CN102430195B - Iontophoretic transdermal drug delivery system - Google Patents
Iontophoretic transdermal drug delivery system Download PDFInfo
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- CN102430195B CN102430195B CN 201110421485 CN201110421485A CN102430195B CN 102430195 B CN102430195 B CN 102430195B CN 201110421485 CN201110421485 CN 201110421485 CN 201110421485 A CN201110421485 A CN 201110421485A CN 102430195 B CN102430195 B CN 102430195B
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Abstract
The invention discloses an iontophoretic transdermal drug delivery system which comprises a low and middle frequency pulse electronic generator, a conductor wire and a hydrosol pulse electrode; the low and middle frequency pulse electronic generator is connected with the hydrosol pulse electrode through the conductor wire; a drug carrier of the hydrosol pulse electrode of the system is prepared from a medical hydrosol and has the characteristics of good compatibility and permeability promoting property to drugs and good compatibility with human bodies; and the drug carrier can be used as a transdermal drug delivery carrier for macromolecular drugs, micromolecular drugs, hydrophilic drugs, lipophilic drugs and the like and can also be used as a transdermal drug delivery carrier of some biological drugs of polypeptide, protein and the like. Low and middle frequency pulse electrons generated by the system have a good permeability promoting action and a directional introduction function to the drugs.
Description
Technical field
The present invention relates to a kind of iontophoresis transdermal drug delivery system, belong to novel drug-supplying system field.
Background technology
The topical transdermal administration medication that to be medicine absorb by skin refers to that medicinal application after on the skin, passes horny layer, by skin diffusion, in the part or whole body start the effect for the treatment of disease.Compare with traditional oral or drug administration by injection, transdermal administration has a lot of benefits, as keep effective drug effect concentration by continuing transdermal effect, avoid peak valley phenomenon, reduce toxicity, avoid medicine gastrointestinal degraded and absorption, patient independently medication also can cancel medication at any time.But transdermal medicine for treating efficient is low, some macromole such as protein drug transdermal difficulty are this novel medicine-feeding technology bottleneck all the time.
Summary of the invention
Technical problem to be solved by this invention provides a kind of by the importing administration of medium and low frequency pulse ion and the short superimposed a kind of novel transdermal drug delivery system of saturating administration of the hydrosol.
In order to solve the problems of the technologies described above, the invention provides a kind of iontophoresis transdermal drug delivery system, this iontophoresis transdermal drug delivery system comprises medium and low frequency pulsed electron generator, lead and hydrosol pulsed electrode, and described medium and low frequency electronic generator connects hydrosol pulsed electrode by lead.
Further, this iontophoresis transdermal drug delivery system is adjusted transdermal administration speed and transdermal administration amount by wavelength, frequency, energy and the width of the pulse current adjusting described medium and low frequency electronic generator and send.
Further, described hydrosol electrode is made up of conduction button, base fabric, conducting film, hydrosol colloid and sealing coat, and described base fabric, conducting film, hydrosol colloid and sealing coat are superimposed in turn, and described conduction button is installed on the base fabric.
Further, described hydrosol colloid comprises polyacrylamide, polyacrylate, gelatin, ethanol, G ﹠ W.
As a kind of preferred version, described hydrosol colloid is written into Chinese medicine Radix Notoginseng, Flos Carthami, Radix Salviae Miltiorrhizae, Herba speranskiae tuberculatae, Radix Achyranthis Bidentatae and the Radix Aucklandiae as carrier, and this iontophoresis transdermal drug delivery system can be treated the pain disease that cervical spondylosis, lumbar spondylosis, hyperosteogeny and scapulohumeral periarthritis cause.
As another kind of preferred version, described hydrosol colloid is written into Chinese medicine angelica, YUNLING, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Semen Plantaginis Radix Et Rhizoma Rhei, Poria and Herba Menthae as carrier, and this iontophoresis transdermal drug delivery system can be treated the non-viral prostatitis.
As another preferred version, described hydrosol colloid is written into Chinese medicine Radix Aconiti, Radix Angelicae Sinensis, Flos Carthami, Olibanum as carrier, and this iontophoresis transdermal drug delivery system can be treated mastitis, cyclomastopathy.
As a kind of preferred version is arranged, described hydrosol colloid is written into insulin as carrier, and this iontophoresis transdermal drug delivery system can be treated diabetes.
