CN102423398A - Medicament for treating constipation and preparation method thereof - Google Patents
Medicament for treating constipation and preparation method thereof Download PDFInfo
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- CN102423398A CN102423398A CN2011104167823A CN201110416782A CN102423398A CN 102423398 A CN102423398 A CN 102423398A CN 2011104167823 A CN2011104167823 A CN 2011104167823A CN 201110416782 A CN201110416782 A CN 201110416782A CN 102423398 A CN102423398 A CN 102423398A
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Abstract
The invention discloses a medicament for treating constipation. The medicament is characterized in that the medicament comprises a basic medicament A and an adjuvant B, wherein, the basic medicament A comprises the components of dragon blood, pseudo-ginseng, purslane, mint and angleworm powder in a weight ratio of 1:2:3:3:1, and the adjuvant B comprises the components of Chinese date, sulphur, coptis, safflower, dragon bone, rhizoma ligustici wallichii and angleworm powder in a weight ratio of 100:5:30:1:1.5:1:(15-20). The preparation method comprises the steps of preparing the components of the basic medicament A and the adjuvant B according to above ratio to powder, and evenly mixing the powder followed by packaging into capsules or preparing into pills. The medicament for treating constipation disclosed by the invention is on the basis of recognition and treatment principle of constipation pathogenesis, takes modern pharmacology research as reference, and utilizes medicaments capable of diminishing inflammation, expelling toxin, cooling and reducing pathogenic fire to realize the purpose of treating constipation. The medicament is convenient to take and has remarkable treatment effect and no toxic or side effect, relapse does not occur after healing, and the curative rate can reach 95%.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, relate to a kind of medicine of treating constipation and preparation method thereof.
Background technology
Constipation is a kind of symptom of multiple disease, rather than a kind of disease.Concerning different patient, constipation has different implications.The common sympton of constipation is that defecation frequency obviously reduces, and per 2～3 days or longer time, once irregular, excrement matter was stiff, often with the pathological phenomenon of difficult defecation sense.
The reason of constipation often is not single, and directly the reason of morbidity can be divided into two kinds, i.e. the colonic constipation and the blunt proctogenous constipation that causes of rectal reflex that cause of colon bradykinesia or spasm.Specifically, the origin cause of formation of constipation comprises following several kinds:
1, because bad dietary habit, make the mechanicalness of food or chemical irritation not enough, or very few, meticulous because of the food of taking in, intestinal is stimulated reduce, reflexive wriggle weakness and cause constipation.
2, living habit changes, the defecation posture is improper, often take strong cathartic and coloclysis etc., all can cause rectal reflex sensitivity to descend, though so that have feces to get into, and be not enough to cause effective neural impulse, defecation reflex can not be produced and cause constipation.
3, spirit depressing or too exciting makes trained reflex generation obstacle and causes constipation.
4, bad living habit, do not have enough sleep, continue the biotonus of height etc., also can cause the not normal and spastic contraction of wriggling of colon and cause constipation.
And the old people is comparatively common with the constipation of simple property, and its generation is relevant with two factors: 1, the tension force of intestinal tube and wriggle weakness, and food overstays at enteral, and moisture excessively is absorbed; 2, gastro-colic reflex weakens, and mucous membrane of rectum sensitivity descends, and the muscle tone of participating in defecation is low.
Summary of the invention
One of the object of the invention provide a kind of evident in efficacy and more after the medicine of the treatment constipation of not recurring.
For addressing the above problem, the technical scheme that the present invention adopted is:
A kind of medicine of treating constipation is characterized in that: this medicine comprises principal agent A and accessory drugs B, wherein:
1, the component that comprises of principal agent A is: Sanguis Draxonis, Radix Notoginseng, Herba Portulacae, Herba Menthae and Lumbricus powder, and the part by weight of each component is: 1: 2: 3: 3: 1;
2, the component that comprises of accessory drugs B is: Fructus Jujubae, sulfur, Rhizoma Coptidis, Flos Carthami, Os Draconis, Rhizoma Chuanxiong and Lumbricus powder, the part by weight of each component is: 100: 5: 30: 1: 1.5: 1: 15-20.
Say further:
Also include turtle blood among the said accessory drugs B.
Another object of the present invention provides the manufacture method of above-mentioned treatment constipation medicine, it is characterized in that:
1, the making step of said principal agent A is following:
A1, to get Sanguis Draxonis some, clay into power; It is some to get Radix Notoginseng, clays into power; It is some to get Herba Portulacae, clays into power; It is some to get Herba Menthae, clays into power; It is some to get dried earthworms, clays into power;
A2, will grind good Sanguis Draxonis powder, Radix Notoginseng powder, Herba Portulacae powder, Herba Menthae powder and Lumbricus powder: encapsulated behind 3: 1 the part by weight mix homogeneously according to 1: 2: 3.
