CN102240324B - Compound medicament for treating dental ulcer - Google Patents
Compound medicament for treating dental ulcer Download PDFInfo
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- CN102240324B CN102240324B CN 201110245762 CN201110245762A CN102240324B CN 102240324 B CN102240324 B CN 102240324B CN 201110245762 CN201110245762 CN 201110245762 CN 201110245762 A CN201110245762 A CN 201110245762A CN 102240324 B CN102240324 B CN 102240324B
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Abstract
The invention relates to a compound medicament for treating dental ulcer, which consists of the following medicinal materials in percentage by weight: 20 percent of baical skullcap root, 5 percent of liquoric root, 20 percent of astragalus, 5 percent of climbing groundsel herb, 10 percent of rabdosia rubescens, 10 percent of divaricate saposhnikovia root, 10 percent of spanishneedles herb, 20 percent of largehead atractylodes rhizome and dexamethasone powder. Simultaneously, 150 milligrams of the dexamethasone powder is added into each 100 grams of the medicinal materials, and the medicinal materials are ground into powder and are loaded into capsule shells with the dexamethasone powder to prepare capsules. The compound medicament has the advantages of addressing both symptoms and root causes, along with small dose, quick response, high cure rate and no irritation or side effect, is easy to take, and is mainly used for treating recurrent dental ulcer caused by endocrine disorders, weakness of the spleen and the stomach and exuberant irascibility in clinic.
Description
Technical field
The present invention relates to a kind of medicine, relate in particular to a kind of compound medicine of treating oral ulcer, belong to the pharmaceutical preparations technology field.
Background technology
Oral ulcer is a frequently-occurring disease more common in the daily life; Bite as having in the oral cavity, abrade, scald, the wound of scuffing and unknown cause all can cause the generation of oral ulcer, and factors such as psychentonia, endocrine disturbance, immunologic dysfunction digestive system disease can cause the generation of ulcer fond of food that is not salty equally.In case the formation oral ulcer not only can influence patient orthobiosis, working and learning, malpractice even can cause general disease sometimes.Though what serious disease is oral ulcer be not, usually pain makes the difficult peace of patient's sleeping and eating unbearably, and then lowers the resistance of the body, and therefore can not be ignored.At present, though it is a lot of to be used to treat the medicine of oral ulcer on the market, mostly cure the symptoms, not the disease, remove the focus difficulty, more can not control the recurrence of oral ulcer, curative effect is not good enough, and mostly takes inconvenience.
Summary of the invention
The objective of the invention is to overcome and solve the deficiency of existing treatment and provide a kind of treating both the principal and secondary aspects of a disease, dose little, take effect strange fast, cure rate is high, take the compound medicine of simple treatment oral ulcer; Be primarily aimed at endocrine disturbance, weakness of the spleen and stomach, the liver-fire recurrent oral ulceration that causes such as vigorous, its disease sees that aphtha of the mouth and tongue shows effect repeatedly, the light depression of wound surface color; And do not heal for a long time; Conjunctival congestion tinnitus, inappetence, thready and weak pulse.
Technical scheme of the present invention is achieved in that
A kind of compound medicine of treating oral ulcer is characterized in that, by Radix Scutellariae, and Radix Glycyrrhizae, the Radix Astragali; Herba Senecionis Scandentis, Rabdosia rubescens, windproof, Herba Bidentis Bipinnatae, the Rhizoma Atractylodis Macrocephalae and dexamethasone powder are formed; Above-mentioned medical material is Radix Scutellariae 20% by weight ratio, Radix Glycyrrhizae 5%, the Radix Astragali 20%, Herba Senecionis Scandentis 5%, Rabdosia rubescens 10%; Windproof 10%, Herba Bidentis Bipinnatae 10%, the Rhizoma Atractylodis Macrocephalae 20%, in above-mentioned medical material, per 100 gram medical materials add dexamethasone powder 150mg simultaneously.
A kind of method for preparing of treating the compound medicine of oral ulcer is characterized in that, by Radix Scutellariae, and Radix Glycyrrhizae, the Radix Astragali; Herba Senecionis Scandentis, Rabdosia rubescens, windproof, Herba Bidentis Bipinnatae; The Rhizoma Atractylodis Macrocephalae and dexamethasone powder are formed, and above-mentioned medical material is Radix Scutellariae 20% by weight ratio, Radix Glycyrrhizae 5%, the Radix Astragali 20%; Herba Senecionis Scandentis 5%, Rabdosia rubescens 10%, windproof 10%, Herba Bidentis Bipinnatae 10%; The Rhizoma Atractylodis Macrocephalae 20%, simultaneously in above-mentioned medical material, per 100 gram medical materials add dexamethasone powder 150mg, mixing is encased in and processes capsule in the capsule shells with the dexamethasone powder behind the above-mentioned Chinese medicine pulverize.
