CN102429831B - Novel vitamin E emulsifiable solution and preparation method thereof - Google Patents
Novel vitamin E emulsifiable solution and preparation method thereof Download PDFInfo
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- CN102429831B CN102429831B CN 201110411769 CN201110411769A CN102429831B CN 102429831 B CN102429831 B CN 102429831B CN 201110411769 CN201110411769 CN 201110411769 CN 201110411769 A CN201110411769 A CN 201110411769A CN 102429831 B CN102429831 B CN 102429831B
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Abstract
The invention relates to a vitamin E emulsifiable solution and a preparation method thereof. The vitamin oil-in-water type emulsifiable solution provided by the invention is prepared from the following components in weight ratio: 5-35% of liquid vitamin E, 10-20% of solid protector, 5-35% of surfactant and 35-79% of distilled water. According to the vitamin E emulsifiable solution and the preparation method thereof, by adopting the method of mixing the liquid vitamin E, the solid protector, the surfactant and the distilled water in a certain proportion to prepare an O/W-type vitamin E emulsifiable solution having a protection action for a vitamin E, the vitamin E emulsifiable solution can be used in a broad-spectrum (pH 2.5-14) range, and is not damaged or is less damaged so as to maintain the activity of the vitamin E emulsifiable solution, and the approaches for application are wider. Furthermore, the O/W-type vitamin E emulsifiable solution produced by the invention not only can be uniformly dispersed in water in the application, but also has a slow-release action, is extremely convenient to use, and can be widely applied to various cosmetics and other products for daily use.
Description
Technical field
The present invention relates to the daily use chemicals sciemtifec and technical sphere, particularly a kind ofly can directly or indirectly act on a kind of oil-in-water type vitamin E emulsion in cosmetics and other daily products and preparation method thereof.
Background technology
Vitamin E (Vitamin E) is a kind of fatsoluble vitamin, claims tocopherol acetate again, is one of topmost antioxidant, and its effect is very many, below enumerates wherein comparatively common function:
Slow down aging: vitamin E has the effect of delaying sanility, mainly is based on its oxidation resistance.Vitamin E is one of topmost biological free radical scavenger and antioxidant in the body.As a kind of fatsoluble vitamin, vitamin E belongs to the chain rupture antioxidant, and main effect is the reaction chain of blocking-up fat oxidation, is antioxidative the first line of defence in the body.The antioxidation of vitamin E is positioned cell membrane, can block the formation of peroxide in the cell membrane, makes cell membrane avoid the infringement of oxygen-derived free radicals, thus the process of delaying cell aging.
Beauty and skin care: the oxidation resistance that vitamin E is outstanding, make the protein active structure that its can stabilizing cell membrane, promote the normal development of muscle and keep the elasticity of skin, make skin and health maintain vigour; Vitamin E gets into Skin Cell more can directly help the infringement of skin to free radical resisting, ultraviolet and pollutant, prevents that skin from following the string until aging because of some chronic or recessive injuries.
Purify the blood, the protection blood vessel: vitamin E can reduce the concentration of the concentration lipoprotein in the blood.Low density lipoprotein, LDL is attached on the blood vessel wall, causes sclerosis of blood vessels, especially arteriosclerosis.Vitamin E is to the most tangible polyphenoils of all biological membranous ingredient effects, can reduce the concentration of bad cholesterol, effectively improves blood circulation.The survey showed that for the project of a MONICA by name of the United Nations's health organization: Europe is northern to differ 7 times with mediterranean country's heart hematocele pipe disease incidence, and it is the difference of two places vitamin E absorption level that 62% reason is arranged.
Hepatoprotective: it is one of important protection factor of hepatic cell growth that vitamin E is illustrated in the research eighties.American scholar finds that one of last approach that hepatocyte is dead is the exhaustion of vitamin E in the hepatocyte, and hepatic injury has protective effect to vitamin E to various acute, and hepatic fibrosis is had retarding action.When vitamin E was sufficient, liver just had the ability to remove the toxicity of bleach, insecticide, other environmental pollution, and when vitamin E was not enough, these materials all can make liver damage.
Promote sex hormones secretion, improve fertility: vitamin E can promote sex hormones secretion, and man's motility of sperm and quantity are increased; Woman's estrogen concentration is increased, improve fertility, prevention of miscarriage.
