CN102440197B - Stupid-rat-maze-type intelligence rehabilitation training device - Google Patents
Stupid-rat-maze-type intelligence rehabilitation training device Download PDFInfo
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- CN102440197B CN102440197B CN 201010506111 CN201010506111A CN102440197B CN 102440197 B CN102440197 B CN 102440197B CN 201010506111 CN201010506111 CN 201010506111 CN 201010506111 A CN201010506111 A CN 201010506111A CN 102440197 B CN102440197 B CN 102440197B
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Abstract
The invention provides a stupid-rat-maze-type intelligence rehabilitation training device, comprising multiple layers of training cages, the multiple layers of training cages are arranged up and down in a laminating way, adjacent training cages are mutually nested and connected and are communicated by virtue of a ladder; a maze is arranged in each training cage, the mazes comprise relaxation mazes, plug board mazes, elevated anxiety mazes and escape hole mazes, and the mazes can be combined and arranged at will. In the invention, natural behavioral expression of conditioned response of a stupid rate to construct a voluntary activity maze learning memory training device, improvement of stupid rat behaviour function expression is promoted by virtue of a learning memory maze training space which is fresh, changeable, interesting, comfortable and ready to activities, spatial learning capability and memory capability are improved, search capability and retelling capability of an animal can be more accurately and objectively reflected, the stupid-rat-maze-type intelligent rehabilitation training device provided by the invention is beneficial to improvement and evaluation on learning and memory functions of senile dementia, and rehabilitation process is sped up, thus the stupid-rat-maze-type intelligence rehabilitation training device provided by the invention has great significance.
Description
Technical field
The present invention relates to a kind of analog training device, relate in particular to a kind of Stupid-rat-maze-type intelligence rehabilitation training device.
Background technology
Senile dementia mainly comprises Alzheimer ' s disease and vascular dementia, is the elderly's one of the most serious disease that disables, and therefore the learning and memory method of rehabilitation of senile dementia being sought and studied is a pressing problem of Medical circle.
Inside psychology and the intelligence of humans and animals can't observe directly, and can only infer the process that occurs in brain according to interval certain hour after observable irritant reaction and a certain task of execution.Good animal model is the basis of carrying out this disease research.Set up the senile dementia animal model essence and the rehabilitation of being familiar with disease had extremely important effect.Therefore developing a kind of medical institutions, scientific research institution can widely used dementia rats intellectual rehabilitation trainer, significant.
Labyrinth is by the stimulation to each sense organ, make the restructuring of cortex somatesthesia moving loop, the plastic enhancings of brain function such as mouse structure plasticity, learning and memory are all had a significant effect, sensorimotor and learning and memory function are enhanced, for delaying senility, promote intelligence, certain effect being arranged also, is a kind of simple and effective therapy rehabilitation means.At present, medical institutions use wind, illumination, electric shock class labyrinth to force mouse remember and run away mostly, and strong to the mouse excitant, nocuity is large; Also some research institution uses water maze, mouse is forced be placed in water, utilized mouse not like nature movable in water force mouse to remember and climb disembarkation, all mouse will be dried up after training each time or test, operation is trouble, and is often more with the rear sick mouse of training after tested.Above labyrinth all has the mandatory of stimulus to the sense organ; not only a kind of punishment to mouse; be unfavorable for protection of animals; and easily cause stewed mental element; be difficult to get rid of the non-study factors such as dyskinesia, injury of self to the impact of experiment observation index; affect test accuracy, seek for the learning and memory method of rehabilitation of senile dementia disease and research brings difficulty.
Summary of the invention
Purpose of the present invention exactly in order to address the above problem, provides a kind of Stupid-rat-maze-type intelligence rehabilitation training device.
In order to achieve the above object, the present invention has adopted following technical scheme: a kind of Stupid-rat-maze-type intelligence rehabilitation training device, comprise multilayer training cage, and multilayer training cage stacked on top of one another arranges, and mutually nestedly between adjacent training cage is connected and is communicated with by ladder; Be provided with the labyrinth in described training cage, described labyrinth comprises leisure labyrinth, plate labyrinth, overhead anxiety labyrinth and refuge pocket labyrinth, but any combination setting of various labyrinths.
