CN102426711A - Three-dimensional porous bone scaffold discrete model construction method capable of controlling discrete interval - Google Patents
Three-dimensional porous bone scaffold discrete model construction method capable of controlling discrete interval Download PDFInfo
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Abstract
The invention relates to a three-dimensional porous bone scaffold discrete model construction method capable of controlling an interval. The construction method comprises the following steps of: scanning a selected real cancellous bone to get microscopic pore size parameters of the real bone; constructing a three-dimensional bone scaffold solid model according to the parameters; then transforming the solid model to an STL (standard template library) format model represented by a triangle mesh; then performing triangle mesh subdivision on the STL format model represented by the triangle mesh to get a finer triangle mesh model; further calculating a bounding box for the obtained model, and further performing mesh division on the bounding box through an eight-fork tree method according to the designated parameters to get a discrete voxel model; then judging the positions of discrete voxels and marking the discrete voxels in the different positions; and finally sequentially outputting a three-dimensional bone scaffold discrete model according to a three-axis coordinate system. In the construction method, an eight-fork tree is adopted for performing the mesh division on the model according to the designated discrete distance in the construction process, the discrete precision can be controlled through the division times of the eight-fork tree, and the problems that the previous CT (computerized tomography) scanning interval is fixed and the precision can not be further improved are further solved.
Description
Technical field
The present invention relates to a kind of discrete method that is used for the three-dimensional porous entity bone support of LATTICE BOLTZMANN flow field analysis, the three-dimensional porous bone support discrete model construction method that particularly a kind of discrete spacing is controlled.
Background technology
Along with the development of medical skill and computer science and the raising of people's living standard, people are urgent day by day to the requirement of bone defect repair and displacement.The diverse bone types that reparation has wound and disease to cause is damaged, and especially large segmental bone defect is a bone tissue Osteopathic Medicine difficult problem always.Restriction from body bone bone source, the rejection of xenogenesis bone have seriously hindered the development of bone defect repair.The rise of bone tissue engineer is that the damaged repairing and treating of bone has been opened up new research field, cultivates kind of a porous bone support that is implanted with human bone marrow stroma stem cell through the ECP method, is the focus of tissue engineered bone research field.
In the process of in vitro culture; Nutrient solution flows through porous bone support; The human bone marrow stroma stem cell that is not merely in the brace aperture provides the prescribing adequate nutrition material, also carries out mechanical stimulus through the hydrodynamic shear pair cell, promotes human bone marrow stroma stem cell to propagation with to the differentiation of osteocyte.The mechanical stimulus of seeking fluid becomes the focus of bone tissue engineer research to the differentiation influence of human bone marrow stroma stem cell.
Development and grid along with computer hardware technology
BGrid is used in the development that oltzmann is theoretical
BThe oltzmann method is simulated three-dimensional porous bone support, and shearing force becomes the focus that Chinese scholars is paid close attention in the flow field of in vitro culture.To this situation, the construction method of the controlled three-dimensional porous bone support discrete model of a kind of discrete spacing has been proposed.The 3 d-dem model in porous bone support flow field is the basis of using lattice Boltzmann method.Discrete model is the size of reaction entity model not only, has also distinguished entity and hole in the complex space structure of model, and the discrete precision of model is one of important factor in order of flow field analysis precision.In order to satisfy these requirements, it is particularly important that the structure of discrete model just seems.
At present, along with the maturation of biological CAD modeling technique, rapid shaping technique and accurate CT scan technology, bone support discrete model be configured to possibility.But in the process that makes up, generally need produce entity bone support earlier,, and, just can obtain bone support discrete model with the binary image processing again through CT scan.In this building process, because the Flame Image Process error after foozle and the scanning cause final discrete model and initial designing a model to exist than big difference, so that there is bigger trueness error in follow-up numerical simulation result.
Summary of the invention
The objective of the invention is to deficiency, a kind of controlled three-dimensional porous bone support discrete model construction method of dividing based on Octree of discrete spacing is provided to prior art.Construction method is more convenient, and the micromechanism precision of the discrete model of gained is higher, and discrete precision is adjustable, more helps follow-up numerical simulation.
