CN102551736A - Light sensing system - Google Patents
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- CN102551736A CN102551736A CN2012100177303A CN201210017730A CN102551736A CN 102551736 A CN102551736 A CN 102551736A CN 2012100177303 A CN2012100177303 A CN 2012100177303A CN 201210017730 A CN201210017730 A CN 201210017730A CN 102551736 A CN102551736 A CN 102551736A
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Abstract
The invention discloses a light sensing system which is used for solving the technical problem on low resolution of the conventional magnetic resonance scanner. The technical scheme of the invention is as follows: the light sensing system comprises a transmitting part and a receiving part, wherein the transmitting part consists of a pulse power supply, an infrared laser diode, a fiber-optic coupling transfer device and a laser transmitting optical fiber (3); the receiving part consists of an optical fiber receiving end, a signal transmitting optical fiber (4), an infrared detector, a pre-amplifier circuit, a data acquisition device and a data processing system; the laser transmitting optical fiber (3) corresponds to the signal transmitting optical fiber (4); the laser transmitting optical fiber (3) and the signal transmitting optical fiber (4) are alternatively arranged on a line concentration gasket (2) to constitute a visual-center light sensor component Za and a motor center light sensor component Zb. According to the invention, as a light-velocity propagation device is employed, time resolution is increased during the detection.
Description
Technical field
The present invention relates to sensor field, particularly relate to a kind of optical sensor system.
Background technology
Human and a part of animal class, it is dynamic that cerebral tissue is blood oxygen when neural activity, and the cerebral tissue image that utilizes mr imaging technique (MRI) to obtain in the blood oxygen dynamic process is called functional mri (fMRI) technology.Blood flow changes that to change general designation blood oxygen dynamic with blood oxygen concentration, when brain neurological motion, with increasing the consumption of glucose and aerobic and anaerobic metabolism accordingly.Cerebral tissue response metabolic process is the process of blood flow increasing, and 1 to 5 second delay is arranged.Blood oxygen dynamic response to peaking, produced regional aerobic hemoglobin (oxyhemoglobin, HbO in the time of 4 to 5 seconds
2), deoxyhemoglobin (blood flow changes and the blood volume-variation for deoxyhemoglobin, HbR) concentration change, promptly blood oxygen coherent signal (Blood-oxygen-level dependence, BOLD).The ultimate principle of fMRI technology is exactly to utilize the magnetic strength rate of deoxyhemoglobin different and produce T1 or T2
*The gradation of image of weighting is poor.
Existing magnetic resonance cerebral tissue function imaging exists many bottlenecks and unsolved difficult point; First; Magnetic resonance imaging obtains a sub-picture or one section dynamic video data need the sufficiently long time (common more than 1 minute), fully covers the k space or the k-t space just can reach required resolution; Yet blood oxygen of brain concentration change signal (Bold) but is instantaneous synchronous and dynamic two kinds of significant conditions.Therefore there are two defectives in it, and the first, the k spatial data of collection is non-from the same state of blood oxygen of brain concentration change signal (Bold), can't satisfy the requirement of temporal resolution.Second; At present clinical is to use planar pulse echo fast imaging pulse trains such as (EPI) to be reduced to the picture required time with the most frequently used method of research magnetic resonance functional imaging; Its problem is, has the remarkable shortcoming that anamorphose and spatial resolution are low, signal to noise ratio is low, and; Temporal resolution low (greater than 1 second) still can't obtain the high time resolution image.