General vitamin E is liquid of vicidity, and is water insoluble, is dissolved in the organic solvents such as fat and ethanol, and heat, weak acid are stablized, responsive to oxygen to strong acid, alkali instability, insensitive to heat.Because vitamin E is responsive to oxygen, easy oxidized, meeting is slowly decomposed under aerobic environment, thereby also decomposition loss easily under strong acid, alkaline environment loses its effect.How to make vitamin E in wide spectrum (PH 2.5 ~ 14) scope, use and do not receive or be damaged less, more and more become the common problem of paying close attention to of numerous people to keep its activity.
Summary of the invention
The objective of the invention is to above-mentioned existing problems and deficiency; Providing a kind of does not receive wide spectrum (PH 2.5 ~ 14) the scope planted agent of vitamin E in cosmetics or daily product field the time spent or is damaged less; To keep original composition and content can not decline to a great extent and to keep its activity; And zest is little, and the approach that environment is not had to pollute, can be dispersed in water, an application is oil-in-water type vitamin E emulsion and preparation method thereof widely.
Technical scheme of the present invention is achieved in that
Oil-in-water type vitamin E emulsion according to the invention, by processing forming of following weight proportion:
Liquid vitamin E 5-35%, solid protection thing 10-20%, surfactant 5-35%, distilled water 35-79%.
The preferred weight proportioning of above-mentioned each component is following:
Liquid vitamin E 10-20%, solid protection thing 10-20%, surfactant 10-20%, distilled water 50-65%.
Wherein on surfactant selection, the present invention selects the low nonionic surfactant with good biocompatibility of toxicity for use.Nonionic surfactant toxicity is low, and is more stable in solution, is not subject to strong electrolyte, inorganic salts, the influence of soda acid.The available surfactant of the present invention is that in sorbitan ester, the sucrose ester one or both are composite.
The present invention selects at the solid protection thing that vitamin E is had the protective effect material to be had: molecule distillating monoglyceride, modified starch, cycloheptaamylose, TiO2's (nanoscale) is composite.The main effect of this solid protection thing is the protection vitamin E, makes it under the environment of bronsted lowry acids and bases bronsted lowry, also can keep and reduce the loss and keeps active, is unlikely to decompose.
The invention still further relates to said oil-in-water type vitamin E preparation method of emulsion, may further comprise the steps:
(1), take by weighing liquid vitamin E, surfactant, solid protection thing by weight ratio, distilled water is subsequent use;
(2), the preparation of water: protect the thing molecule to add in the distilled water stirring and dissolving or dissolving solid with moistening fully and form protection material aqueous solution as the foreign minister, subsequent use;
(3), the preparation of oil phase: surfactant is added the oil phase that forms in the vitamin E as inner phase, stirring and dissolving;
(4), high-speed shearing machine is put into aqueous phase and unlatching; When treating that the cutter rotating speed is carried to 2000 commentaries on classics-4000 commentaries on classics, slowly add above-mentioned oil phase, accelerating to 6000-13000 after the entry to be completely changes; Shear the high-speed shearing machine rotating speed that slows down after 5-15 minute to stopping fully; Cooling off after 20-40 minute again according to dispersion of nano-particles degree circulation aforesaid operations in the solution, is that 2-10 μ m gets final product up to particle diameter, and the emulsion of gained is oil-in-water type vitamin E emulsion according to the invention.
The present invention mixes the method that vitamin E is had the O/W type vitamin E emulsion of protective effect of processing owing to adopting with liquid vitamin E, solid protection thing, surfactant and distilled water by a certain percentage; Make this vitamin E emulsion in the process of using; Because of protection thing aqueous solution, surfactant can form the thin film that one deck is wrapped in vitamin E, vitamin E has adequately protected.The solid particle of adding protection thing itself can increase thin film again; Can the stable emulsion system; Can completely cut off the effect of extraneous oxygen and strong acid and strong base again to vitamin E, thus make this vitamin E emulsion can be at wide spectrum (PH 2.5 ~ 14) thus use does not receive or is damaged less to keep its activity in the scope.And the O/W type vitamin E emulsion that the present invention produces; Not only in application, can be dispersed in the water; And have a slow releasing function, promptly in intermolecular after the after a while because continuous minimizing of interface energy, interfacial tension can continue to increase; Vitamin E will disengage along with the slowly destruction of system, plays slow releasing function.Disengage vitamin E like need, the material that need only heat or add the destruction system can play the quickening release action, and is extremely easy to use at once, can be widely used in various cosmetics and other daily products.
