CN102410989A - Dual-channel MDOF (multidegree of freedom) adjustment mechanism of optical surface plasma resonance biosensor - Google Patents
Dual-channel MDOF (multidegree of freedom) adjustment mechanism of optical surface plasma resonance biosensor Download PDFInfo
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- CN102410989A CN102410989A CN2011103630945A CN201110363094A CN102410989A CN 102410989 A CN102410989 A CN 102410989A CN 2011103630945 A CN2011103630945 A CN 2011103630945A CN 201110363094 A CN201110363094 A CN 201110363094A CN 102410989 A CN102410989 A CN 102410989A
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Abstract
The invention relates to a dual-channel MDOF (multidegree of freedom) adjustment mechanism of an optical surface plasma resonance biosensor. The mechanism comprises a biochip assembly regulating unit, an optical path regulating unit, an angle regulating unit and a supporting and guiding unit, wherein the optical path regulating unit comprises a laser swing frame and a charge coupled device (CCD) swing frame; the angle regulating unit comprises an elevating assembly, a rotating support arm, a transmission shaft and a driving device; driven by the driving device, the transmission shaft drives the elevating assembly to complete the elevating travel, and at the same time, drives the laser swing frame and the CCD swing frame to form an included angle within a certain range via the corresponding rotating support arm, and form two corresponding optical path detection passages among laser, a CCD image sensor and the biochip assembly. The dual-channel MDOF adjustment mechanism provided by the invention is convenient for operation and accurate in positioning and has high testing precision, and solves the problems, such as debugging difficulty and hard refractivity matching caused when only the biochip with a glass substrate is replaced, thereby increasing the analytic precision of the biosensor and also substantially reducing the using and maintaining cost of the optical surface plasma resonance (SPR) sensor.
Description
Technical field
(Surface plasmon resonance, SPR) field of biosensors are specifically related to a kind of optical SPR biology sensor multiple degrees of freedom adjusting mechanism to the present invention relates to the optical surface plasma resonance.
Background technology
Over nearly 10 years, the optical SPR biosensor technique has all obtained swift and violent development in the expansion of implementation, instrument development and application.The detection mechanism of optical SPR biology sensor is following: the Recognition of Biomolecular film is fixed on optical SPR sensors A u film surface; The molecular recognition film is caught tested analyte; Cause the variations in refractive index on sensors A u film surface; Therefore need not labeled molecule and just can directly test, realize that nondestructive real-time online detects.It is different that the optical SPR biology sensor is pressed the body of excitating surface plasma wave; Optical prism type, optical-waveguide-type, grating type etc. are arranged; By the mode difference of optical modulation so that intensity modulation type, wavelength-modulated type and phase modulation-type etc. to be arranged; The optical fiber biology sensor can detect the sample that adheres to the little variation of optical fiber surface micro, has very high sensitivity, is applicable to the micro-biological and chemical material in the quantitative measurement sample solution.In the last few years; The portability of optical SPR biological analyser is an emerging research focus with microminiaturization; If portable optical SPR biological analyser still adopts traditional replacing chip method; Then make very difficulty of operation, portable optical SPR biological analyser requires integral replacing to have the biochip assembly of Au film.The optical SPR biology sensor is made up of a cover optical detection system and biology sensor body, and single biology sensor is made up of Au film and biological coupling couplet film at glass baseplate surface growth 50nm.The 50nm Au film and the bio-sensitive film of biosensor surface are the keys of optical SPR biology sensor, and in practical application, bio-sensitive film is functional deterioration with the increase that receives the sensing number of times, and then are difficult to sample is produced correct signal response.In use, it is inseparable with optical surface plasma wave generation body that the Au film in the optical SPR biology sensor, biological coupling join film (biochip), at this moment just need biology sensor be changed together.As disclosing the coupling device of a kind of optical SPR biochip, sensor and microfluid pool among the Chinese patent document CN101539570A; But the integrated form biology sensor that this device can only be coupled and utilize external import; Cause the instrument overall cost high; Certainly will increase user's use, maintenance cost, be difficult to be generalizable; A kind of optical surface plasma resonance biological sensor multiple degrees of freedom adjusting mechanism is disclosed among the CN102095684A; But its laser light source is fixed; And a sense channel is only arranged, and the adjustable angular range of incident light is limited, is difficult to satisfy the detection needs of different material composition.
