CN102363011A - Chinese medicinal composition for dispel effects of alcohol, and preparation method thereof - Google Patents
Chinese medicinal composition for dispel effects of alcohol, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for dispel the effects of alcohol, and a preparation method thereof. The medicinal composition consists of the following Chinese medicines in part by weight: 10 to 50 parts of kudzuvine root, 10 to 50 parts of flower of kudzuvine, 10 to 50 parts of reed rhizome, 10 to 50 parts of caulis bambusae in taeniis, 10 to 50 parts of endothelium corneum gigeriae galli, 10 to 50 parts of lotus leaf, 10 to 50 parts of calyx and receptacle of a persimmon, 10 to 50 parts of stonelike omphalia, 10 to 50 parts of chrysanthemum, and 10 to 50 parts of black cardamom. The Chinese medicinal composition has the effects of dispelling the effects of alcohol, and protecting liver.
Description
Technical field
The present invention relates to field of health care food, be specifically related to Chinese medicine composition of a kind of Dealcoholic sobering-up and preparation method thereof.
Background technology
Wine is exactly one of beverage of liking very much of Chinese since ancient times, and whenever party, the friends and family talks animatedly and cheers, and has both increased many celebrating atmosphere, also promotes friendship each other to exchange.But a happiness, unavoidable insobriety causes vomiting, has a stomachache, uncomfortable reaction such as headache, even causes healthy grievous injury.The drunk person knows very well the severity of wine naturally, can usually suffer from difficulty and seek " not liquor-saturated art ", the good recipe of seldom relieving the effect of alcohol.
According to the historical data record, before the Western Han Dynastry, just there is tea cake to brew batchings such as adding Herba Alii fistulosi, Rhizoma Zingiberis Recens, Fructus Citri tangerinae, with this side that refreshes oneself that sobers up." extensively refined " shown of making a bow with hands clasped of opening of the period of Three Kingdoms also put down in writing: " pick tea-leaves between the chaste tree crust and make cake and become meter cream to go out it.If the drink, process earlier make red ... its drink is sobered up.”
Be loaded with in the handbook of Prescription for Emergency of Shanxi and control liquor-saturated side and " desiring the to make difficult liquor-saturated " side of not waking up of drinking day after day, Radix Puerariae drink, Os Draconis drink, Folium Eriobotryae drink " and assorted with dried Pu, pockmarks ", Bitters soak Ovum Gallus domesticus side etc.; Control " Lian Yue drinks, and throat is mashed, gives birth to skin ulcer on the tongue " side in addition.
Relieve the effect of alcohol (dispel the effects of alcohol) as its name suggests, " sober up " exactly, the people is waken up from drunk state comes, recover consciousness or reply possessiveness.Usually not that nature is clear-headed, but adopt certain mode to relieve the effect of alcohol fast, play time-saving purpose, reduce the purpose of ethanol human harm.
Antialcoholic drug totally can be divided into three kinds of chemical drugss, Chinese medicine preparation, health product, and its sober-up function has relation with property of medicine speed.
Mostly chemicals is compositions such as analeptic, vitamin and aminoacid, can play fast relieve the effect of alcohol, sobering-up functions, but most chemical drugs relieving mechanism is only to promote ethanol to decompose, and plays temporary mitigation, is difficult to play liver protection effect.
Chinese medicine preparation at antialcoholic simultaneously, can cause the metabolism burden and produce injury in various degree liver, kidney.
And the health product of integration of edible and medicinal herbs neither can produce any side effect, and can play a part to repair nutrition to impaired liver cell, and are safe and reliable, therefore, obtained the favor of increasing expert and consumer.
Scan vast as the open sea Chinese medicine books, the record of the relevant side of relieving the effect of alcohol medicine is many.One Chinese patent application 02110426.3 discloses a kind of relieving the effect of alcohol and has been processed by following parts by weight of Chinese traditional medicine with the preventing drunkenness Chinese medicine preparation: the Radix Changii of the Semen Hoveniae of 10-30 or the Caulis Bambusae In Taenia of 3-6 or 9-15, the Flos puerariae lobatae of 10-30 or the Radix Puerariae of 10-30, Cortex Moutan 10-30; Radix Glycyrrhizae 3-6; Fructus Crataegi 9-20, Endothelium Corneum Gigeriae Galli 3-12, Fructus Hordei Germinatus 6-20; Rhizoma Phragmitis 15-30, Semen Plantaginis 9-15.Though this patent is explained this medicine and is had antialcoholism action, does not regrettably disclose its concrete enforceable case in an embodiment, therefore, can't learn how to implement this patent through this patent.
