CN102485253A - Traditional Chinese medicine composition with characteristics of clearing heat and detoxifying, cooling blood and freeing strangury as well as its preparation method - Google Patents
Traditional Chinese medicine composition with characteristics of clearing heat and detoxifying, cooling blood and freeing strangury as well as its preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with the characteristics of clearing heat and detoxifying, cooling blood and freeing strangury as well as its preparation method, which belongs to the traditional Chinese medicine modernization field. The active component of the composition with the characteristics of clearing heat and detoxifying, cooling blood and freeing strangury comprises the following raw materials by weight part: 174 parts of phellodendron, 174 parts of honeysuckle flower, 174 parts of Chinese goldthread, 348 parts of patrinia herb, 348 parts of heydyotis, 174 parts of radix paeoniae rubrathe, 174 parts of tree peony bark, 174 parts of hairyvein agrimony, 35 parts of plantain seed and 174 parts of rhizoma alismatis. The invention has the advantages that the quality is stable and controllable, compared with the present sold dosage form, the curative effect is substantially enhanced, and the method of the invention possesses substantial economical and social benefit.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and method for preparing of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria, belong to modern Chinese traditional medicine field.
Background technology
The common paruria of urinary tract infection is frequent micturition, urgent micturition, dysurea, also can see urinary incontinence and urine retention.Urinary tract infection shows as paruria, like frequent micturition, urgent micturition, dysurea, urinary incontinence and urine retention; Urine is unusual: urinary tract infection can cause the abnormal change of urine, and common have bacteriuria, pyuria, hematuria and a pneumaturia etc.; Lumbago: lumbago is clinical common sympton.The clinical symptoms of urinary tract infection has had a strong impact on patient's routine work and life.According to incomplete statistics in recent years, have nearly 20% all to suffer from chronic kidney hypofunction among the urinary tract infection patient, and male sexual disorder and sterile symptom also appear in most of patient, have caused social extensive concern.Simultaneously, get into cryptae urethrae owing to lie concealed in endo-urethral antibacterial, paraurethral gland, the urethra bulb, prostate and seminal vesicle portion, deferent duct, epididymis and testis cause inflammation infection.Gonococcal urethritis abbreviates gonorrhea as, is main route of transmission with sexual intercourse.The male that mainly shows of gonorrhea is an acute urethritis, and can invade prostate, epididymis and cowper gland, can send out through blood to cause arthritis, endocarditis even meningitis, also can be diffused into peritoneum and cause hepatitis externa.Aseptic arthritis is brought out in the urethritis meeting, exists the easy catching a cold gene that certain relation is arranged in this disease and the patient's body.Reactive arthritis is the aseptic arthritis of bringing out after urethritis, the cervicitis, like nongonococcai urethritis afterreaction property arthritis, bacterial diarrhea afterreaction property arthritis.Mycoplasma, spirillum, cloth Shandong bacillus, CPN etc. also can bring out reactive arthritis in addition.
Infirmity clear sheet is present commercially available a kind of heat-clearing and toxic substances removing, the Chinese medicine of reducing heat in the blood and treating stranguria.Be used for the disease such as frequent micturition, urgent micturition, dysurea, short urination, lumbago, sagging distention in the smaller abdomen due to the pyretic stranguria.Clinical pharmacodynamic experiment research proof; Infirmity clear sheet is suitable for treating old people's urinary system infection especially; Proving that infirmity clear sheet truly has tangible antiinflammatory, analgesic activity, is the effective Chinese patent medicine that is used to treat urinary system infection, is specially adapted to prevent and treat old prostatosis.
Infirmity clear tablet recipe and method for making are: Cortex Phellodendri 174g, Flos Lonicerae 174g, Rhizoma Coptidis 174g, Herba Patriniae 348g, Herba Hedyotidis Diffusae 348g, Radix Paeoniae Rubra 174g, Cortex Moutan 174g, Herba Agrimoniae 174g, Semen Plantaginis 35g, Rhizoma Alismatis 174g.More than ten flavors, Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae decocting in water twice, each 1 hour, water cooking liquid filtered, filtrating is condensed into the thick paste of relative density 1.25～1.30 (50～60 ℃); Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis filter with 60% alcohol reflux three times, and filtrating is condensed into cream and merges with the water cooking liquid condensed cream, adds the Rhizoma Alismatis fine powder of pulverizing; Mixing, low-temperature vacuum drying is pulverized, and adds starch; Granulate, drying is pressed into 1000, promptly gets.