Described leisure labyrinth comprises duct type labyrinth and crock formula labyrinth; The duct type labyrinth comprises a plurality of threading a pipe of two passwaies that have at least more, and the ladder of upwards climbing for mouse is installed in pipeline; Crock formula labyrinth comprises the large crock of a plurality of young tripes, and at the bottom of being provided with a plurality of rope ladders and extending to cage from the top oral area of each crock respectively, wherein is stamped lid on the mouth of some crock, there is no lid on the mouth of other crocks.
Described plate labyrinth comprises the horizontal plate of polylith, the vertical plate of polylith and polylith baffle plate; Be equipped with a plurality of equally spaced door openings on each horizontal plate and each vertical plate and be used for the draw-in groove that mutual sleeve is connected, be connected to be staggered by corresponding draw-in groove sleeve between each horizontal plate and each vertical plate and form a plurality of criss-cross rooms, the polylith baffle plate optionally hangs over the door opening that blocks this plate on different plates, thereby form the labyrinth of different routes, comprise the labyrinth of T-shaped route, U-shaped route, cross route.
described overhead anxiety labyrinth is to set up an overhead annex to form on the board plug type labyrinth, take two-layer training cage, high shelf attachment will be positioned at the sealing suitable for reading in corresponding criss-cross room in the board plug type labyrinth of its below, overhead annex comprises that an overhead long slab and two hide the unit, hiding the unit for two is symmetricly set on the both sides of overhead long slab and forms decussate texture with overhead long slab, hiding the unit for two respectively comprises two criss-cross rooms and be respectively equipped with door opening on each dividing plate that distributes along its length, each door opening optionally blocks with baffle plate, hiding unit inside bottom for two is respectively equipped with ladder and leads to following board plug type labyrinth.
Described refuge pocket labyrinth is to establish that a refuge pocket is dull and stereotyped to be formed the high shelf attachment in overhead anxiety labyrinth is added, and the surrounding of refuge pocket flat board is provided with a plurality of duck eyes that penetrate platform, and one of them duck eye has one that ladder leads in high shelf attachment to hide the unit.
The present invention utilizes the non-human act performance of the conditioned reflex of dementia rats, build voluntary activity maze learning memory training device, utilization by fresh changeable, entertaining is comfortable, be happy to movable learning and memory labyrinth space, promote the improvement of dementia form mouse behavioral function performance, improve Spatial learning ability, memory capability, relatively accurately reflect objectively search capability and the repetition ability of animal, the learning and memory function that is conducive to senile dementia improves and evaluation, accelerate the rehabilitation process, significant.
Stupid-rat-maze-type intelligence rehabilitation training device of the present invention makes it have following advantage and disadvantage owing to having adopted above technical scheme:
(1) all detachably assemblings of cage and labyrinth, the convenient cleaning carried.
(2) the leisure labyrinth comprises duct type labyrinth, crock formula labyrinth etc.
(3) the board plug type labyrinth can conveniently be transformed into T-shaped, U-shaped, cross labyrinth, the different difficulty labyrinth of route arbitrarily.
(4) board plug type labyrinth and corresponding accessory are used in combination and can construct overhead anxiety labyrinth, refuge pocket labyrinth etc.
Description of drawings
Fig. 1 is the general structure schematic diagram of Stupid-rat-maze-type intelligence rehabilitation training device of the present invention;
Fig. 2 is the structural representation in the leisure labyrinth in the present invention;
Fig. 3 is the structural representation of the horizontal plate in the present invention, vertical plate and baffle plate;
Fig. 4 is the structural representation in the T-shaped labyrinth in the present invention;
Fig. 5 is the structural representation in the U-shaped labyrinth in the present invention;
Fig. 6 is the structural representation in the cross labyrinth in the present invention;
Fig. 7 is the structural representation in the different difficulty labyrinth of any route in the present invention;
Fig. 8 is the partial structurtes schematic diagram in the overhead anxiety labyrinth in the present invention;
Fig. 9 is the partial structurtes schematic diagram in the refuge pocket labyrinth in the present invention.