The clinical meaning of cerebral tissue function imaging is very important; Because the imaging of magnetic resonance cerebral tissue function exists many bottlenecks and unsolved difficult point; The optical fault camera technique is used for cerebral function imaging and has received the research worker concern; (Joseph P. Culver et.al. Appl.No.:12425743) has announced that a kind of optical fault Detection Techniques survey under resting state and do not have the brain function image under the task foment to " the TASK-LESS OPTICAL MAPPING OF BRAIN FUNCTION USING RESTING STATE FOUNCTIONAL CONNECTIVITY " that the United States Patent (USP) data base delivers.Joseph points out what the conventional magnetic resonance functional imaging normally encouraged based on task, needs the hand exercise excitation as measuring motorium function of cortex state.This method temporal resolution is high, can reach human clinical's standard (millisecond yardstick), also can measure total hemoglobin (total hemoglobin, HbT), aerobic hemoglobin (oxyhemoglobin, HbO
2), deoxyhemoglobin (deoxyhemoglobin, HbR) concentration change and concentration absolute value etc.Yet its shortcoming is that spatial resolution is low, in order to obtain brain function image more clearly; The research of adopting other detection method of nuclear magnetic resonance associating to obtain higher resolution brain function image is arranged, as: magnetic resonance-brain electricity survey meter joint imaging (EEG-FMRI), this method is; Combined application brain electrical resistivity survey survey technology; Brain electrical resistivity survey survey technology, temporal resolution higher (millisecond yardstick) provides the time dependent parameter correction for magnetic resonance functional imaging process.Yet; This method does not have a kind of good synergistic mechanism, has many defectives: one of which, and the radio-frequency magnetic pulse meeting of MR scanner is at cerebral biological electricity exploring electrode induced current; Rf pulse sequence is the time series that disperses, and brain electricity survey meter promptly takes the corresponding time to turn-off measure through needs.They are two years old; The spatial variations gradient magnetic that MR scanner produces also can be at the electrode for encephalograms faradic current; And the gradient magnetic that this type continues to exist is difficult to effectively eliminate the electric current that its induction produces, and there is the interference of sensor current signal in the signal that causes brain electricity survey meter to receive.Its three, head movement also can make the electrode for encephalograms faradic current produce noise under the effect in magnetic field.The 4th, the magnetic strength rate of electrode for encephalograms material can be to magnetostatic field B
0Inhomogeneities exert an influence, and magnetic field bump can be brought scalloping, pseudo-shadow to magnetic resonance system.The heat effect that magnetic resonance-brain electricity survey meter joint imaging technology also exists electrode for encephalograms induced current to produce can be to the problem of skin burn.
Summary of the invention
In order to overcome the low deficiency of existing MR scanner resolution, the present invention provides a kind of optical sensor system.This system alternately places Laser emission optical fiber and signal transmission fiber on the line concentration pad, forms visual centre optical sensor components Za and motorium optical sensor components Zb, owing to adopt the light velocity propagation device, can improve the temporal resolution in the testing process.
The technical solution adopted for the present invention to solve the technical problems is: a kind of optical sensor system is characterized in comprising radiating portion and receiving unit.Radiating portion is made up of the pulse power, infra-red laser diode, optical fiber coupling carrying device and Laser emission optical fiber 3, and the pulse power, infra-red laser diode, optical fiber coupling carrying device and Laser emission optical fiber 3 are electrically connected successively; Receiving unit is by optical fiber receiving terminal, signal transmission fiber 4; Infrared Detectors, preceding discharge road and data acquisition unit, data handling system are formed; Optical fiber receiving terminal, signal transmission fiber 4, Infrared Detectors, preceding discharge road are electrically connected with data acquisition unit, data handling system successively; Laser emission optical fiber 3 is corresponding with signal transmission fiber 4, Laser emission optical fiber 3 corresponding signal transmission fibers 4.Laser emission optical fiber 3 alternately places on the line concentration pad 2 with signal transmission fiber 4, forms visual centre optical sensor components Za and motorium optical sensor components Zb.
The material of said line concentration pad 2 is pyrolytic graphite foamed materialss.
Said visual centre optical sensor components Za is made up of three twelve earthly branches Laser emission optical fiber 3 and three twelve earthly branches signal transmission fibers 4.
Said motorium optical sensor components Zb is made up of 36 Laser emission optical fiber 3 and 36 supported signal Transmission Fibers 4.
Said Laser emission optical fiber 3 is hi bi birefringence fibers.
Said signal transmission fiber 4 is hi bi birefringence fibers.
The invention has the beneficial effects as follows: Laser emission optical fiber and signal transmission fiber are alternately placed on the line concentration pad; Form visual centre optical sensor components Za and motorium optical sensor components Zb; Owing to adopt the light velocity propagation device, improved the temporal resolution in the testing process.
Below in conjunction with the specific embodiment the present invention is elaborated.
Description of drawings
Fig. 1 is an optical sensor system working position formula sketch map of the present invention.
Fig. 2 is an optical sensor system block diagram of the present invention.
Fig. 3 adopts the visual centre optical sensor components Za of optical sensor system composition of the present invention and the sketch map of motorium optical sensor components Zb.
Fig. 4 is an optical sensor system algorithm block diagram of the present invention.
Fig. 5 is an axle location time division type functional mri method flow diagram when adopting optical sensor system optical method of the present invention.