Infirmity clear sheet preparation technology is simple.The present invention improves technology according to the modern Chinese medicine research method on the basis of existing technology, in the hope of further improving curative effect of medication.
Summary of the invention
First technical problem that the present invention will solve provides a kind of Chinese medicine composition of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
A kind of Chinese medicine composition of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria, its active component is processed by the raw material of following parts by weight: 174 parts of Cortex Phellodendris, 174 parts of Flos Loniceraes, 174 parts of Rhizoma Coptidis, 348 parts of Herba Patriniae, 348 parts of Herba Hedyotidis Diffusaes, 174 parts of Radix Paeoniae Rubra, 174 parts of Cortex Moutans, 174 parts of Herba Agrimoniaes, 35 parts of Semen Plantaginiss, 174 parts of Rhizoma Alismatis.
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 6-12 times of water gaging warm macerating 2-3 time under 60-80 ℃ of condition, and each 0.5-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis use concentration of volume percent that 4-10 doubly measures to be the ethanol extraction of 50%-90% 2-3 time; Each 1-3 hour; Merge extractive liquid, is concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.Dry thing I is active component of the present invention.
Said Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 8-10 times of water gaging warm macerating 2-3 time under 60-80 ℃ of condition, and each 1-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis use concentration of volume percent that 6-8 doubly measures to be the ethanol extraction of 60%-80% 2-3 time, and each 1-2 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 10 times of water gagings warm macerating 2 times under 60 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 60% ethanol extraction 2 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 8 times of amounts, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
Said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of said Chinese medicine composition is a peroral dosage form, includes but not limited to pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of method for preparing of Chinese medicine composition of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria takes by weighing 174 parts of Cortex Phellodendris, 174 parts of Flos Loniceraes, 174 parts of Rhizoma Coptidis, 348 parts of Herba Patriniae, 348 parts of Herba Hedyotidis Diffusaes, 174 parts of Radix Paeoniae Rubra, 174 parts of Cortex Moutans, 174 parts of Herba Agrimoniaes, 35 parts of Semen Plantaginiss, 174 parts of Rhizoma Alismatis; Take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 6-12 times of water gaging warm macerating 2-3 time under 60-80 ℃ of condition, and each 0.5-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis use concentration of volume percent that 4-10 doubly measures to be the ethanol extraction of 50%-90% 2-3 time; Each 1-3 hour; Merge extractive liquid, is concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
Preferred manufacturing procedure is: said Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 8-10 times of water gaging warm macerating 2-3 time under 60-80 ℃ of condition, and each 1-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis use concentration of volume percent that 6-8 doubly measures to be the ethanol extraction of 60%-80% 2-3 time, and each 1-2 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
Most preferred method for preparing is: Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 10 times of water gagings warm macerating 2 times under 60 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 60% ethanol extraction 2 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 8 times of amounts, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
Chinese medicine composition that technical scheme of the present invention is related and preparation thereof all have good heat-clearing and toxic substances removing, the reducing heat in the blood and treating stranguria effect.Be used for the pyretic stranguria due to the damp-heat in lower-JIAO, disease is seen frequent micturition, urgent micturition, dysurea, lumbago, sagging distention in the smaller abdomen.Through zoopery, we find that unexpectedly the pharmaceutical composition of prepared of the present invention is compared with former dosage form, have excellent antiinflammatory, analgesic activity.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, research has obtained the method for preparing of reasonable, stable active component.Adopt technical scheme of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, have remarkable economical and social benefit.
