CN102512366A - Toltrazuril suspension emulsion and preparation method thereof - Google Patents
Toltrazuril suspension emulsion and preparation method thereof Download PDFInfo
- Publication number
- CN102512366A CN102512366A CN2011104478485A CN201110447848A CN102512366A CN 102512366 A CN102512366 A CN 102512366A CN 2011104478485 A CN2011104478485 A CN 2011104478485A CN 201110447848 A CN201110447848 A CN 201110447848A CN 102512366 A CN102512366 A CN 102512366A
- Authority
- CN
- China
- Prior art keywords
- toltrazuril
- water
- suspended emulsion
- emulsifying agent
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a toltrazuril suspension emulsion, which comprises the following components by weight part: 1-5 parts of toltrazuril, 20-40 parts of vegetable oil, 5-20 parts of emulsions and 74-45 parts of water. The preparation method of the toltrazuril suspension emulsion comprises the following steps of: (1) taking the toltrazuril and the vegetable oil according to the proportion, grinding the toltrazuril and the vegetable oil through a colloid mill to prepare an oil phase; (2) weighing the emulsions, adding a little bit of water into the emulsions for stirring and dissolving to prepare a water phase; (3) adding the water phase into the oil phase, grinding through the colloid mill, and uniformly mixing; and (4) adding the residual water and stirring to obtain the toltrazuril suspension emulsion. The toltrazuril suspension emulsion has the beneficial effects of good stability and good biocompatibility, the domestic technical blank is filled, and a novel technical field is opened for application of toltrazuril. The preparation method of the toltrazuril suspension emulsion is simple and easy for operation, and the manufacturing cost is low.
Description
Technical field
The invention belongs to the veterinary drug technical field, be specifically related to a kind of Toltrazuril suspended emulsion and preparation method thereof.
Background technology
Coccidiosis is the very wide protozoacide of a kind of distribution; Mainly belong to and causing by eimeria tenella; Cause animal and bird intestines necrosis, diarrhoea, enteritis and poultry dead, obviously reduce livestock and poultry production performance (like meat matter, death rate, rate of body weight gain, the price of deed etc.), cause heavy economic losses.Even low-grade infection also can cause the decline of feed conversion rate, weightening finish to reduce and growth retardation.Coccidiosis serious harm animal husbandry development, the loss that China every year causes because of the coccidiosis of chicken is up to 500,000,000 yuans.
Toltrazuril (Toltrazuil) has another name called methyl triazon, belongs to triazinone compounds, and chemical name is 1-methyl-3-4-[4-(4-trifluoromethyl thio phenyl oxygen)-tolyl]-1,3,5-triazines triketone.Succeed in developing in the eighties in 20th century by Bayer A.G; Has the wide spectrum coccidiostat activity; Can effectively kill a lot of protozoons that comprise eimeria tenella, wherein tender, heap type, huge, murder by poisoning, Bu Shi and 6 kinds of eimeria tenellas such as gentle had efficient killing action, belong to efficient coccidiostat; Because its good disinsection effect, toxicity is low, the anticoccidial scope is wide, is widely used in chicken coccidiosis in the whole world.Toltrazuril is very extensive to the site of action of coccidiosis, and two no sexual cycles of coccidiosis are all had effect, as suppressing schizont, the wall organizator of the karyokinesis of microgametophyte and microgametophyte.Toltrazuril disturbs division of coccidiosis nucleus and mitochondrion, influences breathing and the metabolic function of polypide, and endocytoplasmic reticulum is expanded, and serious ghostization takes place, thereby has the worm of killing effect.
