CN102396703A - Lactobacillus composition with function for preventing children hand-foot-mouth disease, preparation method thereof, and application thereof - Google Patents
Lactobacillus composition with function for preventing children hand-foot-mouth disease, preparation method thereof, and application thereof Download PDFInfo
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- CN102396703A CN102396703A CN2010102781483A CN201010278148A CN102396703A CN 102396703 A CN102396703 A CN 102396703A CN 2010102781483 A CN2010102781483 A CN 2010102781483A CN 201010278148 A CN201010278148 A CN 201010278148A CN 102396703 A CN102396703 A CN 102396703A
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Abstract
The invention discloses a lactobacillus composition with a function for preventing children hand-foot-mouth disease, a preparation method thereof, and an application thereof. The lactobacillus composition comprises lactobacillus acidophilus, milk bifidobacteria, lactobacillus casei subspecies, plant lactobacillus, rhamnose lactobacillus, bifidobacterium longum, lactobacillus delbrueckii Bulgaria subspecies, and streptococcus thermophilus. The invention further discloses a yogurt prepared from the above lactobacillus composition. The yogurt prepared from the lactobacillus composition can be used for preventing children hand-foot-mouth disease.
Description
Technical field
The invention belongs to field of food, be specifically related to have the lactic bacteria compsn and the preparation thereof of prevention in children hand-foot-and-mouth disease effect and use.
Background technology
Children's hand-foot-and-mouth disease is that kind of an enterovirus causes surplus a group about 60, comprises the strange A of Ke Sha (23 kinds), 6 kinds in B virus, and she can virus 32 kinds, enterovirus (68～71 type), polio virus (3 type) etc.
Hand-foot-and-mouth disease mainly through ight soil-＞hand--＞mouthful route, various symptom can appear after the childhood infection, modal is eruption (especially at hand, foot, oral area position) and fever, diarrhoea.After the state of an illness aggravation, can cause encephalitis, myelitis, myocarditis, hemorrhagic conjunctivitis etc., the death rate is high after the infection of newborn.
Because this serum virus somatotype is many, the mankind can't produce antibody, and can not lifetime immunity, do not have preventible vaccine in the world so far.
Summary of the invention
The objective of the invention is through the biotechnology technology, a kind of lactic bacteria compsn and preparation and application with prevention in children hand-foot-and-mouth disease effect is provided.
The present invention screens the functional lactobacillus composition of acquisition, under certain fermentation condition, can produce the sour milk with health-care efficacy, has the effect of prevention in children hand-foot-and-mouth disease.
The present invention at first provides a kind of lactic bacteria compsn; Comprise lactobacillus acidophilus (Lactobacillus acidophilus); Breast Bifidobacterium Bifidum (Bifidobacterium lactis), Lactobacillus casei cheese subspecies (Lactobacillus casei subsp.casei), Lactobacillus plantarum (Lactobacillus plantarum); Lactobacillus rhamnosus (Lactobacillus rhamnosus); Long Bifidobacterium Bifidum (Bifidobacterium longum), lactobacillus delbruockii subspecies bulgaricus (Lactobacillus delbrueckii subsp.bulgaricus), streptococcus thermophilus (Streptococcus thermophilus).
Preferable, in weight portion, the weight portion of each bacterial classification is the 10-30 weight portion.
Lactic bacteria compsn of the present invention can adopt to be cultivated the back respectively with the bacterial classification in the said composition and adopts existing bacterial classification freeze-dry process to process the method that is mixed in proportion behind the freeze-dried powder to obtain.
Lactic acid bacteria of the present invention all can obtain at the microorganism fungus kind center on ground such as China, Taiwan for the public, do not relate to preserving number, and the technical staff in present technique field all can realize production of the present invention.
Lactic bacteria compsn of the present invention can be used for preparing the lactic acid goods.The bacterial classification freeze-dried powder also can directly be worked as electuary and orally used.
Further, lactic bacteria compsn of the present invention can be used for preparing the lactic acid goods with prevention in children hand-foot-and-mouth disease effect.
This lactic bacteria compsn promptly is applicable to the suitability for industrialized production sour milk product, also is applicable to prepare sour milk product voluntarily by the consumer after being sold to the consumer as end product.
