CN102389563A - Transdermal absorption traditional Chinese medicinal blood pressure protection bag and its preparation method - Google Patents
Transdermal absorption traditional Chinese medicinal blood pressure protection bag and its preparation method Download PDFInfo
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- CN102389563A CN102389563A CN2011103800113A CN201110380011A CN102389563A CN 102389563 A CN102389563 A CN 102389563A CN 2011103800113 A CN2011103800113 A CN 2011103800113A CN 201110380011 A CN201110380011 A CN 201110380011A CN 102389563 A CN102389563 A CN 102389563A
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Abstract
The invention relates to a transdermal absorption traditional Chinese medicinal blood pressure protection bag and its preparation method. By the adoption of a method, the transdermal absorption traditional Chinese medicinal blood pressure protection bag is prepared by the following raw materials of: by weight, 10-45 parts of gentrin knotweed, 10-45 parts of Chinese angelica, 10-45 parts of corn silk, 9-40 parts of achyranthcs bidentata blume, 9-40 parts of lumbricus, 9-40 parts of white peony root, 9-40 parts of Aconitum kusnezoffii, 8-30 parts of Jiukongzi, 8-30 parts of sophora flower, 8-30 parts of uncaria, 8-30 parts of banksia rose, 5-25 parts of oyster, 5-25 parts of kendir, 5-25 parts of whole worm, 5-15 parts of hawthorn, 5-15 parts of cassia seed, 5-15 parts of epimedium, 2-10 parts of root of kudzu vine, 2-10 parts of taxillus, 2-10 parts of haematitum, 2-10 parts of safflower, 2-10 parts of Radix Saposhnikoviae, 8-25 parts of licorice, 5-15 parts of prunella vulgaris, 2-15 parts of Paeonia veitchii, 2-10 parts of ginger, 5-25 parts of Radix Astragali, 5-25 parts of rehmanniae radix, 5-25 parts of Radix Rehmanniae Preparata, 5-15 parts of chrysanthemum, 2-10 parts of orange shell and 25-70 parts of a medicinal transdermal absorption catalyst. By the adoption of the preparation method, quick-acting performance, high effectiveness and security of the medicament can be raised.
Description
One, technical field:
The present invention relates to a kind of Transdermal absorption Chinese medicine and protect pressure bag and preparation method thereof.
Two, background technology:
Chronic disease becomes human maximum killer at present, and the hypertension in the cardiovascular and cerebrovascular disease then is No.1 killer.Data shows according to the relevent statistics: China has Hypertensive Population 1. 5 hundred million now, and increases with annual 3000000 people's speed.The consciousness that present person in middle and old age's sub-health population puts prevention first is also progressively strengthened, but corresponding product seldom.Along with science and technology development with rapid changepl. never-ending changes and improvements; Natural Chinese medicinal herb is used among hyperpietic's the rehabilitation more widely, and is acknowledged as the medicament that has no side effect fully, but existing Chinese herbal medicine product is the Chinese herbal medicine product of more single composition; Exist compatibility composition bad adaptability in various degree; Effect is undesirable, and processed technology falls behind, and can't satisfy the shortcoming that effective treatment hypertension requires.And present transdermal pharmaceutical is most of to be processed for western medicine composition, plays the effect that promotes drug absorption, because the Western medicine side effect is bigger, so the field of Chinese medicines being is is being researched and developed the transdermal pharmaceutical that adopts the Chinese medicine preparation.Also having some to adopt Chinese medicine is the transdermal pharmaceutical that raw material is processed; But all be sorbefacient single preparation mostly; Exist DeGrain; And certain side effect is arranged, people thirst for having always a kind of pure Chinese medicinal preparation modern Chinese medicine blood pressure lowering, adjust blood pressure, voltage stabilizing, protect stampings and outstanding effect Transdermal absorption medicine easy to use.Do not find to have the relevant report of success at present as yet.
Three, summary of the invention:
The present invention provides in a kind of Transdermal absorption in order to solve the weak point in the above-mentioned background technology
Medicine protects presses bag and preparation method thereof, and it is for diseases of cardiovascular and cerebrovascular systems, particularly hypertension symptom
Treatment and prevention dual-use function are arranged, solved antagonism and synergism between the medicine, incorporate Chinese medicine
The Transdermal absorption catalyst promotes the subcutaneous infiltration of Chinese medicine, and the through affected area of targeting property is treated, in
Sick external treatment, safety has no side effect.
