carthami extract; Berberine sulfate content>=98%; Osthole content≤98% in the Fructus cnidii extract, osthole minimum content>=50%.
Stachydrine hydrochloride, Herba Epimedii extract, Flos Carthami extract, berberine sulfate, Fructus cnidii extract are measured stachydrine hydrochloride, icariin, S-A Hydroxysafflor yellow A, berberine sulfate, osthole content respectively with high performance liquid chromatograph.
Production technology
1, Herba Epimedii extract is with an amount of propylene glycol cosolvent heating for dissolving;
2, Fructus cnidii extract is with an amount of propylene glycol cosolvent heating for dissolving;
3, stachydrine hydrochloride, Flos Carthami extract, berberine sulfate with suitable quantity of water dissolving, mixing, add tween 80 respectively;
4, will go up 1 ~ 3 and be mixed in the pill tank, add the nearly 1000ml of water, stir, regulate pH5 ~ 7;
5, supply water, stir, filter sampling Detection stachydrine hydrochloride, icariin, S-A Hydroxysafflor yellow A, berberine sulfate, osthole index of correlation;
6, after the assay was approved, sucking filtration, embedding, sterilization are 15 minutes;
7, pack, put in storage for sale.
Cleanout fluid three
The female animal uterus cleanout fluid of forming the combination of 1000ml Chinese medicine extract
Stachydrine hydrochloride 15 grams
Herba Epimedii extract is by icariin 2.5 grams
Flos Carthami extract is by S-A Hydroxysafflor yellow A 1.5 grams
Berberine sulfate is by berberine sulfate 20 grams
Fructus cnidii extract is by osthole 15 grams
Tween 80 10ml
Propylene glycol cosolvent 300～900ml
Distilled water adds to 1000ml
Raw material is by following requirement control of quality
Stachydrine hydrochloride content>=98%; Icariin content≤98% in the Herba Epimedii extract, icariin minimum content>=50%; Safflower yellow A content>=50% in the Flos Carthami extract; Berberine sulfate content>=98%; Osthole content≤98% in the Fructus cnidii extract, osthole minimum content>=50%.
Stachydrine hydrochloride, Herba Epimedii extract, Flos Carthami extract, berberine sulfate, Fructus cnidii extract are measured stachydrine hydrochloride, icariin, S-A Hydroxysafflor yellow A, berberine sulfate, osthole content respectively with high performance liquid chromatograph.
Production technology
1, Herba Epimedii extract is with an amount of propylene glycol cosolvent heating for dissolving;
2, Fructus cnidii extract is with an amount of propylene glycol cosolvent heating for dissolving;
3, stachydrine hydrochloride, Flos Carthami extract, berberine sulfate with the suitable quantity of water dissolving, add tween 80 respectively;
4, will go up 1 ~ 3 and be mixed in the pill tank, add the nearly 1000ml of water, stir, regulate pH5 ~ 7;
5, supply water, stir, filter sampling Detection stachydrine hydrochloride, icariin, S-A Hydroxysafflor yellow A, berberine sulfate, osthole index of correlation;
6, after the assay was approved, sucking filtration, embedding, sterilization are 15 minutes;
7, pack, put in storage for sale.
One, experimental example
The clinical effectiveness of experimental example 1 1721 routine sow prolonged lochias
The swelling of clinical symptoms sow external genital, vaginal orifice always have canescence or the milky viscous solution or the purulent secretion of a large amount of corruptibility stinks.
Be diagnosed as sow puerperal and breeding back lochiorrhea
Treatment is cleaned the uterus with normal saline or disinfectant earlier, gets the female animal uterus cleanout fluid 20ml perfusion of Chinese medicine extract combination again.Once a day, or the next day once, treat 3 times.
Curative effect and criterion: local symptom exists though the produce effects symptom disappears basically, infertile person's gestation; Effectively symptom significantly alleviates; Worsen the local symptom no change behind the invalid cardinal symptom no change again or the trend of increasing the weight of is arranged.
Conclusion: 172 routine produce effects 170 examples account for 98.84% effective 2 examples and account for 1.16% total effective rate 100%.The female animal uterus cleanout fluid treatment of Chinese medicine extract combination stopped to arrange lochia after 3-4 days.
The clinical effectiveness of experimental example 2 542 routine sow endometritis
Clinical symptoms has acute endometritis and chronic endometritis from the clinical symptoms branch.
Acute endometritis: puerperal or the morbidity of a few days post-abortion, sick temperature of pig body raises, and loss of appetite or useless exhausted is reluctant to stand up for sleeping inly, and the nose border is dry.The peculiar symptom of primary disease is that the disease pig often has micturition, exerts duty frequently, and vagina flows out stickiness or purulent secretion, is filthy red, and stench flavor is arranged, and with the afterbirth fragment, is attached to outside root of the tail and the vaginal orifice.
