CN102370643A - Berberine hydrochloride medicinal composition and preparation method thereof - Google Patents
Berberine hydrochloride medicinal composition and preparation method thereof Download PDFInfo
- Publication number
- CN102370643A CN102370643A CN201110203293XA CN201110203293A CN102370643A CN 102370643 A CN102370643 A CN 102370643A CN 201110203293X A CN201110203293X A CN 201110203293XA CN 201110203293 A CN201110203293 A CN 201110203293A CN 102370643 A CN102370643 A CN 102370643A
- Authority
- CN
- China
- Prior art keywords
- berberine hydrochloride
- pharmaceutical composition
- berberine
- medicinal composition
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a berberine hydrochloride medicinal composition and a preparation method thereof, which are used for increasing the dissolution rate of berberine hydrochloride in water and enhance the in-vivo absorption of berberine hydrochloride. According to the specific technical scheme, berberine hydrochloride serves as a medicinal active ingredient of the composition; and a filling agent, a disintegrating agent, a flavoring agent and a lubricating agent in the weight ratio (1-50):(25-60):(3-15):(1.5-3):(0.4-1.2) serve as auxiliary materials. The method for preparing the berberine hydrochloride medicinal composition comprises the following steps of: (1) dissolving; (2) drying; (3) screening; and (4) tableting. The berberine hydrochloride medicinal composition prepared with the method has high disintegrating and dissolving speeds and a good medicament effect, and the problems of low solubility and unstable absorption of berberine hydrochloride are solved. The berberine hydrochloride medicinal composition is effective to enteral infection caused by dysentery bacillus and colon bacillus, and is used for treating enteral infection and diarrhea.
Description
Technical field
The invention belongs to the medicine new technical field, particularly a kind of berberine hydrochloride pharmaceutical composition and preparation method thereof.
Background technology
Berberine hydrochloride has another name called berberine, is made up of along the alkaloid that extracts in pin, Cortex Phellodendri and other berberine plants Rhizoma Coptidis, three.Be a kind of main alkaloid in the ranunculaceae plant Rhizoma Coptidis rhizome, also available manual method is synthetic.Has a broad antifungal spectrum, external to multiple Grain-positive and the equal tool bacteriostasis of negative bacterium, wherein to Hemolytic streptococcus, golden Portugal bacterium, vibrio cholera.Meningococcus, shigella, Bacillus typhi, diphtheria corynebacterium etc. have stronger inhibitory action, and be antibacterial during low concentration, antibacterial during high concentration.Influenza virus, ameba, leptospira, some dermatophytes also there is certain inhibitory action.Experiment in vitro confirms that berberine can strengthen the phagocytic activity of leukocyte and liver reticuloendothelial system.Dysentery bacterium, Hemolytic streptococcus, golden Portugal bacterium etc. very easily produce drug resistance to these article.These article do not have cross resistance with penicillin, streptomycin etc.
Berberine hydrochloride is effective to the intestinal infection that dysentery bacterium, escherichia coli cause, is used to treat intestinal infection, diarrhoea.
But its general formulation has slightly soluble in water, and bioavailability is relatively poor, and onset waits not enough slowly.
Summary of the invention
Of the prior art for overcoming, the invention discloses a kind of berberine hydrochloride pharmaceutical composition and preparation method thereof.
The present invention adopts following technical proposals: the berberine hydrochloride pharmaceutical composition is active component with the berberine hydrochloride, and adjuvant is filler, disintegrating agent, correctives, lubricant, and weight ratio is 1～50:25～60:3～15:1.5～3:0.4～1.2.
Wherein preferential scheme is that said berberine hydrochloride pharmaceutical composition, filler are one or more in mannitol, dextrin, lactose, microcrystalline Cellulose, the starch.
Wherein preferential scheme also has, and described berberine hydrochloride pharmaceutical composition, disintegrating agent are one or more in crospolyvinylpyrrolidone, Sodium Hydroxymethyl Stalcs, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, the alginate.
Wherein preferential scheme also has, and described berberine hydrochloride pharmaceutical composition, correctives are one or more in xylitol, lactose, mannitol, sucrose, citric acid, the citric acid.
Wherein preferential scheme also has, and described berberine pharmaceutical composition, lubricant are one or more in stearic acid, magnesium stearate, calcium stearate, zinc stearate, Polyethylene Glycol, the Pulvis Talci.
A kind of method for preparing above-mentioned berberine hydrochloride pharmaceutical composition may further comprise the steps:
⑴ dissolving takes by weighing berberine hydrochloride, filler, disintegrating agent, correctives, lubricant, is 1～50:25～60:3～15:1.5～3:0.4～1.2 mix homogeneously with weight ratio, and it is an amount of to add ethanol, processes suitable soft material;
⑵ sieve: get above-mentioned soft material, cross 30 mesh sieves and process wet granular;
⑶ oven dry: get above-mentioned wet granular, drying is 2～3 hours under 50～60 ℃;
⑷ tabletting: get above-mentioned drying composite, tabletting, packing.
