CN102448987B - Anti-VEGF monoclonal antibody and pharmaceutical composition comprising said antibody - Google Patents
Anti-VEGF monoclonal antibody and pharmaceutical composition comprising said antibody Download PDFInfo
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- CN102448987B CN102448987B CN201080018409.6A CN201080018409A CN102448987B CN 102448987 B CN102448987 B CN 102448987B CN 201080018409 A CN201080018409 A CN 201080018409A CN 102448987 B CN102448987 B CN 102448987B
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (12)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201080018409.6A CN102448987B (en) | 2009-08-28 | 2010-08-27 | Anti-VEGF monoclonal antibody and pharmaceutical composition comprising said antibody |
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Application Number | Priority Date | Filing Date | Title |
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CN2009101715509A CN102002104A (en) | 2009-08-28 | 2009-08-28 | Anti-VEGF monoclonal antibody and medicinal composition containing same |
CN200910171550.9 | 2009-08-28 | ||
PCT/CN2010/076420 WO2011023130A1 (en) | 2009-08-28 | 2010-08-27 | Anti-vegf monoclonal antibody and pharmaceutical composition comprising said antibody |
CN201080018409.6A CN102448987B (en) | 2009-08-28 | 2010-08-27 | Anti-VEGF monoclonal antibody and pharmaceutical composition comprising said antibody |
Publications (2)
Publication Number | Publication Date |
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CN102448987A CN102448987A (en) | 2012-05-09 |
CN102448987B true CN102448987B (en) | 2014-06-04 |
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CN2009101715509A Pending CN102002104A (en) | 2009-08-28 | 2009-08-28 | Anti-VEGF monoclonal antibody and medicinal composition containing same |
CN201080018409.6A Active CN102448987B (en) | 2009-08-28 | 2010-08-27 | Anti-VEGF monoclonal antibody and pharmaceutical composition comprising said antibody |
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CN2009101715509A Pending CN102002104A (en) | 2009-08-28 | 2009-08-28 | Anti-VEGF monoclonal antibody and medicinal composition containing same |
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US (1) | US8986692B2 (en) |
EP (1) | EP2471814B1 (en) |
JP (1) | JP5738294B2 (en) |
CN (2) | CN102002104A (en) |
ES (1) | ES2657226T3 (en) |
WO (1) | WO2011023130A1 (en) |
Families Citing this family (20)
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AU2008353479B2 (en) * | 2008-03-26 | 2014-02-20 | Epitomics, Inc. | Anti-VEGF antibody |
CN102002104A (en) | 2009-08-28 | 2011-04-06 | 江苏先声药物研究有限公司 | Anti-VEGF monoclonal antibody and medicinal composition containing same |
CN102875676B (en) * | 2011-07-13 | 2014-11-05 | 无锡天演生物技术有限公司 | Human anti-human VEGF monoclonal antibody molecule and application thereof |
CN103417964A (en) * | 2012-05-17 | 2013-12-04 | 江苏先声药物研究有限公司 | Application of anti-VEGF antibody |
CN103417965B (en) * | 2012-05-17 | 2018-04-13 | 江苏先声药业有限公司 | A kind of pharmaceutical composition containing anti-VEGF antibody |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
ES2833530T3 (en) | 2015-01-06 | 2021-06-15 | Zhuhai Essex Bio Pharmaceutical Co Ltd | Anti-VEGF antibody |
BR112017020948A2 (en) | 2015-03-31 | 2018-07-10 | Ildong Pharm Co., Ltd. | pharmaceutical composition, method for preparing an agent, method for treating an eye disease and use of a fusion protein |
KR102128966B1 (en) | 2015-09-01 | 2020-07-01 | 일동제약(주) | Pharmaceutical compositions for preventing and treating of cancer or angiogenesis related disease comprising fusion protein of tumor penetrating peptide and anti-angiogenesis agent |
JP2018533620A (en) * | 2015-09-14 | 2018-11-15 | ギャラクシー・バイオテック・リミテッド・ライアビリティ・カンパニーGalaxy Biotech, LLC | High titer monoclonal antibody against angiogenic factors |
RU2744860C2 (en) | 2015-12-30 | 2021-03-16 | Кодиак Сайенсиз Инк. | Antibodies and their conjugates |
EP3401331B1 (en) | 2016-01-06 | 2022-04-06 | Order-Made Medical Research Inc. | High-affinity anti-vegf antibody |
JP6925981B2 (en) | 2016-01-06 | 2021-08-25 | 株式会社オーダーメードメディカルリサーチ | Antibodies that block the binding of VEGF to NRP1 |
CN107537036A (en) * | 2016-06-27 | 2018-01-05 | 江苏泰康生物医药有限公司 | A kind of pharmaceutical preparation of human vessel endothelium growth factor resisting monoclonal antibody and its application |
CN110003328B (en) * | 2018-01-05 | 2022-04-19 | 百奥泰生物制药股份有限公司 | Long-acting low-toxicity recombinant anti-VEGF humanized monoclonal antibody and production method thereof |
BR112022001017A2 (en) * | 2019-07-19 | 2022-04-12 | Sinocelltech Ltd | Humanized anti-vegf monoclonal antibody |
AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
TW202246328A (en) * | 2021-02-10 | 2022-12-01 | 大陸商上海濟煜醫藥科技有限公司 | Anti-vegf antibody and application thereof |
CN115850470B (en) * | 2022-12-12 | 2023-07-07 | 三门峡市眼科医院 | VEGF antibodies and uses thereof |
CN116003619B (en) * | 2022-12-12 | 2023-08-04 | 三门峡市眼科医院 | Humanized anti-Ang-2 and VEGF bifunctional antibody and medical application thereof |
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CN101918442A (en) * | 2007-11-30 | 2010-12-15 | 基因技术公司 | VEGF antibody |
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2009
- 2009-08-28 CN CN2009101715509A patent/CN102002104A/en active Pending
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2010
- 2010-08-27 EP EP10811290.5A patent/EP2471814B1/en active Active
- 2010-08-27 US US13/393,185 patent/US8986692B2/en active Active
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- 2010-08-27 CN CN201080018409.6A patent/CN102448987B/en active Active
- 2010-08-27 WO PCT/CN2010/076420 patent/WO2011023130A1/en active Application Filing
Patent Citations (4)
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CN1863818A (en) * | 2003-08-01 | 2006-11-15 | 健泰科生物技术公司 | Anti-VEGF antibodies |
CN102006885A (en) * | 2006-10-20 | 2011-04-06 | 先灵公司 | Fully human anti-vegf antibodies and methods of using |
CN101918442A (en) * | 2007-11-30 | 2010-12-15 | 基因技术公司 | VEGF antibody |
CN102065888A (en) * | 2008-03-26 | 2011-05-18 | 宜康公司 | Anti-VEGF antibody |
Also Published As
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US8986692B2 (en) | 2015-03-24 |
EP2471814A1 (en) | 2012-07-04 |
CN102448987A (en) | 2012-05-09 |
ES2657226T3 (en) | 2018-03-02 |
CN102002104A (en) | 2011-04-06 |
EP2471814A4 (en) | 2013-04-03 |
JP5738294B2 (en) | 2015-06-24 |
EP2471814B1 (en) | 2018-01-03 |
JP2013502445A (en) | 2013-01-24 |
WO2011023130A1 (en) | 2011-03-03 |
US20120231011A1 (en) | 2012-09-13 |
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