2, the making step of said accessory drugs B is following:
B1, according to 100: 5: 30: 1: 1.5: 1: it is some that the part by weight of 15-20 is respectively got Fructus Jujubae, sulfur, Rhizoma Coptidis, Flos Carthami, Os Draconis, Rhizoma Chuanxiong and dried earthworms;
B2, Fructus Jujubae and sulfur one are reinstated fire and are burned to becoming ash; Rhizoma Coptidis, Flos Carthami, Os Draconis, Rhizoma Chuanxiong and dried earthworms grind respectively becomes powder;
Encapsulated or process pill behind B3, ash, Rhizoma Coptidis powder, Flos Carthami powder, Os Draconis Powder, Rhizoma Chuanxiong power and the Lumbricus powder mix homogeneously with Fructus Jujubae and sulfur.
Say further:
Also be added with the Trionyx sinensis Wiegmann blood powder in the making of said accessory drugs B.
In the prescription of treatment constipation of the present invention:
Sanguis Draxonis: have blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, astringing to arrest bleeding, remarkable efficacy such as hard masses softening and resolving, promoting tissue regeneration and ulcer healing.
Radix Notoginseng: have the dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain.Cure mainly have blood in stool, metrorrhagia, traumatic hemorrhage.
Herba Portulacae: the herb hyoscine has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, antiinflammatory.
Herba Menthae: have itching-relieving efficacies, be applicable to that skin is itched, disease such as colic, dysentery and scrofula, external has slight analgesic effect.
Lumbricus: Chinese medicine is claimed Pheretima, and is cold in nature, salty in the mouth.Have heat clearing away, spasmolytic function.
Fructus Jujubae: have supplementing QI for promoting the production of body fluid, transfer battalion to defend, separate the function of poison of drug; Control the weak loose stool of spleen, qi-blood-body fluid is not enough.
Sulfur: the external use anti pruritic parasite killing is treated skin ulcer; The fiery supporing yang relieving constipation of benefit for oral administration.
Rhizoma Coptidis: have heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, dysentery, hyperactivity of heart-fire, heat in blood is told nosebleed, quenches one's thirst the carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Flos Carthami: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Be used for that lochia is not all right, lump in the abdomen mass in the abdomen, traumatic injury.
Os Draconis: kidney tonifying is relieving convulsion, ends cloudy malaria, removing dampness gas, proctoptosis, promoting tissue regeneration and ulcer healing.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.
Turtle blood: have the sterilizing effect.
The present invention is divided into principal agent and accessory drugs, and principal agent is mainly used in blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; And accessory drugs is mainly used in eliminating fire and detoxication, promoting blood circulation to restore menstrual flow.
Clinical experiment
Histopathologic examination is used to treat the clinical experiment that the constipation disease has been carried out 318 routine patients with contrast product of the present invention.Single at random blind method, experimental group 206 examples, matched group 112 examples are adopted in experiment.
1, case choice criteria: (1) acute constipation; (2) chronic constipation.
2, group technology: (1) treatment group: Chinese medicine preparation of the present invention, outpatient service random packet; (2) matched group: Western medicine mosapride, outpatient service random packet, single blind contrast.
3, medication: the capsule of the oral system of the present invention of experimental group, one time 10, one day three times, a week is a course of treatment;
Matched group is taken mosapride, one time 1,2 times on the one, a week is a course of treatment.
4, grouping situation:
(1) treatment group: 206 examples (comprising acute and chronic constipation), male 95 examples, women 111 examples; 24-34 year 20 examples, 35-60 year 130 examples, 56 examples more than 61 years old.
(2) matched group: 112 row (comprising acute and chronic constipation), male 60 examples, women 52 examples; 20-34 year 20 examples, 35-60 year 77 examples, 15 examples more than 61 years old.
The result shows: test group and matched group total effective rate are respectively 95.89% and 62.19%.
Wherein, in the matched group, mosapride is comparatively obvious to the chronic constipation effect, and is relatively poor to acute constipation effect, and follows side effect such as inappetence, retch, recurrence again after some patient cures;
In the test group,, have no side effect to acute or the chronic constipation therapeutic effect is all comparatively obvious, and the patient of recovery from illness, recurrence all do not had.
Through statistical procedures, P＜0.03 shows that test group has significant curative effect, and statistical significance is arranged.
The medicine of treatment constipation according to the invention is based on pathogenetic understanding of constipation and Therapeutic Principle; With reference to modern pharmacological research; The medicine of utilization antiinflammatory, toxin expelling and refrigerant pathogenic fire reducing; Reach the purpose of treatment constipation, taking convenience, evident in efficacy, have no side effect, do not recur after more, cure rate reaches 95%.