Below specify technical scheme of the present invention through embodiment, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription: Cortex Phellodendri 174g Flos Lonicerae 174g Rhizoma Coptidis 174g Herba Patriniae 348g Herba Hedyotidis Diffusae 348g Radix Paeoniae Rubra 174g Cortex Moutan 174g Herba Agrimoniae 174g Semen Plantaginis 35g Rhizoma Alismatis 174g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 10 times of water gagings warm macerating 2 times under 60 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 60% ethanol extraction 2 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 8 times of amounts, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I and is active component 450 grams of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription: Cortex Phellodendri 1740g Flos Lonicerae 1740g Rhizoma Coptidis 1740g Herba Patriniae 3480g Herba Hedyotidis Diffusae 3480g Radix Paeoniae Rubra 1740g Cortex Moutan 1740g Herba Agrimoniae 1740g Semen Plantaginis 350g Rhizoma Alismatis 1740g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 8 times of water gagings warm macerating 2 times under 80 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 80% ethanol extraction 2 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 6 times of amounts, and each 1.5 hours, merge extractive liquid, was concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I and is active component 3950 grams of the present invention.
Embodiment 3: the preparation Chinese medicine extract
One. prescription: Cortex Phellodendri 174g Flos Lonicerae 174g Rhizoma Coptidis 174g Herba Patriniae 348g Herba Hedyotidis Diffusae 348g Radix Paeoniae Rubra 174g Cortex Moutan 174g Herba Agrimoniae 174g Semen Plantaginis 35g Rhizoma Alismatis 174g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 10 times of water gagings warm macerating 2 times under 60 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 60% ethanol extraction 2 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 8 times of amounts, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I and is active component 430 grams of the present invention.
Embodiment 4: the preparation Chinese medicine extract
One. prescription: Cortex Phellodendri 174g Flos Lonicerae 174g Rhizoma Coptidis 174g Herba Patriniae 348g Herba Hedyotidis Diffusae 348g Radix Paeoniae Rubra 174g Cortex Moutan 174g Herba Agrimoniae 174g Semen Plantaginis 35g Rhizoma Alismatis 174g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 6 times of water gagings warm macerating 3 times under 80 ℃ of conditions, and each 3 hours, merge warm macerating liquid, be concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 50% ethanol extraction 3 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 4 times of amounts, and each 3 hours, merge extractive liquid, was concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I and is active component 480 grams of the present invention.
Embodiment 5: the preparation Chinese medicine extract
One. prescription: Cortex Phellodendri 174g Flos Lonicerae 174g Rhizoma Coptidis 174g Herba Patriniae 348g Herba Hedyotidis Diffusae 348g Radix Paeoniae Rubra 174g Cortex Moutan 174g Herba Agrimoniae 174g Semen Plantaginis 35g Rhizoma Alismatis 174g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 12 times of water gagings warm macerating 2 times under 70 ℃ of conditions, and each 2.5 hours, merge warm macerating liquid, be concentrated into that relative density is 1.07 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 90% ethanol extraction 1 time that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 10 times of amounts, and each 2.5 hours, merge extractive liquid, was concentrated into that relative density is 1.07 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I and is active component 440 grams of the present invention.
Embodiment 6: the preparation Chinese medicine extract
One. prescription: Cortex Phellodendri 174g Flos Lonicerae 174g Rhizoma Coptidis 174g Herba Patriniae 348g Herba Hedyotidis Diffusae 348g Radix Paeoniae Rubra 174g Cortex Moutan 174g Herba Agrimoniae 174g Semen Plantaginis 35g Rhizoma Alismatis 174g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 8 times of water gagings warm macerating 2 times under 80 ℃ of conditions, and each 3 hours, merge warm macerating liquid, be concentrated into that relative density is 1.04 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 80% ethanol extraction 2 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 6 times of amounts, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.04 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I and is active component 460 grams of the present invention.
Embodiment 7: the preparation Chinese medicine extract
One. prescription: Cortex Phellodendri 174g Flos Lonicerae 174g Rhizoma Coptidis 174g Herba Patriniae 348g Herba Hedyotidis Diffusae 348g Radix Paeoniae Rubra 174g Cortex Moutan 174g Herba Agrimoniae 174g Semen Plantaginis 35g Rhizoma Alismatis 174g
Two. method for making:
Take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 10 times of water gagings warm macerating 3 times under 60 ℃ of conditions, and each 1.5 hours, merge warm macerating liquid, be concentrated into that relative density is 1.09 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 80% ethanol extraction 2 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 8 times of amounts, and each 1.5 hours, merge extractive liquid, was concentrated into that relative density is 1.09 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I and is active component 450 grams of the present invention.
