CN102522039B - Making method for fracture model of artificial bone - Google Patents
Making method for fracture model of artificial bone Download PDFInfo
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- CN102522039B CN102522039B CN 201110395007 CN201110395007A CN102522039B CN 102522039 B CN102522039 B CN 102522039B CN 201110395007 CN201110395007 CN 201110395007 CN 201110395007 A CN201110395007 A CN 201110395007A CN 102522039 B CN102522039 B CN 102522039B
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Abstract
The invention discloses a making method for a fracture model of artificial bone, which comprises the following steps: carrying out continuous spiral CT (computed tomography) scanning on affected bone along the cross section to obtain a multi-layer image, storing according to a Dicom 3.0 standard and making out a three-dimensional reconstruction model of the bone and a fractured section by utilizing Mimics software; fractioning the model to be processed by UG (Unigraphics) software and making an appearance mold of the bone and a mark groove for the position of a fracture line of the archetypalbone by numerically-controlled mill processing; and carrying out three-dimensional printing to obtain a fractured section model, also placing at the position of the mark groove of the corresponding bone appearance mold, jointing an upper mold and a lower mold, filling polymethyl methacrylate, standing at room temperature, solidifying and taking out the fractured section model so as to obtain a specimen of the fracture model of the artificial bone. In this way, the prepared fracture model is made in one step, and the complicated processes of obtaining a bone specimen and afterwards making fracture artificially, the consumption of equipment and the worry of enhancing the cost are omitted. The condition of stress between fractured sections is comprehensively and truly reflected by an obtained fracture interface, and the assistance is provided to the treatment of clinical fracture.
Description
Technical field
The present invention relates to the method that fracture model is made, particularly a kind ofly can reproduce Clinical symptoms, the method for making of the fracture model of artificial bone at realistic fracture interface.
Background technology
Along with aging population, being widely used of hormone medicine and increasing of traffic hazard, the incidence of fracture obviously rises, for the fracture of different parts and the difference of biomechanical characterization thereof, should take as early as possible corresponding treating method, with complication, improve prognosis, reduce case fatality rate.Therefore, test and the research work for the biomechanical property of bone is subject to people's attention day by day.
The problems such as limited and cost is higher for the source that solves people's corpse bone, Chinese patent 101602056 discloses a kind of " adopting polymethylmethacrylate to prepare the method for artificial femur sample ", make unified bone model by the method material, artificial fracture is analyzed the stressing conditions between fracture face.Polymethylmethacrylate (PMMA) is polymerized with pulvis and liquor two parts, and the mechanical characteristic that the synthetic PMMA of different powder liquid proportionals possesses is different.In recent years, the bone model sample that the method is made is widely used in the biomechanics Research, and the mechanical strength that it is higher and the character of viscoelasticity have obtained approval both domestic and external.
For a long time, people obtain after the artificial bone archetype, often adopt the method for simple vertical cross-section or oblique fracture for the foundation of fracture model, the biomechanical property between the research section.The method is made fracture model and existed obvious shortcoming to be: the fracture interface of adopting manual method to obtain is comparatively single, can not reflect clinically complicated and diversified fracture interface fully, also there is a certain distance in the Mechanical Data between measured section with the stressing conditions of reality fracture face; Simultaneously since the method for building up of fracture model substantially all be the people for making by hand, cause existing unavoidably between each model certain error, the difference between this individuality will certainly exert an influence to the data of experimental result.
Summary of the invention
The present invention is exactly for solving in the prior art, and the fracture interface is comparatively single, can not reflect clinically complicated and diversified fracture interface fully, and also there is a certain distance in the Mechanical Data between measured section with the stressing conditions of reality fracture face; And make the problems such as interindividual variation that cause by hand, and the method for making of the fracture model of artificial bone at the clinical fracture of a kind of energy altitude simulation interface is provided.
The present invention is according to following Technical Design.
