CN102349855A - Glass bottle with inorganic silicon membranous layer for medical packaging and production process thereof - Google Patents
Glass bottle with inorganic silicon membranous layer for medical packaging and production process thereof Download PDFInfo
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- CN102349855A CN102349855A CN2011101704840A CN201110170484A CN102349855A CN 102349855 A CN102349855 A CN 102349855A CN 2011101704840 A CN2011101704840 A CN 2011101704840A CN 201110170484 A CN201110170484 A CN 201110170484A CN 102349855 A CN102349855 A CN 102349855A
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- vial
- bottle
- glass bottle
- rete
- membranous layer
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Abstract
The invention discloses a glass bottle with an inorganic silicon membranous layer for medical packaging and a production process thereof. The glass bottle comprises a bottle body, wherein a silicon dioxide membranous layer for isolating liquor and the inner surface of the bottle body is evenly covered on the inner surface of the bottle body. The process comprises the following steps of: (1) conveying a qualified glass bottle onto plasma-reinforced chemical vapor deposition method equipment; (2) vacuumizing a cavity body of the equipment; (3) introducing the mixed gas of SiH4 and O2 into the glass bottle; (4) enabling the temperature of the gas in the glass bottle to reach 100 to 400 DEG C and the working air pressure to reach 20 to 150Pa by utilizing glow discharge; and (5) generating a reaction between plasmas so as to deposit out a silicon dioxide membranous layer onto the inner surface of the glass bottle. Compared with the prior art, the glass bottle with the inorganic silicon membranous layer for medical packaging and the production process thereof have the following beneficial effects that: (1) the adhesion of the silicon dioxide membranous layer on the glass bottle is firm, and the problems of pH change of a solution and precipitation of harmful ions are solved; (2) the accuracy of the dose of a medicine is ensured; and (3) the component of the silicon dioxide membranous layer is the same as the main body material of glass, and the safety of the use of the medicine is ensured.
Description
Technical field
The invention belongs to the technical field of vial surface modification treatment, a kind of specifically medical packaging vial and production technology thereof with inorganic silicon rete.
Background technology
At medical field, the injection consumption is big, and purposes is wide, because its tool stable curative effect, advantage such as rapid have irreplaceable effect at medical field.Application development in China through decades, the category and the specification of injection are quite complete at present, and the injection packing does not change all the time.The glass control injection bottle of injection packing can not satisfy the suitability, the security requirement of medicine, and vial deposits that to have alkali metal oxide in the process (mainly be Na owing to receive thermal-flame calcination and later stage in the process of machine-shaping
2O) volatilize in a large number and separate out; Alkaline matter from glass, separate out with solution in H+ exchange migration takes place in the splendid attire medicine; In use cause the PH of medicinal liquid to raise; If reach a sufficiently high pH value glass will be suffered erosion once more; Be subjected to the influence of medicinal liquid simultaneously; Some ions in the glass can be separated out (for example metal ion), thereby influence the safety of medicinal liquid.In order to change this situation, be necessary vial is carried out inner surface treatment, the purpose of inner surface treatment be promote when the glass container inner surface with understand the interactional resistance of generation after medicinal liquid contact.Have technology at present at vial inner surface plating organosilicone film; Isolated medicine and glass, can reduce separating out of alkali metal ion, but organosilicon is because the architectural characteristic of himself; The rete firmness that forms at glass surface is little, in use comes off easily; Simultaneously also new material element can be introduced, the stability and the safety of medicine can not be guaranteed.Improve glass surface character and become the task of top priority.
Have two big drawbacks at vial inner surface plating one deck organosilicone film: 1, poor stability: the organosilicon material that constitutes organic silicon film is because himself structure and group characteristic; Can not react with the group of glass surface; The rete that forms can not be firm be overlying on glass surface; In use come off easily, influence drug safety.
2, contamination of products property is big: the composition that the organosilicon rete comprises is more, and different with the composition of glass, in use can introduce new material element, causes some that the responsive stability of drug of element-specific is affected.
Summary of the invention
The present invention is directed to deficiency of the prior art, provide a kind of simple in structure, the rete adhesion-tight, and can not introduce the medical packaging vial with inorganic silicon rete of new material element.