Toltrazuril dissolves in organic solvents such as ethanolamine, Polyethylene Glycol, propylene glycol, have the effect of good wide spectrum anticoccidial, but Toltrazuril is water insoluble, and therefore, the application of Toltrazuril is restricted.The product of Toltrazuril listing at present is generally pre-mixing agent and oral solution.Pre-mixing agent occurs mixing inhomogeneous easily, the poultry non-uniform phenomenon of ingesting, and indivedual poultry eat too much toxigenicity effect, or indivedual poultry food ration is not enough, and curative effect is reduced; And oral solution all adopts the organic solvent preparation at present; Like number of patent application is that the Chinese invention patent of CN200610038079.2 discloses and contains anticoccidial solution of Toltrazuril and preparation method thereof; The use of a large amount of organic solvents is restricted on transportation, storage and container selection; Cause the rising of cost, and with an organic solvent also there is certain pollution in environment in a large number; In addition, the poor stability of solution, the dilution back medicine can occur and separate out phenomenon in the livestock and fowl drinking water process, fail to reach due curative effect.
Except that pre-mixing agent and oral solution; Other dosage forms that the report Toltrazuril is also arranged; Like number of patent application is that the Chinese invention patent of CN200780030355.3 discloses the percutaneous dosing compound in triazine class with the control coccidium infection; But the percutaneous dosing application is domestic animals such as pig, cattle, and coccidiosis to take place maximum be birds such as chicken, so this patent application is restricted; Number of patent application is that the Chinese invention patent of CN200810154579.1 discloses and can effectively be dispersed in the Toltrazuril suspension in the water, but in fact, suspension is difficult to shake up in use, uses inconvenience; CN200810118075.4 discloses a kind of anti-coccidium microemulsion that contains Toltrazuril and preparation method thereof, and likewise, this method has been used a large amount of emulsifying agents; Number of patent application is that the Chinese invention patent of CN200910061394.0 discloses a kind of Toltrazuril---Preparation methods of cyclodextrin inclusion complexes, but this method for preparing is loaded down with trivial details, is not suitable for batch production production.
(Suspoemulsions SE), claims outstanding emulsion, suspension emulsion again to suspended emulsion, is by the water-insoluble solid medicine, and promptly the solid suspension body mixes the suspension emulsus system that forms with emulsion.The three-phase high dispersive mixture that suspended emulsion is made up of oil phase, water and solid phase, wherein continuous phase can be water, also can be non-aqueous system, suspended emulsion can make water preparation, oil preparation and three kinds of dosage forms of suspensoid lump together.Suspended emulsion is a kind of new relatively complex system, and most suspended emulsions all are oil-in-water type suspended emulsions, promptly is continuous phase (disperse medium) with water, and oil phase and solid phase are discontinuous phase.The safety of processing, storing and use is all fine, does not have a large amount of hazardous solvent problem of environment pollution caused.It is the medicament that has different physicochemical properties for adaptation, needs to mix to use to grow up; Make by routine and will be processed into the medicament that two kinds of dosage forms just can be used with, become and be processed into a dosage form and can use, significantly reduced the use amount of pharmaceutical auxiliary agent and packaging material, also be convenient to storing and use.The research of relevant suspended emulsion is used more in pesticidal preparations, industrial preparation in the later stage eighties 20th century at present in the world.
Suspended emulsion is the mixed type dosage form of aqueous suspension agent and Emulsion, has the characteristic of solution, suspensoid and Emulsion, but also has following unique advantage:
(1) potion multiple-effect.Suspended emulsion can be loaded in several kinds of active component bags in oil phase, water or the solid phase in the system, can play potion multiple-effect function like this.For example in the oil-in-water type suspended emulsion; Emulsion can wrap and carry one or more active substances; Wherein some component can be water miscible; Some active component can be oil-soluble, carries the effective ingredient that exists with solid particulate form and in continuous phase, can wrap, and also can wrap to carry water-soluble actives.
(2) improve bioavailability.Suspended emulsion can wrap simultaneously and carry the various active composition, and each component with collaborative or potentiation is present in the same system, enlarges the prevention and treatment range of preparation, thereby improves bioavailability.
(3) slow releasing function.Suspended emulsion can delay or control drug release; Can process the suspended emulsion dosage form to oiliness medicine or pressed powder medicine; The performance long-acting; Also avoided simultaneously the preparation liquid dosage form to need shortcoming with an organic solvent, reduced product cost and toxicity, avoided with an organic solvent and dust medicine pollution on the environment.
(4) preparation is simple, easy to use, but approach such as oral administration, injection use.