Embodiment 8: the preparation tablet
The active component 100g that embodiment 1 obtains adds microcrystalline Cellulose 30g, cross-linked pvp 5g, and tabletting gets tablet, and every is 0.45g.
Embodiment 9: the preparation capsule
The active component 1000g that embodiment 2 obtains adds starch 200g, and the encapsulating capsule gets capsule, and every is 0.50g.
Embodiment 10: effect experiment
1. test material
1.1 laboratory animal:
The ICR mice, body weight 18～22g, male and female half and half are provided by Beijing Vital River Experimental Animals Technology Co., Ltd., the quality certification number: SCXK (capital) 2007-0001.
1.2 medicine and reagent:
Infirmity clear sheet (commercially available article) and infirmity clear extract (pressing embodiment 3 preparations) provide by Longshunrong Pharmaceutical Factory, Tianjin Zhongxin Pharmaceutical Group Co., Ltd.
Infirmity clearing capsule, auspicious South Sea Pharmaceutical Co of Chongqing section
Bamyl (aspirin) (aspirin effervescent tablets), AstraZeneca pharmaceutical Co. Ltd
Glacial acetic acid, Tianjin northization glass purchase and sale center
1.3 instrument:
JA1203N type electronic balance, Shanghai Precision Scientific Apparatus Co., Ltd produces.
2. method and result
2.1 antiinflammatory action (mice auricular concha swelling test)
Get healthy nothing and hinder 60 of mices; Be divided into 6 groups at random: blank group, positive control aspirin group (0.3g/kg), infirmity clear sheet group, infirmity clear extract are low, high dose group, infirmity clearing capsule group, 10 every group, give pure water, infirmity clear sheet (5g crude drug/kg), infirmity clear extract (2.5g crude drug/kg, 5g crude drug/kg) respectively; Infirmity clearing capsule (the 5g crude drug/kg); Continuous 5 days of gastric infusion, the administration volume is 20mL/kg, and the positive drug aspirin is in experiment administration on the same day 1 time.1 hour every mouse right ear both sides is coated with xylene 0.05ml after the last administration.After causing scorching 40 minutes, disconnected neck is put to death animal and is won left and right two ears, downcuts two ear disks with diameter 8mm trepan and weighs, and asks its swelling rate to represent the inflammation degree, and calculates the inflammation suppression ratio.Adopt the SPSS11.0 statistics, the result sees table 1.
Swelling rate=(auris dextra weight left side ear weight)/left ear weight
Inflammation suppression ratio=(administration group swelling rate-blank group swelling rate)/blank group swelling rate
The influence of table 1. pair mice auricular concha inflammation
Compare * P＜0.05 * * P＜0.01 with the blank group
The result shows: (((5g crude drug/kg) all has obvious suppression effect (P＜0.05 to the auricular concha inflammation due to the mice xylene to infirmity clear sheet for 2.5g crude drug/kg, 5g crude drug/kg), infirmity clearing capsule for 5g crude drug/kg), infirmity clear extract; P＜0.01); Under the same dose (the 5g crude drug/kg); The effect of infirmity clear extract slightly is superior to infirmity clear sheet and infirmity clearing capsule, but does not have statistical significance.The infirmity clear extract multiple dosing of prompting new technology has the effect that remarkable inflammation-inhibiting takes place.
2.2 analgesic activity (test of mice acetic acid twisting)
Get healthy nothing and hinder 60 of male mices; Be divided into 6 groups at random: blank group, positive control aspirin group (0.2g/kg), infirmity clear sheet group, infirmity clear extract are low, high dose group, infirmity clearing capsule group, 10 every group, give pure water, infirmity clear sheet (5g crude drug/kg), infirmity clear extract (2.5g crude drug/kg, 5 crude drugs/kg) respectively; Infirmity clearing capsule (the 5g crude drug/kg); Continuous 5 days of gastric infusion, the administration volume is 20mL/kg, and the positive drug aspirin is in experiment administration on the same day 1 time.After after the last administration 30 minutes, lumbar injection 0.6% acetum 0.2ml/, observation and record mice were turned round the body number of times in 15 minutes.Adopt the SPSS11.0 statistics, the result sees table 2.
