CN102441086A - Guiqi blood-nourishing oral liquid - Google Patents
Guiqi blood-nourishing oral liquid Download PDFInfo
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- CN102441086A CN102441086A CN2011103911671A CN201110391167A CN102441086A CN 102441086 A CN102441086 A CN 102441086A CN 2011103911671 A CN2011103911671 A CN 2011103911671A CN 201110391167 A CN201110391167 A CN 201110391167A CN 102441086 A CN102441086 A CN 102441086A
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Abstract
The invention relates to Guiqi blood-nourishing oral liquid. A prescription for the oral liquid is as follows: 100 to 140 g of Chinese angelica, 15 to 25 g of Cyperus Rotundus L (processed), 15 to 25 g of Radix Codonopsis (processed with honey), 15 to 25 g of Radix Astragali (processed with honey), 15 to 25 g of Ligusticum wallichii (processed), 15 to 25 g of white peony root (processed), 30 to 50 g of prepared rehmannia root, 15 to 25 g of licorice (processed with honey) and 15 to 25 g of Poria cocos. A preparation method for the oral liquid comprises the following steps: percolating Chinese angelica and Ligusticum wallichii by using a percolation method for a fluid extract and an extract with ethanol as a solvent and collecting colature; decocting obtained herb residue and the rest of the above-mentioned materials with water, carrying out filtration, combining decoction, condensing filtrate into thick paste, adding ethanol, carrying out uniform stirring, standing and filtration, recovering ethanol, diluting an obtained product with water, adding cane sugar and an antiseptic agent, dissolving the cane sugar and the antiseptic agent under agitation, adding the colature of Chinese angelica and Ligusticum wallichii, adding water until an obtained mixture has a total volume of 1000 ml and carrying out uniform stirring, filtration, filling and disinfection so as to obtain the oral liquid.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation, particularly the Chinese medicine preparation of menstruation regulating blood nourishing medicinal is returned stilbene blood nourishing oral liquid and preparation thereof.
Background technology:
Return the stilbene blood-nourishing syrup to belong to traditional Chinese patent medicine, [function with cure mainly] menstruation regulating blood nourishing medicinal.Be used for menoxenia, anemia is dizzy, postpartum anaemia and weak.20g is prepared from Radix Angelicae Sinensis 120g Rhizoma Cyperi (system) 20g Radix Codonopsis (processed with honey) the 20g Radix Astragali (processed with honey) 20g Rhizoma Chuanxiong (system) the 20g Radix Paeoniae Alba (system) 20g Radix Rehmanniae Preparata 40g Radix Glycyrrhizae (processed with honey) 20g Poria; Existing syrup; Its preparation method is following: above nine flavors; Radix Angelicae Sinensis, Rhizoma Chuanxiong are that solvent carries out percolation with 70% ethanol, collect the about 230ml of liquid that filters; Seven flavor decocte with water secondaries such as medicinal residues and all the other Rhizoma Cyperis, collecting decoction filters, and filtrating is condensed into thick paste; Add 70% ethanol 350ml, stir, leave standstill, filter; Reclaim ethanol, add sucrose 500g, stir and make dissolving medical education net collection arrangement, add an amount of antiseptic, caramel and the Radix Angelicae Sinensis and the liquid of filtering of Rhizoma Chuanxiong; Add water or ethanol makes into 1000ml, filter, promptly get.Character: these article are brown liquid; Gas is fragrant, sweet in the mouth, peppery.Because sugaring 50% in the syrup, so mouthfeel is poor, rich greasy.
For the preparation mouthfeel good return the stilbene blood-nourishing syrup, the present invention has carried out process modification to prior art.