In order to achieve the above object; Design of the present invention is: at first selected true cancellous bone is carried out electron-microscope scanning; To obtain true bone microscopic void dimensional parameters; Utilize UGNX6.0 software to make up three-dimensional bone support solid model then, and be converted into the STL form model of representing by tri patch to solid model by this parameter.Utilize Magics software that the STL model is carried out triangular gridding subdivision, obtain meticulousr triangle grid model.To gained Model Calculation bounding box, and bounding box is carried out grid dividing by designated parameter, obtain the discrete bodies prime model with the Octree method.Judge the position of discrete voxel, and to the different value of discrete voxel mark of diverse location.Export the discrete model of three-dimensional bone support at last successively by three-axis reference.
According to the foregoing invention design, the present invention adopts following technical proposals:
The three-dimensional porous bone support discrete model construction method that a kind of discrete spacing is controlled is characterized in that operation steps is following:
(1) natural cancellous bone is scanned, obtain natural reality cancellous bone microscopic void dimension information;
(2) make up 3D solid porous bone support model according to step (1) gained pore size, obtain microcosmic three-dimensional micropore dimension information and three-dimensional space position information;
(3) be the STL form model of forming by tri patch with step (2) gained 3D solid porous bone support model conversion;
(4) step (3) gained STL form model is carried out triangular gridding subdivision and obtain meticulousr three-dimensional space model numerical data;
(5) bounding box of the whole three-dimensional model of structure, definite cumulative volume of wanting discrete model;
(6) with the Octree method step (5) gained bounding box volume is carried out grid dividing by designated parameters, obtain the discrete voxel of designated parameter;
(7) character of determining step (6) each discrete voxel of gained judges whether discrete voxel is entity and cavity, and the different value of difference mark, obtains model entity and cavity information by discrete voxel value representation;
The three-dimensional of (8) press solid model to the value of the discrete voxel of step (7) gained is exported, and promptly obtains the three-dimensional porous bone support model that disperses.
The present invention compared with prior art; Have following conspicuous outstanding substantive distinguishing features and remarkable advantage: make up three-dimensional entity model with UGNX6.0; And be converted into the STL model that tri patch is represented, carrying out tri patch segmentation, the STL form model that obtains through Magics then; Again through calculating bounding box; Utilize the grid dividing of Octree method, obtain the discrete bodies prime model of different discrete spacings, for the discrete model that obtains different accuracy is provided convenience to the controlled discrete spacing of bounding box; And existing discrete model is to obtain through CT scan, and the sweep span of CT scan has determined the discrete spacing and the precision of discrete model, if the spacing of the discrete gap ratio CT scan that obtains is littler, then will inevitably cause significant errors.It is to accomplish through software operation that this method makes up discrete model, need not employ huge CT scan equipment, and cost is lower, and the processing time is shorter, and efficient is higher.
Description of drawings
Fig. 1 is the flow chart of the three-dimensional porous bone support of structure of the present invention discrete model.
Fig. 2 be the present invention by the electron-microscope scanning digital data, the 3D solid porous bone support illustraton of model that uses UGNX6.0 to make up.
Fig. 3 is that the present invention uses UGNX6.0 software solid model to be converted into the STL form illustraton of model of being represented by tri patch.
Fig. 4 is the bone support illustraton of model after the present invention uses Mimics software refinement tri patch.
Fig. 5 and Fig. 6 are that the present invention is through calculating bounding box, Octree grid dividing, the discrete bone support model of exporting behind the mark voxel then.
