CN102512468A - Semi-bionic and flooding extraction and preparation method for surface portion of American ginseng - Google Patents
Semi-bionic and flooding extraction and preparation method for surface portion of American ginseng Download PDFInfo
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- CN102512468A CN102512468A CN2011104571018A CN201110457101A CN102512468A CN 102512468 A CN102512468 A CN 102512468A CN 2011104571018 A CN2011104571018 A CN 2011104571018A CN 201110457101 A CN201110457101 A CN 201110457101A CN 102512468 A CN102512468 A CN 102512468A
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- panacis quinquefolii
- radix panacis
- aerial parts
- liquid flooding
- preparing
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Abstract
The invention provides semi-bionic and flooding extraction preparation technology for a surface portion of American ginseng, which belongs to the technical field of natural plant pharmaceutical extraction. Extraction and preparation steps of the technology include extracting by a semi-bionic and flooding extraction method, refining by a macro absorption resin method, concentrating eluent for eluating macro absorption resin columns in a vacuum manner, and obtaining extract of the surface portion of the American ginseng after spraying drying. A technical preparation method is advanced in technology, high in extraction yield and suitable for industrial production, is simple and easy, and has a wide application prospect. The extract of the surface portion of the American ginseng can be prepared into tablets, capsules and orally taken preparation.
Description
Technical field
The invention belongs to natural medicinal plants extractive technique field, i.e. half of the Radix Panacis Quinquefolii aerial parts bionical method for preparing that adds the liquid flooding extraction.
Background technology
In the prior art, (formal name used at school: be equal congener with the former plant of Radix Ginseng Panax quinquefolius), contained big constituents is basic identical, and the main pharmacodynamics composition is the ginsenoside for Radix Panacis Quinquefolii.
Fructus Panacis Quinquefolii is the fruit of araliaceae ginseng plant's Radix Panacis Quinquefolii.Fructus Panacis Quinquefolii contains compositions such as ginsenoside, aminoacid, inorganic salt, polysaccharide, protein, lipoid, organic acid and phenols, and wherein saponin component content is higher.Result of study proves, has chemical composition and the biological activity identical with similar with American ginseng root in the Fructus Panacis Quinquefolii.Pharmacological research finds that the Fructus Panacis Quinquefolii total saponins has significantly effect such as antiviral, blood sugar lowering, resisting myocardial ischemia.
The Radix Panacis Quinquefolii flower is the alabastrum of araliaceae ginseng plant's Radix Panacis Quinquefolii.Contain compositions such as saponin, trace element, polysaccharide, fatty acid, flavone, tight equality from the Radix Panacis Quinquefolii alabastrum, carry the total saponins yield up to 32.5%, content is 6 times of American ginseng root content up to 30.09%.
Stem and leaf of Radix Panacis Quinquefolii is the dry stem and leaf of araliaceae ginseng plant's Radix Panacis Quinquefolii.Stem and leaf of Radix Panacis Quinquefolii contains compositions such as ginsenoside, volatile oil, aminoacid, polysaccharide and polyacetylene, but main active ingredient is the ginsenoside.Content of effective such as saponin in the Radix Panacis Quinquefolii leaf and polysaccharide are up to more than 10%, are 2 times of content in the American ginseng root.The stem and leaf of Radix Panacis Quinquefolii saponin has defying age, keeps form, function and the metabolism of scarce sugar, anoxybiotic myocardial cell, antitumor, resisting fatigue, effects such as raise immunity.
The former plant of Radix Panacis Quinquefolii and Radix Ginseng is all Araliaceae, and contained big constituents is basic identical, and wherein the main pharmacodynamics composition is the ginsenoside, and the obvious difference of Radix Panacis Quinquefolii and Radix Ginseng is: 1, the contained Rb of Radix Panacis Quinquefolii
1Be higher than Radix Ginseng with the saponin total amount.2, contain pseudo-ginsenoside F in the Radix Panacis Quinquefolii
11With pseudo-ginsenoside RT
5, they belong to the grand pure type saponin of omeprazole ladder, and in Radix Ginseng, do not find as yet.
Research shows, pseudo-ginsenoside F
11Cardiac function had positive inotropic action; Has the calcium channel activation; Pseudo-ginsenoside F
11Can keep environment in the normal brain through the anti-cerebral ischemia anoxia, thereby the hypofunction of protecting cerebral ischemia, anoxia to cause promotes the learning and memory ability.Pseudo-ginsenoside F
11The effect that also has anti-morphine addiction.Ginsenoside Rb
1, have the effect that improves myocardial ischemia reperfusion injury, have a protective effect to stress sexual behaviour damaged.And utilize the abundant aerial parts resource of Radix Panacis Quinquefolii fully, and extract the effective ingredient of Radix Panacis Quinquefolii aerial parts, be used for useful in preparing drug formulations, bring into play the drug action of its endemic element, have broad application prospects.
