CN102504801A - Irreversible (37 DEG C) thermochromic developer and preparation method thereof - Google Patents

Abstract

The invention provides an irreversible (37 DEG C) thermochromic developer and apreparation method thereof. The irreversible thermochromic developer contains a component A (namely polyvinyl alcohol); a component B selected from methanol, ethanol, propyl alcohol, isopropanol and a combination thereof; a component C (namely an ammonium salt or a compound ammonium salt), and a component E (namely an aqueous solution of sodium carbonate or sodium hydroxide). The preparation method comprise the following steps: (1) loading 84 to 95% (w/w) of the component A and 0.01 to 1.5% (w/w) of the component B in order into a reaction kettle, and slowly and uniformly stirring to thoroughly mix, to obtain a reaction product I; (2) loading 0.001 to 0.5% (w/w) of the component C into the reaction product I, and stirring at a uniform speed for 5 to 15 min under sealed conditions, to obtain a reaction product II, (3) adding 0.01 to 1.5% (w/w) of the component D into the reaction product II, and uniformly stirring, to obtain a reaction product III; and (4) curing the reaction product III for 5 to 10 min under sealed conditions, adding 4 to 15% (w/w) of the component E, and rapidly stirring for 5 to 25 min, to obtain the final product. The invention can be widely applied to biochemical products sensitive to temperature change.

Description

A kind of 37 ℃ can not become developer and preparation method thereof by the backheating warm colour

 

Technical field

The present invention relates to a kind of 37 ℃ and can not become developer and preparation method thereof by the backheating warm colour.

Background technology

Temperature becomes material and is meant within the specific limits, and material is because of being heated or cooling off, and a kind of intelligent material of transformation takes place with temperature variation its color.Existing 37 ℃ of hot warm colours become materials, and mostly its variable color is a reversible, so just can't write down the true death condition of the article of surveying such as blood products, vaccine, biological products etc.Existing in addition temperature becomes material and often uses heavy metallic salt and azo compound, and these materials can cause bigger pollution to environment in process of production.

Summary of the invention

The object of the invention is to provide a kind of 37 ℃ can not become developer and preparation method thereof by the backheating warm colour, and it has highly sensitive; Stability is strong, long service life, the simple advantage of synthesis technique; Simultaneously; It is environment friendly and pollution-free also to have its raw material and technology, and the characteristics that the irreversible look of its product when thermometric becomes can be widely used in fields such as medicine, blood products, biological products, the preservation of vaccine cold chain.

The present invention is achieved in that said a kind of 37 ℃ can not become developer by the backheating warm colour, and it contains:

A material: Z 150PH;

The B material: methyl alcohol, ethanol, propyl alcohol, Virahol, equal portions get one or both or three kinds or four kinds wherein;

C material: black T in Lip river or bromine thymol blue;

D material: ammonium salt or ammonium salt compound;

E material: yellow soda ash or aqueous sodium hydroxide solution.

A kind of 37 ℃ of preparing methods that can not the backheating warm colour become developer according to the invention:

(1) with A material 84-95% (W/W), B material 0.01-1.5% (V/W), successively the adding band stirs in the enamel reaction still, at the uniform velocity stirs slowly, and fully mixing gets reactant one;

(2) C material 0.001-0.5% (W/W) is dropped in the reactant one, sealing was at the uniform velocity stirred 5-15 minutes down, got reactant two;

(3) D material 0.01-1.5% (W/W) is dropped in the reactant two, continue at sealing and stir down, must reactant three;

(4) reactant three sealing slakings after 5-10 minutes, are added E material 4-15 % (V/W), stir 5-25 minutes rapidly after, pack, promptly get 37 ℃ can not backheating warm colour change developer.

The invention has the beneficial effects as follows; It has overcome existing hot warm colour and has become developer mostly into the change of temperature look reversible is, poor with the gradually changeable of product, poor stability and the raw material and the high shortcoming of production cost of production; It is irreversible that its look becomes; Abundant and the environmental protection in starting material source, utilization rate of raw materials reaches 100% in the production process.Can be widely used in temperature variation is required responsive biological products, blood products, vaccine, reagent class, medicine and field of food.

Embodiment

Embodiment one

A kind of 37 ℃ according to the invention can not become developer by the backheating warm colour, and it contains:

A material: Z 150PH;

B material: methyl alcohol, ethanol equal portions two kinds;

C material: black T in Lip river or bromine thymol blue;

D material: a kind of two kinds of arriving equal portions in the ammonium salt;

E material: sodium carbonate solution.

A kind of 37 ℃ of preparing methods that can not the backheating warm colour become developer according to the invention:

(1) with A material 84-95% (W/W), B material 0.01-1.5% (V/W), successively the adding band stirs in the enamel reaction still, at the uniform velocity stirs slowly, and fully mixing gets reactant one;

(2) C material 0.001-0.5% (W/W) is dropped in the reactant one, sealing was at the uniform velocity stirred 5-15 minutes, got reactant two;

(3) D material 0.01-1.5% (W/W) is dropped in the reactant two, continue at sealing and stir down, must reactant three;

(4) reactant three sealing slakings after 5-10 minutes, are added E material 4-15 % (V/W), stir 5-25 minutes rapidly after, pack, promptly get 37 ℃ can not backheating warm colour change developer.

Embodiment two

A kind of 37 ℃ can not become developer by the backheating warm colour, and it contains:

A material: Z 150PH;

The B material: equal portions ethanol Virahol is got it;

C material: black T in Lip river or bromine thymol blue;

D material: ammonium salt compound;

E material: aqueous sodium hydroxide solution.