One Chinese patent application 200910216584.5 discloses a kind of Flos puerariae lobatae Folium Nelumbinis tea, can alcoholic intoxication.But flavour of a drug are simple, and coordinative role is few between the medicine, influenced the effect of relieving the effect of alcohol greatly.In addition, the Radix Puerariae Folium Nelumbinis tea does not possess the effect of liver-protecting and stomach-protecting.
Above-mentioned two compound recipes all have certain effect of relieving the effect of alcohol, but deficiency is respectively arranged, and a kind of relieving the effect of alcohol biases toward diuresis and transfer stomach with the preventing drunkenness Chinese medicine preparation, thereby influenced the antialcoholic effect, and the trend that a presumptuous guest usurps the role of the host is arranged.A kind of Radix Puerariae Folium Nelumbinis tea then flavour of a drug does not simply have collaborative mutually effect, thereby has lowered the antialcoholic curative effect, and does not get rid of the effect of alcoholism liver-protecting and stomach-protecting.
Therefore, a kind of effectively Dealcoholic sobering-up need be provided, and the compound recipe of liver-protecting and stomach-protecting.
Summary of the invention
The Chinese medicine composition that the purpose of this invention is to provide a kind of Dealcoholic sobering-up.
Another object of the present invention provides the method for preparing of above-mentioned Chinese medicine composition.
The Chinese medicine composition of Dealcoholic sobering-up provided by the invention; Process by following parts by weight of Chinese traditional medicine: Radix Puerariae 10-50 part, Flos puerariae lobatae 10-50 part, Rhizoma Phragmitis 10-50 part, Caulis Bambusae In Taenia 10-50 part, Endothelium Corneum Gigeriae Galli 10-50 part, Folium Nelumbinis 10-50 part, Calyx Kaki 10-50 part, Omphalia 10-50 part, Flos Chrysanthemi 10-50 part, Fructus Tsaoko 10-50 part.
Preferably; Chinese medicine composition provided by the invention is processed by following parts by weight of Chinese traditional medicine: Radix Puerariae 20-40 part, Flos puerariae lobatae 20-40 part, Rhizoma Phragmitis 20-40 part, Caulis Bambusae In Taenia 20-40 part, Endothelium Corneum Gigeriae Galli 20-40 part, Folium Nelumbinis 20-40 part, Calyx Kaki 20-40 part, Omphalia 20-40 part, Flos Chrysanthemi 20-40 part, Fructus Tsaoko 20-40 part.
Further preferred, Chinese medicine composition provided by the invention is processed by following parts by weight of Chinese traditional medicine: 30 parts of Radix Puerariaes, 30 parts of Flos puerariae lobataes, 30 parts of Rhizoma Phragmitiss, 30 parts of Caulis Bambusae In Taenia, 30 parts of Endothelium Corneum Gigeriae Galli, 30 parts on Folium Nelumbinis, 30 parts of Calyx Kaki, 30 parts of Omphalias, 30 parts of Flos Chrysanthemis, 30 parts of Fructus Tsaokos.
The unit of said weight portion can be known unit of weights such as μ g, mg, g, kg.
Chinese medicine composition provided by the invention is tablet, oral liquid, soft capsule, hard capsule, granule, hard capsule or pill, is preferably oral liquid, soft capsule or granule.
The present invention also provides a kind of method for preparing above-mentioned Chinese medicine composition, may further comprise the steps:
Radix Puerariae, Flos puerariae lobatae, Rhizoma Phragmitis, Caulis Bambusae In Taenia, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Calyx Kaki, Omphalia, Flos Chrysanthemi, Fructus Tsaoko water decoct 2-4 time, add the water that 5-10 doubly measures at every turn; Each decocting time is 1-3 hour; Collecting decoction filters, and being concentrated into relative density is the extractum of 1.05-1.30 (60 ℃); Spray drying adds pharmaceutically acceptable carrier or diluent and processes preparation.
Preferably, the method for preparing of Chinese medicine composition provided by the invention may further comprise the steps:
Radix Puerariae, Flos puerariae lobatae, Rhizoma Phragmitis, Caulis Bambusae In Taenia, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Calyx Kaki, Omphalia, Flos Chrysanthemi, Fructus Tsaoko water decoct 3 times, add the water of 6 times of amounts at every turn; Each decocting time is 1.5 hours; Collecting decoction filters, and being concentrated into relative density is the extractum of 1.10-1.15 (60 ℃); Spray drying adds pharmaceutically acceptable carrier or diluent and processes preparation.
Said pharmaceutically acceptable carrier or diluent are meant the pharmaceutical carrier that pharmaceutical field is conventional, are selected from filler, binding agent, disintegrating agent, lubricant, suspending agent, wetting agent, solvent, surfactant or the correctives one or more.