The present invention also provides a kind of sour milk, for milk, and defatted milk, the recombined milk that the milk powder bath forms or the mixed liquor of soya-bean milk and milk are raw material, adopt above-mentioned lactic bacteria compsn fermentation acquisition.
The fermentation process of said sour milk is: with above-mentioned bacterial classification inoculation in the mixed liquor of recombined milk that milk, defatted milk, milk powder water form or soya-bean milk and milk, in 38-45 ℃ of indirect fermentation 6-10 hour to the pH value be between the 3.8-4.5, obtain to solidify the shape sour milk.The lactic acid viable count in the sour milk can reach every milliliter and contained 1,000,000,000 more than this moment.
The Zymolysis Equipment of above-mentioned sour milk can adopt industrial fermentation tank, commercial fermentation cabinet or home-use sour milk pot.
Freeze-dried powder of the present invention and sour milk are direct-edible, also can be used as raw material and adopt existing technology to mix the lactic acid goods of various tastes.
Further, sour milk of the present invention can be used for preparing the lactic acid goods with prevention in children hand-foot-and-mouth disease effect, like solidification type yoghourt, and liquid-type sour milk, freeze-dried powder or divergence type whey etc.
Because hand-foot-and-mouth disease virus can be invaded the human intestine at first through hydrochloric acid in gastric juice; And can on intestinal epithelial cell, duplicate, then destroy the chorionic villi on the intestines wall mucous membrane again, make the permeability of enteron aisle increase; And cause a large amount of viruses to get in the body, stretch to each organ.Utilize the characteristic of several kinds of lactic acid bacterias in the lactic bacteria compsn provided by the invention, process sour milk after, can produce specific IgA antibody to this viroid, make its not transreplication.In addition, the lactic acid bacteria among the present invention can be protected the intestines wall, reduces the permeability of enteron aisle, and then prevents that virus from getting into other organ, reaches the purpose of prevention in children hand-foot-and-mouth disease.
But the present invention's prevention in children hand-foot-and-mouth disease, there is the inhibition ability the edible back of the sour milk of processing for hand-foot-and-mouth disease virus, can suppress duplicating of hand-foot-and-mouth disease virus, is the sour milk with health care.Be not only applicable to suitability for industrialized production, more can instruct the housewife in the own home, to make the sour milk of this effect type easily, healthy to reach everybody, the target of keeping fit to make the country prosperous.
The specific embodiment
Below enumerate specific embodiment with further elaboration the present invention, should be understood that instance is not to be used to limit protection scope of the present invention.
Embodiment 1
The preparation of lactic bacteria compsn
Freeze-dried vaccine powder after cultivating with conventional condition of culture is a raw material, by the prescription routine of table 1 lactic bacteria compsn that is mixed.
Table 1 (unit: g adds up to be made into 150g)
| Bacterial classification | Prescription 1 | Prescription 2 | Prescription 3 | Prescription 4 | Prescription 5 | Prescription 6 |
| Lactobacillus acidophilus | 10 | 14 | 30 | 17 | 15 | 23 |
| The breast Bifidobacterium Bifidum | 10 | 24 | 20 | 15 | 30 | 17 |
| Lactobacillus casei cheese subspecies | 20 | 22 | 10 | 30 | 16 | 13 |
| Lactobacillus plantarum | 30 | 13 | 21 | 28 | 15 | 10 |
| Lactobacillus rhamnosus | 18 | 11 | 23 | 10 | 14 | 30 |
| Long Bifidobacterium Bifidum | 13 | 30 | 15 | 22 | 10 | 19 |
| Lactobacillus delbruockii subspecies bulgaricus | 30 | 20 | 10 | 18 | 20 | 23 |
| Streptococcus thermophilus | 19 | 16 | 21 | 10 | 30 | 15 |
Embodiment 2
The preparation of sour milk:
The bacterial classification of above-mentioned prescription 1 is inoculated in the milk by conventional inoculum concentration, is about 4.5, obtain to solidify the shape sour milk in 38 ℃ of indirect fermentations 6 hours to pH value.