A kind of 37 ℃ of preparing methods that can not the backheating warm colour become developer:

(1) with A material 84-95% (W/W), B material 0.01-1.5% (V/W), successively the adding band stirs in the enamel reaction still, at the uniform velocity stirs slowly, and fully mixing gets reactant one;

(2) C material 0.001-0.5% (W/W) is dropped in the reactant one, sealing was at the uniform velocity stirred 5-15 minutes, got reactant two;

(3) D material 0.01-1.5% (W/W) is dropped in the reactant two, continue at sealing and stir down, must reactant three;

(4) reactant three sealing slakings after 5-10 minutes, are added E material 4-15 % (V/W), stir 5-25 minutes rapidly after, pack, promptly get 37 ℃ can not backheating warm colour change developer.

Embodiment three

A kind of 37 ℃ can not become developer by the backheating warm colour, and it contains:

A material: Z 150PH;

B material: propyl alcohol; The methyl alcohol equal portions

C material: black T in Lip river or bromine thymol blue;

D material: other ammonium salts;

E material: aqueous sodium carbonate.

A kind of 37 ℃ of preparing methods that can not the backheating warm colour become developer:

(1) with A material 84-95% (W/W), B material 0.01-1.5% (V/W), successively the adding band stirs in the enamel reaction still, at the uniform velocity stirs slowly, and fully mixing gets reactant one;

(2) C material 0.001-0.5% (W/W) is dropped in the reactant one, sealing was at the uniform velocity stirred 5-15 minutes, got reactant two;

(3) D material 0.01-1.5% (W/W) is dropped in the reactant two, continue at sealing and stir down, must reactant three;

(4) reactant three sealing slakings after 5-10 minutes, are added E material 4-15 % (V/W), stir 5-25 minutes rapidly after, pack, promptly get 37 ℃ can not backheating warm colour change developer.

Embodiment four

A kind of 37 ℃ can not become developer by the backheating warm colour, and it contains:

A material: Z 150PH;

The B material: methyl alcohol, ethanol, propyl alcohol, Virahol, equal portions get one or both or three kinds or four kinds wherein;

C material: black T in Lip river or bromine thymol blue;

D material: ammonium salt or ammonium salt compound;

E material: yellow soda ash or aqueous sodium hydroxide solution.

A kind of 37 ℃ of preparing methods that can not the backheating warm colour become developer:

(1) with A material 84-95% (W/W), B material 0.01-1.5% (V/W), successively the adding band stirs in the enamel reaction still, at the uniform velocity stirs slowly, and fully mixing gets reactant one;

(2) C material 0.001-0.5% (W/W) is dropped in the reactant one, sealing was at the uniform velocity stirred 5-15 minutes down, got reactant two;

(3) D material 0.01-1.5% (W/W) is dropped in the reactant two, continue at sealing and stir down, must reactant three;

(4) reactant three sealing slakings after 5-10 minutes, are added E material 4-15 % (V/W), stir 5-25 minutes rapidly after, pack, promptly get 37 ℃ can not backheating warm colour change developer.

The temperature variation indication that the present invention produces is pasted, in 37 ℃ environment, when occurrence temperature changes; Can be through the form of colour-change; Temperature variations in the reaction certain hour scope, and the color after changing is irreversible can monitoring record goes out the temperature variations of the analyte in the certain hour scope; Reflect its biological activity, the quality guaranteed period is played supervisory function bit.

The temperature variation indication that the present invention makes is pasted, can realization response 37 ⁰In the C environment, through 7 days time, the color gradient obvious characteristic was following: by bluish voilet, and--------light green--------yellowish green----light yellow----yellow----deep yellow finishes light yellow green lilac.

So the present invention requires responsive biological products, blood products, vaccine, reagent class, medicine and foodstuff etc. that very important use value is arranged to temperature variation in the time of 37 ℃.

The present invention has overcome and existingly becomes developers at 37 ℃ of hot warm colours and mostly become poor stability and raw material and the higher shortcoming of production cost reversible, production for the temperature look; Have that look becomes irreversible, raw material sources abundant, the notable feature of raw material availability 100% in the production process; Meet green, cleaner production requirement, be convenient to realize suitability for industrialized production.

Claims (2)

1. one kind 37 ℃ can not become developer by the backheating warm colour, and it contains:

A material: Z 150PH;

The B material: methyl alcohol, ethanol, propyl alcohol, Virahol, equal portions get one or both or three kinds or four kinds wherein;

C material: black T in Lip river or bromine thymol blue;

D material: ammonium salt or ammonium salt compound;

E material: yellow soda ash or aqueous sodium hydroxide solution.

2. one kind 37 ℃ preparing methods that can not the backheating warm colour become developer:

(1) with A material 84-95% (W/W), B material 0.01-1.5% (V/W), successively the adding band stirs in the enamel reaction still, at the uniform velocity stirs slowly, and fully mixing gets reactant one;

(2) C material 0.001-0.5% (W/W) is dropped in the reactant one, sealing was at the uniform velocity stirred 5-15 minutes down, got reactant two;

(3) D material 0.01-1.5% (W/W) is dropped in the reactant two, continue at sealing and stir down, must reactant three;

(4) reactant three sealing slakings after 5-10 minutes, are added E material 4-15% (V/W), stir 5-25 minutes rapidly after, pack, promptly get 37 ℃ can not backheating warm colour change developer.