Among the figure, 1-nuclear magnetic resonance birdcage magnetic coil; 2-line concentration pad; 3-Laser emission optical fiber; The 4-signal transmission fiber.
The specific embodiment
With reference to Fig. 1～5, optical sensor system of the present invention comprises radiating portion and receiving unit.Radiating portion is made up of the pulse power, infra-red laser diode, optical fiber coupling carrying device and Laser emission optical fiber 3, and the pulse power, infra-red laser diode, optical fiber coupling carrying device and Laser emission optical fiber 3 are electrically connected successively; Receiving unit is by optical fiber receiving terminal, signal transmission fiber 4; Infrared Detectors, preceding discharge road and data acquisition unit, data handling system are formed; Optical fiber receiving terminal, signal transmission fiber 4, Infrared Detectors, preceding discharge road are electrically connected with data acquisition unit, data handling system successively; Laser emission optical fiber 3 is corresponding with signal transmission fiber 4, Laser emission optical fiber 3 corresponding signal transmission fibers 4.Laser emission optical fiber 3 alternately places on the line concentration pad 2 with signal transmission fiber 4, forms visual centre optical sensor components Za and motorium optical sensor components Zb.
Based on the post-stimulatory cerebral tissue cortex of incident blood oxygen dynamic response, measure the spatial distribution state set M of blood oxygen dynamic change by optical sensor system, the selected particular state M of the dynamic process of cortex response
ABe decision state.When detecting current state is decision state M
AThe time, trigger magnetic resonance coil emission magnetic resonance signal driving pulse, gradient coding, data acquisition.When detecting the current state change, magnetic resonance device quits work.Repeating above-mentioned flow process to k space or k-t space data collection finishes.
Laser emission optical fiber 3 alternately places on the line concentration pad 2 with signal transmission fiber 4, and line concentration pad 2 is adjacent to detected person's head, and nuclear magnetic resonance birdcage magnetic coil 1 produces excitation radio-frequency pulse and receiving magnetic resonance signals.
Laser emission optical fiber 3, signal transmission fiber 4 adopt high birefringence rate (high-birefringence) optical fiber, to suppress magneto-optic effect, promptly suppress the interference of the magnetic field of MR scanner to optical signal transmission.
Visual centre optical sensor components Za, motorium optical sensor components Zb, realize detection to 2 dimension space distributions of the HC of cortex and blood flow; Adopt 32 Laser emission optical fiber 3 and 32 supported signal Transmission Fibers 4 to constitute visual centre optical sensor components Za; Adopt 36 Laser emission optical fiber 3 and 36 supported signal Transmission Fibers 4 to constitute motorium optical sensor components Zb; Be distributed in correspondence positions such as visual centre behind head and the brain, motorium respectively, Laser emission optical fiber 3 corresponding signal transmission fibers 4.
Visual centre optical sensor components Za, 32 pairs of assemblies place the visual centre correspondence position behind the brain, motorium optical sensor components Zb, 36 pairs of assemblies place head motorium correspondence position.
The assay method principle of state M does, each is a component to light source and detector output signal for 2 polynary light sources of dimension and photo-detector group, and important output two-dimensional matrix data will be confirmed spatiality M.The component sensing principle does, adopts the Wavelength modulation spectroscopy method of index rolling average filtering, can realize real-time resolution, and control lag also can be with breathing and top layer blood flow high-frequency signal noise filtering.
By the pulse power, infra-red laser diode, optical fiber coupling carrying device, Laser emission optical fiber 3, optical fiber receiving terminal, signal transmission fiber 4, Infrared Detectors, preceding discharge road and data acquisition unit, data handling system are formed optical sensor system.
Detection signal receives through optic fibre connector and transfers to snowslide optical pickocff port by fibre bundle; The snowslide optical pickocff obtains the spectral signal of variation; Respectively by 32 road and 36 circuit-switched data harvesters; The signal that data acquisition unit is gathered is by Computer Processing, and the data after the processing form law curve and are used for state-detection and judgement.
The wavelength-modulated signal, promptly infrared diode laser and snowslide Infrared Detectors group sensing total hemoglobin, oxygen hemoglobin, deoxyhemoglobin concentration are to spectral absorption.Laser Power Devices drive the infrared diode laser drive current makes wavelength variations stride across 600nm to 1000nm, and modulation becomes ω=50MHz sine wave.Suppress the laser instrument 1/f noise through the quick adjustment wavelength.The Wavelength modulation spectroscopy method absorbs the back light intensity, adopts lambert Bill (Beer-Lambert) law physical modeling, and is decomposed into the Fourier space that first-harmonic is ω on the mathematics.