For realizing above-mentioned purpose; The technical scheme that the present invention adopts is: a kind of Transdermal absorption Chinese medicine protects presses bag; Described Chinese medicine protects presses the bag raw material to be made up of the raw material of following weight portion: Rhizoma Polygoni Cuspidati 10-45, Radix Angelicae Sinensis 10-45, Stigma Maydis 10-45, Radix Achyranthis Bidentatae 9-40, the sub-9-40 of Pheretima, Radix Paeoniae Alba 9-40, Radix Aconiti Kusnezoffii 9-40, Fructus Liquidambaris 8-30, Flos Sophorae 8-30, Ramulus Uncariae Cum Uncis 8-30, Radix Aucklandiae 8-30, Concha Ostreae 5-25, Herba Apocyni veneti 5-25, Scorpio 5-25, crataegus pin natifida var. Major 5-15, Semen Cassiae 5-15, excessive sheep flower bud 5-15, Radix Puerariae 2-10, Herba Taxilli 2-10, He Shi 2-10, Flos Carthami 2-10, windproof 2-10, Radix Glycyrrhizae 8-25, Spica Prunellae 5-15, CHUANSHAO 2-15, Rhizoma Zingiberis Recens 2-10, astragalus 5-25, Radix Rehmanniae 5-25, Radix Rehmanniae Preparata 5-25, Flos Chrysanthemi 5-15, Fructus Aurantii 2-10 and drug transdermal absorbing catalyst 25-70.
Described drug transdermal absorbing catalyst by following raw material by weight forming Actinolitum: Fluoritum: PIMAO: Plumbum preparatium: Borneolum Syntheticum=30-50:20-35:2-8:15-45:2-8.
The method for preparing of described drug transdermal absorbing catalyst is: saidly get Actinolitum, Fluoritum, PIMAO, Plumbum preparatium, Borneolum Syntheticum by above-mentioned weight ratio, mix after pulverizing one by one medicated powder; Medicated powder is put on the medicine bell, filter paper is covered on the medicated powder, cover on filter paper, guarantee the seal of ceramic vessel and medicated powder with a ceramic vessel; Alcohol stove in the medicine stove is lighted,, heated and stop heating after 5-10 minute to the medicated powder heating; Take off ceramic vessel, on the inwall of ceramic vessel, generate alabastrine crystalline solid, this crystalline solid is taken off, airtight in the bottle of packing into, promptly get.
A kind of Transdermal absorption Chinese medicine protects the method for preparing of pressing bag, with each raw material components respectively with 60 ℃
-200 ℃ of water cleaning and dipping, purification, 160 minutes water treatment when carrying out being with 75 ℃ of temperature fire-450C ℃ respectively again, the concentration that adds 5 times of amounts then respectively is that 45% ethanol carries out the room temperature lixiviate; Lixiviate is 3 times altogether, each 10 hours, 3 times lixiviating solution is merged; Filter filtrating, reclaim ethanol to do not have alcohol distinguish the flavor of extractum, extractum repeatedly extracts with the acetic acid ethyl ester of convention amount after with the water suspendible of 2 times of amounts; Till extract is colourless, merge the cruel extract of acetic acid second, be concentrated into the thick paste shape; Drying gets dry powder; With the dry powder blend that obtains respectively, get powder raw material medicament, powder raw material medicament is mixed with the drug transdermal absorbing catalyst; With per 6 gram medicated core of packing into, with the medicated core medicated bag of packing into, get final product again after the mixing.
Described water treatment extracting pressure is controlled to be 345Mpa.
Compared with prior art, the advantage and the effect that have of the present invention is following:
1, monarch, minister in the prescription of the present invention, help, make medicine clear and definite, dosage is accurate.
2, the present invention is beneficial to the pharmacology coordination and special procures the flavour of a drug compatible combination, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, principle-method-recipe-medicines, and inner disease outer treat, typing rationally, quantitatively, outstanding key property.
3, treating both the principal and secondary aspects of a disease of the present invention, scientific composition is treated the patient who does not still reach the excellent control target to carrying out reasonable diet treatment and oral blood pressure lowering medicine; And congenital hereditary and play immunization therapy and auxiliary treatment effect because of the hypertension that diet etc. causes the day after tomorrow, to hyperpietic's rehabilitation a new treatment technology is provided.