The pharmacological effect of each component of medicine of the present invention is following:
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Glycyrrhizae: with middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.Control weakness of the spleen and stomach, lack of appetite, the stomachache loose stool, the overstrain heating, cardiopalmus is fainted from fear; Give birth to usefulness, control laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.
The Radix Astragali: benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.
Herba Senecionis Scandentis: heat clearing away, detoxifcation, parasite killing makes eye bright.Control various acute inflammatory diseases, the wind-fire acute conjunctivitis, corneal nebula, typhoid fever, bacillary dysentery, lobar pneumonia, tonsillitis, enteritis, jaundice, influenza, toxemia, septicemia, carbuncle furuncle poison, dried exudative dermatitis skin ulcer, erysipelas, eczema is scalded trichomonal vaginitis.Be used for anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema furuncle.
Rabdosia rubescens: heat-clearing and toxic substances removing, anti-inflammatory analgetic, be good for the stomach and invigorate blood circulation.
Windproof: expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion is jerked surely, is used for headache due to common cold, rubella pruritus, rheumatic arthralgia, tetanus opisthotonus, gnathospasma, tic spasm.
Herba Bidentis Bipinnatae: heat-clearing and toxic substances removing; Expelling wind and removing dampness; Promoting blood circulation and detumescence.Be used for laryngopharynx swelling and pain; Have loose bowels; Dysentery; Jaundice; The intestinal carbuncle; Furuncle swelling toxin; Serpentis is early bitten; Rheumatic arthralgia; Traumatic injury.
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Dexamethasone: antiinflammatory, antiallergic, rheumatism, immunosuppressive action are mainly used in the treatment severe bacterial infections and reach the eye inflammation responsive to glucocorticoid with serious anaphylactic disease, various thrombocytopenic purpura, granulocytopenia, serious dermatosis, the immunological rejection of organ transplantation, oncotherapy.
Medicine of the present invention has endocrine regulation, invigorating the spleen and replenishing QI, invigorating the spleen for eliminating dampness; Heat-clearing and toxic substances removing, the effect of clearing heart fire, the Radix Astragali in the said medicine component, windproof, the synthetic YUPINGFENG SAN of the Rhizoma Atractylodis Macrocephalae; Endocrine regulation is arranged, the effect of enhancing immunity, and the dexamethasone powder has the effect of quick antiinflammatory; With can also alleviate its side effect after YUPINGFENG SAN combines, and then performance drug effect that can be bigger.For endocrine disturbance, weakness of the spleen and stomach, the liver-fire recurrent oral ulceration that causes such as vigorous special effect is arranged, through the clinical verification cure rate up to 95%.Medicine of the present invention can eaten in each recurrence, slowly will enhancing immunity, reduce the probability of recurrence.
To use clinical effectiveness report of the present invention as follows at present:
Patient age: 5-35 year, women's 17 examples, male's 33 examples.
One, all patients cause that recurrent oral ulceration, clinical manifestation have aphtha of the mouth and tongue to show effect repeatedly because endocrine disturbance, weakness of the spleen and stomach, liver-fire are vigorous etc. all in daily life, the light depression of wound surface color, and do not heal conjunctival congestion tinnitus, inappetence, thready and weak pulse for a long time; Trial product adopts the compound medicine of the treatment oral ulcer of producing according to above-mentioned prescription and method for preparing.
Two, test method: all patients do detailed inspection by the expert, confirm medication dose according to the state of an illness, and are oral, three times on the one, one time 1, one after each meal, and enjoin the patient to take medicine is on request paid a return visit two days later, observes the ulcer healing situation.
Three, evaluation methodology: after one week, observe the ulcer healing situation with the compound medicine of treating oral ulcer.Healing is divided into: first class, second class, third class healing, statistics healing state rate.After this, to patient's follow-up investigation two months, whether record patient recurred.
Four, evaluation criterion: first class healing: refer to that ulcer healing is good, fully healing.Second class healing: refer to that ulcer healing is not good enough, also have inflammatory reactions such as redness.Third class healing: refer to not healing of ulcer, need do Surgery Treatment.
Five, result of the test: all ulcer: 50 routine 80 place's wounds, the first class healing, healing rate is 95%, and all malaise symptoms of patient all disappear, and relapse rate is 5%.
Six, untoward reaction: the patient take medicine occur weight increase two days later, feel sick, serious discomfort appears in vomiting, inappetence, peptic ulcer patient.In drug withdrawal all disappearances automatically of these discomforts after a day.