Said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.;
Said binding agent is selected from cellulose derivative, starch, alginate, gelatin or polyvinylpyrrolidone etc.;
Said disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose;
Said lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, micropowder silica gel, Pulvis Talci or magnesium stearate;
Said suspending agent is selected from micropowder silica gel, Cera Flava, cellulose, solid polyethylene glycol;
Said wetting agent is selected from glycerol, tween 80, ethyoxyl castor oil hydrogenated or lecithin;
Said solvent is selected from ethanol, liquid polyethylene glycol, isopropyl alcohol, tween 80, glycerol, propylene glycol or vegetable oil, and said vegetable oil is selected from soybean oil, Oleum Ricini, Oleum Arachidis hypogaeae semen, mediation wet goods;
Said surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, polyoxyethylene-polyoxypropylene copolymer, the fatty acid Pyrusussuriensis is smooth or Polysorbate (tween) etc.;
Said sweeting agent is selected from aspartame, Sucralose, essence, citric acid or saccharin sodium.
The present invention also provides the application of Chinese medicine composition in the health product of preparation Dealcoholic sobering-up, applicable to drunk Dealcoholic sobering-up, and the drunk symptoms such as headache after being still drank after a night.
Intending consumption is 10-5000mg/ time, takes when drinking, after drinking, and has a headache in the back that also can be used for being still drank after a night.
More than each component the statement of composition and effect as follows:
Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Have relieving muscles diaphoresis, yang invigorating quenches the thirst, and analgesic merit of promoting the production of body fluid arrogates to oneself that to control wine long-pending." property of medicine opinion " of the Tang Dynasty Zhen Quan said Radix Puerariae ability " whetting the appetite, alcoholic intoxication ".Thereafter, the supplement to the Herbal of CHEN Zang-Qi is said, Radix Puerariae " paddy of can breaking is not hungry for steamed wheaten foods, the alcoholism that disappears "; " Kaibao Bencao " also carries: " make powder, quench the thirst, sharp defecation is relieved the effect of alcohol, and goes dysphoria with smothery sensation "; " prescriptions worth thousand gold " record, drink fresh puerariae radix juice can be controlled " drunk awake ".Control drunk awake.Modern science and technology is isolated 13 kinds of isoflavone and 3 kinds of saponins from Radix Puerariae, and has confirmed their structure.In the experiment to human body cell, they find that a kind of saponin wherein has powerful liver-protecting efficacy, and isoflavone then has the effect of intensive elimination activity oxygen.Scientist thinks that in immune system and hormonal system performance coordinative role, they can improve the pathobolism that causes because of ethanol respectively for saponin that contains in the Radix Puerariae and isoflavone, and the relieving alcoholism and protecting the liver effect is showing.The scientific basis of relieving the effect of alcohol and providing for Radix Puerariae.
Flos puerariae lobatae is the dried floral of leguminous plant Pueraria lobota Puerarialobata (Willd.) Ohwi, but relieving acute alcoholism and recuperating the spleen, the wine that cures the wound heating excessive thirst, anorexia, discharging fresh blood stool is spitted blood in the vomiting acid regurgitation.
Rhizoma Phragmitis, another name: reed Rhizoma Imperatae, reed root, reed head, reed stems root, reed mushroom root,, reed root logical, reed bud root, sweet stalk along Jiang Long, reed.Sweet in the mouth is cold and nontoxic.Can clearing away lung-heat, again can clearing away stomach-heat and the preventing or arresting vomiting that promotes the production of body fluid.The alcohol user so that middle Jiao has heat, taste are dry, body fluid being unable to be produced, sweet can stomach reinforcing with in, cold can the heat extraction pathogenic fire reducing, pyrolysis harmonization of the stomach, then free flow of body fluid and restlessness and thirst ends.The hot person of wine, pathogenic heat also, the sweet cold pathogenic heat of removing, then wine heat is explained by oneself.The lung being the upper source of fluids, spleen-QI transporting the essence to the whole body, on belong to lung, the beginning can regulating fluid apssage, following defeated bladder, the kidney being a water ZANG-organ and main two just, Gu Sanjia has wine heat to the greatest extent from urinating.
Caulis Bambusae In Taenia is the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.All can gather and process the whole year, gets fresh stem, removes crust, viridant slightly intermediate layer spread to strand, or chip, and ties up bunchy, dries in the shade.The former claims " Caulis Bambusae In Taenia looses ", and the latter claims " neat Caulis Bambusae In Taenia ".Nature and flavor: cold nature, sweet in the mouth.Function cures mainly: removing heat-phlegm, relieve restlessness and prevent vomiting.Be used for phlegm-heat cough, gallbladder fire and hold expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm.