Wherein preferred scheme has: alcoholic solution concentration is 95%.
The prepared berberine hydrochloride pharmaceutical composition disintegrate stripping of the present invention is rapid, drug effect is high, has solved the berberine hydrochloride indissoluble and has separated, and absorbs problem of unstable.
The specific embodiment
Below in conjunction with embodiment a kind of berberine hydrochloride pharmaceutical composition and preparation method thereof that gets according to the invention is described.
A kind of berberine hydrochloride pharmaceutical composition is an active component with the berberine hydrochloride, and adjuvant: filler is mannitol, dextrin, lactose; Disintegrating agent is Sodium Hydroxymethyl Stalcs, low-substituted hydroxypropyl cellulose; Correctives is sucrose, citric acid; Lubricant is zinc stearate, Polyethylene Glycol; Weight ratio is 36:50:12:1.6:0.4.
A kind of method for preparing above-mentioned berberine hydrochloride pharmaceutical composition may further comprise the steps:
⑴ dissolving takes by weighing berberine hydrochloride, filler mannitol, dextrin, lactose; Disintegrating agent Sodium Hydroxymethyl Stalcs, low-substituted hydroxypropyl cellulose; Correctives sucrose, citric acid; Lubricant stearic acid zinc, Polyethylene Glycol are the 36:50:12:1.6:0.4 mix homogeneously with the weight ratio, and it is an amount of to add 95% ethanol, processes suitable soft material;
⑵ sieve: get above-mentioned soft material, cross 30 mesh sieves and process wet granular;
⑶ oven dry: get above-mentioned wet granular, drying is 3 hours under 55 ℃;
⑷ tabletting: get above-mentioned drying composite, tabletting, packing.
The above; Be merely the preferable specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any technical staff who is familiar with the present technique field is equal to replacement or change according to technical scheme of the present invention and inventive concept thereof in the technical scope that the present invention discloses, all should be encompassed within protection scope of the present invention.
Claims (7)
1. berberine hydrochloride pharmaceutical composition; It is characterized in that: said berberine hydrochloride pharmaceutical composition is active component with the berberine hydrochloride; Adjuvant is filler, disintegrating agent, correctives, lubricant, and weight ratio is 1～50:25～60:3～15:1.5～3:0.4～1.2.
2. berberine hydrochloride pharmaceutical composition according to claim 1 is characterized in that: said filler is one or more in mannitol, dextrin, lactose, microcrystalline Cellulose, the starch.
3. berberine hydrochloride pharmaceutical composition according to claim 1 is characterized in that: said disintegrating agent is one or more in crospolyvinylpyrrolidone, Sodium Hydroxymethyl Stalcs, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, the alginate.
4. berberine hydrochloride pharmaceutical composition according to claim 1 is characterized in that: said correctives is one or more in xylitol, lactose, mannitol, sucrose, citric acid, the citric acid.
5. berberine hydrochloride pharmaceutical composition according to claim 1 is characterized in that: said lubricant is one or more in stearic acid, magnesium stearate, calcium stearate, zinc stearate, Polyethylene Glycol, the Pulvis Talci.
6. one kind prepares any described berberine hydrochloride preparation of drug combination method of claim 1-5, it is characterized in that may further comprise the steps:
⑴ dissolving takes by weighing berberine hydrochloride, filler, disintegrating agent, correctives, lubricant, is 1～50:25～60:3～15:1.5～3:0.4～1.2 mix homogeneously with weight ratio, and it is an amount of to add ethanol, processes suitable soft material;
⑵ sieve: get above-mentioned soft material, cross 30 mesh sieves and process wet granular;
⑶ oven dry: get above-mentioned wet granular, drying is 2～3 hours under 50～60 ℃;
⑷ tabletting: get above-mentioned drying composite, tabletting, packing.
