CN102507468A - Online monitoring system in cooperation with array detector - Google Patents
Online monitoring system in cooperation with array detector Download PDFInfo
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- CN102507468A CN102507468A CN2011103201263A CN201110320126A CN102507468A CN 102507468 A CN102507468 A CN 102507468A CN 2011103201263 A CN2011103201263 A CN 2011103201263A CN 201110320126 A CN201110320126 A CN 201110320126A CN 102507468 A CN102507468 A CN 102507468A
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Abstract
The invention discloses an online monitoring system in cooperation with an array detector. The system comprises a detector and a computer system connected with the detector, wherein the detector comprises a probe and an array spectrometer connected with the probe via an optical fiber, and the array spectrometer receives the monitoring information transmitted from the probe and transmits the spectral information in the monitoring information to the computer system. Comparing with the existing technology, the inventive online monitoring system in cooperation with an array detector can realize continuous long-time online monitoring, can simultaneously analyze and display full-wavelength three-dimensional main spectrum of a graph, spectrogram and chromatogram within the spectrometer wavelength range, performs absorption strength superposition to low-concentration or weak absorption samples, reduces interference and improves detection sensitivity.
Description
Technical field
The invention belongs to chemical field, be specifically related to the on-line monitoring system in a kind of Chemical Manufacture.
Background technology
On-line monitoring plays a key effect for the product monitoring and the technology controlling and process of sweat, concentration process, chemosynthesis process, separation and purification process.
In the one-tenth product and concentration process of biofermentation industry, the real-time information of cell concentration detects product quality permanent stable most important with productive rate optimization; In chemical and medicine synthesize, in time and accurately judge and the termination time of reacting effectively to improve reaction efficiency, the optimization course of reaction; In the separation and purification of chemicals and biological sample, correct judgement sample concentration and sample motion state have great importance for accurate acquisition target compound.
In observation process,, prevent that the cell concentration that monitors from changing and influence the fermentation result through observing and analyzing monitoring target; Prevent that concentration time is long or too short, reach just right effect; Prevent the generation of chemical reaction subsidiary reaction, improve chemical reaction efficiency and selectivity; Prevent the loss of sample in the separation and purification, accurately locate sample position.
Common monitoring system normally single wavelength light source or can only be in the light source scope (deuterium lamp 200～600nm; Tungsten lamp 500～800nm) selects a wavelength (like 254nm) to show; Reason is that detector is a single-point, adopts simple fixedly optical filter or monochromator (motor driven grating).
Array spectrometer technology (like 2048 array spectrometers) occurs; Realized that the multi-wavelength absorbance shows simultaneously; The data of the full spectrum of single normally dual wavelength demonstration, collection wavelength (like 254nm) and monitoring wavelength (like 280nm) are (as 200～800nm); Because data volume big (like 1 second sampling rate, per second had the data of 2048*16bit to store and to analyze) is difficult to all preserve and handle.
These reasons cause conventional online monitoring system and software, and function is powerful inadequately in the observation process, in monitoring, lack analytic function; Monitoring time is too short; Observation process is unstable, and complicated Monitoring Data can not effectively keep etc., causes and can not monitor effectively and analyze.
Summary of the invention
The invention provides a kind of solution of the above problems, the on-line monitoring system of the collocation array detector that a kind of monitoring period is long, all band shows in real time is provided.
Technical scheme of the present invention is a kind of on-line monitoring system of the array detector of arranging in pairs or groups; It comprises detector and the computer system that is connected with said detector; It is characterized in that: said detector comprises probe and connects the array spectrometer of said probe through optical fiber, and said array spectrometer transfers to said computer system with spectral information wherein after receiving the monitoring information that said probe transmits.
Preferably, said probe is immersion cell and/or flow cell probe.
Preferably, said array spectrometer is 1024 or 2048 array spectrometers.
Preferably, said computer system comprises:
Data-storage system: receive the spectral information that said array spectrometer transmits, and it is saved to database;
Data analysis system: the spectral information to said array spectrometer transmits is sampled and all band scanning; Obtain and show the data of said array spectrometer; Model according to said array spectrometer is different, can select the three-dimensional master map spectrum of long absorbance of multi-wavelength's scope all-wave or light intensity.
Preferably, the SF of said data analysis system is 1 second.
Preferably, said data analysis system is that X axle, wavelength are the Y axle, show said three-dimensional master map spectrum with the 3D display mode of color showing absorbance with time.
Preferably, said data analysis system also comprises:
Chromatogram module: from said three-dimensional master map spectrum, obtain and show in arbitrary period and the said spectrometer wavelength scope (like the chromatogram of 200～800nm) any wavelength;
Spectrogram module: the spectrogram that from said three-dimensional master map spectrum, obtains and show random time in arbitrary period and the said spectrometer wavelength scope.