Summary of the invention:
The present invention provides a kind of stilbene blood nourishing oral liquid of returning,
Write out a prescription as follows:
Radix Angelicae Sinensis 100-140g Rhizoma Cyperi (system) 15-25g Radix Codonopsis (processed with honey) 15-25g
The Radix Astragali (processed with honey) 15-25g Rhizoma Chuanxiong (system) the 15-25g Radix Paeoniae Alba (system) 15-25g
Radix Rehmanniae Preparata 30-50g Radix Glycyrrhizae (processed with honey) 15-25g Poria 15-25g
The preferred prescription as follows:
Radix Angelicae Sinensis 120g Rhizoma Cyperi (system) 20g Radix Codonopsis (processed with honey) 20g
The Radix Astragali (processed with honey) 20g Rhizoma Chuanxiong (system) the 20g Radix Paeoniae Alba (system) 20g
Radix Rehmanniae Preparata 40g Radix Glycyrrhizae (processed with honey) 20g Poria 20g
Method for preparing is following: above nine flavors, and Radix Angelicae Sinensis, Rhizoma Chuanxiong are that solvent carries out percolation according to the percolation (appendix I O) under fluid extract and the extractum item with 70% ethanol, collect the about 230ml of liquid that filters; Medicinal residues and all the other Rhizoma Cyperis etc. seven flavor decocte with water secondaries add 10 times in water the 1st time, add 8 times in water, each 1.5 hours, filter collecting decoction for the 2nd time; Filtrating is condensed into thick paste, adds 70% ethanol 350ml, stirs, and leaves standstill, and filters, and reclaims ethanol; Thin up adds sucrose 200g and antiseptic 2g to about 600ml, stirs and makes dissolving, adds the liquid of filtering of Radix Angelicae Sinensis and Rhizoma Chuanxiong, adds water adjustment total amount again to 1000ml; Stir, filter, fill, sterilization promptly gets.
Wherein said antiseptic is selected from: Pyrusussuriensis acids, like sorbic acid, potassium sorbate.Benzoic acids.As: benzoic acid, sodium benzoate.
The present invention screens critical technical parameter on the basis of existing technology, and screening process is following:
(1) Study on extraction
1, the evaluation of medical material and pre-treatment
This institute is with medical material Radix Angelicae Sinensis, Rhizoma Cyperi (system), Radix Astragali Preparata, Radix Codonopsis (processed with honey), Rhizoma Chuanxiong (system), the Radix Paeoniae Alba (system), Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata and Poria; Available from peaceful medical material market, Guangzhou; Differentiate and the assay analysis through appearance character evaluation, thin layer chromatography; Its result of study all meets the pertinent regulations under 2000 editions one each medical material item of Chinese Pharmacopoeia, sees declaration material 8 for details.Radix Angelicae Sinensis, Rhizoma Chuanxiong power are broken into coarse powder, and other medical material cleans remove impurity, or section or cutting.
2, the design of extraction process route
These article are for to return the agent of stilbene blood-nourishing syrup to change kind, do not have in original production process under the change situation of matter and process oral liquid.According to the production technology of returning the stilbene blood-nourishing syrup, confirm the extraction process route of these article, see Fig. 1
3, extraction process technology Study on Conditions
(1) research of decocting condition
1. the moisture content test
Take by weighing Radix Angelicae Sinensis, Rhizoma Cyperi (system), Radix Astragali Preparata, Radix Codonopsis (processed with honey), Rhizoma Chuanxiong (system), the Radix Paeoniae Alba (system), Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata and Poria in the prescription ratio; Add ten times in water, soaked overnight is all soaked into medical material; The unabsorbed water liquid of filtering is tried to achieve water absorption rate and is about 192%.
2. the screening of decocting condition
The former decocting condition of stilbene blood-nourishing syrup of returning is: Radix Angelicae Sinensis, Rhizoma Chuanxiong medicinal residues, Rhizoma Cyperi, Radix Astragali Preparata, Radix Codonopsis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Radix Glycyrrhizae Preparata and Poria decocte with water secondary, amount of water and decocting time are not explained.According to practical condition, confirm that decocting time is 1.5 hours, and amount of water is screened.After Radix Angelicae Sinensis, the Rhizoma Chuanxiong percolation, most of effective ingredient is suggested, so should not be as evaluation index.Main effective ingredient is a peoniflorin in the Radix Paeoniae Alba, therefore adopts the HPLC method to measure content of paeoniflorin in the test sample,, as evaluation index amount of water is screened with the total amount of peoniflorin.
Take by weighing Radix Angelicae Sinensis 60g, Rhizoma Cyperi 10g, Radix Astragali Preparata 10g, Radix Codonopsis 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Alba 10g, Radix Rehmanniae Preparata 20g, Radix Glycyrrhizae Preparata 10g and Poria 10g respectively, totally 4 parts by the prescription usage ratio.Radix Angelicae Sinensis, Rhizoma Chuanxiong are that solvent carries out percolation with 70% ethanol, collect the about 120ml of liquid that filters; Medicinal residues and all the other Rhizoma Cyperis etc. seven flavor adds 12 times in water, 10 times, 8 times and 6 times (also should add 2 times of water absorption rates for the first time) respectively, decocts secondary, and each 1.5 hours, filter, merging filtrate, mixing, measurement volumes promptly gets the 1-4 need testing solution.
