CN102370505B - 向用于医学植入的微线圈的表面添加微观多孔性 - Google Patents

向用于医学植入的微线圈的表面添加微观多孔性 Download PDF

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CN102370505B
CN102370505B CN201110238900.6A CN201110238900A CN102370505B CN 102370505 B CN102370505 B CN 102370505B CN 201110238900 A CN201110238900 A CN 201110238900A CN 102370505 B CN102370505 B CN 102370505B
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M.亨森
R.A.斯特恩
D.A.沃森
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Abstract

本发明涉及一种用于患者脉管系统的治疗处理的脉管阻塞微线圈，所述脉管阻塞微线圈包括具有在其中的多个空隙或孔的表面，在所述微线圈被引入所述患者的脉管系统中后所述多个空隙或孔起到加速所述患者脉管系统中的愈合过程的作用。

Description

向用于医学植入的微线圈的表面添加微观多孔性
相关专利申请的交叉引用
本申请是于2008年2月27日提交的专利申请No.12/038,757的部分继续申请，专利申请No.12/038,757是于2006年1月26日提交的专利申请No.11/340,422(现在是美国专利No.7,361,367)的继续申请，美国专利No.7,361,367是基于2005年1月26日提交的临时申请No.60/647,516。
背景技术
已经开发出可植入动脉瘤的微线圈(microcoil)，作为通过阻塞脉动血流进入生长动脉瘤(promotinganeurysm)的中心而促进愈合的手段。这种器械在治疗脑动脉瘤中和在发现这种畸形时作为治疗和预防中风的方法，已经非常成功。
已知另一栓塞线圈(emboliccoil)，其包括末端粗糙的纹理化表面，所述粗糙表面具有直径约0.125至50微米，深度约0.25至20微米的小袋，以提供改善的血小板粘附和促进凝血。用于处理动脉瘤的颈部(neck)的另一类可移除式阻塞系统包括有孔的网孔部分，从而允许血液流过该网孔部分。尽管这些栓塞器械具有可促进凝血或允许血液流过该器械的空隙或孔，仍然期望提供可进一步促进患者脉管系统愈合的栓塞器械。
已知一种脉管阻塞线圈，其具有增强的治疗性股线结构，所述股线结构可由治疗性或生物活性材料形成或可掺入治疗性或生物性材料，如聚乙醇酸(PGA)或D，L-乳酸/乙醇酸共聚物(PGLA)或其他治疗性材料。已知另一栓塞器械，其包括由亲水性、大孔、聚合物的水凝胶泡沫材料制成的栓塞性元件。
尽管动脉瘤的微线圈治疗在改善患有这种畸形的患者的恢复预后方面是高效的，然而据认为，如果新的且有效的微线圈治疗方法可用于在放置微线圈后增强愈合过程，则该方法的成功率会提高。本发明解决了现有技术器械中的这些和其他局限性。
发明内容
本发明论述了微线圈和其他可植入器械，应用多种蚀刻方法(其可包括等离子体蚀刻、光刻和化学蚀刻)中的一种或多种以在微线圈的表面中产生形状复杂的微观空隙，该微观空隙在该线圈就位后可起到加速愈合过程的作用。
因此，本发明提供了用于患者脉管系统的治疗处理的脉管阻塞微线圈，包括这样的脉管阻塞微线圈，其至少一个部分具有限定其中的多个空隙或孔的表面。本发明还提供了阻塞患者的脉管系统的方法，该方法涉及如下步骤：提供脉管阻塞微线圈，该脉管阻塞微线圈的至少一个部分具有限定其中的多个空隙的表面；以及将该脉管阻塞微线圈引入该患者的脉管系统中，从而该脉管阻塞微线圈的所述多个空隙或孔可起到加速该患者脉管系统中的愈合过程的作用。本发明还提供了利用多种蚀刻方法中的一种或多种在微线圈的表面中形成多孔性的方法，所述蚀刻方法可包括等离子体蚀刻和溅射。
根据下面对优选实施例的详细描述结合以举例方式说明本发明的附图，本发明的其他特征和优势将变得显而易见。
附图说明
该图为根据本发明形成的螺旋单股微线圈的一部分的透视图。
具体实施方式
如图所示，本发明体现为一种脉管阻塞微线圈，该脉管阻塞微线圈的至少一个部分具有限定其中的多个空隙或孔的外表面，其中所述附图是以说明为目的而不是以限制的方式给出。在附图中所示的目前优选的方面中，该脉管阻塞微线圈可由弹性材料和/或超弹性材料(如镍钛合金)和/或不透射线材料(如铂或金)或其他类似的合适不透射线金属的单股柔性股线(strand)10形成。当使用镍钛合金时，镍钛合金通常经热处理使得该合金在适于通过导管引入体内的温度下是高度柔性的。通过选择这种材料用于微线圈等，由微线缆(micro-cable)形成的器械可相对容易地放置进合适的体腔中，在放置后，该器械将呈现出设计用于优化对该器械所期望的治疗目的的形状。
本发明的一个有利的应用是用作由所述脉管阻塞微线圈形成的脉管阻塞器械，用于插入动脉瘤和其他脉管缺陷中，目的是阻塞向动脉瘤的流动。该单股柔性股线可形成为螺旋缠绕线圈12的形状，具有一定维度和构形以配合进微导管内，用于插入待进行治疗操作的区域中。尽管示例了螺旋线圈，但应该理解，可由本发明的脉管阻塞微线圈形成许多其他形状。
如图中所示，脉管阻塞微线圈包括了这样的至少一个部分，其外部表面限定了在该微线圈的表面中的多个微观空隙或孔12，所述空隙或孔12的形状可以是复杂的。该空隙或孔可利用多种溅射和蚀刻方法中的一种或多种在微线圈的表面中形成，所述溅射和蚀刻方法可包括例如等离子蚀刻、光刻和化学蚀刻，以及它们的任何组合或多种组合。在可植入器械的表面中产生微观空隙或孔的其他方法可以是有效的。一旦线圈就位后，该空隙或孔可有利地起到加速愈合过程的作用。
根据上述内容显而易见，虽然已经图示和描述了本发明的具体形式，但是可在不背离本发明的精神和范围的情况下进行多种修改。因此，本发明旨在受所附权利要求书的限制，而非其他限制。