Chronic endometritis: sick pig General Symptoms is not obvious, and a small amount of canescence or yellow heavy-gravity secretions are discharged from intravaginal often in ground for sleeping in, flows out lessly when standing, and around vaginal orifice, can see the secretions incrustation.Sick pig performance is become thin, is oestrused undesired or postpones, and joins infertilely repeatly, even become pregnant embryonic death or miscarriage takes place again soon.
Select the pathogenic bacterium that 30 examples carry out before the medication and separate,, mainly contain escherichia coli, streptococcus, staphylococcus through identifying, other be Salmonella, bacillus pyocyaneus, corynebacterium pyogenes and klebsiella.
Treatment is earlier with 0.1% new hydrogenperoxide steam generator or 0.02% bromo geramine; Perhaps 0.1% ethacridine solution removal is trapped in intrauterine rheuminess thing; The remaining medicinal liquid of flushing back sucking-off, the female animal uterus cleanout fluid 20ml that gets the Chinese medicine extract combination pours into, once a day; Or every other day once, treat 3-5 time continuously.Treatment about about 16 days, is treated its breeding of oestrusing after finishing.
The curative effect of pig endometritis and judgement
Cure 482 examples.Standard is: General Symptoms disappears, and it is normal that spiritual appetite is recovered, and inflammation of uterus disappears, and intrauterine does not have the rheuminess thing and pus is discharged, and inspection vaginal wall color restoration is normal, and external genital swelling disappears, and the secretions transparent clear is oestrused on schedule, normal pregnancy.Cure rate is 88.92%.
Effective 50 examples.Standard is: General Symptoms disappears basically after the medication, and spiritual appetite is clearly better, and inflammation of uterus is obviously alleviated, and uterus secretions is basic near normal, and intravaginal has a small amount of foreign body to flow out, and external genital swelling is not obvious.Effective percentage is 9.23%.
Invalid: General Symptoms does not disappear after the medication, and spiritual appetite is poor, and inflammation of uterus does not see and alleviate that uterus secretions is not seen minimizing, even worsens, not variation before synthetic determination and the medication.This experiment has 10 examples, accounts for 1.8%.
Conclusion: the sow endometritis is effective with the female animal uterus cleanout fluid treatment of Chinese medicine extract combination, and the sow conception rate after curing is unaffected, and total effective rate is 98.2%.
The immobilized clinical effectiveness of experimental example 3 116 routine sow ovaries
The sow non-estrus that clinical symptoms 6-8 monthly age or puerperal weaned 15 days; Or the appearance sign of oestrusing is not obvious, or the sign of oestrusing occurs, and does not ovulate; Examination per rectum; The character and the quality of ovary there are not significant change, touch less than follicle and corpus luteum yet, or only feel on a side ovary that very little corpus luteum vestiges are arranged.
Treatment is cleaned the uterus with normal saline or disinfectant, gets the female animal uterus cleanout fluid 20ml perfusion of Chinese medicine extract combination.Once a day, or the next day once, treat 3 times.
In the first time of feelings in the phase, examination per rectum has follicular development, corpus luteum to occur after curative effect and the criterion medication, oestrus and gestation be produce effects; In second or the 3rd oestrus, examination per rectum has follicular development, corpus luteum to occur, oestrus and gestation for effectively; Surpass the 3rd oestrus, examination per rectum does not have follicular development, does not have corpus luteum yet and occurs, and still non-estrus is invalid.This tests 116 examples, and 97 examples of produce effects account for 83.62%; Effective 18 examples account for 15.57%.
Conclusion: total effective rate 99%.
The clinical effectiveness of experimental example 4 110 routine sow retained corpus luteums
Clinical symptoms body weight, age reach the back sow or the sow non-estrus that weans puerperal that breeding requires; Examination per rectum can contact a side, both sides sometimes, and ovary increases, 10-14 days at interval; Through twice above touch, still contact same corpus luteum at the same position of ovary.Simultaneously, periphery blood plasma progesterone level is measured in 35 routine sow blood samplings in the experimental example, plasma progesterone concentration all more than 6ng/mL, combines with clinical symptoms, and decidable is for suffering from retained corpus luteum.
Treatment is cleaned the uterus with normal saline or disinfectant, gets the female animal uterus cleanout fluid 20ml of Chinese medicine extract combination, perfusion.Once a day, or the next day once, treat 3 times.Simultaneously, the sow that lacks nutrition is wanted intramuscular injection megavitamin A, D, E and selenium preparation, inject 2-3 vitamin A, D, E after, additional zinc preparation.
