CN102526185A - Novel application of red-rooted salvia root extract to preparation of medicament for treating tristimania - Google Patents
Novel application of red-rooted salvia root extract to preparation of medicament for treating tristimania Download PDFInfo
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- CN102526185A CN102526185A CN2012100136182A CN201210013618A CN102526185A CN 102526185 A CN102526185 A CN 102526185A CN 2012100136182 A CN2012100136182 A CN 2012100136182A CN 201210013618 A CN201210013618 A CN 201210013618A CN 102526185 A CN102526185 A CN 102526185A
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- radix salviae
- salviae miltiorrhizae
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- miltiorrhizae extract
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Abstract
The invention relates to the technical field of medicine, in particular to a novel application of a red-rooted salvia root extract. As proved by an animal experiment, the red-rooted salvia root extract has the effect of treating tristimania, and is a natural anti-tristimania agent with a good development prospect, so that the red-rooted salvia root extract can be used for preparing a medicament for treating tristimania.
Description
Technical field
The present invention relates to medical technical field, is Radix Salviae Miltiorrhizae extract in the new purposes that is used to prepare treatment depression medicine, belongs to the natural drug development field.
Background technology
Mood disorders is to describe the unusual medical terminology of mental state; This be when in the face of some matter of regret or be because of the of short duration mood of certain disappointment gloomy; Be common phenomena in a kind of daily life, and when showing lasting, serious affective disorder, be called depression.Depression is a kind of very general disease; The people of about 10-15% has depression in various degree in life some period among the crowd; And patients with depression often has serious suicidal tendency, and annual 30000 people of surpassing of the U.S. commit suiside according to investigations, and depression is considered to a principal element.
The medicine that is used to treat depression at present all is the medicine that designs for target spot with the monoamine system; Mainly be tricyclic antidepressants, oxidase inhibitor and 5-hydroxy tryptamine reuptake inhibitor; But side effect is in various degree arranged all; Like drowsiness, hypertension, convulsions and libido reduction etc., thus big limitations its be widely used.Therefore, from plant, seek antidepressant drug efficient, low toxicity in especially traditional Chinese herbal medicine and become a new research direction in field for this reason.
Radix Salviae Miltiorrhizae is a kind of time-honored Chinese medicine, and complex chemical composition in the Radix Salviae Miltiorrhizae extract mainly is divided into fat-soluble and water solublity two big classes, like TANSHINONES, danshensu, salvianolic acid etc.Pharmaceutical research shows: Radix Salviae Miltiorrhizae can improve the ischemical reperfusion injury of the heart, liver, lung, regulates immunoreation and performance anti-inflammatory anti-infectious function, yet does not see that Radix Salviae Miltiorrhizae extract is used to treat the research report of depression at present as yet.
Summary of the invention
The object of the present invention is to provide a kind of new purposes of Radix Salviae Miltiorrhizae extract.
Finding that through zoopery Radix Salviae Miltiorrhizae extract has antidepressant effect preferably, is a kind of more rising natural antidepressant, can be used for preparing the medicine of treating depression.
The specific embodiment
The antidepressant effect of embodiment 1 Radix Salviae Miltiorrhizae extract in the experiment of mice forced swimming
Experimental technique:
The forced swimming test is set up by Porsolt the earliest; Its ultimate principle is exactly; When mice is in when swimming in the narrow unavoidable container, after struggle originally can be health at water float or slightly retreat to slide and keep a kind of motionless behavior, and this behavior prestige behavior of applauding; When animal has been accepted antidepressant drug before experiment after, can reduce the time of this desperate behavior.
In experiment, 40 mices be divided into normal saline group, low (5mg/kg), in (10mg/kg), high dose (20mg/kg) Radix Salviae Miltiorrhizae extract group and five experimental grouies of imipramine (20mg/kg) group, every group of 8 animals.Respectively in the experiment preceding 24 hours, 1 hour and 0.5 hour intraperitoneal administration, then with mice as in depth of water 12cm, 22 ± 1 ℃ of water temperatures, the 21 * 12cm glass.Keep swimming 6min, and the time that mice is not moved at all in back four minutes of the record statistics.
Experimental result:
Table 1 Radix Salviae Miltiorrhizae extract is for the effect of the time of not moving at all in the experiment of mice forced swimming
Annotate: with compared with normal, * p＜0.05, * * p＜0.01
Find out by result in the table 1: through intraperitoneal administration; The various dose group of Radix Salviae Miltiorrhizae extract all significantly reduces the time that mice is not moved at all in the forced swimming; Its effect is similar with positive controls (imipramine), shows that Radix Salviae Miltiorrhizae extract has the effect of control depression.
The antidepressant effect of embodiment 2 Radix Salviae Miltiorrhizae extracts in the mouse tail suspension experiment
Experimental technique:
Outstanding tail experiment is the screening technique of the acute behavior effect of a kind of antidepressant drug of high flux fast.It is main according to being; When the intact animal is in the unavoidable adverse circumstance of a short-term (such as hanging its afterbody) in liftoff certain altitude; Its behavior meeting is transformed into motionless state from kinestate, and before experiment, gives the time that antidepressant drug just can reduce the motionless behavior in this.