Endothelium Corneum Gigeriae Galli is meant the gizzard inwall of tame chicken, is digestive organs, is used to grind food, and these article are one of Chinese medicine, is used for diseases such as dyspepsia, seminal emission night sweat, and effect is splendid, so name with " gold ".Endothelium Corneum Gigeriae Galli, the taste of chicken are the institute of digesting and absorbing the essence of foodstuff of disappearing also.Its gas lead to large intestine, bladder two warps are drunk into stomach, and liver spleen two is through injured, so that long-pending heat is for suffering from.Endothelium Corneum Gigeriae Galli can be gone into liver and removed liver-heat, goes into spleen and diabetes with polyphagia as the prominent symptom is long-pending, but strengthening the spleen and stomach again, and protection stomach film is drained alcoholism and is just gone out from two.
Folium Nelumbinis is the leaf of nymphaeaceae plant lotus.Bitter in the mouth is hot little puckery, cool in nature, and GUIXIN, liver, spleen channel, delicate fragrance rise looses; Have summer heat relieving and dampness eliminating, the spleen invigorating yang invigorating, dissipating blood stasis hemostatic effect cures mainly: the summer-heat excessive thirst, it is dizzy to have a headache, edema, lack of appetite abdominal distention, dysentery, leucorrhea, proctoptosis is spitted blood, epistaxis, spitting of blood is had blood in stool metrorrhagia, post partum longtime lochia, traumatic blood stasis.
Calyx Kaki is the persistent calyx of Ebenaceae plant Fructus Kaki Diospyros Kaki L.f..Nature and flavor with return through bitter in the mouth, flat, return the stomach warp.Function with cure mainly: stopping nausea and vomiting by lowering the adverse flow of QI.Be used for the fullness in the chest singultus.
Omphalia is the dry sclerotia of the white fungus Omphalia Omphalia lapidescens Schroet. of mushroom section.Removing food stagnancy, parasite killing.Control abdominal pain due to worm stagnation, infantile malnutrition, acute infantile convulsion.
Flos Chrysanthemi, acrid in the mouth, sweet, hardship; Cold nature.Return lung, Liver Channel.Ability suppressing the hyperactive liver fire puts out endogenous wind, presses down the perverse and unreasonable manner of wood gas.The treatment dizziness is dizzy, with floating of YANG due to deficiency of YIN, and the ascension of gas fire, that disturbs on the liver-wind is dizzy.The pyretic toxicity impairing the liver is consumed cloudy Tianjin after drinking, the easiest liver-wind stirring up internally that causes, the vertigo.So with the poor drop-down of Flos Chrysanthemi, receive take the photograph empty sun and receive belong under.With toil a surname network of Flos Chrysanthemi, the poison of wine heat in the treating blood disorders.So the flat then wind breath of wood, then evanescence of heat falls in fire, and alcoholism is explained by oneself.
Fructus Tsaoko cures mainly the chest and diaphragm feeling of fullness, coldness and pain in the epigastrium, and nausea and vomiting, the dysentery of having loose bowels, food stagnation does not disappear, cholera, pestilence, subtertian malaria can also alcoholic intoxication, goes halitosis.
Radix Puerariae, Flos puerariae lobatae is with using Antialcoholic liver-protecting; Rhizoma Phragmitis clearing away stomach-heat alcoholic intoxication makes alcoholism from urinating; Caulis Bambusae In Taenia, Calyx Kaki, a cool temperature, all the merit of tool preventing or arresting vomiting is improved the stomach discomfort symptom; Endothelium Corneum Gigeriae Galli protects stomach, has the effect of protection gastric mucosa; The liver alcoholism is got rid of in Flos Chrysanthemi liver heat removing refreshment; Fructus Tsaoko damp eliminating detoxifcation, the liver protecting; Omphalia is gone into liver, and it is old long-pending specially to disappear, and the liver protecting strengthens the liver metabolism function.The all medicines in full side are collaborative, play alcoholic intoxication, row's alcoholism, and liver-protecting and stomach-protecting, preventing or arresting vomiting is told, and ends headache, improves the effect of various symptoms after drinking.
The Chinese medicine composition that is used for Dealcoholic sobering-up provided by the invention has the following advantages:
1, Chinese medicine composition provided by the invention is condensed forming on the ancient prescription basis, and totally ten flavor Chinese medicines are formed.Can improve the pathobolism and the drunk back retention of damp-heat in the interior that cause because of ethanol, gastral cavity is vexed, nauseating, the symptom of vomiting, has the relieving alcoholism and protecting the liver effect.Have the drunk symptom of quick improvement, reach rapid antialcoholic effect.
2, compared with prior art, Chinese medicine composition provided by the invention not only has various rapports between the medicine, and sober-up function is with strong points, and has auxiliary mutually collaborative each other effect between the medicine, can be the efficacy exertion between the medicine to ultimate attainment.