Embodiment
A preferred embodiment of the present invention is described with reference to the accompanying drawings as follows: the controlled three-dimensional porous bone support discrete model construction method concrete operations step of this discrete spacing is (referring to Fig. 1) as follows:
(1) use the electron-microscope scanning method that natural cancellous bone is scanned:
Use Electronic Speculum that selected natural cancellous bone is scanned, obtain natural reality cancellous bone microscopic void dimension information;
(2) use UG NX6.0 design 3D solid porous bone support model:
Use UG NX6.0 to make up 3D solid porous bone support model (see figure 2), obtain microcosmic three-dimensional micropore dimension information and three-dimensional space position information by true pore size;
(3) use UG NX6.0 software that 3D solid porous bone support model conversion is STL form model:
Use UG NX6.0 above-mentioned three-dimensional entity model to be converted into the STL form model (see figure 3) of forming by tri patch;
(4) utilize Magics software that the tri patch model is carried out triangular gridding subdivision:
With Magics software STL form model is carried out the grid segmentation, obtain meticulousr three dimensions (see figure 4) model numerical data;
(5) make up the model bounding box:
Make up the bounding box of whole three-dimensional model, confirm to want the cumulative volume of discrete model;
(6) with the Octree method bounding box uniform grid is divided:
With the Octree method bounding box volume is carried out grid dividing by designated parameters, can obtain the discrete voxel of designated parameter;
(7) each voxel properties of mark:
Judge voxel properties, judge whether discrete voxel is entity and cavity, and the different value of difference mark, model entity and cavity information obtained by discrete voxel value representation;
(8) obtain discrete voxel:
Three-dimensional output the value of discrete voxel is pressed solid model promptly obtains the three-dimensional porous bone support model (seeing Fig. 5 and Fig. 6) that disperses.
Claims (1)
1. three-dimensional porous bone support discrete model construction method that discrete spacing is controlled is characterized in that operation steps is following:
(1) natural cancellous bone is scanned, obtain natural reality cancellous bone microscopic void dimension information;
(2) make up 3D solid porous bone support model according to step (1) gained pore size, obtain microcosmic three-dimensional micropore dimension information and three-dimensional space position information;
(3) be the STL form model of forming by tri patch with step (2) gained 3D solid porous bone support model conversion;
(4) step (3) gained STL form model is carried out triangular gridding subdivision and obtain meticulousr three-dimensional space model numerical data;
(5) bounding box of the whole three-dimensional model of structure, definite cumulative volume of wanting discrete model;
(6) with the Octree method step (5) gained bounding box volume is carried out grid dividing by designated parameters, obtain the discrete voxel of designated parameter;
(7) character of determining step (6) each discrete voxel of gained judges whether discrete voxel is entity and cavity, and the different value of difference mark, obtains model entity and cavity information by discrete voxel value representation;
The three-dimensional of (8) press solid model to the value of the discrete voxel of step (7) gained is exported, and promptly obtains the three-dimensional porous bone support model that disperses.
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| CN103971372A (en) * | 2014-05-21 | 2014-08-06 | 南华大学 | Fast artificial bone forming method |
| CN104385586A (en) * | 2014-09-23 | 2015-03-04 | 四川理工学院 | Method for obtaining carbon black microscopic morphology enlarging entity through 3D printing |
| CN105241911A (en) * | 2015-09-23 | 2016-01-13 | 中国石油大学(北京) | LBM-based simulated low field nuclear magnetic resonance fluid analysis method and device |
| CN105976425A (en) * | 2016-04-13 | 2016-09-28 | 深圳市艾科赛龙科技有限公司 | Method and device for structural design |