Embodiment
Below in conjunction with accompanying drawing, Stupid-rat-maze-type intelligence rehabilitation training device of the present invention is described further, accompanying drawing is depicted as a preferred embodiment of the present invention, the invention is not restricted to the present embodiment.
Referring to Fig. 1, Stupid-rat-maze-type intelligence rehabilitation training device of the present invention comprises multilayer training cage 1,2,3,4, and multilayer training cage stacked on top of one another arranges, and mutually nestedly between adjacent training cage is connected and is communicated with by ladder; Training is provided with the labyrinth in cage, comprises leisure labyrinth, plate labyrinth, overhead anxiety labyrinth and refuge pocket labyrinth, but any combination setting of various labyrinths.The basic structure of each training cage comprises one with rectangular frame and a base plate of peep hole, and the labyrinth is arranged on base plate.Be provided with a cover plate on the superiors' training cage.
Referring to Fig. 2, the leisure labyrinth in the present invention comprises duct type labyrinth 11 and crock formula labyrinth 12; Duct type labyrinth 11 comprises a plurality of threading a pipe of two passwaies that have at least, such as two-way pipeline, three-way pipeline, four-way pipeline, five-way pipeline etc. more.In the vertical pipeline that arranges, the ladder of upwards climbing for mouse is installed.Crock formula labyrinth 12 comprises the large crock of a plurality of young tripes, and at the bottom of being provided with a plurality of rope ladders 13 and extending to cage from the top oral area of each crock respectively, wherein is stamped lid 14 on the mouth of some crock, there is no lid on the mouth of other crocks.The crock the inside of being stamped lid does not have food, does not have the crock the inside of lid that food is housed, and mouse is down below the time, can't see crock whether lid is arranged, could find after can only climbing up rope ladder, mouse is by after the study of a period of time, can nature remembers and makes great efforts to climb the crock that food is housed.
Referring to Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, the plate labyrinth in the present invention comprise the horizontal plate 21(of polylith referring to Fig. 3 a), the vertical plate 22(of polylith is referring to Fig. 3 b) and polylith baffle plate 23(referring to Fig. 3 c); Be equipped with on each horizontal plate 21 and each vertical plate 22 a plurality of equally spaced door openings 211,221 with the draw-in groove 212,222 that is used for mutual sleeve and is connected, be connected to be staggered by corresponding draw-in groove sleeve between each horizontal plate 21 and each vertical plate 22 and form a plurality of criss-cross room 24, polylith baffle plate 23 optionally hangs over the door opening that blocks this plate on different plates, thereby form the labyrinth of different routes, comprise the labyrinth of T-shaped route, U-shaped route, cross route.Figure 4 shows that T-shaped route labyrinth, Figure 5 shows that U-shaped route labyrinth, Figure 6 shows that cross route labyrinth, Figure 7 shows that any route labyrinth.The labyrinth that all kinds of difficulty are different can progressively improve spatial memory capacity and the abilities such as resolving ability, learning cognition of ill mouse.The high size of whole length and width in board plug type labyrinth generally can be climbed up and over height according to the area of layer, mouse size and its and be decided.The board plug type labyrinth is detachable, and convenient the cleaning installed, and can place diet box as award at place, unit, required labyrinth, also can place telescopic ladder, expands activity space.
referring to Fig. 8, overhead anxiety labyrinth in the present invention is to set up an overhead annex to form on the board plug type labyrinth, take two-layer training cage, high shelf attachment will be positioned at the sealing suitable for reading in corresponding criss-cross room in the board plug type labyrinth of its below, overhead annex comprises that an overhead long slab 31 and two hide unit 32, hiding unit 32 for two is symmetricly set on the both sides of overhead long slab 31 and forms decussate texture with overhead long slab, hiding the unit for two respectively comprises two criss-cross rooms and be respectively equipped with door opening 33 on each dividing plate that distributes along its length, each door opening optionally blocks with baffle plate, hiding two of unit for two hides the unit inside bottom and is respectively equipped with ladder and leads to following board plug type labyrinth.The high-altitude anxiety of ill mouse can be progressively improved in overhead anxiety labyrinth, improves the abilities such as memory capability and escape conditioned reflex.