Beneficial effect of the present invention is:
1, the pharmaceutical carrier of the hydrosol pulsed electrode of native system is to be made by the medical hydrosol, having has good compatibility that the characteristics of the fine compatibility are arranged with short saturating property, to human body to medicine, can be used as the transdermal administration carrier of medicines such as macromole, micromolecule, hydrophilic, close ester, also can be used as polypeptide and the protein-based transdermal administration carrier that waits some bio-pharmaceuticals; The medium and low frequency pulse current that native system produces has good transdermal enhancing effect and directed import feature to medicine.
2, the invention of native system has improved transdermal administration kind, transdermal administration speed and transdermal administration amount greatly.This brand-new drug-supplying system, multiple disease is effectively treated by the transdermal administration technology becomes possibility, can not only significantly reduce the therapeutic process Chinese medicine to the toxic and side effects of human body, can also effectively reduce dosage and medical treatment cost.
3, pulse ion importing transdermal drug delivery system of the present invention is to import administration and the short superimposed a kind of novel transdermal drug delivery system of saturating administration of the hydrosol by the medium and low frequency pulse ion.It is a kind of efficient, safe transdermal delivery system that typically has the integrated innovation meaning.The present invention preferably resolves the bottleneck difficult problem of traditional patch, is a kind of brand-new medical skill that promotes the well-being of mankind invention.
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail.
Description of drawings
Fig. 1 is the structural representation of iontophoresis transdermal drug delivery system of the present invention.
Fig. 2 is the structural representation of the hydrosol electrode in the iontophoresis transdermal drug delivery system of the present invention.
The Reference numeral note:
1, medium and low frequency pulsed electron generator; 2, lead; 3, hydrosol pulsed electrode; 4, conduction button; 5, base fabric; 6, conducting film; 7, hydrosol colloid; 8, sealing coat.
The specific embodiment
As shown in Figure 1, iontophoresis transdermal drug delivery system provided by the invention comprises medium and low frequency pulsed electron generator 1, lead 2 and hydrosol pulsed electrode 3, described medium and low frequency electronic generator 1 connects hydrosol pulsed electrodes 3 by lead 2, and this iontophoresis transdermal drug delivery system is adjusted transdermal administration speed and transdermal administration amount by wavelength, frequency, energy and the width of the pulse current adjusting described medium and low frequency electronic generator 1 and send; Wavelength, frequency, energy and width button that the regulating impulse electric current is arranged on this medium and low frequency electronic generator, pulse current wavelength, frequency, energy and width be can adjust by above-mentioned push-botton operation, and then transdermal administration speed and the transdermal administration amount of hydrosol pulsed electrode 3 adjusted.
As shown in Figure 2, hydrosol pulsed electrode 3 provided by the invention is made up of conduction button 4, base fabric 5, conducting film 6, hydrosol colloid 7 and sealing coat 8, described base fabric 5, conducting film 6, hydrosol colloid 7 and sealing coat 8 are superimposed from top to bottom in turn, and described conduction button 4 is installed in base fabric 5 upper surfaces.
Hydrosol colloid of the present invention is made up of polyacrylamide, polyacrylate, gelatin, ethanol, G ﹠ W.
Hydrosol colloid of the present invention is written into compositions such as Chinese medicine Radix Notoginseng, Flos Carthami, Radix Salviae Miltiorrhizae, Herba speranskiae tuberculatae, Radix Achyranthis Bidentatae and the Radix Aucklandiae as carrier, can be used for treating the pain disease that cervical spondylosis, lumbar spondylosis, hyperosteogeny and scapulohumeral periarthritis etc. cause.
Hydrosol colloid of the present invention is written into compositions such as Chinese medicine angelica, YUNLING, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Semen Plantaginis, Radix Et Rhizoma Rhei, Poria and Herba Menthae as carrier, can be used for treating the non-viral prostatitis.
Hydrosol colloid of the present invention is written into compositions such as Chinese medicine Radix Aconiti, Radix Angelicae Sinensis, Flos Carthami, Olibanum as carrier, can be used for treating mastitis, cyclomastopathy.
Hydrosol colloid of the present invention is written into insulin as carrier and can be used for treating diabetes.
Protection domain of the present invention is not limited to above-mentioned embodiment, and every technology distortion of doing according to the technology of the present invention principle all falls within protection scope of the present invention.
Claims (5)
1. an iontophoresis transdermal drug delivery system is characterized in that, this iontophoresis transdermal drug delivery system comprises medium and low frequency pulsed electron generator, lead and hydrosol pulsed electrode, and described medium and low frequency electronic generator connects hydrosol pulsed electrode by lead; This iontophoresis transdermal drug delivery system is adjusted transdermal administration speed and transdermal administration amount by pulse current wavelength, frequency, energy and the width adjusting described medium and low frequency electronic generator and send;
Described hydrosol pulsed electrode is made up of conduction button, base fabric, conducting film, hydrosol colloid and sealing coat, and described base fabric, conducting film, hydrosol colloid and sealing coat are superimposed in turn, and described conduction button is installed on the base fabric;
Described hydrosol colloid comprises polyacrylamide, polyacrylate, gelatin, ethanol, G ﹠ W.