At present to be used for veterinary drug actually rare for suspended emulsion, is that the Chinese invention patent of CN200810220327.4 discloses a kind of suspension emulsion of florfenicol like number of patent application.In sum, suspended emulsion has unique usefulness and effect.Because technology limitation, existing Toltrazuril dosage form has oral liquid, pre-mixing agent etc., does not temporarily have the Toltrazuril suspended emulsion to appear on the market, and does not also have relevant technology report.
Summary of the invention
The objective of the invention is deficiency to the above prior art existence; Utilize the anticoccidial effect of unique usefulness enhancing Toltrazuril of suspended emulsion; Provide simple, reduce product cost, improve the Toltrazuril suspended emulsion of the biological utilisation of stability of formulation and medicine.
Another object of the present invention provides a kind of method for preparing of Toltrazuril suspended emulsion.
For achieving the above object, technical scheme of the present invention is: the Toltrazuril suspended emulsion, process by the component that comprises following parts by weight:
Toltrazuril 1～5,
Vegetable oil 20～40,
Emulsifying agent 5～20,
Water 74～45.
Said vegetable oil comprises a kind of or two or more mixing of Oleum Arachidis hypogaeae semen, soybean oil, Semen Maydis oil, Oleum Camelliae, Oleum Gossypii semen, Oleum Sesami, Oleum Ricini or olive oil, and two or more vegetable oil can use by any mixed.Particularly preferably be soybean oil.
Said emulsifying agent comprises naturally occurring emulsifying agent and surfactant-based emulsifying agent.Naturally occurring emulsifying agent mainly comprises lecithin, tragakanta, arabic gum, gelatin, apricot glue and soybean phospholipid.Surfactant-based emulsifying agent preferred nonionic surfactants; Comprise polyoxyethylene sorbitan fatty acid ester (tween series), sorbitan fatty acid ester (span series), polyoxyethylene fatty acid ester (Myrij series), polyoxyethylene aliphatic alcohol ether (Brij series), castor oil polyoxyethylene ether (EL series), fatty glyceride, sucrose fatty acid ester, poloxamer (Poloxamer); They can singlely be used; But yet Combined application, mixed proportion is not done specific (special) requirements during Combined application.Preferred especially tween of emulsifying agent or lecithin.
In case of necessity, also comprise auxiliary agent in the said Toltrazuril suspended emulsion; Said auxiliary agent comprises co-emulsifier, emulsifying agent stabilizing agent, suspending agent, antioxidant and/or antibacterial antiseptic.The addition of auxiliary agent is confirmed to get final product according to pharmaceutical technology field routine techniques.
Said co-emulsifier is the nonionic surfactant of medicinal short chain alcohol or suitable HLB value; Commonly used have ethanol, ethylene glycol, propylene glycol, glycerol, n-butyl alcohol, a Polyethylene Glycol etc.
The application of said emulsifying agent stabilizing agent can improve the viscosity of suspended emulsion of the present invention, strengthens the emulsifying film strength, prevents that emulsion droplet from merging, and strengthens the stability of suspended emulsion.The emulsifying agent stabilizing agent comprises:
(a) the emulsifying agent stabilizing agent of increase water viscosity: sodium carboxymethyl cellulose, sodium alginate, agar, methylcellulose, hydroxypropyl cellulose, arabic gum, tragakanta, xanthan gum or pectin.
(b) the emulsifying agent stabilizing agent of increase oil phase viscosity: stearic acid or stearyl alcohol, Cera Flava, spermol, glyceryl monostearate;
Said suspending agent is carboxymethyl cellulose (sodium), polyvinylpyrrolidone, arabic gum, methylcellulose, xanthan gum, molecular weight greater than 2000 Polyethylene Glycol, castor oil hydrogenated or aluminium stearate;
Said antioxidant is lipophile antioxidant and water solublity antioxidant, preferred gallic acid of lipophile antioxidant and esters thereof, BHA, BHT, tocopherol; The preferred ascorbic acid of water solublity antioxidant, pyrosulfite, sulphite, thiourea.