The present invention can also excrete alcoholism in addition, does not retain in vivo, can also reduce the absorption of liver to alcoholism simultaneously, has alleviated the burden of liver greatly.And can effectively improve various after drinking symptoms, thereby reach the effect of giving consideration to both the incidental and fundamental.
The specific embodiment
Following examples are used to explain the present invention, but should not be used for limiting scope of the present invention.
Embodiment 1: the tablet of Dealcoholic sobering-up
1, prescription: Radix Puerariae 30g, Flos puerariae lobatae 30g, Rhizoma Phragmitis 30g, Caulis Bambusae In Taenia 30g, Endothelium Corneum Gigeriae Galli 30g, Folium Nelumbinis 30g, Calyx Kaki 30g, Omphalia 30g, Flos Chrysanthemi 30g, Fructus Tsaoko 30g (adding up to 300g).
2, method for preparing: Radix Puerariae, Flos puerariae lobatae, Rhizoma Phragmitis, Caulis Bambusae In Taenia, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Calyx Kaki, Omphalia, Flos Chrysanthemi, Fructus Tsaoko water decoct 3 times, and amount of water is respectively the water of 4,6,8 times of amounts; Decocting time was respectively 1.5,1.5,2 hours, and collecting decoction filters; Being concentrated into relative density is the extractum of 1.10 (60 ℃), and spray drying adds the microcrystalline Cellulose of extract powder weight 30%, 45% lactose according to the equivalent method of progressively increasing; Mixing, direct compression.
3, usage and dosage: the 300mg/ sheet, 1-5 sheet/inferior is taken in drinking or after drinking, and takes the circumstances into consideration plus-minus according to drunk degree.
Embodiment 2: the oral liquid of Dealcoholic sobering-up
1, prescription: Radix Puerariae 45g, Flos puerariae lobatae 15g, Rhizoma Phragmitis 35g, Caulis Bambusae In Taenia 35g, Endothelium Corneum Gigeriae Galli 25g, Folium Nelumbinis 25g, Calyx Kaki 25g, Omphalia 15g, Flos Chrysanthemi 30g, Fructus Tsaoko 30g (adding up to 280g).
2, method for preparing: Radix Puerariae, Flos puerariae lobatae, Rhizoma Phragmitis, Caulis Bambusae In Taenia, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Calyx Kaki, Omphalia, Flos Chrysanthemi, Fructus Tsaoko water decoct 2 times, and amount of water is respectively the water of 6,8 times of amounts, and decocting time was respectively 3,2 hours; Collecting decoction filters, and filtrating is concentrated into the thick paste that relative density is 1.10 (60 ℃), spray drying; Add the aspartame of extract powder weight 1%, 2% apple essence according to the equivalent method of progressively increasing, mixing left standstill 12 hours, filtered; Packing, sterilization promptly gets.
3, usage and dosage: 10ml/ props up (containing crude drug 100mg), takes 2-5 at every turn and props up, and takes in drinking or after drinking, and takes the circumstances into consideration plus-minus according to drunk degree.
Embodiment 3: the soft capsule of Dealcoholic sobering-up
1, prescription: Radix Puerariae 10g, Flos puerariae lobatae 50g, Rhizoma Phragmitis 40g, Caulis Bambusae In Taenia 40g, Endothelium Corneum Gigeriae Galli 50g, Folium Nelumbinis 15g, Calyx Kaki 30g, Omphalia 10g, Flos Chrysanthemi 15g, Fructus Tsaoko 40g (adding up to 300g).
2, method for preparing:
1) soft capsule shell liquid: processed by gelatin, water and glycerol, wherein three's ratio is 1: 1: 0.5, and is subsequent use;
2) content of soft capsule: Radix Puerariae, Flos puerariae lobatae, Rhizoma Phragmitis, Caulis Bambusae In Taenia, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Calyx Kaki, Omphalia, Flos Chrysanthemi, Fructus Tsaoko water decoct 2 times, add the water of 6 times of amounts for the first time, decoct 1.5 hours; Add for the second time the water of 8 times of amounts, decocted 2 hours, collecting decoction, filtration, being concentrated into relative density is the extractum of 1.15 (60 ℃), spray drying joins the soybean oil of 60 ℃ extract powder weight 20%, 20% Macrogol 2000,5% Cera Flava, mixing;
3) content of the soft capsule of above-mentioned preparation and soft capsule shell liquid are put into soft capsule and produce pelleting in the filling machine, screening, qualified, promptly get.
3, consumption: the 0.5g/ grain, 2-10 grain/inferior is taken in drinking or after drinking, and takes the circumstances into consideration plus-minus according to drunk degree.