Referring to Fig. 9, refuge pocket labyrinth in the present invention is that the added refuge pocket dull and stereotyped 41 of establishing of high shelf attachment in overhead anxiety labyrinth forms, the surrounding of refuge pocket flat board 41 is provided with a plurality of duck eyes 42 that penetrate platform, one of them duck eye has one that ladder 43 leads in high shelf attachment to hide the unit, as the place of hiding of laboratory animal; Other duck eye is unsettled, can't lead to the unit of hiding in overhead anxiety labyrinth from this duck eye, forms the refuge pocket labyrinth, is conducive to learning ability and memory capability rehabilitation.
The assemble method of Stupid-rat-maze-type intelligence rehabilitation training device of the present invention is:
At first the leisure labyrinth is set in ground floor training cage, places duct type labyrinth, crock formula labyrinth, rope ladder, scalable ladder etc.Then the second layer that superposes training cage, assembling board plug type labyrinth in second layer training cage, the different difficulty labyrinth of formation capable of being combined such as T-shaped, U-shaped, cross, any route etc.The 3rd layer of training cage (removing base plate) that superpose again placed high shelf attachment in the 3rd layer of training cage, be combined to form overhead anxiety labyrinth together with the board plug type labyrinth of the second layer; The 4th layer of training cage (removing base plate) that superpose again placed refuge pocket dull and stereotyped in the 4th layer of training cage, be combined to form the refuge pocket labyrinth together with overhead anxiety labyrinth.
Above-mentioned is one of them implementation process, and when reality was used, changeable training number of plies amount changed cage height or training layer height, also can be arbitrarily made with double-deck training cage or individual layer training cage etc.
Board plug type labyrinth in the present invention is when building, and the labyrinth element number of structure is more, and the space of each unit, labyrinth is less.When removing some horizontal plate or vertical plate, the labyrinth element number of structure is less but the space is larger.Generally, in unit, a labyrinth, 4 door openings are arranged at most as passage, block wherein two passages if hang up two baffle plates, form the one-in-and-one-out passage.If adjacent unit, labyrinth is also the one-in-and-one-out passage with it, form unit, the easiest labyrinth, degree-of-difficulty factor is 1; Block one of them passage if hang the lastblock baffle plate, form the one-in-and-two-out passage, if adjacent unit, labyrinth is also the one-in-and-two-out passage with it, degree-of-difficulty factor is 4; If do not put into gear plate, form one and advance three and go out passage, if be also to go out passage into three in it adjacent unit, labyrinth, degree-of-difficulty factor is 27.This shows, the board plug type labyrinth can indiscriminately ad. as one wishes build the different difficulty labyrinth of any route.
Below take T-shaped route labyrinth as example, the embodiment of board plug type maze learning and memory training is described:
(1) construction method in T-shaped route labyrinth
T-shaped route labyrinth when all horizontal plates with after vertically plate all assembles, is opened the door opening of all the vertical plates between cage wall and adjacent transverse plate, and is closed other door opening of all vertical plates as shown in Fig. 4; The middle door opening of open all horizontal plates is closed other door openings, has formed to comprise 2 T-shaped labyrinths of selecting arm (the laterally two ends of plate) and a beginning arm (a vertically end of plate).Mouse is placed on beginning arm end, diet box is placed on two, T-shaped labyrinth selects the arm end, select to distinguish centered by arm and beginning arm intersection region.T-shaped labyrinth can be used for studying space learning, alternative behavior, condition identification learning and working memory.