Described antibacterial antiseptic is phenol derivmives blend biology, p-Hydroxybenzoate, phenoxyethanol, benzyl alcohol, methaform, quaternary ammonium compound, benzoic acid (sodium), sorbic acid (potassium);
A kind of method for preparing of Toltrazuril suspended emulsion, it may further comprise the steps:
(1) gets Toltrazuril and vegetable oil according to the above than row, grind, make oil phase through colloid mill;
(2) take by weighing emulsifying agent and add the low amounts of water stirring and dissolving, make water;
(3) water is added oil phase, grind mix homogeneously through colloid mill;
(4) add remainder water, stir and promptly get the Toltrazuril suspended emulsion.
The present invention provides the application of said Toltrazuril suspended emulsion simultaneously, it is characterized in that being applied to prepare the treating animal coccidiosis oral liquid.
Compared with prior art, the invention has the beneficial effects as follows: good stability, good biocompatibility, it is blank to have filled up domestic technique, for new technical field has been opened up in the application of Toltrazuril.The method for preparing of said suspended emulsion is simple, low cost of manufacture.
The specific embodiment
Come further explain the present invention below in conjunction with specific embodiment.
Embodiment 1
The Toltrazuril suspended emulsion, process by the component that comprises following parts by weight:
Toltrazuril 1,
Vegetable oil 20,
Emulsifying agent 50,
Water 45.
Embodiment 2
The Toltrazuril suspended emulsion, process by the component that comprises following parts by weight:
Toltrazuril 5,
Vegetable oil 40,
Emulsifying agent 20,
Water 74.
Embodiment 3
The Toltrazuril suspended emulsion, process by the component that comprises following parts by weight:
Toltrazuril 3,
Vegetable oil 30,
Emulsifying agent 13,
Water 60.
A kind of method for preparing of Toltrazuril suspended emulsion, it may further comprise the steps:
(1) gets Toltrazuril and vegetable oil according to the above than row, grind, make oil phase through colloid mill;
(2) take by weighing emulsifying agent and add low amounts of water (5-30% of water cumulative volume) stirring and dissolving, make water;
(3) water is added oil phase, grind mix homogeneously through colloid mill;
(4) add remainder water, stir and promptly get the Toltrazuril suspended emulsion.
Embodiment 4
The Toltrazuril suspended emulsion, by comprising that following component processes:
Toltrazuril 2.5% (w/V);
Soybean oil 20% (W/V);
Tween 80 7.5% (W/V);
The water surplus.
The method for preparing of said Toltrazuril suspended emulsion is:
(1) proportionally measures Toltrazuril and soybean oil, grind, make oil phase through colloid mill;
(2) take by weighing tween 80 and add a small amount of water for injection stirring and dissolving, make water;
(3) water is added oil phase, grind mix homogeneously through colloid mill;
(4) add water to full dose, stir and promptly get the Toltrazuril suspended emulsion.
Embodiment 5
The Toltrazuril suspended emulsion, by comprising that following component processes:
Toltrazuril 2.5% (w/V);
Soybean oil 15% (W/V);
Oleum Arachidis hypogaeae semen 10% (W/V);
Tween 80 7.5% (W/V);
N-butyl alcohol 10% (W/V);
Water adds to 100% (V/V)
The method for preparing of said Toltrazuril suspended emulsion is:
(1) proportionally measures Toltrazuril and soybean oil, Oleum Arachidis hypogaeae semen, grind, make oil phase through colloid mill;
(2) take by weighing tween 80 and add a small amount of water for injection stirring and dissolving, add n-butyl alcohol, make water;
(3) water is added oil phase, grind mix homogeneously through colloid mill;
(4) add water to full dose, stir and promptly get the Toltrazuril suspended emulsion.
Embodiment 6
The Toltrazuril suspended emulsion, by comprising that following component processes:
Toltrazuril 2.5% (w/V);
Soybean oil 20% (W/V);
Lecithin 5% (W/V);
Polyvinylpyrrolidone 2% (W/V);
Water surplus.