Seven, conclusion (of pressure testing): this clinical test results shows that this drug administration amount is little, and it is strange fast to take effect, and cure rate is high, and cure rate is up to 95%, and relapse rate is 5%, can alleviate patient's misery fast, promotes ulcer healing.
Eight: indication: by endocrine disturbance, weakness of the spleen and stomach, the liver-fire recurrent oral ulceration that causes such as vigorous, its clinical manifestation has aphtha of the mouth and tongue to show effect repeatedly, the light depression of wound surface color, and do not heal conjunctival congestion tinnitus, inappetence, thready and weak pulse for a long time.
Nine, points for attention: must not serve on above 5-7 days, the careful usefulness of patient of peptic ulcer is arranged, hypertension, diabetics take the circumstances into consideration to take, anemia of pregnant woman's forbidding.
The specific embodiment
Below in conjunction with embodiment the present invention is done further detailed description.
Dispose this medicine of 100g, take off the row raw material:
Radix Scutellariae 20g, Radix Glycyrrhizae 5g, Radix Astragali 20g, Herba Senecionis Scandentis 5g, Rabdosia rubescens 10g, windproof 10g, Herba Bidentis Bipinnatae 10g, Rhizoma Atractylodis Macrocephalae 20g, dexamethasone powder 150mg; Process capsule in the capsule shells mixing to be encased in the dexamethasone powder behind the above-mentioned Chinese medicine pulverize, amount to 200 capsules.Oral, every day three times, one time 1, one after each meal.
Claims (2)
1. a compound medicine of treating oral ulcer is characterized in that, by Radix Scutellariae, and Radix Glycyrrhizae, the Radix Astragali; Herba Senecionis Scandentis, Rabdosia rubescens, windproof, Herba Bidentis Bipinnatae, the Rhizoma Atractylodis Macrocephalae and dexamethasone powder are formed; Above-mentioned medical material is Radix Scutellariae 20% by weight ratio, Radix Glycyrrhizae 5%, the Radix Astragali 20%, Herba Senecionis Scandentis 5%, Rabdosia rubescens 10%; Windproof 10%, Herba Bidentis Bipinnatae 10%, the Rhizoma Atractylodis Macrocephalae 20%, in above-mentioned medical material, per 100 gram medical materials add dexamethasone powder 150mg simultaneously.
2. a method for preparing of treating the compound medicine of oral ulcer is characterized in that, by Radix Scutellariae, and Radix Glycyrrhizae, the Radix Astragali; Herba Senecionis Scandentis, Rabdosia rubescens, windproof, Herba Bidentis Bipinnatae; The Rhizoma Atractylodis Macrocephalae and dexamethasone powder are formed, and above-mentioned medical material is Radix Scutellariae 20% by weight ratio, Radix Glycyrrhizae 5%, the Radix Astragali 20%; Herba Senecionis Scandentis 5%, Rabdosia rubescens 10%, windproof 10%, Herba Bidentis Bipinnatae 10%; The Rhizoma Atractylodis Macrocephalae 20%, simultaneously in above-mentioned medical material, per 100 gram medical materials add dexamethasone powder 150mg, mixing is encased in and processes capsule in the capsule shells with the dexamethasone powder behind the above-mentioned Chinese medicine pulverize.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110245762 CN102240324B (en) | 2011-08-25 | 2011-08-25 | Compound medicament for treating dental ulcer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110245762 CN102240324B (en) | 2011-08-25 | 2011-08-25 | Compound medicament for treating dental ulcer |
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| CN102240324A CN102240324A (en) | 2011-11-16 |
| CN102240324B true CN102240324B (en) | 2012-12-19 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102935088A (en) * | 2012-10-25 | 2013-02-20 | 祁建春 | Injection therapy and drug constitutes for curing recurrent aphthous ulcer |
| CN103877178B (en) * | 2014-03-19 | 2015-09-09 | 张勇哲 | A kind of pharmaceutical composition and application thereof for the treatment of recurrent oral ulceration |
| CN105343157A (en) * | 2015-11-14 | 2016-02-24 | 黄平县野洞河镇丰岩生态种养殖专业合作社 | Externally applied drug for treating aphtha in Capra aegagrus hircus |
| CN107753952A (en) * | 2017-10-30 | 2018-03-06 | 无锡福祈制药有限公司 | A kind of pharmaceutical composition for treating canker sore |
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| CN101264250B (en) * | 2008-04-23 | 2010-06-23 | 刘风信 | Chinese medicinal composition for treating mouth ulcer |
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