CN102492001A - Method for preparing N-acetyl-D-(+)-glucosamine - Google Patents
Method for preparing N-acetyl-D-(+)-glucosamine Download PDFInfo
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- CN102492001A CN102492001A CN2011104188514A CN201110418851A CN102492001A CN 102492001 A CN102492001 A CN 102492001A CN 2011104188514 A CN2011104188514 A CN 2011104188514A CN 201110418851 A CN201110418851 A CN 201110418851A CN 102492001 A CN102492001 A CN 102492001A
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- glucosamine
- organic amine
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Abstract
The invention provides a method for preparing N-acetyl-D-(+)-glucosamine, which comprises the following steps: performing the replacement reaction of a glucosamine raw material and an organic amine to obtain a glucosamine monomer, wherein the organic amine may be decyl amine, fatty amine or amylamine; adding acetic anhydride to acetylize the glucosamine monomer; filtering out the harmful matters such as bacteria, iron rust and colloid from the glucosamine monomer, and retaining trace elements and minerals, which are good for human body, in water; and performing graded precipitation and filtering, re-dissolving the obtained material and recrystallizing, separating solid from liquid, drying the liquid under vacuum, and obtaining the finished N-acetyl-D-(+)-glucosamine. The preparation method can be carried out at normal temperature. The adoption of the organic amine preparation method and an advanced acetylization technology greatly reduces production cost and makes the process simple and practical, the production process safer and product quality more stable, and the product yield may reach over 99 percent.
Description
Technical field
The present invention relates to biochemical technology, be meant a kind of preparation method of N-acetylglucosamine specifically.
Background technology
The preparation method of existing N-acetylglucosamine; Its concrete technical process is following: add sodium methylate in the GS raw material and carry out replacement(metathesis)reaction, remove the cl ions in the GS, add aceticanhydride again it is carried out acetylize; Remove objectionable impuritiess such as wherein bacterium, iron rust, colloid through ultrafiltration; Connect and after the fractionation precipitation, filtration, weigh cementing crystalline substance and solid-liquid separation again, vacuum-drying gained material later is finished product.
Adopted the sodium methylate method; Make earlier acetylize again behind the monomer of GS, because the extremely unstable of monomer whose, make its technology difficulty very that becomes; All processes all need carried out below 0 ℃; Temperature changes slightly, and quality product is just unstable, and accidents such as whole process is very easily burnt, blast.
Summary of the invention
The present invention provides a kind of preparation method of N-acetylglucosamine, and its main purpose is to solve the problems referred to above that prior art exists.
Technical scheme of the present invention is following:
A kind of preparation method of N-acetylglucosamine may further comprise the steps:
A) organic amine replacement(metathesis)reaction: at first GS raw material and organic amine are carried out replacement(metathesis)reaction, produce the monomer of GS;
B) aceticanhydride acetylize: add aceticanhydride it is carried out acetylize;
C) ultrafiltration: objectionable impuritiess such as wherein bacterium of filtering, iron rust, colloid keep in the water trace element and mineral substance to the human body beneficial;
D) finished product: after carrying out fractionation precipitation again, filtering, the material that obtains weigh the cementing crystalline substance, connects and after the solid-liquid separation, vacuum-drying, the gained article are finished product.
Organic amine in the said step a) can be certain herbaceous plants with big flowers amine or aliphatic amide or amylamine.
This preparation method all can carry out at normal temperatures.
Can know by the above-mentioned description of this invention, compare, the invention has the advantages that with prior art:
The present invention has adopted the organic amine preparation method, and the acetylize technology of application of advanced can reduce production costs greatly, features simple and practical process, and production process is safer, and quality product is also more stable, and yield rate can reach more than 99%.
The present invention designs uniqueness, and is novel, be very practical, so the present invention has wide application prospect.
Embodiment
Embodiment one
Present embodiment is a kind of preparation method of N-acetylglucosamine, may further comprise the steps:
A) organic amine replacement(metathesis)reaction: at first GS raw material and certain herbaceous plants with big flowers amine are carried out replacement(metathesis)reaction, produce the monomer of GS;
B) aceticanhydride acetylize: add aceticanhydride it is carried out acetylize;
C) ultrafiltration: objectionable impuritiess such as wherein bacterium of filtering, iron rust, colloid keep in the water trace element and mineral substance to the human body beneficial;
D) finished product: after carrying out fractionation precipitation again, filtering, the material that obtains weigh the cementing crystalline substance, connects and after the solid-liquid separation, vacuum-drying, the gained article are finished product.
This preparation method all can carry out at normal temperatures.
Embodiment two
Present embodiment is described to be that a kind of preparation method and embodiment one of N-acetylglucosamine is roughly the same, and its key distinction is the replacement(metathesis)reaction of organic amine, and GS raw material and aliphatic amide are carried out replacement(metathesis)reaction, produces the monomer of GS.
Embodiment three
Present embodiment is described to be that a kind of preparation method and embodiment one and embodiment two of N-acetylglucosamine is roughly the same; Its key distinction is the replacement(metathesis)reaction of organic amine; GS raw material and amylamine are carried out replacement(metathesis)reaction, produce the monomer of GS.
The present invention has adopted the organic amine preparation method, and the acetylize technology of application of advanced can reduce production costs greatly, features simple and practical process, and production process is safer, and quality product is also more stable, and yield rate can reach more than 99%.