| CN106933522A (en) * | 2017-03-06 | 2017-07-07 | 武汉中天元科技有限公司 | A kind of long-range 3D printing method and system |
| CN106934116A (en) * | 2017-02-22 | 2017-07-07 | 华南理工大学 | A kind of bone support aperture distribution control method based on genetic algorithm |
| CN107111895A (en) * | 2015-01-30 | 2017-08-29 | 惠普发展公司有限责任合伙企业 | Variable density is modeled |
| CN108230441A (en) * | 2018-01-09 | 2018-06-29 | 华南理工大学 | A kind of method for building cigarette threedimensional model and its improving cavity |
| CN105608744B (en) * | 2015-12-24 | 2018-10-02 | 中国科学院重庆绿色智能技术研究院 | The internal void design method of imitative period minimal surface based on tetrahedral grid |
| CN109872386A (en) * | 2019-01-18 | 2019-06-11 | 北京理工大学 | A kind of the physical property of product modeling method based on the accurate voxelization of STL model |
| CN109977507A (en) * | 2019-03-15 | 2019-07-05 | 浙江大学 | A kind of complex topography porous support efficiently produces method |
| CN111223179A (en) * | 2020-01-03 | 2020-06-02 | 上海交通大学 | Method and device for processing porosity information of bone scaffold model |
| CN111899346A (en) * | 2020-07-16 | 2020-11-06 | 天津理工大学 | Mathematical modeling method of controllable porous bone tissue engineering scaffold |
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| CN103616494A (en) * | 2013-11-28 | 2014-03-05 | 中国石油天然气集团公司 | Method and system for simulating pore space fluid distribution of core |
| CN103971372A (en) * | 2014-05-21 | 2014-08-06 | 南华大学 | Fast artificial bone forming method |
| CN104385586A (en) * | 2014-09-23 | 2015-03-04 | 四川理工学院 | Method for obtaining carbon black microscopic morphology enlarging entity through 3D printing |
| CN107111895A (en) * | 2015-01-30 | 2017-08-29 | 惠普发展公司有限责任合伙企业 | Variable density is modeled |
| EP3251097A4 (en) * | 2015-01-30 | 2018-09-26 | Hewlett-Packard Development Company, L.P. | Variable density modeling |
| CN105241911A (en) * | 2015-09-23 | 2016-01-13 | 中国石油大学(北京) | LBM-based simulated low field nuclear magnetic resonance fluid analysis method and device |
| CN105241911B (en) * | 2015-09-23 | 2017-07-21 | 中国石油大学(北京) | The method and device that low-field nuclear magnetic resonance analyzes fluid is simulated based on LBM |
| CN105608744B (en) * | 2015-12-24 | 2018-10-02 | 中国科学院重庆绿色智能技术研究院 | The internal void design method of imitative period minimal surface based on tetrahedral grid |
| CN105976425B (en) * | 2016-04-13 | 2019-12-03 | 深圳市艾科赛龙科技股份有限公司 | A kind of method and device of structure design |
| CN105976425A (en) * | 2016-04-13 | 2016-09-28 | 深圳市艾科赛龙科技有限公司 | Method and device for structural design |
| CN106934116A (en) * | 2017-02-22 | 2017-07-07 | 华南理工大学 | A kind of bone support aperture distribution control method based on genetic algorithm |
| CN106934116B (en) * | 2017-02-22 | 2020-09-22 | 华南理工大学 | Bone scaffold pore size distribution control method based on genetic algorithm |
| CN106933522A (en) * | 2017-03-06 | 2017-07-07 | 武汉中天元科技有限公司 | A kind of long-range 3D printing method and system |
| CN108230441A (en) * | 2018-01-09 | 2018-06-29 | 华南理工大学 | A kind of method for building cigarette threedimensional model and its improving cavity |
| CN108230441B (en) * | 2018-01-09 | 2021-09-21 | 华南理工大学 | Method for constructing cigarette three-dimensional model and optimizing flow channel thereof |
| CN109872386A (en) * | 2019-01-18 | 2019-06-11 | 北京理工大学 | A kind of the physical property of product modeling method based on the accurate voxelization of STL model |
| CN109977507A (en) * | 2019-03-15 | 2019-07-05 | 浙江大学 | A kind of complex topography porous support efficiently produces method |
| CN111223179A (en) * | 2020-01-03 | 2020-06-02 | 上海交通大学 | Method and device for processing porosity information of bone scaffold model |
| CN111223179B (en) * | 2020-01-03 | 2022-11-25 | 上海交通大学 | Method and device for processing porosification information of bone scaffold model |
| CN111899346A (en) * | 2020-07-16 | 2020-11-06 | 天津理工大学 | Mathematical modeling method of controllable porous bone tissue engineering scaffold |
| CN111899346B (en) * | 2020-07-16 | 2024-05-07 | 天津理工大学 | Mathematical modeling method of controllable porous bone tissue engineering scaffold |
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