4, the present invention changes and protects pressing rerum natura ability in the past; Adopt new material and mode; Satisfied green consumption demand in market simple to operation; The reinforcement osmosis of performance inner disease outer treat improves sanguimotor effect, gives full play to drug effect and performance, has improved quick-acting, high efficiency, the safety of medicine to a greater extent.
Four, the specific embodiment:
Embodiment 1:
Get Rhizoma Polygoni Cuspidati 35 grams; Radix Angelicae Sinensis 30 grams; Stigma Maydis 30 grams; Radix Achyranthis Bidentatae 30 grams; Pheretima 30 grams; The Radix Paeoniae Alba 28 grams; Radix Aconiti Kusnezoffii 28 grams; Fructus Liquidambaris 25 grams; Flos Sophorae 25 grams; Ramulus Uncariae Cum Uncis 25 grams; The Radix Aucklandiae 25 grams; Concha Ostreae 15 grams; Herba Apocyni veneti 15 grams; Scorpio 15 grams; Crataegus pin natifida var. Major 10 grams; Semen Cassiae 10 grams; Excessive sheep flower bud 10 grams; Radix Puerariae 8 grams; Herba Taxilli 8 grams; He Shi 8 grams; Flos Carthami 8 grams; Windproof 8 grams; Radix Glycyrrhizae 5 grams; Spica Prunellae 5 grams; CHUANSHAO 5 grams; Rhizoma Zingiberis Recens 5 grams; Astragalus 5 grams; The Radix Rehmanniae 5 grams; Radix Rehmanniae Preparata 5 grams; Flos Chrysanthemi 5 grams; Fructus Aurantii 4 grams; Drug transdermal absorbing catalyst 30 grams.
Said medicine Transdermal absorption Preparation of catalysts method is following:
Get Actinolitum 12 gram, Fluoritum 9 grams, PIMAO 4 grams, Plumbum preparatium 3 grams, Borneolum Syntheticum 2 grams by said weight ratio, mix after pulverizing one by one medicated powder; Medicated powder is put on the medicine bell, filter paper is covered on the medicated powder, cover on filter paper, guarantee the seal of ceramic vessel and medicated powder with a ceramic vessel; Alcohol stove in the medicine stove is lighted,, heated and stop heating after 5-10 minute to the medicated powder heating; Take off ceramic vessel, on the inwall of ceramic vessel, generate alabastrine crystalline solid, inferior crystalline solid is taken off, airtight in the bottle of packing into, promptly get.
A kind of Transdermal absorption Chinese medicine protects the method for preparing of pressing bag: with each raw material components respectively with 60 ℃ of-200 ℃ of water cleaning and dipping, purification, 160 minutes water treatment when carrying out being with 75 ℃ of temperature fire-450C ℃ respectively again, described water treatment extracting pressure is controlled to be 345Mpa; The concentration that adds 5 times of amounts then respectively is that 45% ethanol carries out the room temperature lixiviate, and lixiviate is 3 times altogether, each 10 hours; 3 times lixiviating solution are merged, filter filtrating, reclaim ethanol to do not have alcohol distinguish the flavor of extractum; Extractum repeatedly extracts with the acetic acid ethyl ester of convention amount after with the water suspendible of 2 times of amounts, till extract is colourless, merges the cruel extract of acetic acid second; Be concentrated into the thick paste shape, drying gets dry powder; With the dry powder blend that obtains respectively, get powder raw material medicament, powder raw material medicament is mixed with the drug transdermal absorbing catalyst; With per 6 gram medicated core of packing into, with the medicated core medicated bag of packing into, get final product again after the mixing.
Embodiment 2:
Get Rhizoma Polygoni Cuspidati 35 grams; Radix Angelicae Sinensis 35 grams; Stigma Maydis 35 grams; Radix Achyranthis Bidentatae 35 grams; Pheretima 35 grams; The Radix Paeoniae Alba 23 grams; Radix Aconiti Kusnezoffii 23 grams; Fructus Liquidambaris 20 grams; Flos Sophorae 20 grams; Ramulus Uncariae Cum Uncis 20 grams; The Radix Aucklandiae 20 grams; Concha Ostreae 15 grams; Herba Apocyni veneti 15 grams; Scorpio 15 grams; Crataegus pin natifida var. Major 10 grams; Semen Cassiae 12 grams; Excessive sheep flower bud 10 grams; Radix Puerariae 8 grams; Herba Taxilli 8 grams; He Shi 8 grams; Flos Carthami 8 grams; Windproof 6 grams; Radix Glycyrrhizae 6 grams; Spica Prunellae 5 grams; CHUANSHAO 5 grams; Rhizoma Zingiberis Recens 5 grams; Astragalus 5 grams; The Radix Rehmanniae 5 grams; Radix Rehmanniae Preparata 5 grams; Flos Chrysanthemi 3 grams; Fructus Aurantii 3 grams; Drug transdermal absorbing catalyst 42 grams.