Below in conjunction with the specific embodiment the present invention is done further description.
The specific embodiment
Embodiment:
A kind of medicine of treating constipation, this medicine comprise principal agent A and accessory drugs B, wherein:
1, the component that comprises of principal agent A is: Sanguis Draxonis, Radix Notoginseng, Herba Portulacae, Herba Menthae and Lumbricus powder, and the part by weight of each component is: 1: 2: 3: 3: 1;
2, the component that comprises of accessory drugs B is: Fructus Jujubae, sulfur, Rhizoma Coptidis, Flos Carthami, Os Draconis, Rhizoma Chuanxiong and Lumbricus powder, the part by weight of each component is: 100: 5: 30: 1: 1.5: 1: 15-20.
In order to improve curative effect, also include the turtle blood of trace among the accessory drugs B, and the preferred Xinjiang of Fructus Jujubae Fructus Jujubae.
The manufacture method of above-mentioned treatment constipation medicine is:
1, the making step of principal agent A is following:
A1, to get Sanguis Draxonis some, clay into power; It is some to get Radix Notoginseng, clays into power; It is some to get Herba Portulacae, clays into power; It is some to get Herba Menthae, clays into power; It is some to get dried earthworms, clays into power;
A2, will grind good Sanguis Draxonis powder, Radix Notoginseng powder, Herba Portulacae powder, Herba Menthae powder and Lumbricus powder: encapsulated behind 3: 1 the part by weight mix homogeneously according to 1: 2: 3.
2, the making step of said accessory drugs B is following:
B1, according to 100: 5: 30: 1: 1.5: 1: it is some that the part by weight of 15-20 is respectively got Fructus Jujubae, sulfur, Rhizoma Coptidis, Flos Carthami, Os Draconis, Rhizoma Chuanxiong and dried earthworms;
B2, Fructus Jujubae and sulfur one are reinstated fire and are burned to becoming ash; Rhizoma Coptidis, Flos Carthami, Os Draconis, Rhizoma Chuanxiong and dried earthworms grind respectively becomes powder;
Encapsulated or process pill behind B3, ash, Rhizoma Coptidis powder, Flos Carthami powder, Os Draconis Powder, Rhizoma Chuanxiong power and the Lumbricus powder mix homogeneously with Fructus Jujubae and sulfur.
In order to improve curative effect, also be added with the Trionyx sinensis Wiegmann blood powder in the making of said accessory drugs B.
Instructions of taking of the present invention is: oral, took three times in 1st, and take 10 of 10 of principal agent A capsule or pills, accessory drugs B capsule or pills at every turn, a week is a course of treatment.
Below be the case that part is cured:
Hu XX, woman, 45 years old, the worker of Shouguang packing house, 2011.1.7
Patient's feces is dried, hard, and anal canal pain has laceration during defecation, and clinical diagnosis is acute constipation, takes medicine of the present invention five days, transference cure, and defecation is normal, does not have recurrence in half a year.
Cao XX, woman, 47 years old, the teacher of Shouguang City experimental middle school, 2011.1.19
Patient's feces is dried, hard, difficult defecation, and perianal abscess, clinical diagnosis is acute constipation, takes medicine of the present invention seven days, transference cure, defecation is normal, does not have recurrence in half a year.
Zhao X, man, 51 years old, city, Shouguang City, 2011.2.5
The average 2-3 of patient days bowel movement once, difficulty during defecation, epigastrium is glutted, nauseating, regurgitation, abdominal discomfort and hypogastralgia, clinical diagnosis is a chronic constipation, takes medicine of the present invention seven days, transference cure, defecation is normal, does not have in half a year and recurs.
Horse XX, the man, 62 years old, the Sheng Chengjie of Shouguang City did, 2011.2.14
The patient defecates irregular, and difficulty when draining, and there is inflammation the part, has bearing down and defecation to feel not to the utmost, and clinical diagnosis is a chronic constipation, takes medicine of the present invention five days, transference cure, and defecation is unobstructed, regular, does not have in three months and recurs.
Horse XX, woman, 36 years old, the worker of Shouguang textile mills, 2011.2.25
Patient's defecation is irregular, and feces does, hard, anal canal pain, and, regurgitation glutted, nauseating, abdominal discomfort and hypogastralgia symptom with epigastrium, clinical diagnosis is acute constipation, takes medicine of the present invention after seven days, transference cure does not have in three months and recurs.
Limit XX, man, 52 years old, the workman of Shouguang City machinery plant, 2011.3.2
Patient's defecation is not smooth, companion tormina, abdominal distention and symptoms of emesis, and clinical diagnosis is acute constipation, takes medicine of the present invention after seven days, transference cure, five recurrences in three months.