At present, some new state-of-the-art technologys also are not applied to the extraction and the preparation of Radix Panacis Quinquefolii aerial parts.Want to make full use of the resource of Radix Panacis Quinquefolii aerial parts, improve yield, improve the extract bioavailability, and suitable suitability for industrialized production, only on original technology basis, improve technology, use the deficiency that modern extractive technique overcomes traditional handicraft.
Summary of the invention
The objective of the invention is to above-mentioned deficiency and to provide a kind of be raw material with the Radix Panacis Quinquefolii aerial parts, provide a kind of advanced person, that yield is high, improve drug bioavailability, be fit to the extraction method for preparing of the Radix Ginseng aerial parts of suitability for industrialized production.
Technical solution of the present invention is: the half bionical method for preparing that adds the liquid flooding extraction of Radix Panacis Quinquefolii aerial parts, its step is following: (1) is raw material with the Radix Panacis Quinquefolii aerial parts, and raw material is placed the liquid flooding extractor, adds respectively and contains different H
+The aqueous solution of ion concentration boils, and extracts 2-4 hour, filters, and must filtrate;
(2) or with the Radix Panacis Quinquefolii aerial parts is raw material, and raw material is placed the liquid flooding extractor, adds H
+Ion and OH
-Aqueous solution when ion concentration reaches balance boils, and extracts 2-4 hour, filters; Must filtrate, filtrating through macroporous adsorptive resins be adsorbed to saturated after, use the 60%-80% ethanol elution, the collection eluent; With the eluent vacuum concentration, spray drying promptly gets ginsenoside extract.
Use H described in the step (1)
+Ion concentration is 10
-2-10
-3The extracting solution that the mol/L solvent extracts is used to prepare ginsenoside's secondary glycoside and aglycon.Use H
+Ion concentration is 10
-2-10
-3When the mol/L solvent extracts, the H of simulation human gastric juice
+Ion concentration, and heating, ginsenoside's hydrolysis, cyclization generates panoxadiol and panaxatriol's derivant, thereby obtains secondary glycoside.The content of secondary ginsenoside in Radix Ginseng is few, so be called rare ginsenoside again.This process meets the transhipment absorption process of medicine in human stomach, thereby strengthens oral drugs absorbing under one's belt, improves drug bioavailability.
Use H described in the step (1)
+Ion concentration is 10
-11-10
-12The extracting solution that the mol/L solvent extracts is used to prepare ginsenoside's secondary glycoside and the primary sapogenin of ginsenoside.Use H
+Ion concentration is 10
-11-10
-12When the mol/L solvent extracts, the H of simulation human body intestinal canal
+Ion concentration, heating, the ginsenoside is at this H
+The environment reaction of ion concentration is gentle, can not make reactions such as aglycon dewaters, cyclization, double-bond shift usually, and obtain primary sapogenin of ginsenoside and secondary ginsenoside.This process meets the transhipment absorption process of medicine in human body intestinal canal, thereby strengthens oral drugs absorbing in intestinal, improves drug bioavailability.
The described H that uses
+Ion and OH
-Ion concentration reach extracting solution that equilibrated solvent extracts through macroporous adsorptive resins be adsorbed to saturated after, use the 60%-80% ethanol elution, the collection eluent, with the eluent vacuum concentration, spray drying promptly gets ginsenoside extract.Use H
+Ion and OH
-When the solvent when ion concentration reaches balance extracted, glycosidic bond was stable usually, so can obtain more stable Radix Ginseng total saponins.This environment ability better protect ginsenoside prevents hydrolysis, improves extract yield.
Add the contain H of volume for 5-20 times of input volume of material
+Ionic aqueous solution boils, and extracts.Contain H
+Ionic aqueous solution is to be adjusted to H with acid
+Ion concentration is 10
-2-10
-3Mol/L, its used acid is hydrochloric acid or citric acid etc., or is adjusted to H with alkali
+Ion concentration is 10
-11-10
-12Mol/L, its used alkali is sodium hydroxide or sodium bicarbonate etc.
Described Radix Panacis Quinquefolii aerial parts is meant a kind of or its mixing in stem and leaf of Radix Panacis Quinquefolii, Radix Panacis Quinquefolii flower, the Fructus Panacis Quinquefolii.