The method for preparing of said Toltrazuril suspended emulsion is:
(1) proportionally measures Toltrazuril and soybean oil, lecithin, grind, make oil phase through colloid mill;
(2) take by weighing polyvinylpyrrolidone and add a small amount of water for injection stirring and dissolving, make water;
(3) water is added oil phase, grind mix homogeneously through colloid mill;
(4) add water to full dose, stir and promptly get the Toltrazuril suspended emulsion.
Embodiment 7
The Toltrazuril suspended emulsion, by comprising that following component processes:
Toltrazuril 2.5% (w/V);
Soybean oil 15% (W/V);
Oleum Arachidis hypogaeae semen 10% (W/V);
Tween 80 5% (W/V);
Lecithin 5% (W/V);
Sodium carboxymethyl cellulose: 0.1% (W/V);
Propylene glycol 10% (W/V);
BHA 0.05％(W/V)；
Thiourea 0.1% (W/V);
Water adds to 100% (V/V)
The method for preparing of said Toltrazuril suspended emulsion is:
(1) proportionally measures Toltrazuril and soybean oil, Oleum Arachidis hypogaeae semen, lecithin, BHA, grind, make oil phase through colloid mill;
(2) take by weighing sodium carboxymethyl cellulose and add a small amount of water for injection and stir, treat the sodium carboxymethyl cellulose dissolving after, add a small amount of water for injection that is dissolved with thiourea, propylene glycol, make water;
(3) water is added oil phase, grind mix homogeneously through colloid mill;
(4) add water to full dose, stir and promptly get the Toltrazuril suspended emulsion.
The effect experiment
For verifying that the Toltrazuril suspended emulsion is to the chicken coccidiosis therapeutic effect; Our company cultures broiler plant of Group Co.,Ltd and makes an experiment in Nanjing, Guangxi; Test chicken is 10 age in days partridge chickens; The medicine of Toltrazuril suspended emulsion test group is pressed embodiment 1 preparation, and every 1ml converts water 1kg and drinks water (being equivalent to contain Toltrazuril 25mg in every 1kg water) to chicken; The Toltrazuril matched group stirs by adding Toltrazuril 2.5 grams in every 100kg feedstuff and searches for food (being equivalent to contain Toltrazuril 25mg in every 1kg feedstuff) to chicken.Test used Toltrazuril raw material and come business corporation available from sea, Zhuhai Special Economic Zone profit.Therapeutic outcome sees the following form:
The Toltrazuril suspended emulsion is to chicken coccidiosis therapeutic test result
Visible by last watch test result, cure rate, total effective rate difference extremely remarkable (P＜0.01) between Toltrazuril suspended emulsion test group and the Toltrazuril matched group.The Toltrazuril suspended emulsion has notable therapeutic effect to chicken coccidiosis.
The foregoing description is not to be limitation of the present invention; The those of ordinary skill in relevant technologies field; Under the situation that does not break away from the spirit and scope of the present invention; Can also make various variations and modification, so all technical schemes that are equal to also should belong to category of the present invention, scope of patent protection of the present invention should be limited each claim.
Claims (10)
1. the Toltrazuril suspended emulsion is characterized in that, is processed by the component that comprises following parts by weight:
Toltrazuril 1～5,
Vegetable oil 20～40,
Emulsifying agent 5～20,
Water 74～45.
2. Toltrazuril suspended emulsion according to claim 1 is characterized in that, said vegetable oil comprises a kind of or two or more mixing of Oleum Arachidis hypogaeae semen, soybean oil, Semen Maydis oil, Oleum Camelliae, Oleum Gossypii semen, Oleum Sesami, Oleum Ricini or olive oil.
3. Toltrazuril suspended emulsion according to claim 1 is characterized in that, said emulsifying agent comprises naturally occurring emulsifying agent and surfactant-based emulsifying agent; Naturally occurring emulsifying agent comprises lecithin, tragakanta, arabic gum, gelatin, apricot glue and soybean phospholipid; Surfactant-based emulsifying agent is a non-ionic surface active agent, comprises polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, castor oil polyoxyethylene ether, fatty glyceride, sucrose fatty acid ester and poloxamer.