The particle diameter of the emulsion that the present invention is prepared is 2-10 μ m, can long storage time and the maintenance system is evenly not stratified, through evidence its to keep emulsive temperature be 10-60 degrees centigrade.
The specific embodiment
Oil-in-water type vitamin E emulsion according to the invention, by processing forming of following weight proportion:
Liquid vitamin E 5-35%, solid protection thing 10-20%, surfactant 5-35%, distilled water 35-79%.
The preferred weight proportioning of above-mentioned each component is following:
Liquid vitamin e1 0-20%, solid protection thing 10-20%, surfactant 10-20%, distilled water 50-65%.
Above-mentioned surfactant is one or both combinations in sorbitan ester, the sucrose ester.
Above-mentioned solid protection thing is that one or more of molecule distillating monoglyceride, modified starch, cycloheptaamylose, nanoscale (particle diameter is below 100 nanometers) TiO2 are compound.
Oil-in-water type vitamin E preparation method of emulsion according to the invention may further comprise the steps:
(1), take by weighing liquid vitamin E, surfactant, solid protection thing by weight ratio, distilled water is subsequent use;
(2), the preparation of water: protect the thing molecule to add in the distilled water stirring and dissolving or dissolving solid with moistening fully and form protection material aqueous solution as the foreign minister, subsequent use;
(3), the preparation of oil phase: surfactant is added the oil phase that forms in the vitamin E as inner phase, stirring and dissolving;
(4), high-speed shearing machine is put into aqueous phase and unlatching; When treating that the cutter rotating speed is carried to 2000-4000 commentaries on classics, slowly add above-mentioned oil phase, accelerating to 6000-13000 after the entry to be completely changes; Shear after 5-15 minute deceleration cutter rotating speed to stopping fully; Cooling off after 20-40 minute again according to emulsion dispersion of nano-particles degree circulation aforesaid operations, is that 2-10 μ m gets final product up to particle diameter, and the emulsion of gained is oil-in-water type vitamin E emulsion according to the invention.
The preferred version of said method for preparing of the present invention is: in above-mentioned steps (2); Solid protection thing molecule distillating monoglyceride, modified starch, the cycloheptaamylose that will be dissolvable in water water earlier add stirring and dissolving in the distilled water; Treat all to add water-fast nanoscale TiO2 again after the dissolving, fully stir and treat that its complete wetting forms the protection material aqueous solution as the foreign minister.
Come further to illustrate the present invention through the detailed description of the specific embodiment below, but be not, only make example description the restriction of invention.
Embodiment one:
Constituent mass/g
Liquid vitamin E 10
Surfactant (sucrose ester) 10
Solid protection thing (molecule distillating monoglyceride) 2
Solid protection thing (modified starch) 10
Solid protection thing (cycloheptaamylose) 2
Solid protection thing (nanoscale TiO2) 1
Distilled water 65
Oil-in-water type vitamin E preparation method of emulsion according to the invention may further comprise the steps:
(1), take by weighing by above-mentioned weight proportion: the liquid vitamin E, surfactant, solid protection thing (molecule distillating monoglyceride, modified starch, cycloheptaamylose, TiO2), and distilled water, subsequent use;
(2), the preparation of water: the solid protection thing molecule (distillation monoglyceride, modified starch, cycloheptaamylose) that will be dissolvable in water water earlier adds stirring and dissolving in the distilled water; Treat to add water-insoluble solid protection thing molecule (nanoscale TiO2) again after all dissolvings; Fully stir and treat that its complete wetting forms the protection material aqueous solution as the foreign minister, subsequent use;
(3), oil phase preparation: stirring and dissolving in the surfactant that weighs up (sucrose ester) the adding vitamin E is even;
(4), high-speed shearing machine is put into aqueous phase and unlatching; The cutter rotating speed is carried to 4000 commentaries on classics more than 2000 commentaries on classics; Slowly add oil phase, accelerating to 6000-13000 after the entry to be completely changes, and shears that deceleration cutter rotating speed extremely stops fully after 5-15 minute; Get emulsion and add in an amount of water and watch its degree of scatter, cool off after 20-40 minute the recirculation aforesaid operations 1-2 time.