Suppression ratio=(the blank group is turned round body mean-administration group and turned round the body mean)/blank group is turned round the body mean
The influence of table 2. pair mice acetic acid twisting
With blank group ratio, * P＜0.05, * * P＜0.01; Compare △ P＜0.05 with infirmity clearing capsule
The result shows: (((5g crude drug/kg) all Dichlorodiphenyl Acetate mice pain of bringing out has obvious suppression effect (P＜0.05 to infirmity clear sheet for 2.5g crude drug/kg, 5g crude drug/kg), infirmity clearing capsule for 5g crude drug/kg), infirmity clear extract; P＜0.01); (the 5g crude drug/kg), the effect of infirmity clear extract obviously is superior to infirmity clearing capsule (P＜0.05) under the same dose.The infirmity clear extract multiple dosing of prompting new technology has the effect of remarkable analgesic, and drug effect is better than the infirmity clearing capsule of commercially available article.
Claims (10)
1. the Chinese medicine composition of a heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria, it is characterized in that: its active component is processed by the raw material of following parts by weight: 174 parts of Cortex Phellodendris, 174 parts of Flos Loniceraes, 174 parts of Rhizoma Coptidis, 348 parts of Herba Patriniae, 348 parts of Herba Hedyotidis Diffusaes, 174 parts of Radix Paeoniae Rubra, 174 parts of Cortex Moutans, 174 parts of Herba Agrimoniaes, 35 parts of Semen Plantaginiss, 174 parts of Rhizoma Alismatis.
2. the Chinese medicine composition of a kind of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria according to claim 1 is characterized in that said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 6-12 times of water gaging warm macerating 2-3 time under 60-80 ℃ of condition, and each 0.5-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis use concentration of volume percent that 4-10 doubly measures to be the ethanol extraction of 50%-90% 2-3 time; Each 1-3 hour; Merge extractive liquid, is concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
3. the Chinese medicine composition of a kind of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria according to claim 2 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; Said Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 8-10 times of water gaging warm macerating 2-3 time under 60-80 ℃ of condition, and each 1-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis use concentration of volume percent that 6-8 doubly measures to be the ethanol extraction of 60%-80% 2-3 time, and each 1-2 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
4. the Chinese medicine composition of a kind of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria according to claim 3 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 10 times of water gagings warm macerating 2 times under 60 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 60% ethanol extraction 2 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 8 times of amounts, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
5. according to the Chinese medicine composition of any one described a kind of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria in the claim 1 to 4, it is characterized in that: said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
6. the Chinese medicine composition of a kind of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria according to claim 5 is characterized in that: said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
7. the Chinese medicine composition of a kind of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria according to claim 5 is characterized in that: the dosage form of said Chinese medicine composition is a peroral dosage form, comprises pill, tablet, capsule or oral liquid.