Preferably, said chromatogram module can superpose and show the chromatogram of a plurality of periods; Said spectrogram module can superpose and show the spectrogram of a plurality of periods.
Preferably, said chromatogram module is calculated and is shown absorbance or the integrated value of light intensity in the said spectrometer wavelength scope.
Preferably, said chromatogram module is calculated and is shown absorbance ratio and the difference of absorbance in the said spectrometer wavelength scope.
Preferably, said computer system also comprises the output module of outwards connected control system output function instruction.
Preferably, said data-storage system time limit of storing said sampled data is no less than 1 month.
The on-line monitoring system of a kind of array detector of arranging in pairs or groups of the present invention is compared prior art, has following beneficial effect: can be continuously, long-time on-line monitoring; Three-dimensional master map spectrum, spectrogram and the chromatogram can analyze simultaneously, the interior all-wave of display light spectrometer wavelength coverage grown; Low concentration or weak absorption sample are carried out the stack of absorption intensity, reduce and disturb, improve the sensitivity that detects.
Description of drawings
Fig. 1 is the structural representation of the on-line monitoring system of a kind of array detector of arranging in pairs or groups of the present invention;
Fig. 2 is the display mode synoptic diagram of three-dimensional master map spectrum.
Embodiment
Following specific embodiments of the invention is described in further detail.
As shown in Figure 1, the on-line monitoring system of a kind of array detector of arranging in pairs or groups of the present invention comprises light source, immersion cell and/or flow cell probe, array spectrometer and computer system.All connect between light source, probe and the array spectrometer through optical fiber.
The present invention can be applied to on-line monitoring and technology controlling and process in the processes such as sweat, concentration process, chemosynthesis process, separation and purification.During its work, at first the real-time optical information of production run is monitored, after the video information that the array spectrometer receiving transducer transmits, wherein spectral information is transferred to computer system by probe.Wherein, array spectrometer is 2048 array spectrometers, can realize long record of all-wave and analysis to multiple spectral signals such as ultraviolet/visible absorbance, infrared absorption, Raman spectrums.
Computer system comprises:
Data-storage system: the spectral information that the receiving array spectrometer transmits, and it is saved to database; The time limit of data-storage system storage spectral information is no less than 1 month; To make things convenient for the playback analysis;
Data analysis system: the spectral information to said array spectrometer transmits is sampled, and SF is 1 second; Then it is carried out all band scanning; Automatically calculate absorbance after setting absorbance ratio and the absorbance difference under the different wave length; (as: the three-dimensional master map spectrum that 200～800nm) all-waves are long, the three-dimensional master map spectrum of acquisition can show in real time in the spectrometer wavelength scope to obtain.The method of its demonstration is as shown in Figure 2, is that X axle, wavelength are the Y axle, show said three-dimensional master map spectrum with the 3D display mode of color showing absorbance with time.It can also show chromatogram and spectrogram (not shown) up and down synchronously.
Wherein, data analysis system also comprises:
Chromatogram module: from three-dimensional master map spectrum, obtain and show (as: the chromatograms of any wavelength in 200～800nm) in arbitrary period and the spectrometer wavelength scope;
Spectrogram module: from three-dimensional master map spectrum, obtain and show (as: the spectrograms of any wavelength in 200～800nm) in arbitrary period and the spectrometer wavelength scope.
Chromatogram and the stack spectrogram of a plurality of periods of demonstration that data analysis system can superpose when showing chromatogram and show a plurality of periods; So that low concentration or weak absorption sample are carried out the stack of absorption intensity, reduce the interference of noise, thereby Sensitive Detection is to all sample signals.
Computer system also comprises output module, and output module can so just can be realized the production automatic control function according to the outside connected control system output function instruction of monitoring result.
Above embodiment is merely the present invention's a kind of embodiment wherein, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that for the person of ordinary skill of the art under the prerequisite that does not break away from the present invention's design, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with accompanying claims.
Claims (12)
1. the on-line monitoring system of the array detector of arranging in pairs or groups; It comprises detector and the computer system that is connected with said detector; It is characterized in that: said detector comprises probe and connects the array spectrometer of said probe through optical fiber, and said array spectrometer transfers to said computer system with spectral information wherein after receiving the monitoring information that said probe transmits.
2. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 1 is characterized in that: said probe is immersion cell and/or flow cell probe.
3. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 1 is characterized in that: said array spectrometer is 1024 or 2048 array spectrometers.
4. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 1 is characterized in that: said computer system comprises:
Data-storage system: receive the spectral information that said array spectrometer transmits, and it is saved to database;
Data analysis system: the spectral information to said array spectrometer transmits is sampled and all band scanning; Model according to said array spectrometer is different, can obtain and show the absorbance of multi-wavelength's scope all-wave length or the three-dimensional master map spectrum of light intensity.
5. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 4 is characterized in that: the SF of said data analysis system is 1 second.
6. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 4 is characterized in that: said data analysis system is that X axle, wavelength are the Y axle, show said three-dimensional master map spectrum with the 3D display mode of color showing absorbance with time.
7. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 4 is characterized in that: said data analysis system also comprises:
Chromatogram module: the chromatogram that from said three-dimensional master map spectrum, obtains and show any wavelength in arbitrary period and the said spectrometer wavelength scope;
Spectrogram module: the spectrogram that from said three-dimensional master map spectrum, obtains and show random time in arbitrary period and the said spectrometer wavelength scope.
8. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 7 is characterized in that: said chromatogram module can superpose and show the chromatogram of a plurality of periods; Said spectrogram module can superpose and show the spectrogram of a plurality of periods.
9. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 7 is characterized in that: said chromatogram module is calculated and is shown absorbance or the integrated value of light intensity in the said spectrometer wavelength scope.
10. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 7 is characterized in that: said chromatogram module is calculated and is shown absorbance ratio and the difference of absorbance in the said spectrometer wavelength scope.
11. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 1 is characterized in that: said computer system also comprises the output module of outwards connected control system output function instruction.
12. the on-line monitoring system of a kind of array detector of arranging in pairs or groups according to claim 5 is characterized in that: the time limit that said data-storage system is stored said sampled data is no less than 1 month.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102507753A (en) * | 2011-10-21 | 2012-06-20 | 利穗科技(苏州)有限公司 | Chromatogram preparation system matched with array detector |
| CN104007054A (en) * | 2014-06-13 | 2014-08-27 | 南京工业大学 | Device and method for detecting cell concentration on line in biological fermentation process |
| CN104880422A (en) * | 2015-05-06 | 2015-09-02 | 江苏大学 | Signal characterization method of visual array sensor |
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| EP1785719A1 (en) * | 2004-08-31 | 2007-05-16 | Gl Sciences Incorporated | Optical detection method and optical detector |
| US20090153865A1 (en) * | 2007-12-13 | 2009-06-18 | Shimadzu Corporation | Analysis system |
| CN101566564A (en) * | 2009-06-01 | 2009-10-28 | 浙江大学 | Detecting system and method for detecting ethanol concentration by reflecting interference spectrum |
| CN101614659A (en) * | 2009-07-24 | 2009-12-30 | 上海现代中医药技术发展有限公司 | The Chinese medicine leaching process is carried out the apparatus and method of online detection and control |
| CN101614663A (en) * | 2009-07-30 | 2009-12-30 | 浙江大学 | As seen and near infrared spectrum bee pollen variety discriminating |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1785719A1 (en) * | 2004-08-31 | 2007-05-16 | Gl Sciences Incorporated | Optical detection method and optical detector |
| US20090153865A1 (en) * | 2007-12-13 | 2009-06-18 | Shimadzu Corporation | Analysis system |
| CN101566564A (en) * | 2009-06-01 | 2009-10-28 | 浙江大学 | Detecting system and method for detecting ethanol concentration by reflecting interference spectrum |
| CN101614659A (en) * | 2009-07-24 | 2009-12-30 | 上海现代中医药技术发展有限公司 | The Chinese medicine leaching process is carried out the apparatus and method of online detection and control |
| CN101614663A (en) * | 2009-07-30 | 2009-12-30 | 浙江大学 | As seen and near infrared spectrum bee pollen variety discriminating |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102507753A (en) * | 2011-10-21 | 2012-06-20 | 利穗科技(苏州)有限公司 | Chromatogram preparation system matched with array detector |
| CN102507753B (en) * | 2011-10-21 | 2013-09-18 | 利穗科技(苏州)有限公司 | Chromatogram preparation system matched with array detector |
| CN104007054A (en) * | 2014-06-13 | 2014-08-27 | 南京工业大学 | Device and method for detecting cell concentration on line in biological fermentation process |
| CN104880422A (en) * | 2015-05-06 | 2015-09-02 | 江苏大学 | Signal characterization method of visual array sensor |
| CN104880422B (en) * | 2015-05-06 | 2017-06-16 | 江苏大学 | A kind of characterization method of visualized array sensor |
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| CN102507468B (en) | 2013-08-28 |
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