A. material and instrument
High performance liquid chromatograph comprises Waters 1525 pumps, 2487 dual pathways UV-detectors, Waters column oven, Breeze liquid chromatograph work station, Brasson ultrasonic cleaning appearance.(Nat'l Pharmaceutical & Biological Products Control Institute supplies assay usefulness, lot number: 0736-200014) to the peoniflorin reference substance.Methanol is U.S. Tedia chromatographically pure, and water is ultra-pure water, and other reagent is analytical pure.
B. chromatographic condition
Chromatographic column: Phenomenex Luna C18 (2), 4.6mm * 150mm, 5 μ m; Column temperature: 35 ℃; Mobile phase: methanol-0.05mol/L potassium dihydrogen phosphate-acetic acid-isopropyl alcohol (67:173:4:4); Detect wavelength: 230nm; Flow velocity: 1ml/min.
C. method and result
The preparation precision of reference substance solution takes by weighing peoniflorin reference substance 4.14mg, puts in the 10ml measuring bottle, with dissolve with methanol and be diluted to scale, shakes up; Precision is measured peoniflorin solution 1ml, puts in the 10ml measuring bottle, adds methanol to scale, shakes up, and promptly gets (every 1ml contains peoniflorin 0.0414mg).
Accurate respectively reference substance solution and each the 5 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid, measure, and promptly get.
The result sees table 1.According to content of paeoniflorin (mg/ml) in the decocting liquid and total amount (mg), amount of water should doubly be good with 8-10, considers the production practical situation, practices thrift water source and energy consumption, reduces production costs, and confirms that amount of water is 8 times, also should add 2 times of water absorption rates for the first time.
The examination of table 1 amount of water
White Peony Root paeoniflorin content: 1.75% peoniflorin total amount: 175mg
(2) concentration technology research
1, decocting liquid concentrates
During the research of laboratory lab scale, decocting liquid straight fire on electric furnace is concentrated into thick paste, and the pilot scale scale-up adopts triple effect to concentrate, and temperature is controlled at about 70 ℃, is concentrated into thick paste (relative density is 1.15-1.20 (70 ℃)).
2, alcoholic solution reclaims and concentrates
During the research of laboratory lab scale, adopt Rotary Evaporators decompression recycling ethanol (60-70 ℃), aqueous solution straight fire on electric furnace is concentrated into does not have the alcohol flavor.The pilot scale scale-up adopts triple effect to concentrate decompression recycling ethanol, and temperature is controlled at about 70 ℃, and being concentrated into does not have the alcohol flavor, and is subsequent use.
(3) preparations shaping Journal of Sex Research
1, the screening of sweeting agent
Oral solutions should have delicious, is prone to, select for use sucrose to be made into variable concentrations respectively and compare for regulating the mouthfeel of these article for the characteristics that patient accepted, and the result sees table 2.
The screening comparative result of table 2 sweeting agent
+ show better; ++ express friendship; +++show is fine
Visible by table 2 result, select sucrose both can improve the taste of oral liquid, and appearance character do not change, and be that 20% o'clock sugariness is best, so the sucrose consumption is 20% during dosing with sucrose.
2, choice of preservatives
Oral liquid is half sterile preparation, and packing is under half aseptic condition, to carry out.In order to guarantee the quality of preparation, prevent the microbial growth breeding, need to add antiseptic.
Kind, consumption to antiseptic carry out analysis-by-synthesis.
Antiseptic is selected for use: sorbic acid, potassium sorbate, benzoic acid, sodium benzoate.
Table 3 antiseptic screening test relatively
| Antibacterial | Mycete | Escherichia coli | Overall merit | |
| Potassium sorbate | Good antimicrobial effect | Generally | Good | Better, but water solublity is low |
| Sorbic acid | Good antimicrobial effect | Generally | Good | Better, good water solubility |
| Benzoic acid | Generally | Effective | Generally | Generally, poorly water-soluble |
| Sodium benzoate | Generally | Effective | Generally | Generally, good water solubility |
Result of the test shows, selects for use sorbic acid better
Through bacteriostatic test, compare the consumption of sorbic acid
The amount ratio of table 4 sorbic acid
Experimental result confirms that finally the consumption of sorbic acid is 0.2%.
Select for use the sorbic acid mouthfeel better, confirm sorbic acid, but adopt potassium sorbate good.
3, pH value
The pH value of medicinal liquid when dosing is about about 4.5, medicinal liquid clarification this moment.For investigating of the influence of different pH value, make an experiment by table 5 to medicinal liquid clarity.