Said medicine Transdermal absorption Preparation of catalysts method is following:
A kind of Transdermal absorption Chinese medicine protects the method for preparing of pressing bag: get Actinolitum 15 grams, Fluoritum 12 grams, PIMAO 7 grams, Plumbum preparatium 5 grams, Borneolum Syntheticum 3 grams by said weight ratio, mix after pulverizing one by one medicated powder; Medicated powder is put on the medicine bell, filter paper is covered on the medicated powder, cover on filter paper, guarantee the seal of ceramic vessel and medicated powder with a ceramic vessel; Alcohol stove in the medicine stove is lighted,, heated and stop heating after 5-10 minute to the medicated powder heating; Take off ceramic vessel, on the inwall of ceramic vessel, generate alabastrine crystalline solid, inferior crystalline solid is taken off, airtight in the bottle of packing into, promptly get.
With each raw material components respectively with 60 ℃ of-200 ℃ of water cleaning and dipping, purification, 160 minutes water treatment when carrying out being with 75 ℃ of temperature fire-450C ℃ respectively again, described water treatment extracting pressure is controlled to be 345Mpa; The concentration that adds 5 times of amounts then respectively is that 45% ethanol carries out the room temperature lixiviate, and lixiviate is 3 times altogether, each 10 hours; 3 times lixiviating solution are merged, filter filtrating, reclaim ethanol to do not have alcohol distinguish the flavor of extractum; Extractum repeatedly extracts with the acetic acid ethyl ester of convention amount after with the water suspendible of 2 times of amounts, till extract is colourless, merges the cruel extract of acetic acid second; Be concentrated into the thick paste shape, drying gets dry powder; With the dry powder blend that obtains respectively, get powder raw material medicament, powder raw material medicament is mixed with the drug transdermal absorbing catalyst; With per 6 gram medicated core of packing into, with the medicated core medicated bag of packing into, get final product again after the mixing.
Embodiment 3:
Get Rhizoma Polygoni Cuspidati 30 grams; Radix Angelicae Sinensis 30 grams; Stigma Maydis 30 grams; Radix Achyranthis Bidentatae 30 grams; Pheretima 25 grams; The Radix Paeoniae Alba 20 grams; Radix Aconiti Kusnezoffii 20 grams; Fructus Liquidambaris 20 grams; Flos Sophorae 20 grams; Ramulus Uncariae Cum Uncis 20 grams; The Radix Aucklandiae 20 grams; Concha Ostreae 15 grams; Herba Apocyni veneti 15 grams; Scorpio 15 grams; Crataegus pin natifida var. Major 10 grams; Semen Cassiae 18 grams; Excessive sheep flower bud 15 grams; Radix Puerariae 10 grams; Herba Taxilli 10 grams; He Shi 9 grams; Flos Carthami 8 grams; Windproof 7 grams; Radix Glycyrrhizae 7 grams; Spica Prunellae 6 grams; CHUANSHAO 6 grams; Rhizoma Zingiberis Recens 6 grams; Astragalus 6 grams; The Radix Rehmanniae 6 grams; Radix Rehmanniae Preparata 6 grams; Flos Chrysanthemi 5 grams; Fructus Aurantii 5 grams; Drug transdermal absorbing catalyst 50 grams.
Said medicine Transdermal absorption Preparation of catalysts method is following:
Get Actinolitum 20 gram, Fluoritum 12 grams, PIMAO 8 grams, Plumbum preparatium 7 grams, Borneolum Syntheticum 3 grams by said weight ratio, mix after pulverizing one by one medicated powder; Medicated powder is put on the medicine bell, filter paper is covered on the medicated powder, cover on filter paper, guarantee the seal of ceramic vessel and medicated powder with a ceramic vessel; Alcohol stove in the medicine stove is lighted,, heated and stop heating after 5-10 minute to the medicated powder heating; Take off ceramic vessel, on the inwall of ceramic vessel, generate alabastrine crystalline solid, inferior crystalline solid is taken off, airtight in the bottle of packing into, promptly get.