4. Toltrazuril suspended emulsion according to claim 1 is characterized in that, also comprises auxiliary agent in the said Toltrazuril suspended emulsion; Said auxiliary agent comprises co-emulsifier, emulsifying agent stabilizing agent, suspending agent, antioxidant and/or antibacterial antiseptic.
5. Toltrazuril suspended emulsion according to claim 4 is characterized in that, described co-emulsifier is the nonionic surfactant of medicinal short chain alcohol or suitable HLB value; Comprise ethanol, ethylene glycol, propylene glycol, glycerol, n-butyl alcohol and Polyethylene Glycol.
6. Toltrazuril suspended emulsion according to claim 4 is characterized in that, the emulsifying agent stabilizing agent comprises:
(a) the emulsifying agent stabilizing agent of increase water viscosity: sodium carboxymethyl cellulose, sodium alginate, agar, methylcellulose, hydroxypropyl cellulose, arabic gum, tragakanta, xanthan gum or pectin.
(b) the emulsifying agent stabilizing agent of increase oil phase viscosity: stearic acid or stearyl alcohol, Cera Flava, spermol or glyceryl monostearate.
7. Toltrazuril suspended emulsion according to claim 4; It is characterized in that said suspending agent is sodium carboxymethyl cellulose, polyvinylpyrrolidone, arabic gum, methylcellulose, xanthan gum, molecular weight greater than 2000 Polyethylene Glycol, castor oil hydrogenated or aluminium stearate.
8. Toltrazuril suspended emulsion according to claim 4 is characterized in that, said antioxidant is lipophile antioxidant and water solublity antioxidant, and lipophile antioxidant comprises gallic acid and esters thereof, BHA, BHT, tocopherol; Water solublity antioxidant comprises ascorbic acid, pyrosulfite, sulphite and thiourea.
9. Toltrazuril suspended emulsion according to claim 4 is characterized in that, said antibacterial antiseptic is phenol derivmives blend biology, p-Hydroxybenzoate, phenoxyethanol, benzyl alcohol, methaform, quaternary ammonium compound, sodium benzoate or potassium sorbate.
10. according to the method for preparing of the arbitrary described Toltrazuril suspended emulsion of claim 1-9, it is characterized in that it may further comprise the steps:
(1) gets Toltrazuril and vegetable oil according to the above than row, grind, make oil phase through colloid mill;
(2) take by weighing emulsifying agent and add part water stirring and dissolving, make water;
(3) water is added oil phase, grind mix homogeneously through colloid mill;
(4) add remainder water, stir and promptly get the Toltrazuril suspended emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104478485A CN102512366A (en) | 2011-12-28 | 2011-12-28 | Toltrazuril suspension emulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104478485A CN102512366A (en) | 2011-12-28 | 2011-12-28 | Toltrazuril suspension emulsion and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102512366A true CN102512366A (en) | 2012-06-27 |
Family
ID=46283628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104478485A Pending CN102512366A (en) | 2011-12-28 | 2011-12-28 | Toltrazuril suspension emulsion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102512366A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743334A (en) * | 2012-07-30 | 2012-10-24 | 郑州后羿制药有限公司 | Toltrazuril injection and preparation method thereof |
| CN104288136A (en) * | 2014-04-30 | 2015-01-21 | 郑州百瑞动物药业有限公司 | Chlorhexidine acetate uterus injectant for dairy cow, and preparation method thereof |
| EP2928454B1 (en) | 2012-12-07 | 2020-03-18 | CEVA Santé Animale SA | Triazines for treating protozoan diseases |
| EP3566695B1 (en) | 2012-12-07 | 2020-08-05 | Ceva Sante Animale | Treatment of coccidiosis with intramuscular triazine compositions |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336901A (en) * | 2008-08-07 | 2009-01-07 | 北京伟嘉人生物技术有限公司 | Anti-coccidium microemulsion containing toltrazuril and preparation method thereof |