Semi-bionic extraction is from biopharmaceutical angle whole medicine organon to be combined with the molecular medicine organon, imitates oral drugs and at the gastrointestinal transport process, adopts different H
+The solvent of ion concentration extracts, and its objective is to extract to contain the high active mixture of index components, improves drug bioavailability.
It is the steam that is produced when making full use of heated solvent that the liquid flooding method is extracted, and with reverse contact of condensed fluid of refluxing, has increased the less turbulence of liquid phase, improves the diffusion rate of solute in the medical material.Simultaneously,, make the higher Concentraton gradient of maintenance between solute and solvent, significantly improved alternate mass transfer force, extraction ratio is improved because constantly there is fresh solvent to add.
Extract with the half bionical liquid flooding extraction method that adds, refining with macroreticular resin absorbing method, with the eluent vacuum concentration of eluting macroporous resin column, spray drying promptly gets ginsenoside extract.Radix Panacis Quinquefolii overground part extract preparation curative effect in clinical practice is obvious; Toxic and side effects is little; Can be used for preparing medicine; With the extract raw material is effective ingredient, and the pharmaceutical carrier with commonly used in the pharmacy can be mixed and made into tablet, capsule, granule, powder, pill, liquid preparation or other conventional formulation like excipient or adjuvant.
Advantage of the present invention is: what the present invention adopted is the half bionical liquid flooding extraction method that adds, and promptly uses different H
+Solvent under the ion concentration carries out liquid flooding to the Radix Panacis Quinquefolii aerial parts and extracts, and can extract the different ginsenosides and the ginsengenin that are suitable for gastrointestinal absorption, and yield is high, improves ginsenoside's bioavailability; Simultaneously, its method for distilling collection extracts, filters, concentrates in one, shortens the production cycle, and yield is high, and advanced technology is fit to suitability for industrialized production, has broad application prospects.
To combine embodiment that embodiment of the present invention is described in further detail below.
The specific embodiment
Embodiment 1
Half bionical liquid flooding extraction and the method for preparing of adding of Radix Panacis Quinquefolii aerial parts:
Get dry stem and leaf of Radix Panacis Quinquefolii 100 grams, cut off 5cm, drop in the liquid flooding extractor, add H
+Ion and OH
-Aqueous solution when ion concentration reaches balance, volume is for dropping into 20 times of volume of material, and heated and boiled was extracted 2 hours, used plate-and-frame filtration, and filtrating is put into storage tank, and filtering residue discards.Filtrating gets into D101 type or AB-8 type macroporous resin adsorption and will filtrate through macroporous resin adsorption after saturated, and using percent by volume is 65% ethanol elution, the collection eluent.Vacuum concentration pumps into eluent in the vacuum concentration recycling can, carries out vacuum concentration, and thickening temperature 60-80 ℃, pressure-0.05～-0.1MPa.After reclaiming ethanol to nothing alcohol flavor, being concentrated into relative density is 1.00-1.30 (60 ℃ of mensuration).Spray drying atomizes behind the concentrated solution entering spray drying device with pure washing liquid, contacts with hot-air again, in moment most of moisture is removed, and makes the solid matter in the concentrated solution be dried to powder, promptly gets about 6.0 grams of Radix Ginseng total saponins extract.
Embodiment 2
Half bionical liquid flooding extraction and the method for preparing of adding of Radix Panacis Quinquefolii aerial parts:
Get fresh Fructus Panacis Quinquefolii 100 grams, drop in the liquid flooding extractor, add H
+Ion and OH
-Aqueous solution when ion concentration reaches balance, volume is for dropping into 5 times of volume of material, and heated and boiled was extracted 2 hours, used plate-and-frame filtration, and filtrating is put into storage tank, and filtering residue discards.Filtrating gets into macroporous resin adsorption and will filtrate through D101 type or AB-8 type macroporous resin adsorption after saturated, with 65% ethanol elution of percent by volume, and the collection eluent.Vacuum concentration pumps into eluent in the vacuum concentration recycling can, carries out vacuum concentration, 60 ℃-80 ℃ of thickening temperatures, and pressure-0.05～-0.1MPa.After reclaiming ethanol to nothing alcohol flavor, being concentrated into relative density is 1.00-1.30 (60 ℃ of mensuration).Spray drying atomizes behind the concentrated solution entering spray drying device with pure washing liquid, contacts with hot-air again, in moment most of moisture is removed, and makes the solid matter in the concentrated solution be dried to powder, promptly gets about 0.9 gram of Radix Ginseng total saponins extract.