Merchant XX, the woman, 63, the Sheng Chengjie of Shouguang City does, 2011.3.9
Patient's hypogastric region or rectum, anal distending pain discomfort firmly solve hard and thick excrement group back distending pain and alleviate, and clinical diagnosis is a proctogenous constipation, takes medicine of the present invention after two weeks, and transference cure does not have in half a year and recurs.
Liu X, woman, 34 years old, Shouguang City Building Materials Factory, 2011.4.6
Patient's left lower quadrant dull pain is uncomfortable, solve the hard excrement group that is the Semen Castaneae shape after, dull pain is alleviated, clinical diagnosis is spastic colon or irritable bowel syndrome (constipation a kind of), takes two week of medicine back recovery from illness of the present invention, does not have recurrence so far.
Horse XX, man, 33 years old, discipline platform town, Shouguang City, 2011.4.9
Patient's constipation and diarrhoea alternately, and have umbilicus week or in, hypogastric region dull pain, clinical diagnosis is acute constipation, takes medicine of the present invention after two courses of treatment, transference cure does not have recurrence so far.
In sum, medicine of the present invention has reducing swelling and alleviating pain, the promoting blood circulation and detumescence blood stasis dispelling, and effects such as removing the necrotic tissue and promoting granulation, promoting blood circulation to restore menstrual flow, remarkable to treatment acute and chronic constipation effect, cure rate is high, is difficult for recurrence.
Claims (4)
1. medicine of treating constipation, it is characterized in that: this medicine comprises principal agent A and accessory drugs B, wherein:
(1) component that comprises of principal agent A is: Sanguis Draxonis, Radix Notoginseng, Herba Portulacae, Herba Menthae and Lumbricus powder, and the part by weight of each component is: 1: 2: 3: 3: 1;
(2) component that comprises of accessory drugs B is: Fructus Jujubae, sulfur, Rhizoma Coptidis, Flos Carthami, Os Draconis, Rhizoma Chuanxiong and Lumbricus powder, the part by weight of each component is: 100: 5: 30: 1: 1.5: 1: 15-20.
2. according to the medicine of the said treatment constipation of claim 1, it is characterized in that: also include turtle blood among the said accessory drugs B.
3. treat the manufacture method of constipation medicine according to claim 1, it is characterized in that:
(1) making step of said principal agent A is following:
A1) it is some to get Sanguis Draxonis, clays into power; It is some to get Radix Notoginseng, clays into power; It is some to get Herba Portulacae, clays into power; It is some to get Herba Menthae, clays into power; It is some to get dried earthworms, clays into power;
A2) will grind good Sanguis Draxonis powder, Radix Notoginseng powder, Herba Portulacae powder, Herba Menthae powder and Lumbricus powder according to 1: 2: 3: encapsulated or process pill behind 3: 1 the part by weight mix homogeneously.
(2) making step of said accessory drugs B is following:
B1) according to 100: 5: 30: 1: 1.5: 1: it is some that the part by weight of 15-20 is respectively got Fructus Jujubae, sulfur, Rhizoma Coptidis, Flos Carthami, Os Draconis, Rhizoma Chuanxiong and dried earthworms;
B2) Fructus Jujubae and sulfur one are reinstated the fire burning to becoming ash; Rhizoma Coptidis, Flos Carthami, Os Draconis, Rhizoma Chuanxiong and dried earthworms grind respectively becomes powder;
B3) encapsulated or process pill behind ash, Rhizoma Coptidis powder, Flos Carthami powder, Os Draconis Powder, Rhizoma Chuanxiong power and the Lumbricus powder mix homogeneously with Fructus Jujubae and sulfur.
4. the manufacture method of treatment constipation medicine according to claim 3 is characterized in that: also be added with the Trionyx sinensis Wiegmann blood powder in the making of said accessory drugs B.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104167823A CN102423398A (en) | 2010-11-29 | 2011-11-24 | Medicament for treating constipation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105617809A CN102008616A (en) | 2010-11-29 | 2010-11-29 | Drug for curing constipation and preparing method thereof |
| CN201010561780.9 | 2010-11-29 | ||
| CN2011104167823A CN102423398A (en) | 2010-11-29 | 2011-11-24 | Medicament for treating constipation and preparation method thereof |
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| CN102423398A true CN102423398A (en) | 2012-04-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010105617809A Pending CN102008616A (en) | 2010-11-29 | 2010-11-29 | Drug for curing constipation and preparing method thereof |
| CN2011104167823A Pending CN102423398A (en) | 2010-11-29 | 2011-11-24 | Medicament for treating constipation and preparation method thereof |
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| CN2010105617809A Pending CN102008616A (en) | 2010-11-29 | 2010-11-29 | Drug for curing constipation and preparing method thereof |
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Application publication date: 20120425 |