The present invention designs uniqueness, and is novel, be very practical, so the present invention has wide application prospect.
The above-mentioned embodiment that is merely invention, but design concept of the present invention is not limited thereto allly utilizes this design that the present invention is carried out the change of unsubstantiality, all should belong to the behavior of invading protection domain of the present invention.
Claims (3)
1. the preparation method of a N-acetylglucosamine is characterized in that may further comprise the steps:
A) organic amine replacement(metathesis)reaction: at first GS raw material and organic amine are carried out replacement(metathesis)reaction, produce the monomer of GS;
B) aceticanhydride acetylize: add aceticanhydride it is carried out acetylize;
C) ultrafiltration: objectionable impuritiess such as wherein bacterium of filtering, iron rust, colloid keep in the water trace element and mineral substance to the human body beneficial;
D) finished product: after carrying out fractionation precipitation again, filtering, the material that obtains weigh the cementing crystalline substance, connects and after the solid-liquid separation, vacuum-drying, the gained article are finished product.
2. the preparation method of a kind of N-acetylglucosamine according to claim 1 is characterized in that: the organic amine in the said step a) can be certain herbaceous plants with big flowers amine or aliphatic amide or amylamine.
3. the preparation method of a kind of N-acetylglucosamine according to claim 1 is characterized in that: this preparation method all can carry out at normal temperatures.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104188514A CN102492001A (en) | 2011-12-15 | 2011-12-15 | Method for preparing N-acetyl-D-(+)-glucosamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104188514A CN102492001A (en) | 2011-12-15 | 2011-12-15 | Method for preparing N-acetyl-D-(+)-glucosamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102492001A true CN102492001A (en) | 2012-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011104188514A Pending CN102492001A (en) | 2011-12-15 | 2011-12-15 | Method for preparing N-acetyl-D-(+)-glucosamine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103709208B (en) * | 2014-01-16 | 2016-08-17 | 江苏九寿堂生物制品有限公司 | A kind of preparation method of glucosamine monomer |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004003175A2 (en) * | 2002-07-01 | 2004-01-08 | Arkion Life Sciences Llc | Process and materials for production of glucosamine and n-acetylglucosamine |
| CN1560063A (en) * | 2004-03-10 | 2005-01-05 | 南通双林生物制品有限公司 | Production process of N-acetylamino gluceo metho aldehyde acetal |
| CN1796395A (en) * | 2004-12-22 | 2006-07-05 | 济南海得贝海洋生物工程有限公司 | Method for preparing N - acetyl - D - glucosamine (NAG) |
| US20060178344A1 (en) * | 2001-02-16 | 2006-08-10 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine and methods of making the same fungal biomass |
| CN1836730A (en) * | 2005-03-23 | 2006-09-27 | 王善科 | Intensified additive for chondroitin sulfate capsule formulation and tablet and its preparation method |
| CN1847255A (en) * | 2006-05-17 | 2006-10-18 | 扬州日兴生物化工制品有限公司 | Production process of N-acetyl D-amino glucose |
| CN1907993A (en) * | 2006-08-22 | 2007-02-07 | 王松叶 | Process for preparing refined N-acetyl-D-aminoglucose |
| CN101235058A (en) * | 2008-02-29 | 2008-08-06 | 上海大学 | Method for synthesizing N-acetaminoglucose |
| WO2011060807A1 (en) * | 2009-11-23 | 2011-05-26 | Pharma Base S.A. | Method for producing n-acetyl-d-glucosamine |
-
2011
- 2011-12-15 CN CN2011104188514A patent/CN102492001A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060178344A1 (en) * | 2001-02-16 | 2006-08-10 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine and methods of making the same fungal biomass |
| WO2004003175A2 (en) * | 2002-07-01 | 2004-01-08 | Arkion Life Sciences Llc | Process and materials for production of glucosamine and n-acetylglucosamine |
| CN1560063A (en) * | 2004-03-10 | 2005-01-05 | 南通双林生物制品有限公司 | Production process of N-acetylamino gluceo metho aldehyde acetal |
| CN1796395A (en) * | 2004-12-22 | 2006-07-05 | 济南海得贝海洋生物工程有限公司 | Method for preparing N - acetyl - D - glucosamine (NAG) |
| CN1836730A (en) * | 2005-03-23 | 2006-09-27 | 王善科 | Intensified additive for chondroitin sulfate capsule formulation and tablet and its preparation method |
| CN1847255A (en) * | 2006-05-17 | 2006-10-18 | 扬州日兴生物化工制品有限公司 | Production process of N-acetyl D-amino glucose |
| CN1907993A (en) * | 2006-08-22 | 2007-02-07 | 王松叶 | Process for preparing refined N-acetyl-D-aminoglucose |
| CN101235058A (en) * | 2008-02-29 | 2008-08-06 | 上海大学 | Method for synthesizing N-acetaminoglucose |
| WO2011060807A1 (en) * | 2009-11-23 | 2011-05-26 | Pharma Base S.A. | Method for producing n-acetyl-d-glucosamine |
Non-Patent Citations (1)
| Title |
|---|
| 殷竟洲，等: "N-乙酰-D-氨基葡萄糖的制备条件优化及废液回收利用", 《应用化工》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103709208B (en) * | 2014-01-16 | 2016-08-17 | 江苏九寿堂生物制品有限公司 | A kind of preparation method of glucosamine monomer |
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Application publication date: 20120613 |