(2) learning process:
Accommodating food in the selection arm end diet box of turning left, select in arm end food boxes not accommodating food turning right, mouse is placed on beginning arm end, closing center turns left in the district and selects arm entrance and the selection arm entrance of turning right according to the order of sequence respectively, allow the mouse learning cognition select the arm entrance that food is arranged from turning left, select the arm entrance there is no food from turning right, allow mouse at labyrinth learning 20-30 minute, be familiar with and adapt to the labyrinth.
(3) Memory Process
A. simultaneously the open center district turns left and selects the arm entrance and turn right and select the arm entrance, observe that mouse enters the number of times of selecting properly arm and time, the number of times of wrong choice arm and time, in time of staying of center.Test in this way and train under regular situation, the memory capability of mouse.
B. after test after a while, then food be placed on to turn right select in the diet box of arm end, when again observing mouse conversion probing direction, mouse enters the number of times of selecting properly arm and time, the number of times of wrong choice arm and time, in time of staying of center.Test in this way and train in the simple change situation memory capability of mouse.
C. again after test after a while, select only to place a food in arm end diet box left and right turning respectively, only in the situation that all eating up just, bilateral food again places a food at bilateral, when again observing mouse conversion probing direction, mouse enters the number of times of selecting properly arm and time, the number of times of wrong choice arm and time, in time of staying of center.Test in this way and train under complicated situation of change the memory capability of mouse.
(3) observation index:
When observing animal and not having conversion probing direction in stress situation, non-human act under the comparison condition of former experience and present environment shows, with mouse enter number of times and the time of selecting properly arm, the number of times that enters the wrong choice arm and time, reference index in time of staying of center as learning and memory.And this behavior is subject to the memory impact, and three free intervals of stage in experiment are to guarantee that animal is to being familiar with the memory degree of arm.
Other plate labyrinths such as U-shaped route labyrinth are as shown in Figure 5, cross route labyrinth as shown in Figure 6, the route labyrinth is as shown in Fig. 7 arbitrarily, its building mode is similar to T-shaped labyrinth, and difference is baffle plate is hung on required diverse location, blocks corresponding door opening, just do not hang any baffle plate if build highly difficult labyrinth, if be placed on central area with mouse this moment, find food, the difficulty requirement of learning and memory has just been well imagined!
Overhead anxiety labyrinth
(1) construction method in overhead anxiety labyrinth
Overhead anxiety labyrinth is formed by board plug type labyrinth and overhead accessory combination structure as shown in Fig. 8.Increase the high shelf attachment of one deck on the board plug type labyrinth, high shelf attachment by overhead long slab 31 with hide unit 32 with vertical 2 of being connected of overhead long slab and form, overhead long slab 31 is as open arms, hide unit 32 as closure arm, hiding the unit can become and really hide the unit, namely open the interior hole 33 of hiding the unit, there is the diet box that food is housed inboard, interior hole, and have towards the ladder 34 in board plug type labyrinth, hide the unit and also can close the interior hole 33 of hiding the unit, become vacation and hide the unit, can only again walk out after mouse enters, again to overhead long slab; High shelf attachment is placed on top, board plug type labyrinth, and making both sides, overhead long slab below is all each empty unit, labyrinth, completes the experiment place with this and builds, and forms overhead anxiety labyrinth.This labyrinth utilizes animal probing into habit and the fear of uphanging out arm being formed the contradiction state of animal, anxiety and the memory capability of reflection animal novel environment.
(2) learning process:
Make a left side hide the unit for really hiding the unit, it is that the unit is hidden in vacation that the unit is hidden on the right side, and mouse is placed on overhead long slab starting end, and anxiety walking on overhead long slab, allows mouse study find and really hides the unit, and at labyrinth learning 20-30 minute, is familiar with and adapts to the labyrinth.
(3) Memory Process:
A. the interval is 10 minutes, observe mouse enter the true and false number of times of hiding the unit and entry time, in time of staying of open arms and closure arm.Test in this way and train under regular situation, anxiety and the memory capability of mouse in overhead anxiety situation.