Summary of the invention
The technical matters that the present invention will solve provides the parallel microfluid pool angular modulation mechanism of a kind of optical SPR biology sensor double light path; Utilize this device can change biochip assembly (Au film, biological coupling join film and the optical surface plasma wave produces body) quickly and easily; Can reduce manufacturing, the working service cost of optical SPR sensor significantly, and accuracy of detection improves greatly.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is:
Design the parallel microfluid pool angular modulation mechanism of a kind of optical SPR (surface plasma resonance) biology sensor double light path; Comprise: biochip assembly regulon, light path regulon, angle regulating unit and support guide unit; Said biochip assembly regulon comprises V-type positioning edge mirror bracket, locating piece and adjusting hold-down mechanism up and down; Said support guide unit comprises entablature, sill, base and is installed in the riser on the base dual-side that said light path regulon comprises laser instrument rocker, CCD rocker, on the said laser instrument rocker laser instrument, rotating mirror and light is installed and divides tread assembly; On the said CCD rocker ccd image sensor is installed; Said angle regulating unit comprises lifting assembly, rotating support arm, transmission shaft and drive unit, and said transmission shaft is installed in the said support guide unit, and its upper end is movably connected on the said sill; Its lower end activity is connected to said base and connects its drive unit; Said laser instrument rocker, CCD rocker symmetry be distributed in said transmission shaft both sides, the two upper end is movably connected in the top of said support guide unit via common rotating shaft, said lifting assembly is sleeved on the said transmission shaft; Both threaded transmissions, this lifting assembly via the rotating support arm of correspondence be connected to said laser instrument rocker, CCD rocker in, the bottom; Said rotation axis is under the driving of drive unit; When driving said lifting assembly and accomplish lifting travel; Promote said laser instrument rocker and the CCD rocker forms the certain included angle scope via the rotating support arm of correspondence, and make between said laser instrument, ccd image sensor and the biochip assembly and form two corresponding detection path channels.
Said biochip assembly adjustment unit comprises the biprism carriage on the entablature that is installed in the said support guide unit, the Au film prism that caters to the biprism carriage, microfluid pool and shared briquetting, briquetting coupling shelf, pull bar and pull bar regulating device from bottom to up; Said pull bar lower end is connected and fixed on said briquetting coupling shelf; Said pull bar regulating device contains spring, spring screens cap, hold-doun nut, is installed in top board, the up-down adjustment cam of pull bar upper end; Said spring, spring screens cap are sleeved on the bottom of said pull bar successively; Said horizontal support plate, hold-doun nut are sleeved on the said spring screens cap outside from the bottom to top successively; And this horizontal support plate one end is fixed on the said back up pad, and said up-down adjustment cam is installed on the front supporting plate through cam shaft, and makes the be complementary up-down of adjusting yoke of itself and said top board; Said front supporting plate is installed on the said horizontal support plate; Said cam shaft one end is provided with adjusting handle, regulates the relative position of said up-down adjustment cam, spring screens cap and hold-doun nut, can make microfluid pool respectively with the biprism carriage in two Au film prisms closely agree with.
Said light divides tread assembly to comprise supplementary lens, beam splitter, be installed on rearmounted double lens in the double lens frame side by side; The reflected light of the said rotating mirror that said supplementary lens will receive becomes directional light; Be divided into the two-beam directional light through said beam splitter; This two-beam directional light is projected to respectively in the prism of the correspondence in the said biochip assembly after said rearmounted double lens focuses on, and forms two-way and detects light.
Said laser instrument rocker and CCD rocker are symmetrically distributed in vertical rotating shaft both sides, and the swing angle of its rotating support arm and pedal line is 40 °～80 °
Said rotating support arm top is divided into the thread spindle rotating support arm, the length of scalable support arm, and the rotating support arm bottom is divided into optical axis, and arm closely is rotatably assorted with trapping.
In said lifting assembly, be provided with spacing guide pole, the support frame as described above vertical plates on both sides is provided with vertical gathering sill, and the gathering sill of said spacing guide pole two ends and both sides closely is slidingly matched.
The rotating speed of said rotating mirror is 1800～2200rpm.
Said CCD rocker is provided with focal length of lens apparatus for adjusting position, is used for the focusing fine setting of ccd image sensor.
Said drive unit is a stepper motor.