A kind of Transdermal absorption Chinese medicine protects the method for preparing of pressing bag: with each raw material components respectively with 60 ℃ of-200 ℃ of water cleaning and dipping, purification, 160 minutes water treatment when carrying out being with 75 ℃ of temperature fire-450C ℃ respectively again, described water treatment extracting pressure is controlled to be 345Mpa; The concentration that adds 5 times of amounts then respectively is that 45% ethanol carries out the room temperature lixiviate, and lixiviate is 3 times altogether, each 10 hours; 3 times lixiviating solution are merged, filter filtrating, reclaim ethanol to do not have alcohol distinguish the flavor of extractum; Extractum repeatedly extracts with the acetic acid ethyl ester of convention amount after with the water suspendible of 2 times of amounts, till extract is colourless, merges the cruel extract of acetic acid second; Be concentrated into the thick paste shape, drying gets dry powder; With the dry powder blend that obtains respectively, get powder raw material medicament, powder raw material medicament is mixed with the drug transdermal absorbing catalyst; With per 6 gram medicated core of packing into, with the medicated core medicated bag of packing into, get final product again after the mixing.
Modern Chinese medicine Transdermal absorption method of the present invention is protected the method for using of pressing bag:
With 40 ℃～45 ℃ warm water foot was soaked 30 minutes, reach and make sole acupoint unimpeded, the open purpose of pore.After foot dried this medicated bag is placed in the Yongquan acupoint position of sole, in this operating process, must be with the medicine heart position alignment Yongquan acupoint of medicated bag, thus make medicine directly act on this acupuncture point through Transdermal absorption.
The present invention uses curative effect statistics (according to embodiment 1):
X=121. 60 X=21. 73 X=15. 18 1. healings, 2. produce effects 3. are effective
Test Example:
Clinical effectiveness:
Mr. Cao (according to embodiment 1): Baoji, Shaanxi province city Fufeng County Tian Du people from town, 39 years old, performance asthma, dizziness, tinnitus, cardiopalmus, dim eyesight, absent minded, hypomnesis, fatigue and weak, symptom such as easy fidgety.Be diagnosed as hypertension through hospital expert, blood pressure is up to 160mmHg.
The patient adheres to using this product according to method for using every day, and the above symptom of two week back patients is clearly better, and blood pressure also begins to drop to 130 mmHg, almost returns to normal value.
Mrs Wang (according to embodiment 1): Xi'an Communications University 41 years old, headache, feeling of fullness in the head, dizzy occur
Symptoms such as tinnitus, the soreness of waist back of the body, numbness of hands and feet, cardiopalmus asthma are essential hypertension through doctor's inspection, and pressure value reaches 172mmHg.
After the patient uses this medicine every day, transference cures such as a week back headache, feeling of fullness in the head, dizzy, tinnitus, blood pressure returns to 123mmHg.
Mr. Hu (according to embodiment 1): Xibei Univ. of Agricultural & Forest Science & Technology 50 years old, hemiplegia of limb, distortion of commissure occur; Vomiting, gatism, the stupor that continues, breathing deepness have the snore sound, phenomenons such as the pupil size is asymmetric, bradykinesia; Be diagnosed as severe hypertension, pressure value reaches 180mmHg.
The patient adheres to using this medicine after two weeks every day, and it is light that hemiplegia symptom obviously changes.
Claims (5)
1. a Transdermal absorption Chinese medicine protects and presses bag; It is characterized in that: described Chinese medicine protects presses the bag raw material to be made up of the raw material of following weight portion: Rhizoma Polygoni Cuspidati 10-45, Radix Angelicae Sinensis 10-45, Stigma Maydis 10-45, Radix Achyranthis Bidentatae 9-40, the sub-9-40 of Pheretima, Radix Paeoniae Alba 9-40, Radix Aconiti Kusnezoffii 9-40, Fructus Liquidambaris 8-30, Flos Sophorae 8-30, Ramulus Uncariae Cum Uncis 8-30, Radix Aucklandiae 8-30, Concha Ostreae 5-25, Herba Apocyni veneti 5-25, Scorpio 5-25, crataegus pin natifida var. Major 5-15, Semen Cassiae 5-15, excessive sheep flower bud 5-15, Radix Puerariae 2-10, Herba Taxilli 2-10, He Shi 2-10, Flos Carthami 2-10, windproof 2-10, Radix Glycyrrhizae 8-25, Spica Prunellae 5-15, CHUANSHAO 2-15, Rhizoma Zingiberis Recens 2-10, astragalus 5-25, Radix Rehmanniae 5-25, Radix Rehmanniae Preparata 5-25, Flos Chrysanthemi 5-15, Fructus Aurantii 2-10 and drug transdermal absorbing catalyst 25-70.