B. the interval is 10 minutes, then the unit is hidden on the right side is true, and it is false that the unit is hidden on a left side, observes mouse and enters true and false number of times and the entry time of hiding the unit, in the time of staying of open arms and closure arm.Again after test after a while, make simultaneously and true and falsely hide the unit and be very, observe mouse enter the number of times of hiding the unit and entry time, in time of staying of open arms and closure arm.Test in this way and train in the simple change situation, overhead anxiety situation and the memory capability of mouse in overhead anxiety situation.
(4) observation index:
Be used for the memory capability of test mouse in overhead anxiety situation by entering true and false number of times and the entry time of hiding the unit; Enter the number of times of open arms and be used for the pinnacled anxiety degree of test animal in the open arms holdup time; Animal enters open arms and closure arm number of times, in open arms and closure arm and run duration, move distance in the central area of labyrinth, with enter open arms number of times and the percentage that always enters the arm number of times when in open arms the percentage of the total time in run duration and open arms closure arm represent the angst resistance effect index.
The refuge pocket labyrinth
(1) construction method in refuge pocket labyrinth
The refuge pocket labyrinth is for assessment of the Spatial learning and memory ability.Increase one deck refuge pocket flat board 41 on overhead anxiety labyrinth, the refuge pocket flat board is made of the square platform that a periphery is covered with the duck eye 42 that much penetrates platform, refuge pocket flat board 41 is placed in top, overhead anxiety labyrinth, only have bottom, hole to have ladder 43 to lead to overhead anxiety labyrinth in all holes and really hide unit 32, be called the target hole, in the diet box that food is housed is arranged, become the place of hiding of laboratory animal; The bottom in other hole is unsettled, does not hide the place, completes the experiment place with this and builds, and forms to hide the type labyrinth.The refuge pocket labyrinth does not need high light, wind and electric shock, therefore to animal stress be less.Experiment is very little for the physical fitness requirement of animal, can MIN minimizing because of the impact of the physically-draining due to age factor on experimental result, the thickness of its platform, width of cave entrance and number are different according to the laboratory animal size dimension and different.
(2) learning process:
When training begins at every turn, mouse is placed on the dull and stereotyped central authorities in refuge pocket labyrinth, the visual reference thing that animal use provides, the effectively position at place, definite target hole.Allow mouse be familiar with in 20-30 minute and to adapt to the labyrinth at the dull and stereotyped learning of refuge pocket.Mouse all carries out wiping with alcohol to the labyrinth after training at every turn, and rotation refuge pocket labyrinth is dull and stereotyped, but does not change the relative tertiary location in target hole, comes search of food to prevent the information such as mouse utilization smell.
(3) Memory Process:
Between isolation 10 minutes, observe the number of times at mouse target approach hole and wrong hole and entry time, in time of staying of the dull and stereotyped central authorities in refuge pocket labyrinth.Test in this way and train under regular situation, measuring animal for the spatial memory capacity in target hole.
(4) observation index:
Recording laboratory animal finds the time at correct hole, and the number of times that enters wrong hole is with the spatial reference memory ability of reaction animal, also can repeat to enter wrong hole number and measures the working memory of animal by recording animal.
Claims (3)
1. Stupid-rat-maze-type intelligence rehabilitation training device comprises multilayer training cage, and multilayer training cage stacked on top of one another arranges, and mutually nestedly between adjacent training cage is connected and is communicated with by ladder; Be provided with the labyrinth in described training cage, described labyrinth comprises leisure labyrinth, plate labyrinth, overhead anxiety labyrinth and refuge pocket labyrinth; Each training cage comprises one with rectangular frame and a base plate of peep hole; Will remove base plate when assemblage of elevated anxiety labyrinth and refuge pocket labyrinth so that overhead anxiety labyrinth can be assembled on the plate labyrinth, the refuge pocket labyrinth can be assembled on overhead anxiety labyrinth;
It is characterized in that: described leisure labyrinth comprises duct type labyrinth and crock formula labyrinth; The duct type labyrinth comprises a plurality of threading a pipe of two passwaies that have at least more, and the ladder of upwards climbing for mouse is installed in pipeline; Crock formula labyrinth comprises the large crock of a plurality of young tripes, and at the bottom of being provided with a plurality of rope ladders and extending to cage from the top oral area of each crock respectively, wherein is stamped lid on the mouth of some crock, there is no lid on the mouth of other crocks.