The pH value comparative result of table 5 oral liquid
-: clarification; +: color is little to deepen; ++: darken
Visible by table 5, pH value was at 3～9 o'clock, and medicinal liquid is all clarified.The pH value of medicinal liquid when dosing is about 4.5, and the sterilization no significant change in back is not so these article require the adjustment pH value when preparing.
4, dosing and fill
Concentrated solution behind the recovery ethanol adds sucrose, sorbic acid and percolate, stirs and makes dissolving, adds water or ethanol and is adjusted to required total amount, stirs, filter, and fill, sterilization promptly gets and returns the stilbene blood nourishing oral liquid.
Description of drawings:
Fig. 1 is the process chart of oral liquid of the present invention.
The specific embodiment:
Below further specify the present invention through embodiment, but not as limitation of the present invention.
Embodiment 1
Return the stilbene blood nourishing oral liquid
[prescription]
Radix Angelicae Sinensis 120g Rhizoma Cyperi (system) 20g Radix Codonopsis (processed with honey) 20g
The Radix Astragali (processed with honey) 20g Rhizoma Chuanxiong (system) the 20g Radix Paeoniae Alba (system) 20g
Radix Rehmanniae Preparata 40g Radix Glycyrrhizae (processed with honey) 20g Poria 20g
[method for making] above nine flavors, Radix Angelicae Sinensis, Rhizoma Chuanxiong are that solvent carries out percolation according to the percolation (appendix I O) under fluid extract and the extractum item with 70% ethanol, collect the about 230ml of liquid that filters; Medicinal residues and all the other Rhizoma Cyperis etc. seven flavor decocte with water secondaries add 10 times in water the 1st time, add 8 times in water, each 1.5 hours, filter collecting decoction for the 2nd time; Filtrating is condensed into thick paste, adds 70% ethanol 350ml, stirs, and leaves standstill, and filters, and reclaims ethanol; Thin up adds sucrose 200g and sorbic acid 2g to about 600ml, stirs and makes dissolving, adds the liquid of filtering of Radix Angelicae Sinensis and Rhizoma Chuanxiong, adds water adjustment total amount again to 1000ml; Stir, filter, fill, sterilization promptly gets.
Embodiment 2
Radix Angelicae Sinensis 100g Rhizoma Cyperi (system) 15g Radix Codonopsis (processed with honey) 15g
The Radix Astragali (processed with honey) 15g Rhizoma Chuanxiong (system) the 15g Radix Paeoniae Alba (system) 15g
Radix Rehmanniae Preparata 30g Radix Glycyrrhizae (processed with honey) 15g Poria 15g
[method for making] above nine flavors, Radix Angelicae Sinensis, Rhizoma Chuanxiong are that solvent carries out percolation according to the percolation (appendix I O) under fluid extract and the extractum item with 70% ethanol, collect the about 230ml of liquid that filters; Medicinal residues and all the other Rhizoma Cyperis etc. seven flavor decocte with water secondaries add 10 times in water the 1st time, add 8 times in water, each 1.5 hours, filter collecting decoction for the 2nd time; Filtrating is condensed into thick paste, adds 70% ethanol 350ml, stirs, and leaves standstill, and filters, and reclaims ethanol; Thin up adds sucrose 200g and sorbic acid 2g to about 600ml, stirs and makes dissolving, adds the liquid of filtering of Radix Angelicae Sinensis and Rhizoma Chuanxiong, adds water adjustment total amount again to 1000ml; Stir, filter, fill, sterilization promptly gets.
Embodiment 3
Radix Angelicae Sinensis 140g Rhizoma Cyperi (system) 25g Radix Codonopsis (processed with honey) 25g
The Radix Astragali (processed with honey) 25g Rhizoma Chuanxiong (system) the 25g Radix Paeoniae Alba (system) 25g
Radix Rehmanniae Preparata 50g Radix Glycyrrhizae (processed with honey) 25g Poria 25g
[method for making] above nine flavors, Radix Angelicae Sinensis, Rhizoma Chuanxiong are that solvent carries out percolation according to the percolation (appendix I O) under fluid extract and the extractum item with 70% ethanol, collect the about 230ml of liquid that filters; Medicinal residues and all the other Rhizoma Cyperis etc. seven flavor decocte with water secondaries add 10 times in water the 1st time, add 8 times in water, each 1.5 hours, filter collecting decoction for the 2nd time; Filtrating is condensed into thick paste, adds 70% ethanol 350ml, stirs, and leaves standstill, and filters, and reclaims ethanol; Thin up adds sucrose 200g and sorbic acid 2g to about 600ml, stirs and makes dissolving, adds the liquid of filtering of Radix Angelicae Sinensis and Rhizoma Chuanxiong, adds water adjustment total amount again to 1000ml; Stir, filter, fill, sterilization promptly gets.