1. the method for making of a fracture model of artificial bone is characterized in that said method comprising the steps of:
(1) to the trouble bone of the suitable fracture patient chosen clinically along transversal section continuous helical CT scan, with the multi-layer image that obtains, with the Dicom3.0 standard storage, then utilize the Mimics software development to go out complete bone and the Three-dimension Reconstruction Model of fracture face;
(2) model that utilizes UG software to process is fractal, sort again, stationary knife road, Tool-path Generation, clamp reliably and calibration of workpieces, then produce bone profile mould with NC Milling, pass by in the journey at stationary knife, notice that assigned address is namely made the fracture line position of the prototype bone of bone profile mould at the mould assigned address groove that makes marks;
(3) obtain the fracture face model by three-dimensional printing technology, with the marker groove position that coincide;
(4) the fracture face model is placed on the marker groove position of corresponding bone profile mould, involutory upper and lower mould, fixing;
(5) in the profile mould, pour into polymethylmethacrylate, described polymethylmethacrylate, by by weight self-curing denture acrylic: dental basse acrylic resin liquid is that the ratio of 1-2:1 is in harmonious proportion; Left standstill 3-4 hour under 25 ℃ of room temperatures, treat to solidify fully, take out the fracture face model, obtain the fracture model of artificial bone sample.
The invention has the beneficial effects as follows: use the present invention and make fracture model, it is easy and simple to handle, and is functional, and fracture model settles at one go, has removed from obtaining behind the bone specimen the again complex process of artificial fracture, equipment loss and the misgivings that raise the cost.And resulting fracture interface, highly consistent with clinically fracture, be used for testing more approach clinic, experimental results has more clinical meaning.Simultaneously such sample has unified fracture interface and mechanical property, has removed the Confounding Factor such as individual difference that produce because of artificial fracture model.Thereby carry out infrastest better to instruct clinical position.And can reflect really the stressing conditions between fracture face comprehensively, and add the interior fixing rear suffered stress situation of inside-fixture, for the treatment of clinical fracture is offered help.
Embodiment
Be described in detail below in conjunction with embodiments of the invention.
A kind of method for making of fracture model of artificial bone may further comprise the steps:
(1) to the trouble bone of the suitable fracture patient chosen clinically along transversal section continuous helical CT scan, with the multi-layer image that obtains, with the Dicom3.0 standard storage, then utilize the Mimics software development to go out complete bone and the Three-dimension Reconstruction Model of fracture face;
(2) model that utilizes UG software (Unigraphics) to process is fractal, mould is divided into upper die and lower die two parts, recycling Numerical Control Programming Software cimatron E8, adopt working position to divide the order method (for a lot of part of processing content, can the processing part be divided into several parts by its design feature, such as interior shape, profile, curved surface or plane etc.General first processing plane, locating surface, rear machining hole; Process first simple geometric configuration, the geometric configuration that reprocessing is complicated; The elder generation lower position of machining precision, the higher position of reprocessing accuracy requirement.) mould is sorted, stationary knife road, Tool-path Generation, namely by the cutting position (motion track of cutter) of path locus reflection mold elements, clamp reliably and calibration of workpieces, then produce bone profile mould with NC Milling, pass by in the journey at stationary knife, attention makes marks at the mould assigned address, and assigned address is namely made the fracture line position of the prototype bone of bone profile mould, along the correspondence position cutting one dark 1mm of fracture line outer peripheral edges at mould, wide 1mm, groove serves as a mark;
(3) obtain the fracture face model by three-dimensional printing technology, model thickness is 1mm, and periphery Width raw bone plane of rupture increases 1mm with the marker groove position that coincide;
(4) the fracture face model is placed on the marker groove position of corresponding bone profile mould, involutory upper and lower mould, fixing;
(5) pour into polymethylmethacrylate in the profile mould, by by weight self-curing denture acrylic: dental basse acrylic resin liquid is that the ratio of 1-2:1 is in harmonious proportion, and leaves standstill 3-4 hour under 25 ℃ of room temperatures, treats to solidify fully, takes out the fracture face model, obtains the fracture model of artificial bone sample.
Described continuous helical CT scan is to adopt 16 row's spiral CT continuous sweeps, obtains multi-layer image.
Described polymethylmethacrylate, by by weight self-curing denture acrylic: dental basse acrylic resin liquid is that the ratio of 1.5:1 is in harmonious proportion.