2. iontophoresis transdermal drug delivery system according to claim 1, it is characterized in that, described hydrosol colloid is written into Chinese medicine Radix Notoginseng, Flos Carthami, Radix Salviae Miltiorrhizae, Herba speranskiae tuberculatae, Radix Achyranthis Bidentatae and the Radix Aucklandiae as carrier, and this iontophoresis transdermal drug delivery system can be treated the pain disease that cervical spondylosis, lumbar spondylosis, hyperosteogeny and scapulohumeral periarthritis cause.
3. iontophoresis transdermal drug delivery system according to claim 1, it is characterized in that, described hydrosol colloid is written into Chinese medicine angelica, YUNLING, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Semen Plantaginis, Radix Et Rhizoma Rhei, Poria and Herba Menthae as carrier, and this iontophoresis transdermal drug delivery system can be treated the non-viral prostatitis.
4. iontophoresis transdermal drug delivery system according to claim 1 is characterized in that, described hydrosol colloid is written into Chinese medicine Radix Aconiti, Radix Angelicae Sinensis, Flos Carthami and Olibanum as carrier, and this iontophoresis transdermal drug delivery system can be treated mastitis, cyclomastopathy.
5. iontophoresis transdermal drug delivery system according to claim 1 is characterized in that, described hydrosol colloid is written into insulin as carrier, and this iontophoresis transdermal drug delivery system can be treated diabetes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110421485 CN102430195B (en) | 2011-12-16 | 2011-12-16 | Iontophoretic transdermal drug delivery system |
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| CN 201110421485 CN102430195B (en) | 2011-12-16 | 2011-12-16 | Iontophoretic transdermal drug delivery system |
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| CN102430195A CN102430195A (en) | 2012-05-02 |
| CN102430195B true CN102430195B (en) | 2013-08-21 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104368084B (en) * | 2014-10-31 | 2016-11-30 | 厦门微科格瑞生物科技有限公司 | Wearable intellectual drug import system |
| CN107551390A (en) * | 2017-08-21 | 2018-01-09 | 常熟佳禾生物科技有限公司 | It is a kind of to be used to treat Chinese medicine brassiere paster of hyperplasia of mammary glands and preparation method thereof |
| CN107854770B (en) * | 2017-10-20 | 2020-11-24 | 西安交通大学医学院第一附属医院 | Auxiliary breast cancer recovery device for introducing organic selenium negative ions |
| CN108478638B (en) * | 2018-06-28 | 2021-07-23 | 成都春霞堂健康咨询有限公司 | External traditional Chinese medicine extract for dredging mammary gland, preparation method and raw material composition thereof |
| CN111529921B (en) * | 2020-04-10 | 2022-03-29 | 常州华佳医疗器械有限公司 | Medicine carrying tray |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1044049A (en) * | 1990-02-06 | 1990-07-25 | 董国臣 | Electronic medicinal plaster |
| US6048545A (en) * | 1994-06-24 | 2000-04-11 | Biozone Laboratories, Inc. | Liposomal delivery by iontophoresis |
| US5788666A (en) * | 1995-06-15 | 1998-08-04 | Empi, Inc. | Iontophoresis electrode |
| US6496727B1 (en) * | 2000-05-31 | 2002-12-17 | Becton, Dickinson And Company | Medicament-loaded transdermal reservoir and method for its formation |
| CN1520897A (en) * | 2003-01-31 | 2004-08-18 | 杨越培 | Electronic physical therapy plaster |
| CN201423082Y (en) * | 2009-06-20 | 2010-03-17 | 西藏宇妥文化发展有限公司 | Long-acting ion introduction patch convenient for storing and carrying |
| CN202478400U (en) * | 2011-12-16 | 2012-10-10 | 焦作市银达生物制品有限公司 | Iontophoresis skin medication device |
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Effective date of registration: 20160428 Address after: 030000, Shanxi, Taiyuan province Heping District, Heping North Road battalion village S No. 1, Taiyuan City Huai Medical Equipment Co., Ltd. Patentee after: Taiyuan Huai Cheng medical instruments Co., Ltd. Address before: 454000, No. 2, No. 2, C, Pioneer Center, hi tech Zone, Henan, Jiaozuo Patentee before: Jiaozuo City Yin Da biological product company limited |