In order to solve the problems of the technologies described above; The present invention is able to solve through following technical proposals: a kind of medical packaging vial with inorganic silicon rete; Comprise having body and the bottle bottle at the end, evenly be coated with the silica coating that is used to isolate medicinal liquid and said bottle inner surface on the inner surface of said bottle.The present invention has the rete adhesion-tight, and difficult drop-off has guaranteed the safety of packing container to medicine; The film material composition is identical with the glass body composition simultaneously, has avoided the introducing of novel substance element, has stopped the pollution of packing container to medicine.
As preferably, the thickness of above-mentioned coatings is between 100 nm～200nm.In order to guarantee that rete has isolation effect completely, thicknesses of layers can meet the requirements of effect between 100～200nm, and rete is too thin not to reach complete isolated effect, the excessive transparency that then can influence vial of thickness, and also cost is also higher.
Another object of the present invention provides a kind of production technology with medical packaging vial of inorganic silicon rete.
The present invention is able to solve through following technical proposals: a kind of production technology with medical packaging vial of inorganic silicon rete is characterized in that may further comprise the steps: 1) at first will be delivered on the plasma enhanced chemical vapor deposition method equipment through detecting qualified vial through bottle managing machine; 2) the cavity evacuation to said equipment makes its air pressure inside less than 100 Pa; 3) in said vial, feed SiH
4And O
2Mist, wherein, SiH
4And O
2Volume ratio be 1:4; 4) utilize glow discharge to make the interior gas temperature of said vial reach 100 ℃～400 ℃, operating air pressure reaches 20 Pa～150Pa, and at this moment, said mist is the local plasma that forms in said vial; 5) react between the said plasma, on said vial inner surface, deposit the silica coating of thickness between 100 nm～200nm then.This method is simple to operate, and the formed plasma activity of mist is very strong, be easy to react, so it requires temperature lower, and formed silica coating has the thickness advantage of uniform.
As preferably, the temperature of gas is 100 ℃～200 ℃ in the vial described in the step 4.Through the experiment to the heat stability of rete, the rete that forms under 100 ℃～200 ℃ conditions can bear 350 ℃ of high temperature sterilizes and can not be damaged, and has energy savings, reduces cost, and improves the advantage of production capacity.
The present invention compared with prior art; Has following beneficial effect: 1) silica coating adhesion-tight on vial; And effectively isolated medicine and vial, stoped separating out of vial intermediate ion, solved the problem that pH value of solution changes and harmful ion is separated out simultaneously.2) silica coating forms surface hydrophobic through surface treatment, has guaranteed the accuracy of drug dose.3) the silicon dioxide film composition of layer is identical with the material of main part of glass, does not introduce new material element, has guaranteed the safety that medicine uses.
Description of drawings
Fig. 1 is the structural representation of the embodiment of the invention 1.
The specific embodiment
Below in conjunction with the specific embodiment and accompanying drawing the present invention is described in further detail.
A kind of medical packaging vial with inorganic silicon rete; Comprise and have body 11 and the bottle bottle 1 at the end 12; Evenly be coated with the rete 2 that is used to isolate medicinal liquid and said bottle 1 inner surface on the inner surface of said bottle 1; Said rete 2 is a silica coating, and the THICKNESS CONTROL of above-mentioned rete 2 is at 150nm.
Below only be wherein a kind of embodiment of the present invention, in fact,, can adjust according to actual needs that 100nm and 200nm or arbitrary one-tenth-value thickness 1/10 between the two all can reach the purpose that the present invention isolates medicinal liquid and vial for the thickness of rete 2.
A kind of production technology with medical packaging vial of inorganic silicon rete may further comprise the steps: 1) at first will be delivered on the plasma enhanced chemical vapor deposition method equipment through detecting qualified vial through bottle managing machine; 2) the cavity evacuation to said equipment makes its air pressure inside less than 100 Pa; 3) in said vial, feed SiH
4And O
2Mist, wherein, SiH
4And O
2Volume ratio be 1:4; 4) utilize glow discharge to make the interior gas temperature of said vial reach 100 ℃～400 ℃, operating air pressure reaches 20Pa～150Pa, and at this moment, said mist is the local plasma that forms in said vial; 5) react between the said plasma, on said vial inner surface, deposit the silica coating of thickness between 100nm～200nm then.
Claims (4)
1. medical packaging vial with inorganic silicon rete; Comprise have body (11) and the bottle end (12) bottle (1); Evenly be coated with the rete (2) that is used to isolate medicinal liquid and said bottle (1) inner surface on the inner surface of said bottle (1), it is characterized in that: said rete (2) is a silica coating.
2. a kind of medical packaging vial with inorganic silicon rete according to claim 1, it is characterized in that: the thickness of said rete (2) is between 100 nm～200nm.