(5), product places microscopically to check the particle situation, is that 2-10 μ m gets final product up to particle diameter, the emulsion of gained is oil-in-water type vitamin E emulsion according to the invention.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.
Embodiment two:
Constituent mass/g
Liquid vitamin E 5
Surfactant (sorbitan ester) 20
Solid protection thing (molecule distillating monoglyceride) 2
Solid protection thing (modified starch) 10
Solid protection thing (cycloheptaamylose) 2
Solid protection thing (TiO2) 1
Distilled water 60
Method for preparing is with instance one.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.
Embodiment three:
Constituent mass/g
Liquid vitamin E 10
Surfactant (sorbitan ester) 5
Surfactant (sucrose ester) 10
Solid protection thing (molecule distillating monoglyceride) 2
Solid protection thing (modified starch) 10
Solid protection thing (cycloheptaamylose) 3
Distilled water 60
Oil-in-water type vitamin E preparation method of emulsion according to the invention may further comprise the steps:
(1), take by weighing by above-mentioned weight proportion: the liquid vitamin E, sorbitan ester, sucrose ester, solid protection thing molecule (molecule distillating monoglyceride, modified starch, cycloheptaamylose), distilled water, subsequent use;
(2), the preparation of water: the solid protection thing molecule (distillation monoglyceride, modified starch, cycloheptaamylose) that will be dissolvable in water water adds stirring and dissolving in the distilled water, forms the protection material aqueous solution as the foreign minister, and is subsequent use;
(3), oil phase preparation: stirring and dissolving in the surfactant that weighs up (sucrose ester) the adding vitamin E is even;
(4), high-speed shearing machine is put into aqueous phase and unlatching; The cutter rotating speed is carried to 4000 commentaries on classics more than 2000 commentaries on classics; Slowly add oil phase, accelerating to 6000-13000 after the entry to be completely changes, and shears that deceleration cutter rotating speed extremely stops fully after 5-15 minute; Get emulsion and add in an amount of water and watch its degree of scatter, cool off after 20-40 minute the recirculation aforesaid operations 2 times.
(5), product places microscopically to check the particle situation, is that 2-10 μ m gets final product up to particle diameter, the emulsion of gained is oil-in-water type vitamin E emulsion according to the invention.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.
Embodiment four:
Constituent mass/g
Liquid vitamin E 15
Surfactant (sorbitan ester) 5
Surfactant (sucrose ester) 5
Solid protection thing (molecule distillating monoglyceride) 2
Solid protection thing (modified starch) 12
Solid protection thing (TiO2) 1
Distilled water 60
Method for preparing is with instance one.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.
Embodiment five:
Constituent mass/g
Liquid vitamin E 20
Surfactant (sorbitan ester) 10
Solid protection thing (molecule distillating monoglyceride) 3
Solid protection thing (modified starch) 15
Solid protection thing (cycloheptaamylose) 2
Distilled water 50
Method for preparing is with instance three.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.Place in stable conditionly after one month, layering, oil slick phenomenon do not take place.But the emulsion flowability is not fine.
Embodiment six:
Constituent mass/g
Liquid vitamin E 20
Surfactant (sucrose ester) 10
Solid protection thing (molecule distillating monoglyceride) 2
Solid protection thing (modified starch) 10
Solid protection thing (cycloheptaamylose) 2
Solid protection thing (TiO2) 1
Distilled water 55
Method for preparing is with instance one.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.Place in stable conditionly after one month, layering, oil slick phenomenon do not take place.Flowability is also better.
Embodiment seven:
Constituent mass/g
Liquid vitamin E 15
Surfactant (sucrose ester) 10
Solid protection thing (molecule distillating monoglyceride) 2
Solid protection thing (modified starch) 5
Solid protection thing (cycloheptaamylose) 2
Solid protection thing (TiO2) 1
Distilled water 65
Method for preparing is with instance one.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.Place in stable conditionly after one month, layering, oil slick phenomenon do not take place.Flowability is also better.