Embodiment 3
Half bionical liquid flooding extraction and the method for preparing of adding of Radix Panacis Quinquefolii aerial parts:
Get dry Radix Panacis Quinquefolii and spend 100 grams, drop in the liquid flooding extractor, add H
+Ion and OH
-Aqueous solution when ion concentration reaches balance, volume is for dropping into 10 times of volume of material, and heated and boiled was extracted 2 hours, used plate-and-frame filtration, and filtrating is put into storage tank, and filtering residue discards.Filtrating gets into macroporous resin adsorption and will filtrate through D101 type or AB-8 type macroporous resin adsorption after saturated, with 65% ethanol elution of percent by volume, and the collection eluent.Vacuum concentration pumps into eluent in the vacuum concentration recycling can, carries out vacuum concentration, and thickening temperature 60-80 ℃, pressure-0.05～-0.1MPa.After reclaiming ethanol to nothing alcohol flavor, being concentrated into relative density is 1.00-1.30 (60 ℃ of mensuration).Spray drying atomizes behind the concentrated solution entering spray drying device with pure washing liquid, contacts with hot-air again, in moment most of moisture is removed, and makes the solid matter in the concentrated solution be dried to powder, promptly gets about 10 grams of Radix Ginseng total saponins extract.
Embodiment 4
Half bionical liquid flooding extraction and the method for preparing of adding of Radix Panacis Quinquefolii aerial parts:
Get dry stem and leaf of Radix Panacis Quinquefolii 100 grams, cut off 5cm, drop in the liquid flooding extractor, add H
+Ion concentration is 10
-11-10
-12The aqueous solution of mol/L, volume is for dropping into 20 times of volume of material, and heated and boiled was extracted 2 hours, used plate-and-frame filtration, and filtrating is put into storage tank, and filtering residue discards, and filtrating is used to prepare ginsenoside's secondary glycoside and the primary aglycon of ginsenoside.
Embodiment 5
Half bionical liquid flooding extraction and the method for preparing of adding of Radix Panacis Quinquefolii aerial parts:
Get fresh Fructus Panacis Quinquefolii 100 grams, drop in the liquid flooding extractor, add H
+Ion concentration is 10
-11-10
-12The aqueous solution of mol/L, volume is for dropping into 5 times of volume of material, and heated and boiled was extracted 2 hours, used plate-and-frame filtration, and filtrating is put into storage tank, and filtering residue discards, and filtrating is used to prepare ginsenoside's secondary glycoside and the primary aglycon of ginsenoside.
Embodiment 6
Half bionical liquid flooding extraction and the method for preparing of adding of Radix Panacis Quinquefolii aerial parts:
Get dry Radix Panacis Quinquefolii and spend 100 grams to drop in the liquid flooding extractor, add H
+Ion concentration is 10
-11-10
-12The aqueous solution of mol/L, volume is for dropping into 10 times of volume of material, and heated and boiled was extracted 2 hours, used plate-and-frame filtration, and filtrating is put into storage tank, and filtering residue discards, and filtrating is used to prepare ginsenoside's secondary glycoside and the primary aglycon of ginsenoside.
Embodiment 7
Half bionical liquid flooding extraction and the method for preparing of adding of Radix Panacis Quinquefolii aerial parts:
Get dry Radix Panacis Quinquefolii and spend 100 grams, drop in the liquid flooding extractor, add H
+Ion concentration is 10
-2-10
-3The aqueous solution of mol/L, volume is for dropping into 10 times of volume of material, and heated and boiled was extracted 2 hours, used plate-and-frame filtration, and filtering residue discards.Filtrating is used to prepare ginsenoside's secondary glycoside and aglycon.
Embodiment 8
Half bionical liquid flooding extraction and the method for preparing of adding of Radix Panacis Quinquefolii aerial parts:
Get fresh Fructus Panacis Quinquefolii 100 grams, drop in the liquid flooding extractor, add H
+Ion concentration is 10
-2-10
-3The aqueous solution of mol/L, volume is for dropping into 5 times of volume of material, and heated and boiled was extracted 2 hours, used plate-and-frame filtration, and filtering residue discards.Filtrating is used to prepare ginsenoside's secondary glycoside and aglycon.