Claims (10)
1. return the stilbene blood nourishing oral liquid for one kind, it is write out a prescription as follows:
Radix Angelicae Sinensis 100-140g Rhizoma Cyperi (system) 15-25g Radix Codonopsis (processed with honey) 15-25g
The Radix Astragali (processed with honey) 15-25g Rhizoma Chuanxiong (system) the 15-25g Radix Paeoniae Alba (system) 15-25g
Radix Rehmanniae Preparata 30-50g Radix Glycyrrhizae (processed with honey) 15-25g Poria 15-25g
Method for preparing is following: above nine flavors, and Radix Angelicae Sinensis, Rhizoma Chuanxiong are that solvent carries out percolation according to the percolation (appendix I O) under fluid extract and the extractum item with 70% ethanol, collect the about 230ml of liquid that filters; Medicinal residues and all the other Rhizoma Cyperis etc. seven flavor decocte with water secondaries add 10 times in water the 1st time, add 8 times in water, each 1.5 hours, filter collecting decoction for the 2nd time; Filtrating is condensed into thick paste, adds 70% ethanol 350ml, stirs, and leaves standstill, and filters, and reclaims ethanol; Thin up adds sucrose 200g and antiseptic 2g to about 600ml, stirs and makes dissolving, adds the liquid of filtering of Radix Angelicae Sinensis and Rhizoma Chuanxiong, adds water adjustment total amount again to 1000ml; Stir, filter, fill, sterilization promptly gets.
2. return the stilbene blood nourishing oral liquid for one kind, it is write out a prescription as follows:
Radix Angelicae Sinensis 120g Rhizoma Cyperi (system) 20g Radix Codonopsis (processed with honey) 20g
The Radix Astragali (processed with honey) 20g Rhizoma Chuanxiong (system) the 20g Radix Paeoniae Alba (system) 20g
Radix Rehmanniae Preparata 40g Radix Glycyrrhizae (processed with honey) 20g Poria 20g
Method for preparing is following: above nine flavors, and Radix Angelicae Sinensis, Rhizoma Chuanxiong are that solvent carries out percolation according to the percolation (appendix I O) under fluid extract and the extractum item with 70% ethanol, collect the about 230ml of liquid that filters; Medicinal residues and all the other Rhizoma Cyperis etc. seven flavor decocte with water secondaries add 10 times in water the 1st time, add 8 times in water, each 1.5 hours, filter collecting decoction for the 2nd time; Filtrating is condensed into thick paste, adds 70% ethanol 350ml, stirs, and leaves standstill, and filters, and reclaims ethanol; Thin up adds sucrose 200g and antiseptic 2g to about 600ml, stirs and makes dissolving, adds the liquid of filtering of Radix Angelicae Sinensis and Rhizoma Chuanxiong, adds water adjustment total amount again to 1000ml; Stir, filter, fill, sterilization promptly gets.
3. oral liquid according to claim 1 is characterized in that, said antiseptic is selected from: Pyrusussuriensis acids, benzoic acids.
4. oral liquid according to claim 3 is characterized in that, said Pyrusussuriensis acids is selected from: sorbic acid, potassium sorbate.
5. oral liquid according to claim 3 is characterized in that, said benzoic acids is selected from: benzoic acid, sodium benzoate.
6. claim 1 or 2 any method for preparinies of returning the stilbene blood nourishing oral liquid; It is characterized in that step is following: above nine flavors, Radix Angelicae Sinensis, Rhizoma Chuanxiong are according to the percolation (appendix I O) under fluid extract and the extractum item; With 70% ethanol is that solvent carries out percolation, collects the about 230ml of liquid that filters; Medicinal residues and all the other Rhizoma Cyperis etc. seven flavor decocte with water secondaries add 10 times in water the 1st time, add 8 times in water, each 1.5 hours, filter collecting decoction for the 2nd time; Filtrating is condensed into thick paste, adds 70% ethanol 350ml, stirs, and leaves standstill, and filters, and reclaims ethanol; Thin up adds sucrose 200g and antiseptic 2g to about 600ml, stirs and makes dissolving, adds the liquid of filtering of Radix Angelicae Sinensis and Rhizoma Chuanxiong, adds water adjustment total amount again to 1000ml; Stir, filter, fill, sterilization promptly gets.