Embodiment 4: the hard capsule of Dealcoholic sobering-up
1, prescription: Radix Puerariae 40g, Flos puerariae lobatae 40g, Rhizoma Phragmitis 20g, Caulis Bambusae In Taenia 20g, Endothelium Corneum Gigeriae Galli 50g, Folium Nelumbinis 20g, Calyx Kaki 30g, Omphalia 15g, Flos Chrysanthemi 25g, Fructus Tsaoko 40g (adding up to 300g).
2, method for preparing:
Radix Puerariae, Flos puerariae lobatae, Rhizoma Phragmitis, Caulis Bambusae In Taenia, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Calyx Kaki, Omphalia, Flos Chrysanthemi, Fructus Tsaoko water decoct 3 times, and amount of water is respectively the water of 6,6,8 times of amounts; Decocting time was respectively 1.5,2,2 hours, and collecting decoction filters; Being concentrated into relative density is the extractum of 1.10 (60 ℃), and spray drying adds the microcrystalline Cellulose of extract powder weight 20%, 5% starch, 40% lactose according to the equivalent method of progressively increasing; Mixing, fill 1# capsule promptly gets.
3, usage and dosage: the 0.5g/ grain, 1-10 grain/inferior is taken in drinking or after drinking, and takes the circumstances into consideration plus-minus according to drunk degree.
Embodiment 5: the granule of Dealcoholic sobering-up
1, prescription: Radix Puerariae 50g, Flos puerariae lobatae 20g, Rhizoma Phragmitis 30g, Caulis Bambusae In Taenia 30g, Endothelium Corneum Gigeriae Galli 40g, Folium Nelumbinis 20g, Calyx Kaki 15g, Omphalia 20g, Flos Chrysanthemi 25g, Fructus Tsaoko 25g (adding up to 275g).
2, method for preparing:
Radix Puerariae, Flos puerariae lobatae, Rhizoma Phragmitis, Caulis Bambusae In Taenia, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Calyx Kaki, Omphalia, Flos Chrysanthemi, Fructus Tsaoko water decoct 3 times, and amount of water is respectively the water of 4,6,8 times of amounts, and decocting time was respectively 2,1.5,2 hours; Collecting decoction filters, and being concentrated into relative density is the extractum of 1.10 (60 ℃); Spray drying adds the aspartame of extract powder weight 1%, 2% citric acid according to the equivalent method of progressively increasing, and stirs; Dry granulation, packing promptly gets.
3, usage and dosage: 1-3 bag/inferior, the 600mg/ bag is taken in drinking or after drinking, and takes the circumstances into consideration plus-minus according to drunk degree.
Comparative Examples 1: with reference to 02110426.3
1,02110426.3 prescription is chosen its maximum, form as follows: Caulis Bambusae In Taenia 6g, Flos puerariae lobatae 30g, Radix Puerariae 30g, Cortex Moutan 30g, Radix Glycyrrhizae 6g, Fructus Crataegi 20g, Endothelium Corneum Gigeriae Galli 12g, Fructus Hordei Germinatus 20g, Rhizoma Phragmitis 30g, Semen Plantaginis 15g.
2, method for preparing:
Take by weighing above-mentioned Chinese medicine, water decocts 2 times, and amount of water is respectively the water of 6,8 times of amounts, and decocting time was respectively 3,2 hours; Collecting decoction filters, and being concentrated into relative density is the thick paste of 1.10 (60 ℃), spray drying; Add the aspartame of extract powder weight 1%, 2% apple essence according to the equivalent method of progressively increasing, mixing adds water 1000ml, leaves standstill 12 hours; Filter, packing, sterilization promptly gets.
3, usage and dosage: 10ml/ props up, and takes 2-5 at every turn and props up, and takes in drinking or after drinking, and takes the circumstances into consideration plus-minus according to drunk degree.
Comparative Examples 2: method with reference to 200910216584.5
1, raw material is chosen: get Flos puerariae lobatae 10 grams, half on Folium Nelumbinis;
2, batching: Folium Nelumbinis is cut into silk, goes in the pot together with Flos puerariae lobatae, add water to submerge material, boiled 10 minutes, the extracting juice that removes slag promptly makes the Flos puerariae lobatae Folium Nelumbinis tea.
Experimental example: clinical trial
1, case is selected
Treatment case 500 examples, male's 346 examples, women's 154 examples, the oldest is 60 years old, minimum is 18 years old, 37 years old mean age.Getting rid of fatty liver etc. in the above-mentioned case has the patient of hepatic disease, cardiovascular disease.
2, Therapeutic Method:
Experiment is divided into groups, and 500 cases are divided into 1,2 groups of embodiment 1-5 group, Comparative Examples at random, and wherein embodiment 1-5 organizes each 80 example, 1,2 groups of each 50 examples of Comparative Examples.
Every group of dosage is 500mg crude drug amount/inferior, takes in drinking or after drinking.