Embodiment 9
Half bionical liquid flooding extraction and the method for preparing of adding of Radix Panacis Quinquefolii aerial parts:
Get dry stem and leaf of Radix Panacis Quinquefolii 100 grams, cut off 5cm, drop in the liquid flooding extractor, add H
+Ion concentration is 10
-2-10
-3The aqueous solution of mol/L, volume is for dropping into 20 times of volume of material, and heated and boiled was extracted 2 hours, used plate-and-frame filtration, and filtering residue discards.Filtrating is used to prepare ginsenoside's secondary glycoside and aglycon.
Embodiment 10
Press embodiment 1, embodiment 2, embodiment 3, extract, refining, concentrate, dry, fallow or yellowish-brown amorphous powder, process tablet, capsule or oral liquid.
Claims (8)
1. half of the Radix Panacis Quinquefolii aerial parts bionically adds the method for preparing that liquid flooding is extracted, and it is characterized in that step is following:
(1) is raw material with the Radix Panacis Quinquefolii aerial parts, raw material is placed the liquid flooding extractor, add respectively and contain different H
+The aqueous solution of ion concentration boils, and extracts 2-4 hour, filters, and must filtrate;
(2) or with the Radix Panacis Quinquefolii aerial parts is raw material, and raw material is placed the liquid flooding extractor, adds H
+Aqueous solution when ion and 0H ion concentration reach balance boils, and extracts 2-4 hour, filters; Must filtrate, filtrating through macroporous adsorptive resins be adsorbed to saturated after, use the 60%-80% ethanol elution, the collection eluent; With the eluent vacuum concentration, spray drying promptly gets ginsenoside extract.
2. the half bionical method for preparing that adds the liquid flooding extraction of Radix Panacis Quinquefolii aerial parts according to claim 1 is characterized in that the H described in the step (1)
+Ion concentration is 10
-2-10
-3Mol/L, filtrating is used to prepare ginsenoside's secondary glycoside and aglycon.
3. the half bionical method for preparing that adds the liquid flooding extraction of Radix Panacis Quinquefolii aerial parts according to claim 1 is characterized in that the H described in the step (1)
+Ion concentration is 10
-11-10
-12Mol/L, filtrating is used to prepare ginsenoside's secondary glycoside and the primary sapogenin of ginsenoside.
4. the half bionical method for preparing that adds the liquid flooding extraction of Radix Panacis Quinquefolii aerial parts according to claim 1 is characterized in that adding the contain H of volume for 5-20 times of input volume of material
+Ionic aqueous solution.
5. the half bionical method for preparing that adds the liquid flooding extraction of Radix Panacis Quinquefolii aerial parts according to claim 1 is characterized in that containing H
+Ionic aqueous solution is to be adjusted to H with acid
+Ion concentration is 10
-2-10
-3Mol/L, its used acid is hydrochloric acid or citric acid, or is adjusted to H with alkali
+Ion concentration is 10
-11-10
-12Mol/L, its used alkali is sodium hydroxide or sodium bicarbonate.
6. the half bionical method for preparing that adds the liquid flooding extraction of Radix Panacis Quinquefolii aerial parts according to claim 1 is characterized in that vacuum concentration, and thickening temperature is 60 ℃-80 ℃, pressure-0.05～-0.1MPa.
7. the half bionical method for preparing that adds the liquid flooding extraction of Radix Panacis Quinquefolii aerial parts according to claim 1 is characterized in that said Radix Panacis Quinquefolii aerial parts is meant a kind of or its mixing in stem and leaf of Radix Panacis Quinquefolii, Radix Panacis Quinquefolii flower, the Fructus Panacis Quinquefolii.
8. half of Radix Panacis Quinquefolii aerial parts according to claim 1 bionically adds the method for preparing that liquid flooding is extracted, and it is characterized in that the Radix Panacis Quinquefolii overground part extract directly makes or add that pharmaceutical carrier, adjuvant commonly used in the pharmacy process tablet, capsule, granule, powder or liquid preparation.
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|---|---|---|---|
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|---|---|---|---|
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103735689A (en) * | 2014-01-21 | 2014-04-23 | 吉林省中医药科学院 | Application of natural medicinal composition in preparing anti-hypoxia medicines and health-care products |
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| CN102058642A (en) * | 2009-11-17 | 2011-05-18 | 天津天士力制药股份有限公司 | Ginseng saponin extract and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103735689A (en) * | 2014-01-21 | 2014-04-23 | 吉林省中医药科学院 | Application of natural medicinal composition in preparing anti-hypoxia medicines and health-care products |
| CN103735689B (en) * | 2014-01-21 | 2016-01-20 | 吉林省中医药科学院 | A kind of natural drug composition is preparing the application in anoxia enduring medicine and health product |
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Application publication date: 20120627 |