Claims (11)

1.一种用于患者脉管系统的治疗处理的脉管阻塞微线圈，所述脉管阻塞微线圈由单股柔性股线形成，所述单股柔性股线包括至少一个具有适于接触待处理的患者组织的外表面的部分，所述单股柔性股线的所述外表面限定了其中的多个具有复杂形状的空隙，一旦所述线圈就位后所述空隙能起到加速愈合过程的作用。
2.根据权利要求1所述的脉管阻塞微线圈，其中所述单股柔性股线被形成为螺旋缠绕线圈的形状。
3.根据权利要求1所述的脉管阻塞微线圈，其中所述单股柔性股线包含超弹性材料。
4.根据权利要求1所述的脉管阻塞微线圈，其中所述单股柔性股线包含镍钛合金。
5.根据权利要求1所述的脉管阻塞微线圈，其中所述单股柔性股线包含不透射线材料。
6.根据权利要求5所述的脉管阻塞微线圈，其中所述不透射线材料包含铂。
7.根据权利要求5所述的脉管阻塞微线圈，其中所述不透射线材料包含金。
8.一种为用于医学植入的微线圈的表面添加微观多孔性的方法，所述方法包括如下步骤：
提供由单股柔性股线形成的脉管阻塞微线圈，所述单股柔性股线包括至少一个具有适于接触待处理的患者组织的外表面的部分；以及
在所述单股柔性股线的所述外表面中形成多个具有复杂形状的空隙，一旦所述线圈就位后所述空隙能起到加速愈合过程的作用。
9.根据权利要求8所述的方法，其中形成多个空隙的步骤包括通过等离子体蚀刻所述单股柔性股线的所述外表面而在所述单股柔性股线的所述外表面中形成所述多个空隙。
10.根据权利要求8所述的方法，其中形成多个空隙的步骤包括通过光刻所述单股柔性股线的所述外表面而在所述单股柔性股线的所述外表面中形成所述多个空隙。
11.根据权利要求8所述的方法，其中形成多个空隙的步骤包括通过化学蚀刻所述单股柔性股线的所述外表面而在所述单股柔性股线的所述外表面中形成所述多个空隙。
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US20110054511A1 (en) 2011-03-03
CA2748960A1 (en) 2012-02-11
JP2012035083A (ja) 2012-02-23
EP2417919A2 (en) 2012-02-15
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CN102370505A (zh) 2012-03-14
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