Follicular development on the examination per rectum ovary in 3-5 days has the performance of oestrusing after curative effect and the criterion medication, and what breeding and ability were pregnant is produce effects; All gestation is effective; The follicle aplasia does not have the performance of oestrusing, can not be pregnant be invalid.This tests 110 examples, and 100 examples of produce effects account for 90.9%; Effective 8 examples account for 7.27%.
Conclusion: total effective rate 98%.
The clinical effectiveness of experimental example 5 117 routine cows in postpartum lochiorrheas
Clinical symptoms? Cows performance anxiety, hunched over, Nuze do voiding posture, vulva pus discharge fishy with Harmonia, which mixed bars or blocks of carrion, cows high body temperature, lethargy, mouth mucous membrane flushing, conjunctival cyanosis, carcass weight loss.
Treatment is cleaned the uterus with normal saline or disinfectant, gets the female animal uterus cleanout fluid 30ml perfusion of Chinese medicine extract combination.Once a day, or the next day once, treat 3 times.
Curative effect and criterion: recovery from illness: treatment back lochia stops.Produce effects: treatment back lochia stopped in the 5th day.Effectively: treatment back lochia stopped in the 7th day.Invalid: treatment back lochia is more than.This tests 117 examples,
112 examples of fully recovering account for 96%; Produce effects 3 examples account for 2.56%; Effective 1 example accounts for 1% (0.85%).
Conclusion: treat trouble cattle total effective rate 99% in order to top ruling by law.
Experimental example 6 292 routine cow endometritis
Clinical symptoms acute festering type endometritis is many to be caused by placenta retention, and sick cattle performance spirit is depressed, and loss of appetite is exerted duty frequently, from vaginal orifice, discharges the gray dense sexual secretion that contains floccule, and abnormal smells from the patient is stench.Generally when a minute puerperium placenta retention, difficult labour, stillborn fetus, can not in time discharge owing to cornua uteri shrinks the unable lochia that causes, thereby cause a large amount of bacterial reproductions, purulent secretion is in uterus accumulated and can not be discharged, and forms uterus suppuration disease.Adopt examination per rectum, cornua uteri increases, and is dough appearance, like exudate fluctuation is arranged for a long time.
The sick cattle spirit of the dense membranous endometritis of mucus is depressed, body temperature is slightly high, discharges a small amount of white purulent secretion from vaginal orifice, and pollutes disease oxtail root.
The sick cattle of recessive endometritis does not have tangible clinical symptoms, and sexual cycle is normal basically, joins infertilely repeatly, though becoming pregnant of having but is prone to send out a recessiveness or an early abortion, vagina flows out secretions when oestrusing has muddiness slightly.
The sick cattle of chronic purulence endometritis often shows General Symptoms, sexual cycle disorder or non-estrus, with anemia with become thin, vagina flows out purulent secretion.Lax, the uneven distribution of examination per rectum Uterus wall, a little less than the contractility, when the empyema of uterus, body of uterus and cornua uteri obviously increase, and Uterus wall is nervous and fluctuation arranged.
Select the pathogenic bacterium separation before 25 cow heads carry out medication, through identifying that escherichia coli, staphylococcus, streptococcus and bacillus pyocyaneus are arranged.
Treatment is rinsed the uterus inflammatory exudate and the mucosa that comes off well with normal saline earlier, sees when backflow is transparent, no longer flushing.Dash the female animal uterus cleanout fluid 30ml that gets the Chinese medicine extract combination then and be poured into intrauterine, once a day, or the next day once, treat 3 times.
The treatment curative effect determinate standard is through medication 3-9 time (every day or every other day once), after six days to 18 days, produce effects be: the uterus does not have pus secretions, but limpid or have a little pale secretions; External genital swelling disappears; The quality size and the contractile response of straight inspection cornua uteri recover normal; Follicular development when oestrusing is good.240 examples are arranged.Effectively be: uterus secretions or be mixed with pus, or have a small amount of foreign body to flow out; External genital swelling or not obvious; Or the follicular development when oestrusing is bad.Promptly wherein have one undesired.46 examples are arranged.Invalid is: in above-mentioned several, have two undesired, and non-estrus.Do not have.
Conclusion: 292 routine produce effects 240 examples account for 82.19%; Effective 46 examples account for 15.75%; Total effective rate 98%.
The immobilized clinical effectiveness of experimental example 7 364 routine milch cow ovaries
Clinical symptoms non-estrus in puerperal, vaginal wall, labia mucosal pallor, dry and astringent, the examination per rectum ovary does not have follicle and corpus luteum, and size and quality are normal, and smooth surface maybe can contact very little corpus luteum traces.Ditto checked again in 7-10 days at interval, still no change.
Treatment is cleaned the uterus with normal saline or disinfectant, gets the female animal uterus cleanout fluid 30ml perfusion of Chinese medicine extract combination.Once a day, or the next day once, treat 3 times.