7. according to the method for preparing of claim 6, it is characterized in that wherein thickening temperature is controlled at about 70 ℃, be concentrated into thick paste (relative density is 1.15-1.20 (70 ℃)).
8. according to the method for preparing of claim 6, it is characterized in that the pH value of its herb liquid when dosing is 3-9.
9. according to the method for preparing of claim 6, it is characterized in that the pH value of its herb liquid when dosing is 4.5.
10. return the stilbene blood nourishing oral liquid for one kind, it is write out a prescription as follows:
Radix Angelicae Sinensis 120g Rhizoma Cyperi (system) 20g Radix Codonopsis (processed with honey) 20g
The Radix Astragali (processed with honey) 20g Rhizoma Chuanxiong (system) the 20g Radix Paeoniae Alba (system) 20g
Radix Rehmanniae Preparata 40g Radix Glycyrrhizae (processed with honey) 20g Poria 20g
Method for making: above nine flavors, Radix Angelicae Sinensis, Rhizoma Chuanxiong are that solvent carries out percolation according to the percolation (appendix I O) under fluid extract and the extractum item with 70% ethanol, collect the about 230ml of liquid that filters; Medicinal residues and all the other Rhizoma Cyperis etc. seven flavor decocte with water secondaries add 10 times in water the 1st time, add 8 times in water, each 1.5 hours, filter collecting decoction for the 2nd time; Filtrating is condensed into thick paste, adds 70% ethanol 350ml, stirs, and leaves standstill, and filters, and reclaims ethanol; Thin up adds sucrose 200g and sorbic acid 2g to about 600ml, stirs and makes dissolving, adds the liquid of filtering of Radix Angelicae Sinensis and Rhizoma Chuanxiong, adds water adjustment total amount again to 1000ml; Stir, filter, fill, sterilization promptly gets.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011103911671A CN102441086A (en) | 2011-11-30 | 2011-11-30 | Guiqi blood-nourishing oral liquid |
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| CN2011103911671A CN102441086A (en) | 2011-11-30 | 2011-11-30 | Guiqi blood-nourishing oral liquid |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108079113A (en) * | 2018-01-29 | 2018-05-29 | 江西青春康源制药有限公司 | A kind of pharmaceutical composition for treating the postpartum deficiency of blood and preparation method thereof |
| CN110812428A (en) * | 2019-10-14 | 2020-02-21 | 中山市恒生药业有限公司 | Guiqi blood nourishing oral liquid and preparation method thereof |
| CN114831932A (en) * | 2022-04-11 | 2022-08-02 | 中山市恒生药业有限公司 | Ginseng and astragalus extract concentrated solution, ginseng and astragalus oral liquid and preparation method thereof |
| CN116077554A (en) * | 2022-11-29 | 2023-05-09 | 神威药业集团有限公司 | Preparation method of Guanxinning composition |
-
2011
- 2011-11-30 CN CN2011103911671A patent/CN102441086A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国卫生部药典委员会: "《卫生部药品标准中药成方制剂第14册》", 31 December 1997 * |
| 黄新刚: "归芪养血糖浆的制备质量控制研究", 《中华实用中西医杂志》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108079113A (en) * | 2018-01-29 | 2018-05-29 | 江西青春康源制药有限公司 | A kind of pharmaceutical composition for treating the postpartum deficiency of blood and preparation method thereof |
| CN110812428A (en) * | 2019-10-14 | 2020-02-21 | 中山市恒生药业有限公司 | Guiqi blood nourishing oral liquid and preparation method thereof |
| CN114831932A (en) * | 2022-04-11 | 2022-08-02 | 中山市恒生药业有限公司 | Ginseng and astragalus extract concentrated solution, ginseng and astragalus oral liquid and preparation method thereof |
| CN114831932B (en) * | 2022-04-11 | 2023-08-08 | 中山市恒生药业有限公司 | Ginseng and astragalus extract concentrated solution, ginseng and astragalus oral liquid and preparation method thereof |
| CN116077554A (en) * | 2022-11-29 | 2023-05-09 | 神威药业集团有限公司 | Preparation method of Guanxinning composition |
| CN116077554B (en) * | 2022-11-29 | 2023-12-26 | 神威药业集团有限公司 | Preparation method of Guanxinning composition |
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Application publication date: 20120509 |