The present invention has actively useful effect:
1. structural design of the present invention is exquisite, accurate positioning: the consistance of light path between convenient adjustment laser instrument, biochip assembly and the CCD three; The convenient pressure of regulating between microfluid pool and the biochip assembly uses microfluid pool to contact with the Au film close, not only prevents the sample solution leakage but also prevent because of the excessive Au of the damage film of pressure; Convenient promote microfluid pool, and microfluid pool promote with reset after, can keep microfluid pool and biochip assembly accurately to locate;
2. comprised in the biochip assembly that Au film, biological coupling join film and the optical surface plasma wave produces body; Solved and only changed the biochip that has glass substrate and the debug difficulties that causes, the problem that refractive index is difficult to mate; Improve the analysis precision of biology sensor, also reduced the working service cost of optical SPR sensor simultaneously significantly;
3. angle-adjusting mechanism and double beam system that mechanism of the present invention adopts can effectively improve accuracy, reappearance and the efficient of Instrument measuring;
4. this mechanism uses the replacing of biochip in 1min, to accomplish, and shortens the optical SPR biology sensor adjustment time greatly;
5. it is easy to manipulate (replacing chip), does not require that the experimenter has very high operation skill.
Description of drawings
Fig. 1 is a kind of perspective view of optical SPR biology sensor multiple degrees of freedom adjusting mechanism;
Fig. 2 is the perspective view (removing a cant board) of another angle of Fig. 1;
Fig. 3 is the perspective view (removing a cant board) of the another angle of Fig. 1.
1 is the laser instrument pendulum among the figure, and 2 is rotating mirror, and 3 is supplementary lens, and 4 is beam splitter, and 5 is the double lens frame, and 6 is guide rail, and 7,10 is the prism carriage; 8,9 is Au film prism, and 11 is the CCD rocker, and 12 is laser instrument, and 13,21 is riser, and 14 is gathering sill, and 15 is base, and 16 is catoptron; 17 is entablature, and 18 is sill, and 19 is transmission shaft, and 20 is lifting assembly, and 22 is spacing guide pole, and 23 is ccd image sensor, and 24 is briquetting; 25 is the briquetting coupling shelf, and 26 is front supporting plate, and 27 is adjusting handle, and 28 is cam shaft, and 29 is cam, and 30 is pull bar, and 31 is top board; 32 is spring screens cap, and 33 is horizontal support plate, and 34 is spring, and 35 is upper branch arm, and 36 is spacing knob, and 37 are the arm of trapping; 38 is back-up block, and 39 is orienting lug, and 40 is limited block, and 41 is limiting plate, and 42 is slide plate, and 43 is adjusting knob.
Embodiment
Further set forth the present invention below in conjunction with specific embodiment, but be not to be qualification protection domain of the present invention.
1 one kinds of optical SPR biology sensors of embodiment multiple degrees of freedom adjusting mechanism; Referring to Fig. 1, Fig. 2, Fig. 3; Comprise biochip assembly regulon, light path regulon, angle regulating unit and be positioned at the guiding support unit of said biochip assembly regulon below, this guiding support unit comprises entablature 17, sill 18, base 15 and is installed in the riser 13,21 on the base dual-side; Said light path regulon comprises laser instrument rocker 1, CCD rocker 11; Angle regulating unit comprises lifting assembly 20, rotating support arm, transmission shaft 19 and stepper motor (not drawing among the figure) thereof; Laser instrument 12, rotating mirror 2 (rotating speed is 2000rpm) and light are installed on the laser instrument rocker 1 divide tread assembly; This light divides tread assembly to comprise supplementary lens 3, beam splitter 4, reflective mirror 16, be installed on rearmounted double lens in the double lens frame 5 side by side; Supplementary lens 3 becomes directional light with the reflected light of the rotating mirror that receives 2, is divided into the two-beam directional light through beam splitter 4, and this two-beam directional light is projected to respectively in the prism 8,9 of the correspondence in the biochip assembly after rearmounted double lens focuses on; Form two-way and detect light; Ccd image sensor 23 is installed on the CCD rocker 11, and CCD rocker 11 is provided with the focal length of lens apparatus for adjusting position that is made up of slide plate 42, adjusting knob 43 etc., is used for the focusing fine setting of ccd image sensor; Transmission shaft 19 is installed in the guiding support unit; Its upper end is movably connected on the sill 18; Its lower end activity is connected to base 15 and connects stepper motor; Laser instrument rocker 1, CCD rocker 11 symmetries be distributed in transmission shaft 19 both sides, the two upper end is movably connected in the top of support unit via common rotating shaft, said lifting assembly 20 is sleeved on the transmission shaft 19; Both threaded transmissions, this lifting assembly 20 are connected to the middle and lower part of laser instrument rocker 1, CCD rocker 11 via the rotating support arm of correspondence; Rotation axis 19 is under the driving of drive stepping motor; When driving lifting assembly 20 completion lifting travels; Promote laser instrument rocker 1 via the rotating support arm of correspondence and form certain included angle scopes (80 °～160 °), and make between laser instrument 12, ccd image sensor 23 and the biochip assembly and form two corresponding detection path channels with CCD rocker 11.Rotating support arm comprises upper branch arm 35 and the arm 37 of