3, curative effect determinate standard is observed its gastrointestinal reaction simultaneously, and the evaluation and test liver function
Produce effects: take in drinking or after drinking, be not easy drunk, and symptom such as no headache dizziness;
Effectively, take in drinking or after drinking, sx, but the dizzy symptom of slight headache is arranged;
Invalid: after taking, no change.
4, therapeutic effect:
4.1 efficacy result: see table 1
Table 1: take behind the medicine to drunk influence
| Divide into groups | Produce effects | Effectively | Invalid | Total effective rate (%) |
| 1 group of embodiment | 77(96.25％) | 3(3.75％) | ?0 | 100 |
| 2 groups of embodiment | 78(97.5％) | 2(2.5％) | ?0 | 100 |
| 3 groups of embodiment | 76(95％) | 4(5％) | ?0 | 100 |
| 4 groups of embodiment | 78(97.5％) | 2(2.5％) | ?0 | 100 |
| 5 groups of embodiment | 79(98.75％) | 1(1.25％) | ?0 | 100 |
| 1 group of Comparative Examples | 30(60％) | 16(32％) | ?4(8％) | 92 |
| 2 groups of Comparative Examples | 35(70％) | 10(20％) | ?5(10％) | 90 |
Can find out from table 1 result:
Embodiment 1-5 group: produce effects is more than 95%, and total effective rate is 100%;
Comparative Examples 1: produce effects is 60%, and total effective rate is 92%;
Comparative Examples 2: produce effects is 70%, and total effective rate is 90%.
4.2 gastrointestinal reaction and liver function test result:
Among the embodiment 1-5, add up to have 2-4 have slightly feel sick, the phenomenon of vomiting, add these article 500mg after, this phenomenon disappearance; Liver function detects normal, does not cause abnormal liver function because of drinking, and infers that medicine of the present invention not only has the antialcoholic of sobering up effect, can also hepatoprotective;
In the Comparative Examples 1, have 10 examples occurred than embodiment serious feel sick, vomiting, headache, dizzy phenomenon, add 500mg or 1000mg after, sx simultaneously, has 16 examples of short duration unusual of liver function to occur, through behind the 5-10, liver function is normal gradually;
In the Comparative Examples 2, have 15 examples occurred than embodiment serious feel sick, vomiting, headache, dizzy phenomenon, add 1000mg after, sx simultaneously, has 13 examples of short duration unusual of liver function to occur, through behind the 5-10, liver function is normal gradually;
5, result: Chinese medicine composition provided by the invention has the antialcoholic of sobering up function, can alleviate the headache and dizzy after drinking simultaneously, and have the function of hepatoprotective, and curative effect is good than prior art.
Though, used general explanation, the specific embodiment and test in the preceding text, the present invention has been done detailed description, on basis of the present invention, can make some modifications or improvement to it, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (10)
1. the Chinese medicine composition of a Dealcoholic sobering-up; It is characterized in that; This Chinese medicine composition is processed by following parts by weight of Chinese traditional medicine: Radix Puerariae 10-50 part, Flos puerariae lobatae 10-50 part, Rhizoma Phragmitis 10-50 part, Caulis Bambusae In Taenia 10-50 part, Endothelium Corneum Gigeriae Galli 10-50 part, Folium Nelumbinis 10-50 part, Calyx Kaki 10-50 part, Omphalia 10-50 part, Flos Chrysanthemi 10-50 part, Fructus Tsaoko 10-50 part.
2. Chinese medicine composition according to claim 1; It is characterized in that; This Chinese medicine composition is processed by following parts by weight of Chinese traditional medicine: Radix Puerariae 20-40 part, Flos puerariae lobatae 20-40 part, Rhizoma Phragmitis 20-40 part, Caulis Bambusae In Taenia 20-40 part, Endothelium Corneum Gigeriae Galli 20-40 part, Folium Nelumbinis 20-40 part, Calyx Kaki 20-40 part, Omphalia 20-40 part, Flos Chrysanthemi 20-40 part, Fructus Tsaoko 20-40 part.
3. Chinese medicine composition according to claim 1; It is characterized in that; This Chinese medicine composition is processed by following parts by weight of Chinese traditional medicine: 30 parts of Radix Puerariaes, 30 parts of Flos puerariae lobataes, 30 parts of Rhizoma Phragmitiss, 30 parts of Caulis Bambusae In Taenia, 30 parts of Endothelium Corneum Gigeriae Galli, 30 parts on Folium Nelumbinis, 30 parts of Calyx Kaki, 30 parts of Omphalias, 30 parts of Flos Chrysanthemis, 30 parts of Fructus Tsaokos.
4. according to each described Chinese medicine composition of claim 1-3, it is characterized in that this Chinese medicine composition is tablet, oral liquid, soft capsule, granule, hard capsule or pill.