Embodiment 1:
1. adopt 16 row's spiral CTs to the fracture of clavicle patient's that chooses clinically fracture clavicle along transversal section continuous sweep, obtain altogether 32 tomographic images, directly store with the Dicom3.0 standard, then utilize the Mimics software development to go out the Three-dimension Reconstruction Model of complete clavicle and fracture of clavicle section;
2. the test specimen that utilizes UG software to process is fractal, be about to mould and be divided into upper die and lower die two parts, recycling Numerical Control Programming Software cimatron E8, adopt a working position minute order method that mould is sorted, the stationary knife road, Tool-path Generation, the cutting position (motion track of cutter) that namely reflects mold elements by path locus, clamp reliably and calibration of workpieces, then produce clavicle profile mould with NC Milling, pass by in the journey at stationary knife, note making marks at the mould assigned address, assigned address namely refers to the fracture line position of prototype clavicle, along the correspondence position cutting one dark 1mm of fracture of clavicle line outer peripheral edges at mould, wide 1mm, groove serves as a mark;
3. obtain the fracture of clavicle sectional model by three-dimensional printing technology, model thickness is 1mm, and periphery Width raw bone plane of rupture increases 1mm with the marker groove position that coincide;
4. the fracture of clavicle sectional model is placed on the marker groove position of corresponding clavicle profile mould, involutory upper and lower mould, fixing;
5. under the environment of 25 ℃ of room temperatures, pour into PMMA in the profile mould, PMMA is in self-curing denture acrylic: dental basse acrylic resin liquid is that the 1.5:1 ratio is in harmonious proportion, and namely self-curing denture acrylic 60 restrains, dental basse acrylic resin liquid 40 grams;
6. 25 ℃ of conditions of room temperature are lower left standstill 3-4 hour, treated that PMMA solidifies fully, opened mould, took out the fracture of clavicle sectional model, obtained artificial fracture of clavicle archetype.
Embodiment 2:
1. adopt 16 row's spiral CTs to the fracture femur of the patients with fracture of neck chosen clinically along transversal section continuous sweep, obtain altogether 384 tomographic images, directly store with the Dicom3.0 standard, then utilize the Mimics software development to go out the Three-dimension Reconstruction Model of complete femur and femoral neck bone plane of rupture;
2. the test specimen that utilizes UG software to process is fractal, be about to mould and be divided into upper die and lower die two parts, recycling Numerical Control Programming Software cimatron E8, adopt a working position minute order method that mould is sorted, the stationary knife road, Tool-path Generation, the cutting position (motion track of cutter) that namely reflects mold elements by path locus, clamp reliably and calibration of workpieces, then produce femur profile mould with NC Milling, pass by in the journey at stationary knife, attention makes marks at the mould assigned address, assigned address namely refers to the femoral neck bone position of broken line of prototype femur, along the correspondence position cutting one dark 1mm of femoral neck bone broken line outer peripheral edges at mould, wide 1mm, groove serves as a mark;
3. obtain the fracture of neck of femur sectional model by three-dimensional printing technology, model thickness is 1mm, and periphery Width raw bone plane of rupture increases 1mm with the marker groove position that coincide;
4. the fracture of neck of femur sectional model is placed on the marker groove position of respective femur profile mould, involutory upper and lower mould, fixing;
5. under the environment of 25 ℃ of room temperatures, pour into PMMA in the profile mould, PMMA is in self-curing denture acrylic: dental basse acrylic resin liquid is that the 1.5:1 ratio is in harmonious proportion, and namely self-curing denture acrylic 450 restrains, dental basse acrylic resin liquid 300 grams;
6. 25 ℃ of conditions of room temperature are lower left standstill 3-4 hour, treated that PMMA solidifies fully, opened mould, took out the fracture of neck of femur sectional model, obtained the femur model sample of artificial femur fracture of cervical vertebra.