trapping that matches, and upper branch arm 35 the first half are thread spindle, and the length of scalable rotating support arm, the latter half are optical axis, closely are rotatably assorted with the arm 37 of trapping, and on upper branch arm 35, also are provided with spacing knob 36.In lifting assembly 20, be provided with gag lever post 22, on the vertical plates on both sides 13,21 of support guide unit, be respectively arranged with corresponding vertical gathering sill 14, the gathering sill of spacing guide pole 22 two ends and both sides closely is slidingly matched.Said biochip assembly adjustment unit comprises the biprism carriage 7,10 that is installed on the support frame as described above entablature 17 from bottom to up, caters to microfluid pool and briquetting 24, briquetting coupling shelf 25, pull bar 30 and pull bar regulating device on the Au film prism 8,9; Pull bar 30 lower ends are connected and fixed on briquetting coupling shelf 25; The pull bar regulating device contains spring 34, spring screens cap 32, hold-doun nut, the top board 31 that is installed in pull bar 30 upper ends, up-down adjustment cam 29; Spring 34, spring screens cap 32 are sleeved on the bottom of pull bar 30 successively; Horizontal support plate 33, hold-doun nut are sleeved on said spring screens cap 32 outsides from the bottom to top successively; And these horizontal support plate 33 1 ends are fixed on the said back up pad, and said up-down adjustment cam 29 is installed on the front supporting plate through cam shaft 28, and make the be complementary up-down of adjusting yoke 30 of itself and top board 31; Said front supporting plate is installed on the said horizontal support plate 33; Cam shaft 28 1 ends are provided with adjusting handle 27, the relative position of adjustment cam 29, spring screens cap 32 and hold-doun nut, can make microfluid pool respectively with biprism carriage 7,10 in two Au film prisms 8,9 closely agree with.Microfluid pool is the two passage microfluid pools of being processed by the corrosion resisting elastic material.Briquetting 24 is " worker " font, and seals with briquetting coupling shelf 25 with agreeing with and to push down microfluid pool.
The method of manipulating of the parallel microfluid pool angular modulation mechanism of above-mentioned optical SPR biology sensor double light path:
1. clockwise rotate adjusting handle 27 (changeing 90 °), adjusting handle 27 drives up-down adjustment cam 29 and clockwise rotates through cam shaft 28; Jack-up top board 31, thereby raising rod 30 rotate counterclockwise adjusting handle 27 (changeing 90 °); Adjusting handle 27 is through cam shaft 28; Drive up-down adjustment cam 29 and also rotate counterclockwise, pull bar 30 slides up and down under the effect of its underpart spring 34.
2. successively in the crossbearer upper edge orienting lug put into locating piece and the prism carriage 7,10 of Au film prism 8,9 be housed.
3. rotate counterclockwise adjusting handle 27 (changeing 90 °), pull bar 30 descends, microfluid pool with Au film prism 8, compress between 9 and contact.If microfluid pool and Au film prism 8, the snap-in force between 9 are improper, it is suitable up to pressure to regulate hold-doun nut.
4. start stepper motor.
Stepper motor designs in order to change incident angle, along with the variation of incident angle, and the curve that CCD monitoring reflected light light intensity changes with angle.Incident angle changes 80 °～40 ° of scopes.Click startup stepper motor button, angle scanning begins, and preserves the angle scanning curve.
Change each the concrete parameters of structural dimension in the foregoing description, perhaps parts be equal to replacement etc., can form a plurality of concrete embodiment, be common variation range of the present invention, detail no longer one by one at this.
Claims (9)
1. the parallel microfluid pool angular modulation mechanism of an optical surface plasma resonance biological sensor double light path; Comprise biochip assembly regulon, light path regulon, angle regulating unit and support guide unit; Said biochip assembly regulon comprises V-type positioning edge mirror bracket, locating piece and adjusting hold-down mechanism up and down, and said support guide unit comprises entablature, sill, base and is installed in the riser on the base dual-side, it is characterized in that; Said light path regulon comprises laser instrument rocker, CCD rocker; On the said laser instrument rocker laser instrument, rotating mirror and light are installed and divide tread assembly, on the said CCD rocker ccd image sensor is installed, said angle regulating unit comprises lifting assembly, rotating support arm, transmission shaft and drive unit; Said transmission shaft is installed in the said support guide unit; Its upper end is movably connected on the said sill, and its lower end activity is connected to said base and connects its drive unit, said laser instrument rocker, CCD rocker symmetry be distributed in said transmission shaft both sides; The two upper end is movably connected in the top of said support guide unit via common rotating shaft; Said lifting assembly is sleeved on the said transmission shaft, both threaded transmissions, this lifting assembly via the rotating support arm of correspondence be connected to said laser instrument rocker, CCD rocker in, the bottom; Said rotation axis is under the driving of drive unit; When driving said lifting assembly and accomplish lifting travel; Promote said laser instrument rocker and the CCD rocker forms the certain included angle scope via the rotating support arm of correspondence, and make between said laser instrument, ccd image sensor and the biochip assembly and form two corresponding detection path channels.