5. Chinese medicine composition according to claim 4 is characterized in that, this Chinese medicine composition is oral liquid, soft capsule or granule.
6. a method for preparing each described Chinese medicine composition of claim 1-5 is characterized in that, this method may further comprise the steps:
Radix Puerariae, Flos puerariae lobatae, Rhizoma Phragmitis, Caulis Bambusae In Taenia, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Calyx Kaki, Omphalia, Flos Chrysanthemi, Fructus Tsaoko water decoct 2-4 time, add the water that 5-10 doubly measures at every turn; Each decocting time is 1-3 hour; Collecting decoction filters, and being concentrated into relative density is the extractum of 1.05-1.30 (60 ℃); Spray drying adds pharmaceutically acceptable carrier or diluent and processes preparation.
7. method according to claim 6 is characterized in that, this method may further comprise the steps: Radix Puerariae, Flos puerariae lobatae; Rhizoma Phragmitis, Caulis Bambusae In Taenia, Endothelium Corneum Gigeriae Galli, Folium Nelumbinis, Calyx Kaki, Omphalia, Flos Chrysanthemi, Fructus Tsaoko water decoct 3 times, add the water of 6 times of amounts at every turn, and each decocting time is 1.5 hours; Collecting decoction filters, and being concentrated into relative density is the extractum of 1.10-1.15 (60 ℃); Spray drying adds pharmaceutically acceptable carrier or diluent and processes preparation.
8. according to claim 6 or 7 described methods; It is characterized in that said pharmaceutically acceptable carrier or diluent are selected from one or more in filler, binding agent, disintegrating agent, lubricant, suspending agent, wetting agent, solvent, surfactant or the correctives.
9. the application of each described Chinese medicine composition of claim 1-5 in the health product of preparation treatment Dealcoholic sobering-up.
10. application according to claim 9 is characterized in that, is mainly used in drunk Dealcoholic sobering-up, the headache after being still drank after a night.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103637183A (en) * | 2013-11-11 | 2014-03-19 | 高晶晶 | Sobering-up granule electuary and preparation method thereof |
| CN104056162A (en) * | 2013-03-21 | 2014-09-24 | 梅广浦 | Traditional Chinese medicine health care composition capable of dispelling effect of alcohol |
| CN104126796A (en) * | 2014-07-18 | 2014-11-05 | 吴自伟 | Health care food capable of dispelling effects of alcohol |
| CN104383315A (en) * | 2014-10-28 | 2015-03-04 | 湖南中医药大学 | Chinese herbal medicinal composition for protecting liver and sobering and drink containing Chinese herbal medicinal composition |
| CN107485710A (en) * | 2017-09-24 | 2017-12-19 | 蓝莹 | A kind of relieving alcoholism and protecting liver Chinese medicine composition |
| CN114514975A (en) * | 2022-03-02 | 2022-05-20 | 高晓璐 | Bamboo shaving beverage and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1461647A (en) * | 2002-05-29 | 2003-12-17 | 雷世昌 | Traditional Chinese medicine prepn. for sobering up and preventing drunken and its prepn. method |
-
2011
- 2011-11-10 CN CN2011103556576A patent/CN102363011B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1461647A (en) * | 2002-05-29 | 2003-12-17 | 雷世昌 | Traditional Chinese medicine prepn. for sobering up and preventing drunken and its prepn. method |
Non-Patent Citations (2)
| Title |
|---|
| 于大猛: "解酒刍议", 《光明中医》, vol. 22, no. 12, 31 December 2007 (2007-12-31), pages 55 - 56 * |
| 尚学瑞: "这些中药能解酒", 《健康报》, 14 December 2001 (2001-12-14), pages 002 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056162A (en) * | 2013-03-21 | 2014-09-24 | 梅广浦 | Traditional Chinese medicine health care composition capable of dispelling effect of alcohol |
| CN103637183A (en) * | 2013-11-11 | 2014-03-19 | 高晶晶 | Sobering-up granule electuary and preparation method thereof |
| CN104126796A (en) * | 2014-07-18 | 2014-11-05 | 吴自伟 | Health care food capable of dispelling effects of alcohol |
| CN104383315A (en) * | 2014-10-28 | 2015-03-04 | 湖南中医药大学 | Chinese herbal medicinal composition for protecting liver and sobering and drink containing Chinese herbal medicinal composition |
| CN107485710A (en) * | 2017-09-24 | 2017-12-19 | 蓝莹 | A kind of relieving alcoholism and protecting liver Chinese medicine composition |
| CN114514975A (en) * | 2022-03-02 | 2022-05-20 | 高晓璐 | Bamboo shaving beverage and preparation method thereof |
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| CN102363011B (en) | 2013-04-24 |
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