Reference signal, promptly frequency is the cosine signal cos2 ω t of 2 ω.
Index rolling average filtering (exponential moving average), (moving average, MA), its average weighted weight is bigger for the new data of time shaft, can control and reduces time delay, satisfies real-time requirement for promptly a kind of moving average filter.And ability filtering heart beating, breathing and surperficial blood flow noise.
The real-time concentration signal is promptly through the light intensity signal of algorithm demodulation.Operative symbol is a multiplier; Be that Wavelength modulation spectroscopy signal and reference signal 2 ω sinusoidal signals multiply each other through multiplier; And the index moving average filter is a low pass filter, because the Wavelength modulation spectroscopy signal carries first-harmonic ω frequency signal harmonic component, passes through low pass filter through the reference signal modulation; Obtain wavelength-modulated signal 2 ω components, promptly reflect the light intensity signal of real-time concentration signal.
Claims (6)
1. an optical sensor system is characterized in that: comprise radiating portion and receiving unit; Radiating portion is made up of the pulse power, infra-red laser diode, optical fiber coupling carrying device and Laser emission optical fiber (3), and the pulse power, infra-red laser diode, optical fiber coupling carrying device and Laser emission optical fiber (3) are electrically connected successively; Receiving unit is by optical fiber receiving terminal, signal transmission fiber (4); Infrared Detectors, preceding discharge road and data acquisition unit, data handling system are formed; Optical fiber receiving terminal, signal transmission fiber (4), Infrared Detectors, preceding discharge road are electrically connected with data acquisition unit, data handling system successively; Laser emission optical fiber (3) is corresponding with signal transmission fiber (4), the corresponding signal transmission fiber (4) of a Laser emission optical fiber (3); Laser emission optical fiber (3) and signal transmission fiber (4) alternately place on the line concentration pad (2), form visual centre optical sensor components Za and motorium optical sensor components Zb.
2. said optical sensor system of claim 1, it is characterized in that: the material of said line concentration pad (2) is the pyrolytic graphite foamed materials.
3. said optical sensor system of claim 1 is characterized in that: said visual centre optical sensor components Za is made up of three twelve earthly branches Laser emission optical fiber (3) and three twelve earthly branches signal transmission fibers (4).
4. said optical sensor system of claim 1 is characterized in that: said motorium optical sensor components Zb is made up of 36 Laser emission optical fiber (3) and 36 supported signal Transmission Fibers (4).
5. said optical sensor system of claim 1, it is characterized in that: said Laser emission optical fiber (3) is hi bi birefringence fiber.
6. said optical sensor system of claim 1, it is characterized in that: said signal transmission fiber (4) is a hi bi birefringence fiber.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109009159A (en) * | 2018-07-24 | 2018-12-18 | 华中科技大学 | A kind of anti motion interference accelerating circuit suitable for wearable blood oxygen chip |
| CN113557441A (en) * | 2019-01-11 | 2021-10-26 | 皇家飞利浦有限公司 | Automated detection of docking take-up ring position |
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| CN1169665A (en) * | 1995-01-03 | 1998-01-07 | 无创伤诊断技术公司 | Optical coupler for internal examination of biological tissue |
| CN101214146A (en) * | 2008-01-11 | 2008-07-09 | 西北工业大学 | Biological tissue blood microcirculation parameter detecting system |
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Patent Citations (2)
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|---|---|---|---|---|
| CN1169665A (en) * | 1995-01-03 | 1998-01-07 | 无创伤诊断技术公司 | Optical coupler for internal examination of biological tissue |
| CN101214146A (en) * | 2008-01-11 | 2008-07-09 | 西北工业大学 | Biological tissue blood microcirculation parameter detecting system |
Non-Patent Citations (1)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109009159A (en) * | 2018-07-24 | 2018-12-18 | 华中科技大学 | A kind of anti motion interference accelerating circuit suitable for wearable blood oxygen chip |
| CN109009159B (en) * | 2018-07-24 | 2020-06-02 | 华中科技大学 | Anti-motion interference accelerating circuit suitable for wearable blood oxygen chip |
| CN113557441A (en) * | 2019-01-11 | 2021-10-26 | 皇家飞利浦有限公司 | Automated detection of docking take-up ring position |
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