CN102458418B - 一种寡核苷酸化合物的制药用途 - Google Patents

一种寡核苷酸化合物的制药用途 Download PDF

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Publication number
CN102458418B
CN102458418B CN201080028245.5A CN201080028245A CN102458418B CN 102458418 B CN102458418 B CN 102458418B CN 201080028245 A CN201080028245 A CN 201080028245A CN 102458418 B CN102458418 B CN 102458418B
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nucleotides
modified
ribonucleotides
nucleotide
ckd
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Expired - Fee Related
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English (en)
Chinese (zh)
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CN102458418A (zh
Inventor
埃琳娜·费因斯坦
斯维特拉娜·亚当斯基
莎伊·埃利克
布鲁斯·莫利托里斯
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US Department of Veterans Affairs
Quark Pharmaceuticals Inc
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US Department of Veterans Affairs
Quark Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201080028245.5A 2009-06-08 2010-06-07 一种寡核苷酸化合物的制药用途 Expired - Fee Related CN102458418B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18493709P 2009-06-08 2009-06-08
US61/184,937 2009-06-08
US23538109P 2009-08-20 2009-08-20
US61/235,381 2009-08-20
PCT/US2010/037565 WO2010144336A2 (en) 2009-06-08 2010-06-07 Methods for treating chronic kidney disease

Publications (2)

Publication Number Publication Date
CN102458418A CN102458418A (zh) 2012-05-16
CN102458418B true CN102458418B (zh) 2015-09-16

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US (2) US8637482B2 (enExample)
EP (2) EP2440214A4 (enExample)
JP (1) JP2012529430A (enExample)
CN (1) CN102458418B (enExample)
CA (1) CA2763537A1 (enExample)
DK (1) DK3276004T3 (enExample)
IL (1) IL216804A0 (enExample)
WO (1) WO2010144336A2 (enExample)

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US9631170B2 (en) 2011-10-06 2017-04-25 University Of Wyoming Genetically inducible hydrogen peroxide resistance and production
ES2704855T3 (es) 2012-09-12 2019-03-20 Quark Pharmaceuticals Inc Moléculas de oligonucleótido de doble cadena para p53 y métodos de uso de las mismas
CA2880290C (en) 2012-09-12 2020-10-27 Quark Pharmaceuticals, Inc. Double-stranded oligonucleotide molecules targeting p53 and methods of use thereof
US9546364B2 (en) 2013-03-15 2017-01-17 Carnegie Mellon University Synthetic lariat RNA for RNA interference
CN104073517A (zh) * 2013-03-28 2014-10-01 卫生部北京医院 p66Shc重组腺病毒载体及构建和应用
MX391220B (es) * 2013-05-14 2025-03-21 Metabolon Inc Biomarcadores relacionados a la funcion renal y metodos para usar los mismos.
SI3444349T1 (sl) * 2014-05-29 2021-07-30 Quark Pharmaceuticals, Inc. Postopki in sestavki za preprečevanje ishemične reperfuzijske poškodbe v organih
GB201413081D0 (en) * 2014-07-23 2014-09-03 Univ Birmingham Markers for AF
ES2627997B1 (es) * 2015-09-18 2018-05-21 Fundación Instituto De Investigación Sanitaria Fundación Jiménez Díaz Uso de una composición farmacéutica para la fabricación de un medicamento para el tratamiento y/o la prevención del daño renal agudo
EP4442200A3 (en) 2016-04-01 2024-12-04 Cardiac Pacemakers, Inc. Multi-disease patient management
WO2018027149A1 (en) * 2016-08-04 2018-02-08 University Of Miami Methods of treating alport syndrome
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
US11771113B2 (en) 2017-05-31 2023-10-03 Mars, Incorporated Methods of diagnosing and treating chronic kidney disease
CN116726173B (zh) * 2022-03-03 2025-09-23 浙江大学 Trpm2抑制剂的用途

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US20080269156A1 (en) * 2007-02-26 2008-10-30 Elena Feinstein Inhibitors of RTP801 and their use in disease treament

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Also Published As

Publication number Publication date
EP3276004A2 (en) 2018-01-31
CA2763537A1 (en) 2010-12-16
EP3276004B1 (en) 2020-03-18
WO2010144336A3 (en) 2011-02-03
IL216804A0 (en) 2012-02-29
WO2010144336A2 (en) 2010-12-16
US8637482B2 (en) 2014-01-28
US20140140922A1 (en) 2014-05-22
DK3276004T3 (da) 2020-04-06
EP2440214A2 (en) 2012-04-18
US20120141378A1 (en) 2012-06-07
EP2440214A4 (en) 2013-07-31
EP3276004A3 (en) 2018-03-14
JP2012529430A (ja) 2012-11-22
CN102458418A (zh) 2012-05-16

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Address after: California, USA

Applicant after: Quark Pharmaceuticals, Inc.

Applicant after: As the representative of the United States Department of Veterans Affairs (Washington, DC)

Address before: California, USA

Applicant before: Quark Pharmaceuticals, Inc.

Applicant before: As the representative of the United States Department of Veterans Affairs (Washington, DC)

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Granted publication date: 20150916