Claims (3)
1. the method for making of a fracture model of artificial bone is characterized in that said method comprising the steps of:
(1) to the trouble bone of the suitable fracture patient chosen clinically along transversal section continuous helical CT scan, with the multi-layer image that obtains, with the Dicom3.0 standard storage, then utilize the Mimics software development to go out complete bone and the Three-dimension Reconstruction Model of fracture face;
(2) model that utilizes UG software to process is fractal, sort again, stationary knife road, Tool-path Generation, clamp reliably and calibration of workpieces, then produce bone profile mould with NC Milling, pass by in the journey at stationary knife, at the mould assigned address groove that makes marks, assigned address is namely made the fracture line position of the prototype bone of bone profile mould;
(3) obtain the fracture face model by three-dimensional printing technology, with the marker groove position that coincide;
(4) the fracture face model is placed on the marker groove position of corresponding bone profile mould, involutory upper and lower mould, fixing;
(5) in the profile mould, pour into polymethylmethacrylate, described polymethylmethacrylate, by by weight self-curing denture acrylic: dental basse acrylic resin liquid is that the ratio of 1-2:1 is in harmonious proportion, left standstill 3-4 hour under 25 ℃ of room temperatures, treat to solidify fully, take out the fracture face model, obtain the fracture model of artificial bone sample.
2. the method for making of described fracture model of artificial bone according to claim 1 is characterized in that described continuous helical CT scan is to adopt 16 row's spiral CT continuous sweeps, obtains multi-layer image.
3. the method for making of described fracture model of artificial bone according to claim 1 is characterized in that described polymethylmethacrylate, and by by weight self-curing denture acrylic: dental basse acrylic resin liquid is that the ratio of 1.5:1 is in harmonious proportion.
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| CN102961784B (en) * | 2012-11-29 | 2014-09-10 | 华南理工大学 | BC (Bacterial Cellulose)/PVA (Polyvinyl Alcohol) composite material, as well as preparation method and application thereof |
| GB201300171D0 (en) * | 2013-01-07 | 2013-02-20 | Bae Systems Plc | Object production and assessment |
| EP2941677B1 (en) | 2013-01-07 | 2021-03-10 | BAE SYSTEMS plc | Object production using an additive manufacturing process and quality assessment of the object |
| RU2531441C1 (en) * | 2013-08-02 | 2014-10-20 | Федеральное государственное бюджетное учреждение "Нижегородский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения Российской Федерации | Method for simulating fracture defect of long bone |
| CN103707507B (en) * | 2013-12-13 | 2016-08-17 | 吉林大学 | The 3D of Polyether-ether-ketobiomimetic biomimetic artificial bone prints manufacture method |
| CN103871305B (en) * | 2014-02-26 | 2016-04-06 | 南方医科大学 | human anatomy pipeline model and preparation method thereof |
| CN107505192A (en) * | 2017-06-23 | 2017-12-22 | 天津市天津医院 | Acetabular bone simulation fixture and preparation method thereof |
| RU2684356C1 (en) * | 2018-10-04 | 2019-04-08 | Федеральное государственное бюджетное учреждение науки Институт высокотемпературной электрохимии Уральского отделения Российской Академии наук | Method of creating bilateral bone model for research of integration of osteotropic materials in experiment |
| RU2717217C1 (en) * | 2019-04-18 | 2020-03-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Уральский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО УГМУ Минздрава России) | Method for simulating and treating an open fracture of a tubular bone in an experiment |
| CN110610641B (en) * | 2019-10-08 | 2022-03-01 | 贵州省人民医院 | Acetabular osteotomy operation practice method |
| CN110992804B (en) * | 2019-12-05 | 2022-03-15 | 河南中博科技有限公司 | 3D printing method for physical specimen |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2003071505A3 (en) * | 2002-02-01 | 2004-06-03 | Maria-Grazia Ascenzi | Multidirectional morphology and mechanics of osteonic lamellae |
| CN101612065A (en) * | 2009-07-10 | 2009-12-30 | 天津医科大学总医院 | Adopt polymethyl methacrylate to prepare the method for artificial femur specimen |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2003071505A3 (en) * | 2002-02-01 | 2004-06-03 | Maria-Grazia Ascenzi | Multidirectional morphology and mechanics of osteonic lamellae |
| CN101612065A (en) * | 2009-07-10 | 2009-12-30 | 天津医科大学总医院 | Adopt polymethyl methacrylate to prepare the method for artificial femur specimen |
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