2. Stupid-rat-maze-type intelligence rehabilitation training device as claimed in claim 1, it is characterized in that: described overhead anxiety labyrinth is to set up an overhead annex to form on the board plug type labyrinth, take two-layer training cage, high shelf attachment will be positioned at the sealing suitable for reading in corresponding criss-cross room in the board plug type labyrinth of its below, overhead annex comprises that an overhead long slab and two hide the unit, hiding the unit for two is symmetricly set on the both sides of overhead long slab and forms decussate texture with overhead long slab, hiding the unit for two respectively comprises two criss-cross rooms and be respectively equipped with door opening on each dividing plate that distributes along its length, each door opening optionally blocks with baffle plate, hiding unit inside bottom for two is respectively equipped with ladder and leads to following board plug type labyrinth.
3. Stupid-rat-maze-type intelligence rehabilitation training device as claimed in claim 1, it is characterized in that: described refuge pocket labyrinth is to establish that a refuge pocket is dull and stereotyped to be formed the high shelf attachment in overhead anxiety labyrinth is added, the surrounding of refuge pocket flat board is provided with a plurality of duck eyes that penetrate platform, and one of them duck eye has one that ladder leads in high shelf attachment to hide the unit.
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| CN104414825B (en) * | 2013-09-11 | 2016-08-10 | 上海理工大学 | Brain injury in rats Multifunctional rehabilitation exercise device |
| CN104414826B (en) * | 2013-09-11 | 2016-08-24 | 上海理工大学 | Brain injury in rats sensation-balance-motion integrated training devices |
| CN104782524A (en) * | 2015-04-29 | 2015-07-22 | 桂林医学院 | Labyrinth detecting direction positioning capability in cognitive function of experimental animals |
| WO2017210645A1 (en) * | 2016-06-02 | 2017-12-07 | Cedars-Sinai Medical Center | Visual stimuli maze test for detecting visual abnormalities in prodromal alzheimer's disease and in alzheimer's disease |
| CN106472330B (en) * | 2016-09-14 | 2019-06-25 | 中国科学院深圳先进技术研究院 | A kind of integrating device |
| CN110583511B (en) * | 2018-06-12 | 2023-06-13 | 中国科学院昆明动物研究所 | Kiwi three-dimensional maze |
| CN111742852B (en) * | 2020-06-18 | 2022-02-25 | 九江学院 | Rat cognitive behavior comprehensive test method |
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|---|---|---|---|---|
| US5054427A (en) * | 1989-09-21 | 1991-10-08 | Hoover Judith L | Insertable stacking pet toy maze |
| CN201393459Y (en) * | 2009-05-18 | 2010-02-03 | 中国人民解放军国防科学技术大学 | Animal intelligent training system |
| CN201995441U (en) * | 2010-10-14 | 2011-10-05 | 复旦大学附属华山医院 | Dementia rat labyrinth type intellectual rehabilitation training device |
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| CN100471466C (en) * | 2006-02-21 | 2009-03-25 | 沈阳医学院 | Mouse space memory retention model and intelligent action inspecting system |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5054427A (en) * | 1989-09-21 | 1991-10-08 | Hoover Judith L | Insertable stacking pet toy maze |
| CN201393459Y (en) * | 2009-05-18 | 2010-02-03 | 中国人民解放军国防科学技术大学 | Animal intelligent training system |
| CN201995441U (en) * | 2010-10-14 | 2011-10-05 | 复旦大学附属华山医院 | Dementia rat labyrinth type intellectual rehabilitation training device |
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