3. the production technology with medical packaging vial of inorganic silicon rete as claimed in claim 1 is characterized in that may further comprise the steps: 1) at first will be delivered on the plasma enhanced chemical vapor deposition method equipment through detecting qualified vial through bottle managing machine; 2) the cavity evacuation to said equipment makes its air pressure inside less than 100 Pa; 3) in said vial, feed SiH
4And O
2Mist, wherein, SiH
4And O
2Volume ratio be 1:4; 4) utilize glow discharge to make the interior gas temperature of said vial reach 100 ℃～400 ℃, operating air pressure reaches 20 Pa～150Pa, and at this moment, said mist is the local plasma that forms in said vial; 5) react between the said plasma, on said vial inner surface, deposit the silica coating of thickness between 100 nm～200nm then.
4. a kind of production technology according to claim 3 is characterized in that: the temperature of gas is 100 ℃～200 ℃ in the vial described in the step 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101704840A CN102349855A (en) | 2011-06-23 | 2011-06-23 | Glass bottle with inorganic silicon membranous layer for medical packaging and production process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101704840A CN102349855A (en) | 2011-06-23 | 2011-06-23 | Glass bottle with inorganic silicon membranous layer for medical packaging and production process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102349855A true CN102349855A (en) | 2012-02-15 |
Family
ID=45573577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101704840A Pending CN102349855A (en) | 2011-06-23 | 2011-06-23 | Glass bottle with inorganic silicon membranous layer for medical packaging and production process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102349855A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104386918A (en) * | 2014-10-22 | 2015-03-04 | 宁波正力药品包装有限公司 | Preparation method of barrier film for inner wall of glass bottle |
| CN109562984A (en) * | 2016-06-02 | 2019-04-02 | Sgd股份有限公司 | In the method that the surface of container and relevant device forms barrier coat |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10258110A (en) * | 1997-02-18 | 1998-09-29 | Carl Zeiss:Fa | Glass vessel which can be sterilized for medical purpose, particularly for storing medicine or product for diagnosis |
| US20030134060A1 (en) * | 1999-05-07 | 2003-07-17 | Marten Walther | Glass container for medicinal purposes |
| CN1510163A (en) * | 2002-12-24 | 2004-07-07 | 西北工业大学 | Container internal surface chemical vapor depositon coating method |
| CN1631739A (en) * | 2003-12-22 | 2005-06-29 | 玄金科技股份有限公司 | Bottle-shaped container with protective film |
| WO2009019729A1 (en) * | 2007-08-03 | 2009-02-12 | Nuova Ompi S.R.L. | Process for manufacturing glass containers and product obtained therewith |
| CN101585666A (en) * | 2009-06-22 | 2009-11-25 | 浙江新康药用玻璃有限公司 | A kind of inner surface coating technique of medicinal glass bottle |
-
2011
- 2011-06-23 CN CN2011101704840A patent/CN102349855A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10258110A (en) * | 1997-02-18 | 1998-09-29 | Carl Zeiss:Fa | Glass vessel which can be sterilized for medical purpose, particularly for storing medicine or product for diagnosis |
| US20030134060A1 (en) * | 1999-05-07 | 2003-07-17 | Marten Walther | Glass container for medicinal purposes |
| CN1510163A (en) * | 2002-12-24 | 2004-07-07 | 西北工业大学 | Container internal surface chemical vapor depositon coating method |
| CN1631739A (en) * | 2003-12-22 | 2005-06-29 | 玄金科技股份有限公司 | Bottle-shaped container with protective film |
| WO2009019729A1 (en) * | 2007-08-03 | 2009-02-12 | Nuova Ompi S.R.L. | Process for manufacturing glass containers and product obtained therewith |
| CN101585666A (en) * | 2009-06-22 | 2009-11-25 | 浙江新康药用玻璃有限公司 | A kind of inner surface coating technique of medicinal glass bottle |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104386918A (en) * | 2014-10-22 | 2015-03-04 | 宁波正力药品包装有限公司 | Preparation method of barrier film for inner wall of glass bottle |
| CN109562984A (en) * | 2016-06-02 | 2019-04-02 | Sgd股份有限公司 | In the method that the surface of container and relevant device forms barrier coat |
| CN109562984B (en) * | 2016-06-02 | 2022-09-09 | Sgd股份有限公司 | Method of forming a barrier coating on the surface of a container and related apparatus |
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Application publication date: 20120215 |