2. a kind of Transdermal absorption Chinese medicine according to claim 1 protects presses bag; It is characterized in that: described drug transdermal absorbing catalyst by following raw material by weight forming Actinolitum: Fluoritum: PIMAO: Plumbum preparatium: Borneolum Syntheticum=30-50:20-35:2-8:15-45:2-8.
3. a kind of Transdermal absorption Chinese medicine according to claim 1 and 2 protects presses bag; It is characterized in that: the method for preparing of described drug transdermal absorbing catalyst is: saidly get Actinolitum, Fluoritum, PIMAO, Plumbum preparatium, Borneolum Syntheticum by above-mentioned weight ratio, mix after pulverizing one by one medicated powder; Medicated powder is put on the medicine bell, filter paper is covered on the medicated powder, cover on filter paper, guarantee the seal of ceramic vessel and medicated powder with a ceramic vessel; Alcohol stove in the medicine stove is lighted,, heated and stop heating after 5-10 minute to the medicated powder heating; Take off ceramic vessel, on the inwall of ceramic vessel, generate alabastrine crystalline solid, this crystalline solid is taken off, airtight in the bottle of packing into, promptly get.
4. a kind of Transdermal absorption Chinese medicine according to claim 1 protects the method for preparing of pressing bag,
It is characterized in that: with each raw material components respectively with 60 ℃ of-200 ℃ of water cleaning and dipping, purification, 160 minutes water treatment when carrying out being with 75 ℃ of temperature fire-450C ℃ respectively again, the concentration that adds 5 times of amounts then respectively is that 45% ethanol carries out the room temperature lixiviate; Lixiviate is 3 times altogether, each 10 hours, 3 times lixiviating solution is merged; Filter filtrating, reclaim ethanol to do not have alcohol distinguish the flavor of extractum, extractum repeatedly extracts with the acetic acid ethyl ester of convention amount after with the water suspendible of 2 times of amounts; Till extract is colourless, merge the cruel extract of acetic acid second, be concentrated into the thick paste shape; Drying gets dry powder; With the dry powder blend that obtains respectively, get powder raw material medicament, powder raw material medicament is mixed with the drug transdermal absorbing catalyst; With per 6 gram medicated core of packing into, with the medicated core medicated bag of packing into, get final product again after the mixing.
5. a kind of Transdermal absorption Chinese medicine according to claim 3 protects the method for preparing of pressing bag, and it is characterized in that: described water treatment extracting pressure is controlled to be 345Mpa.
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| CN2011103800113A CN102389563A (en) | 2011-11-25 | 2011-11-25 | Transdermal absorption traditional Chinese medicinal blood pressure protection bag and its preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768437A (en) * | 2014-01-23 | 2014-05-07 | 王颖翠 | Pharmaceutical composition for reducing blood pressure and application thereof |
| US20150064269A1 (en) * | 2013-09-03 | 2015-03-05 | Waki Pharmaceutical Co., Ltd. | Method for producing dry earthworm powder |
| CN112587611A (en) * | 2020-12-14 | 2021-04-02 | 长沙清亚灵健康管理有限公司 | Antihypertensive composition and application thereof |
-
2011
- 2011-11-25 CN CN2011103800113A patent/CN102389563A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150064269A1 (en) * | 2013-09-03 | 2015-03-05 | Waki Pharmaceutical Co., Ltd. | Method for producing dry earthworm powder |
| US9089581B2 (en) * | 2013-09-03 | 2015-07-28 | Waki Pharmaceutical Co., Ltd. | Method for producing dry earthworm powder |
| CN103768437A (en) * | 2014-01-23 | 2014-05-07 | 王颖翠 | Pharmaceutical composition for reducing blood pressure and application thereof |
| CN112587611A (en) * | 2020-12-14 | 2021-04-02 | 长沙清亚灵健康管理有限公司 | Antihypertensive composition and application thereof |
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Application publication date: 20120328 |