Embodiment eight
Constituent mass/g
Liquid vitamin E 35
Surfactant (sucrose ester) 5
Solid protection thing (molecule distillating monoglyceride) 2
Solid protection thing (modified starch) 5
Solid protection thing (cycloheptaamylose) 2
Solid protection thing (TiO2) 1
Distilled water 50
Method for preparing is with instance one.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.The oil slick phenomenon can occur but place after one month, system is not very stable.
Embodiment nine
Constituent mass/g
Liquid vitamin E 10
Surfactant (sucrose ester) 35
Solid protection thing (molecule distillating monoglyceride) 2
Solid protection thing (modified starch) 5
Solid protection thing (cycloheptaamylose) 2
Solid protection thing (TiO2) 1
Distilled water 45
Method for preparing is with instance one.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.The emulsion foam is more.
Embodiment ten:
Constituent mass/g
Liquid vitamin E 20
Surfactant (sucrose ester) 10
Solid protection thing 15
(in molecule distillating monoglyceride or modified starch or the cycloheptaamylose any or composite) with TiO2
Distilled water 55
Method for preparing is with instance one.
Interpretation of result: detect particle Pass Test target as a result after the emulsifying, censorship can be in stable condition under wide spectrum (PH 2.5-14) scope.
Although the present invention describes with reference to specific embodiment, this description does not also mean that the present invention is constituted restriction.With reference to description of the invention, other of the disclosed embodiments change, and all can expect to those skilled in the art, and this variation should belong in the affiliated claim institute restricted portion.
Claims (4)
1. oil-in-water type vitamin E emulsion is characterized in that by processing forming of following weight proportion: liquid vitamin E 5-35%, solid protection thing 10-20%,
Surfactant 5-35%, distilled water 35-79%,
Wherein above-mentioned surfactant is that in sorbitan ester, the sucrose ester one or both are composite, and above-mentioned solid protection thing is that among molecule distillating monoglyceride, modified starch, cycloheptaamylose, the nanoscale TiO2 one or more are composite.
2. oil-in-water type vitamin E emulsion according to claim 1 is characterized in that by processing forming of following weight proportion: liquid vitamin e1 0-20%, solid protection thing 10-20%, surfactant 10-20%, distilled water 50-65%.
3. oil-in-water type vitamin E preparation method of emulsion as claimed in claim 1 is characterized in that may further comprise the steps:
(1), take by weighing liquid vitamin E, surfactant, solid protection thing by weight ratio, distilled water is subsequent use;
(2), the preparation of water: solid is protected thing to add in the distilled water stirring and dissolving or dissolving and complete wetting and is formed the protection material aqueous solution as the foreign minister, subsequent use;
(3), the preparation of oil phase: surfactant is added the oil phase that forms in the vitamin E as inner phase, stirring and dissolving;
(4), high-speed shearing machine is put into above-mentioned aqueous phase and unlatching; When treating that the cutter rotating speed is carried to 2000-4000 commentaries on classics, slowly add above-mentioned oil phase, accelerating to 6000-13000 after the entry to be completely changes; Shear after 5-15 minute deceleration cutter rotating speed to stopping fully; Cooling off the number of times that determines the circulation aforesaid operations after 20-40 minute again according to dispersion of nano-particles degree in the solution, is that 2-10 μ m gets final product up to particle diameter, and the emulsion of gained is said oil-in-water type vitamin E emulsion.
4. oil-in-water type vitamin E preparation method of emulsion according to claim 3; It is characterized in that in above-mentioned steps (2); Be that solid protection thing molecule distillating monoglyceride, modified starch, the cycloheptaamylose that will be dissolvable in water water earlier adds stirring and dissolving in the distilled water; Treat all to add water-fast nanoscale TiO2 again after the dissolving, fully stir and treat that its complete wetting forms the protection material aqueous solution as the foreign minister.
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| CN1768033A (en) * | 2003-03-28 | 2006-05-03 | 株式会社可乐丽 | Process for producing carotenoid emulsion |
| CN101647598A (en) * | 2009-08-25 | 2010-02-17 | 曹金党 | Preparing method of nanoscale vitamin microemulsion |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1768033A (en) * | 2003-03-28 | 2006-05-03 | 株式会社可乐丽 | Process for producing carotenoid emulsion |
| CN101647598A (en) * | 2009-08-25 | 2010-02-17 | 曹金党 | Preparing method of nanoscale vitamin microemulsion |
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