The bacterial classification of above-mentioned prescription 2 is inoculated in the milk by conventional inoculum concentration, is about 3.8, obtain to solidify the shape sour milk in 45 ℃ of indirect fermentations 10 hours to pH value.
The bacterial classification of above-mentioned prescription 3 is inoculated in the defatted milk by conventional inoculum concentration, is about 4.0, obtain to solidify the shape sour milk in 40 ℃ of indirect fermentations 8 hours to pH value.
The bacterial classification of above-mentioned prescription 4 is inoculated in the recombined milk by conventional inoculum concentration, is about 3.9, obtain to solidify the shape sour milk in 42 ℃ of indirect fermentations 10 hours to pH value.
Claims (8)
1. a lactic bacteria compsn comprises lactobacillus acidophilus, newborn Bifidobacterium Bifidum, Lactobacillus casei cheese subspecies, Lactobacillus plantarum, Lactobacillus rhamnosus, long Bifidobacterium Bifidum, lactobacillus delbruockii subspecies bulgaricus and streptococcus thermophilus.
2. lactic bacteria compsn according to claim 1 is characterized in that in weight portion, the weight portion of each bacterial classification is the 10-30 weight portion.
3. lactic bacteria compsn is used to prepare the purposes of lactic acid goods according to claim 1 or claim 2.
4. the purposes of lactic bacteria compsn as claimed in claim 3 is characterized in that, said lactic acid goods or all have prevention in children hand-foot-and-mouth disease effect when electuary is edible.
5. sour milk, for milk, defatted milk, the recombined milk that the milk powder bath forms or the mixed liquor of soya-bean milk and milk are raw material, adopt claim 1 or 2 said lactic bacteria compsns fermentation acquisitions.
6. like the said sour milk of claim 5; It is characterized in that; Said sour milk is made by the fermentation of following fermentation process: said lactic bacteria compsn is inoculated in the mixed liquor of milk, defatted milk, recombined milk that milk powder water forms or soya-bean milk and milk; In 38-45 ℃ of indirect fermentation 6-10 hour to the pH value be between the 3.8-4.5, obtain to solidify the shape sour milk.
7. like the said sour milk of claim 6, it is characterized in that the Zymolysis Equipment of said sour milk is fermentation tank, fermentation cabinet or sour milk pot.
8. has the purposes in the lactic acid goods of prevention in children hand-foot-and-mouth disease effect like the said sour milk of arbitrary claim among the claim 5-7 in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102781483A CN102396703A (en) | 2010-09-10 | 2010-09-10 | Lactobacillus composition with function for preventing children hand-foot-mouth disease, preparation method thereof, and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102781483A CN102396703A (en) | 2010-09-10 | 2010-09-10 | Lactobacillus composition with function for preventing children hand-foot-mouth disease, preparation method thereof, and application thereof |
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| CN102396703A true CN102396703A (en) | 2012-04-04 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104705402A (en) * | 2015-04-09 | 2015-06-17 | 辽宁天赐农产品开发有限公司 | Preparation method of soybean yogurt |
| CN112425655A (en) * | 2020-11-24 | 2021-03-02 | 吴兆盈 | Formula milk powder for preventing hyperlipidemia, hyperglycemia and hypertension and preparation method thereof |
| CN116731905A (en) * | 2022-11-30 | 2023-09-12 | 越用越好(上海)生物科技有限公司 | Probiotic composition and application thereof |
-
2010
- 2010-09-10 CN CN2010102781483A patent/CN102396703A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104705402A (en) * | 2015-04-09 | 2015-06-17 | 辽宁天赐农产品开发有限公司 | Preparation method of soybean yogurt |
| CN112425655A (en) * | 2020-11-24 | 2021-03-02 | 吴兆盈 | Formula milk powder for preventing hyperlipidemia, hyperglycemia and hypertension and preparation method thereof |
| CN116731905A (en) * | 2022-11-30 | 2023-09-12 | 越用越好(上海)生物科技有限公司 | Probiotic composition and application thereof |
| CN116731905B (en) * | 2022-11-30 | 2024-02-09 | 越用越好(上海)生物科技有限公司 | Probiotic composition and application thereof |
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Application publication date: 20120404 |