7. a kind of berberine hydrochloride preparation of drug combination method according to claim 6, it is characterized in that: alcoholic solution concentration is 95%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110203293XA CN102370643A (en) | 2011-07-20 | 2011-07-20 | Berberine hydrochloride medicinal composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110203293XA CN102370643A (en) | 2011-07-20 | 2011-07-20 | Berberine hydrochloride medicinal composition and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102370643A true CN102370643A (en) | 2012-03-14 |
Family
ID=45790229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110203293XA Pending CN102370643A (en) | 2011-07-20 | 2011-07-20 | Berberine hydrochloride medicinal composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102370643A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301084A (en) * | 2013-05-30 | 2013-09-18 | 东北制药（沈阳）科技发展有限公司 | Berberine hydrochloride tablet and preparation method thereof |
| CN106687460A (en) * | 2014-07-29 | 2017-05-17 | 深圳君圣泰生物技术有限公司 | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
| CN109464417A (en) * | 2018-12-19 | 2019-03-15 | 中国药科大学 | A kind of demethyleneberberinehydrochloride hydrochloride capsulae enterosolubilis and preparation method thereof |
| CN111067898A (en) * | 2020-02-10 | 2020-04-28 | 上海海洋大学 | Application of berberine hydrochloride in resisting carp herpesvirus II in aquaculture |
| CN111643466A (en) * | 2020-07-27 | 2020-09-11 | 江苏长江药业有限公司 | Preparation method of berberine hydrochloride tablets |
| CN116270516A (en) * | 2023-03-17 | 2023-06-23 | 江苏亚邦爱普森药业有限公司 | Berberine hydrochloride coated tablet and preparation method thereof |
-
2011
- 2011-07-20 CN CN201110203293XA patent/CN102370643A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301084A (en) * | 2013-05-30 | 2013-09-18 | 东北制药（沈阳）科技发展有限公司 | Berberine hydrochloride tablet and preparation method thereof |
| CN106687460A (en) * | 2014-07-29 | 2017-05-17 | 深圳君圣泰生物技术有限公司 | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
| CN106687460B (en) * | 2014-07-29 | 2019-05-17 | 深圳君圣泰生物技术有限公司 | Berberine salt, ursodeoxycholic hydrochlorate, related compound and its preparation method and application |
| US10301303B2 (en) | 2014-07-29 | 2019-05-28 | Shenzhen Hightide Biopharmaceutical, Ltd. | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
| US10988471B2 (en) | 2014-07-29 | 2021-04-27 | Shenzhen Hightide Biopharmaceutical, Ltd. | Pharmaceutical composition comprising berberine ursodeoxycholic acid salt for the treatment of various diseases or disorders |
| US11685735B2 (en) | 2014-07-29 | 2023-06-27 | Shenzhen Hightide Biopharmaceutical, Ltd. | Pharmaceutical composition comprising berberine salts for the treatment of various diseases or disorders |
| CN109464417A (en) * | 2018-12-19 | 2019-03-15 | 中国药科大学 | A kind of demethyleneberberinehydrochloride hydrochloride capsulae enterosolubilis and preparation method thereof |
| CN111067898A (en) * | 2020-02-10 | 2020-04-28 | 上海海洋大学 | Application of berberine hydrochloride in resisting carp herpesvirus II in aquaculture |
| CN111643466A (en) * | 2020-07-27 | 2020-09-11 | 江苏长江药业有限公司 | Preparation method of berberine hydrochloride tablets |
| CN116270516A (en) * | 2023-03-17 | 2023-06-23 | 江苏亚邦爱普森药业有限公司 | Berberine hydrochloride coated tablet and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102370643A (en) | Berberine hydrochloride medicinal composition and preparation method thereof | |
| CN101229236A (en) | Relieve asthma oral liquid preparation and preparing method thereof | |
| CN102178753B (en) | Medicinal preparation with effects of clearing heat, purging intense heat, detoxifying, eliminating blood stasis, cooling blood and stopping bleeding | |
| CN104721207B (en) | A kind of pharmaceutical composition | |
| CN101099730A (en) | Oral solid preparation containing ambroxol hydrochloride and guaifenesin active components | |
| CN102441019B (en) | Chinese medicinal chrysanthemum buccal tablet | |
| JP6272432B2 (en) | Granulated product containing Kamitsumonoyu extract powder | |
| Salome et al. | Formulation and evaluation of Cymbopogon citratus dried leaf-powder tablets | |
| CN102085344A (en) | Aplotaxis carminative sustained-release preparation and preparation method thereof | |
| CN114747760A (en) | Composition for preventing or improving upper respiratory tract infection and application thereof | |
| JP6195428B2 (en) | Granulated product containing Kamitsumonoyu extract powder | |
| CN101167902A (en) | Method for preparing traditional Chinese medicine preparation for treating gout | |
| RU2354403C2 (en) | Auxiliary binding substance and drop-shaped tablet prepared on its base | |
| CA2492156C (en) | Tablet composition containing kampo medicinal extract and its manufacturing process | |
| CN113440487A (en) | Caragana tablets and preparation method thereof | |
| CN110664762B (en) | A solid preparation containing propolis and its preparation method | |
| CN101264172A (en) | Preparation of Chinese medicine composition for drug detoxification and application thereof | |
| CN107898942B (en) | Cold clearing capsule and preparation method thereof | |
| CN103127027B (en) | Polysaccharide sulphate dropping pill | |
| JP6306213B2 (en) | Co-granulate of xanthan gum and acacia gum | |
| JP7265834B2 (en) | Method for producing plant extract powder | |
| CN113599361B (en) | Ginkgo terpene lactone dripping pill and its preparing method | |
| CN1686238A (en) | Medicinal composition for treating diabetes | |
| CN108524875A (en) | A kind of Radix Curcumae extract or preparation for treating enterogastritis | |
| CN104491018A (en) | Lysimachia christinae hance and radix gentianae tablet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120314 |