8. the method for preparing of the Chinese medicine composition of a heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria takes by weighing 174 parts of Cortex Phellodendris, 174 parts of Flos Loniceraes, 174 parts of Rhizoma Coptidis, 348 parts of Herba Patriniae, 348 parts of Herba Hedyotidis Diffusaes, 174 parts of Radix Paeoniae Rubra, 174 parts of Cortex Moutans, 174 parts of Herba Agrimoniaes, 35 parts of Semen Plantaginiss, 174 parts of Rhizoma Alismatis; Take by weighing each raw material by proportioning raw materials; Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 6-12 times of water gaging warm macerating 2-3 time under 60-80 ℃ of condition, and each 0.5-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis use concentration of volume percent that 4-10 doubly measures to be the ethanol extraction of 50%-90% 2-3 time; Each 1-3 hour; Merge extractive liquid, is concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
9. the method for preparing of the Chinese medicine composition of a kind of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria according to claim 8 is characterized in that: said Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 8-10 times of water gaging warm macerating 2-3 time under 60-80 ℃ of condition, and each 1-2 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis use concentration of volume percent that 6-8 doubly measures to be the ethanol extraction of 60%-80% 2-3 time, and each 1-2 hour, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
10. the method for preparing of the Chinese medicine composition of a kind of heat-clearing and toxic substances removing reducing heat in the blood and treating stranguria according to claim 8 is characterized in that: Rhizoma Alismatis is pulverized, and gets fine powder A; Flos Lonicerae, Herba Patriniae, Herba Hedyotidis Diffusae, Herba Agrimoniae be with 10 times of water gagings warm macerating 2 times under 60 ℃ of conditions, and each 1 hour, merge warm macerating liquid, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; It is 60% ethanol extraction 2 times that Rhizoma Coptidis, Cortex Phellodendri, Radix Paeoniae Rubra, Cortex Moutan, Semen Plantaginis are used the concentration of volume percent of 8 times of amounts, and each 2 hours, merge extractive liquid, was concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtains concentrated solution C; Fine powder A, concentrated solution B, C are merged, and drying obtains dry thing I.
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| CN103690754A (en) * | 2013-11-28 | 2014-04-02 | 李红冉 | Traditional Chinese medicine for clearing away heat and toxic materials |
| CN104873829A (en) * | 2015-06-17 | 2015-09-02 | 李思佳 | Traditional Chinese medicine preparation for relieving bladder cancer and preparation method thereof |
| CN105412667A (en) * | 2015-12-19 | 2016-03-23 | 林曦之 | Medicinal liquor for treating urine retention and preparation method of medicinal liquor |
| CN105548405A (en) * | 2016-01-19 | 2016-05-04 | 李兴惠 | Method for detecting traditional Chinese medicinal composition and preparation |
| CN107596029A (en) * | 2017-11-09 | 2018-01-19 | 重庆科瑞南海制药有限责任公司 | A kind of Chinese medicine composition for treating the retention of urine and preparation method thereof |
| CN109394923A (en) * | 2018-12-26 | 2019-03-01 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Treat urinary system infection contamination drug and preparation method thereof |
| CN109394922A (en) * | 2018-12-12 | 2019-03-01 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Application of the Chinese medicine in the drug of preparation prevention and/or treatment chronic pelvic inflammatory disease |
| CN109498713A (en) * | 2018-12-12 | 2019-03-22 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Application of the Chinese medicine composition in the drug of preparation prevention and/or treatment atrophic vaginitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103690754A (en) * | 2013-11-28 | 2014-04-02 | 李红冉 | Traditional Chinese medicine for clearing away heat and toxic materials |
| CN104873829A (en) * | 2015-06-17 | 2015-09-02 | 李思佳 | Traditional Chinese medicine preparation for relieving bladder cancer and preparation method thereof |
| CN105412667A (en) * | 2015-12-19 | 2016-03-23 | 林曦之 | Medicinal liquor for treating urine retention and preparation method of medicinal liquor |
| CN105548405A (en) * | 2016-01-19 | 2016-05-04 | 李兴惠 | Method for detecting traditional Chinese medicinal composition and preparation |
| CN107596029A (en) * | 2017-11-09 | 2018-01-19 | 重庆科瑞南海制药有限责任公司 | A kind of Chinese medicine composition for treating the retention of urine and preparation method thereof |
| CN109394922A (en) * | 2018-12-12 | 2019-03-01 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Application of the Chinese medicine in the drug of preparation prevention and/or treatment chronic pelvic inflammatory disease |
| CN109498713A (en) * | 2018-12-12 | 2019-03-22 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Application of the Chinese medicine composition in the drug of preparation prevention and/or treatment atrophic vaginitis |
| CN109394923A (en) * | 2018-12-26 | 2019-03-01 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Treat urinary system infection contamination drug and preparation method thereof |
| CN109394923B (en) * | 2018-12-26 | 2021-07-20 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Medicine for treating urinary system infection and preparation method thereof |
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