In laboratory, 40 mices be divided into normal saline group, low (5mg/kg), in (10mg/kg), high dose (20mg/kg) Radix Salviae Miltiorrhizae extract group and five experimental grouies of imipramine (20mg/kg) group, every group of 8 animals.Respectively in experiment preceding 24 hours, 1 hour and 0.5 hour intraperitoneal administration, then the mousetail tip is fixed on liftoff 60cm eminence suspension, the time that record video recording 6min and statistics are not wherein moved at all.
Experimental result:
Table 2 Radix Salviae Miltiorrhizae extract is for the effect of the time of not moving at all in the mouse tail suspension experiment
Annotate: with compared with normal, * p＜0.05, * * p＜0.01
Found out by result in the table 2: through intraperitoneal administration, the various dose group of Radix Salviae Miltiorrhizae extract all significantly reduces the time of not moving at all in the mouse tail suspension experiment, shows that in outstanding tail experimental model the antidepressant drug of Radix Salviae Miltiorrhizae extract is active.
The influence that embodiment 3 Radix Salviae Miltiorrhizae extracts are surveyed for spontaneous activity in mice
Experimental technique:
The safe ZZ-6 of alliance mice autonomic activities tester test is adopted in the test of spontaneous activity in mice; In laboratory; 40 mices be divided into normal saline group, low (5mg/kg), in (10mg/kg), high dose (20mg/kg) Radix Salviae Miltiorrhizae extract group and five experimental grouies of imipramine (20mg/kg) group, every group of 8 animals.Respectively in experiment preceding 24 hours, 1 hour and 0.5 hour intraperitoneal administration, mice is placed the measuring cell of tester, make it adapt to 5min, the movable number of times that writes down 10min the inside mice then with stand number of times.
Experimental result:
Table 3 Radix Salviae Miltiorrhizae extract is for the influence of the movable number of times of mice
Annotate: with compared with normal, * p＜0.05, * * p＜0.01
Table 4 Radix Salviae Miltiorrhizae extract is for the stand influence of number of times of mice
Annotate: with compared with normal, * p＜0.05, * * p＜0.01
Show by table 3 and table 4: the Radix Salviae Miltiorrhizae extract drug group (5,10,20mg/kg) all can not influence the central nervous system of mice, further prove Radix Salviae Miltiorrhizae extract and had the effect of prevention and treatment depression.
Claims (5)
1. Radix Salviae Miltiorrhizae extract is used for preventing, alleviate and/or treat the application of the medicine or the health product of affective disorders disease or symptom in preparation.
2. application according to claim 1 is characterized in that the mental sickness of being told is a depression.
3. the application of being told according to claim 1 or 2 is characterized in that the medicine of telling is made up of Radix Salviae Miltiorrhizae extract and pharmaceutically acceptable carrier.
4. the application of being told according to claim 1 or 2 is characterized in that the medicine of telling exists with forms such as tablet, capsule, pill, granule, syrup, solution, injection, injection, spray, aerosol, patches.
5. a prevention, alleviate and/or the medicine or the health product of treatment depression disease, it is characterized in that comprising the compositions of Radix Salviae Miltiorrhizae extract.
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| CN2012100136182A CN102526185A (en) | 2012-01-17 | 2012-01-17 | Novel application of red-rooted salvia root extract to preparation of medicament for treating tristimania |
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| CN2012100136182A CN102526185A (en) | 2012-01-17 | 2012-01-17 | Novel application of red-rooted salvia root extract to preparation of medicament for treating tristimania |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212019A (en) * | 2012-12-10 | 2013-07-24 | 宋爱民 | Chinese materia medica preparation for treating depression |
| CN108272845A (en) * | 2018-04-25 | 2018-07-13 | 电子科技大学 | A kind of anti-anxiety compound preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101375844A (en) * | 2007-08-29 | 2009-03-04 | 张作光 | Anti-depression medicament using salvianolic acid B as raw material and production method thereof |
-
2012
- 2012-01-17 CN CN2012100136182A patent/CN102526185A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101375844A (en) * | 2007-08-29 | 2009-03-04 | 张作光 | Anti-depression medicament using salvianolic acid B as raw material and production method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赵淑娟等: "丹参水溶性酚酸类化合物药理及生物合成途径研究进展", 《中草药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212019A (en) * | 2012-12-10 | 2013-07-24 | 宋爱民 | Chinese materia medica preparation for treating depression |
| CN103212019B (en) * | 2012-12-10 | 2014-10-22 | 宋爱民 | Chinese materia medica preparation for treating depression |
| CN108272845A (en) * | 2018-04-25 | 2018-07-13 | 电子科技大学 | A kind of anti-anxiety compound preparation |
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Application publication date: 20120704 |
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