Observe the performance of oestrusing of milch cow after curative effect and the criterion medication, cure and do; : the first feelings phase become pregnant or continue after oestrus transfer to normal and become pregnant; Effectively be: only oestrus and unpregnancy after the medication; Invalidly be: still do not have after the medication and oestrus.345 examples are cured in this experiment, cure rate 94.78%; Effective 13 examples, effective percentage 3.57%.
conclusion: total effective rate 98.35%.
The clinical effectiveness of experimental example 8 403 routine milch cow retained corpus luteums
Clinical symptoms puerperal or sexual cycle stop to go back non-estrus, and breeding is done examination per rectum after two months, no tire, and the one or both sides ovary is bigger, and retained corpus luteum is arranged in the ovary.
Treatment is cleaned the uterus with normal saline or disinfectant, gets the female animal uterus cleanout fluid 30ml perfusion of Chinese medicine extract combination.Once a day, or the next day once, treat 3 times.
Curative effect and criterion: the standard of judge curing is: observing milch cow after the medication in 10 days has the situation of oestrusing and luteolysis, follicular development situation, the milch cow that breeds and promptly be impregnated in the phase 1～3 feelings; Judge that effective standard is: surpass 10 days after the medication, straight inspection is found the retained corpus luteum degeneration and the follicle of growth is arranged that simultaneously visible dominance or recessiveness are oestrused, and have the part milch cow to be impregnated.367 examples are cured in this experiment, account for 91%; Effective 32 examples account for 8%.
Conclusion: total effective 99%.
Claims (2)
1. the female animal uterus cleanout fluid of Chinese medicine extract combination, it is characterized in that: in the cleanout fluid of 1000ml female animal uterus, the stachydrine hydrochloride consumption is 1.25～15 grams; Herba Epimedii extract is counted 2.5～3.75 grams with icariin; Flos Carthami extract is counted 1.5～5 grams with S-A Hydroxysafflor yellow A; Berberine sulfate 10～20 grams, osthole 4～15 grams; Other has tween 80 10ml, propylene glycol cosolvent 300～900ml and an amount of distilled water.
2. the female animal uterus cleanout fluid of Chinese medicine extract combination according to claim 1; It is characterized in that stachydrine hydrochloride content>=98%, icariin content≤98% in the Herba Epimedii extract, icariin minimum content>=50%; Safflower yellow A content>=50% in the Flos Carthami extract; Berberine sulfate content>=98%, osthole content≤98% in the Fructus cnidii extract, osthole minimum content>=50%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104825478A (en) * | 2015-04-14 | 2015-08-12 | 中国农业科学院兰州畜牧与兽药研究所 | Drug composition for treating milk cow endometritis, and perfusion liquid preparation method thereof |
| CN110664862A (en) * | 2019-10-14 | 2020-01-10 | 宁波第二激素厂 | Pheromone composition spray preparation and preparation method and application thereof |
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| CN1544004A (en) * | 2003-11-13 | 2004-11-10 | 南京农业大学 | Chinese traditional medicine perfusate for preventing and treating female livestock barrenness |
| CN101579430A (en) * | 2008-05-13 | 2009-11-18 | 天津生机集团股份有限公司 | Veterinary drug perfusate for treating apogeny for cows and preparation method thereof |
| CN102000145A (en) * | 2010-12-16 | 2011-04-06 | 南京日升昌生物技术有限公司 | Traditional Chinese medicine and western medicine compound infusion liquid for preventing and treating endometritis of dam and preparing method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1544004A (en) * | 2003-11-13 | 2004-11-10 | 南京农业大学 | Chinese traditional medicine perfusate for preventing and treating female livestock barrenness |
| CN101579430A (en) * | 2008-05-13 | 2009-11-18 | 天津生机集团股份有限公司 | Veterinary drug perfusate for treating apogeny for cows and preparation method thereof |
| CN102000145A (en) * | 2010-12-16 | 2011-04-06 | 南京日升昌生物技术有限公司 | Traditional Chinese medicine and western medicine compound infusion liquid for preventing and treating endometritis of dam and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104825478A (en) * | 2015-04-14 | 2015-08-12 | 中国农业科学院兰州畜牧与兽药研究所 | Drug composition for treating milk cow endometritis, and perfusion liquid preparation method thereof |
| CN104825478B (en) * | 2015-04-14 | 2017-08-29 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of preparation method for being used to treat the pharmaceutical composition and its perfusion liquid of cow endometritis |
| CN110664862A (en) * | 2019-10-14 | 2020-01-10 | 宁波第二激素厂 | Pheromone composition spray preparation and preparation method and application thereof |
| CN110664862B (en) * | 2019-10-14 | 2021-07-30 | 宁波第二激素厂 | Pheromone composition spray preparation and preparation method and application thereof |
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