| CN101766564A (en) * | 2008-12-31 | 2010-07-07 | 青岛中仁药业有限公司 | High-efficiency water-solubility toltrazuril solution and preparation method thereof |
-
2011
- 2011-12-28 CN CN2011104478485A patent/CN102512366A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336901A (en) * | 2008-08-07 | 2009-01-07 | 北京伟嘉人生物技术有限公司 | Anti-coccidium microemulsion containing toltrazuril and preparation method thereof |
| CN101766564A (en) * | 2008-12-31 | 2010-07-07 | 青岛中仁药业有限公司 | High-efficiency water-solubility toltrazuril solution and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郭腾: "动物用抗球虫新药妥曲珠利", 《兽药与饲料添加剂》, vol. 7, no. 5, 31 December 2002 (2002-12-31), pages 16 - 18 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743334A (en) * | 2012-07-30 | 2012-10-24 | 郑州后羿制药有限公司 | Toltrazuril injection and preparation method thereof |
| EP2928454B1 (en) | 2012-12-07 | 2020-03-18 | CEVA Santé Animale SA | Triazines for treating protozoan diseases |
| EP3566695B1 (en) | 2012-12-07 | 2020-08-05 | Ceva Sante Animale | Treatment of coccidiosis with intramuscular triazine compositions |
| CN104288136A (en) * | 2014-04-30 | 2015-01-21 | 郑州百瑞动物药业有限公司 | Chlorhexidine acetate uterus injectant for dairy cow, and preparation method thereof |
| CN104288136B (en) * | 2014-04-30 | 2017-06-23 | 郑州百瑞动物药业有限公司 | A kind of milk cow chlorhexidine acetate uterus injectant and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1074917C (en) | Stable carotenoid emulsions suitable for parenteral administration | |
| CN102440996B (en) | Compound albendazole suspension containing ivermectin nanoemulsion and preparation method thereof | |
| CN101564376B (en) | Decoquinate solid dispersoid and preparation method thereof | |
| CN102512366A (en) | Toltrazuril suspension emulsion and preparation method thereof | |
| CN105766908A (en) | Missible oil preparation taking secbutyl acetate as solvent and preparation method thereof | |
| CN101444484A (en) | Suspension emulsion of florfenicol, preparation method and application thereof | |
| CN101336901B (en) | Anti-coccidium microemulsion containing toltrazuril and preparation method thereof | |
| CN101590055B (en) | Water soluble decoquinate and method for preparing same | |
| CN101982176B (en) | Compound sodium selenite-vitamin E oral nano-emulsion preparation for livestock and preparation method thereof | |
| CN104906044A (en) | Decoquinate nanometer preparation and preparing method and application thereof | |
| Kheawfu et al. | Nanoemulsion: A suitable nanodelivery system of clove oil for anesthetizing Nile tilapia | |
| CN101623255B (en) | Artesunate nanoemulsion drug composition and preparation method thereof | |
| CN102716103A (en) | 2, 2', 6, 6'-tetraisopropyl-4, 4'-2-biphenol soft capsule and method for preparing same | |
| CN104083324B (en) | Veterinary suspoemulsion containing rifaximin as well as preparation method and application thereof | |
| CN103705454A (en) | Oily injection containing valnemulin hydrochloride/poloxamer 407 | |
| CN104069266A (en) | Plant essential oil composition for veterinary use | |
| CN102217633B (en) | Pesticide composition containing sulfoxaflor | |
| CN102805089B (en) | Insect and mite killing composition containing Cyflumetofen and emamectin benzoate | |
| CN106265503A (en) | A kind of high stability diclazuril suspension and preparation method thereof | |
| JP2023053344A (en) | Additive for culture medium containing zwitterion | |
| CN102429918A (en) | Medicinal composition containing florfenicol and tea saponin and preparation method thereof | |
| CN103283740A (en) | Cyantraniliprole-containing pesticidal composition | |
| CN102228055A (en) | Pesticide composite containing fenazaquin | |
| CN114514936A (en) | Application of thiazole thione in preparing bird repellent | |
| CN103830174A (en) | Toltrazuril suspension emulsion and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120627 |