2. according to the parallel microfluid pool angular modulation mechanism of the said optical surface plasma resonance biological sensor of claim 1 double light path; It is characterized in that; Said biochip assembly adjustment unit comprises the Au film prism that is installed in the biprism carriage on the entablature in the said support guide unit, caters to the biprism carriage, and microfluid pool and briquetting, briquetting coupling shelf, pull bar and pull bar regulating device from bottom to up; Said pull bar lower end is connected and fixed on said briquetting coupling shelf; Said pull bar regulating device contains spring, spring screens cap, hold-doun nut, is installed in top board, the up-down adjustment cam of pull bar upper end; Said spring, spring screens cap are sleeved on the bottom of said pull bar successively, and said horizontal support plate, hold-doun nut are sleeved on the said spring screens cap outside from the bottom to top successively, and this horizontal support plate one end is fixed on the said back up pad; Said up-down adjustment cam is installed on the front supporting plate through cam shaft; And make the be complementary up-down of adjusting yoke of itself and said top board, said front supporting plate is installed on the said horizontal support plate, and said cam shaft one end is provided with adjusting handle; Regulate the relative position of said up-down adjustment cam, spring screens cap and hold-doun nut, can make microfluid pool respectively with the biprism carriage in the tight pressing of two Au film prisms.
3. according to the parallel microfluid pool angular modulation mechanism of the said optical surface plasma resonance biological sensor of claim 1 double light path; It is characterized in that; Said light divides tread assembly to comprise supplementary lens, beam splitter, be installed on rearmounted double lens in the double lens frame side by side; The reflected light of the said rotating mirror that said supplementary lens will receive becomes directional light; Be divided into the two-beam directional light through said beam splitter, this two-beam directional light is projected to respectively in the prism of the correspondence in the said biochip assembly after said rearmounted double lens focuses on, and forms two-way and detects light.
4. according to the parallel microfluid pool angular modulation mechanism of the said optical surface plasma resonance biological sensor of claim 1 double light path; It is characterized in that; Said laser instrument rocker and CCD rocker are symmetrically distributed in vertical rotating shaft both sides, and the swing angle of its rotating support arm and pedal line is 40 °～80 °.
5. according to the parallel microfluid pool angular modulation mechanism of the said optical surface plasma resonance biological sensor of claim 1 double light path; It is characterized in that said rotating support arm the first half is a thread spindle, the length of scalable rotating support arm; The latter half is an optical axis, and arm closely is rotatably assorted with trapping.
6. according to the parallel microfluid pool angular modulation mechanism of the said optical surface plasma resonance biological sensor of claim 1 double light path; It is characterized in that; In said support guide unit, be provided with spacing guide pole; The support frame as described above vertical plates on both sides is provided with vertical gathering sill, and the gathering sill of said spacing guide pole two ends and both sides closely is slidingly matched.
7. according to the parallel microfluid pool angular modulation mechanism of the said optical surface plasma resonance biological sensor of claim 1 double light path, it is characterized in that the rotating speed of said rotating mirror is 1800～2200rpm.
8. according to the parallel microfluid pool angular modulation mechanism of the said optical surface plasma resonance biological sensor of claim 1 double light path, it is characterized in that said CCD rocker is provided with focal length of lens apparatus for adjusting position, be used for ccd image sensor light is finely tuned.
9. according to the parallel microfluid pool angular modulation mechanism of the said optical surface plasma resonance biological sensor of claim 1 double light path, it is characterized in that said drive unit is a stepper motor.
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| CN106124778A (en) * | 2016-07-27 | 2016-11-16 | 深圳市博卡生物技术有限公司 | Immunoblotting assay instrument |
| CN107843558A (en) * | 2017-09-21 | 2018-03-27 | 丁利 | A kind of prism-type surface plasma resonance spectrometer angle modulated mechanism |
| CN109581164A (en) * | 2018-12-27 | 2019-04-05 | 广西电网有限责任公司河池供电局 | A kind of switchgear light partial discharge detection device |
| CN111965143A (en) * | 2020-09-17 | 2020-11-20 | 广州大学 | Surface plasma resonance detection device |
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