CN102348721A - 复合物和生产过程 - Google Patents

复合物和生产过程 Download PDF

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Publication number
CN102348721A
CN102348721A CN2010800112651A CN201080011265A CN102348721A CN 102348721 A CN102348721 A CN 102348721A CN 2010800112651 A CN2010800112651 A CN 2010800112651A CN 201080011265 A CN201080011265 A CN 201080011265A CN 102348721 A CN102348721 A CN 102348721A
Authority
CN
China
Prior art keywords
lactalbumin
alpha
recombinant protein
bioactive composite
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800112651A
Other languages
English (en)
Chinese (zh)
Inventor
珍妮·彼得森-凯斯伯格
凯塞纳·斯万保格
肯尼思H·莫
安-克里斯汀·莫新伯格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamlet Pharma AB
Original Assignee
Hamlet Pharma AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0900260A external-priority patent/GB0900260D0/en
Priority claimed from GB0906199A external-priority patent/GB0906199D0/en
Application filed by Hamlet Pharma AB filed Critical Hamlet Pharma AB
Publication of CN102348721A publication Critical patent/CN102348721A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN2010800112651A 2009-01-09 2010-01-08 复合物和生产过程 Pending CN102348721A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0900260A GB0900260D0 (en) 2009-01-09 2009-01-09 Complex and production process
GB0900260.1 2009-01-09
GB0906199.5 2009-04-09
GB0906199A GB0906199D0 (en) 2009-04-09 2009-04-09 Complex and production process
PCT/GB2010/050024 WO2010079362A1 (en) 2009-01-09 2010-01-08 Complex and production process

Publications (1)

Publication Number Publication Date
CN102348721A true CN102348721A (zh) 2012-02-08

Family

ID=42026257

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800112651A Pending CN102348721A (zh) 2009-01-09 2010-01-08 复合物和生产过程

Country Status (8)

Country Link
US (1) US8796218B2 (https=)
EP (1) EP2385954B1 (https=)
JP (1) JP5679992B2 (https=)
CN (1) CN102348721A (https=)
AU (1) AU2010204178B2 (https=)
CA (1) CA2752490C (https=)
DK (1) DK2385954T3 (https=)
WO (1) WO2010079362A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106636157A (zh) * 2016-09-01 2017-05-10 锦州医科大学 一种突变α‑乳清蛋白表达载体、制备方法及其应用
CN110234321A (zh) * 2016-12-20 2019-09-13 哈姆雷特药品Ab 治疗性的活性复合物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2385954T3 (da) 2009-01-09 2013-06-17 Hamlet Pharma Ab Kompleks og fremstillingsproces
DK2643010T3 (en) 2010-11-24 2017-02-27 Hamlet Pharma Ab BIOLOGICAL ACTIVE COMPLEX AND ITS PREPARATION
EP3295953B1 (en) 2012-08-09 2020-10-21 HAMLET Pharma AB Milk protein - fatty acid complex
GB201707715D0 (en) * 2017-05-14 2017-06-28 Hamlet Pharma Ab Preperation of biologically active complexes
US20220323391A1 (en) * 2019-08-20 2022-10-13 Hamlet Pharma Ab Combination of a chemotherapeutic agent and alpha-lactoglubulin-oleic acid complex for cancer therapy
GB202015836D0 (en) 2020-10-06 2020-11-18 Hamlet Pharma Ab Compositions
GB202303177D0 (en) 2023-03-03 2023-04-19 Linnane Pharma Ab Method of predicting response to treatment
WO2025186107A1 (en) 2024-03-04 2025-09-12 Linnane Pharma Ab Therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008138348A1 (en) * 2007-05-09 2008-11-20 Nya Hamlet Pharma Ab Preparation of complexed lactalbumin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837719T2 (de) 1997-11-21 2008-01-31 Nya Hamlet Pharma Ab Herstellungsverfahren von lactalbumin
GB9725126D0 (en) 1997-11-27 1998-01-28 Svanborg Catharina Therapeutic agents
EP1214067A1 (en) 1999-09-09 2002-06-19 EFA Sciences Llc Methods for treating cell proliferative disorders including cancer
US6639089B2 (en) 2000-11-08 2003-10-28 Soda Aromatic Co., Ltd. Anticancer agents, perfumes or foods and drinks
GB0205347D0 (en) 2002-03-07 2002-04-24 Svanborg Catharina Biologically active complex
GB0508880D0 (en) * 2005-05-03 2005-06-08 Hamlet Pharma Ab Novel therapies and methods of screening for therapeutic compounds
US20080115228A1 (en) * 2006-11-15 2008-05-15 Yahoo! Inc. Rights engine
WO2008058547A2 (en) 2006-11-17 2008-05-22 Nya Hamlet Pharma Ab Alpha-lactalbumin composition
DK2385954T3 (da) 2009-01-09 2013-06-17 Hamlet Pharma Ab Kompleks og fremstillingsproces
WO2010131237A1 (en) 2009-05-13 2010-11-18 Agriculture And Food Development Authority (Teagasc) A process for producing a biologically active globular protein complex
DK2643010T3 (en) 2010-11-24 2017-02-27 Hamlet Pharma Ab BIOLOGICAL ACTIVE COMPLEX AND ITS PREPARATION

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008138348A1 (en) * 2007-05-09 2008-11-20 Nya Hamlet Pharma Ab Preparation of complexed lactalbumin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JONAS FAST等: "Stability of HAMLET—A kinetically trapped α-lactalbumin oleic acid complex", 《PROTEIN SCIENCE》 *
M. SVENSSON等: "Conversion of a-lactalbumin to a protein inducing apoptosis", 《MEDICAL SCIENCES》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106636157A (zh) * 2016-09-01 2017-05-10 锦州医科大学 一种突变α‑乳清蛋白表达载体、制备方法及其应用
CN110234321A (zh) * 2016-12-20 2019-09-13 哈姆雷特药品Ab 治疗性的活性复合物

Also Published As

Publication number Publication date
EP2385954B1 (en) 2013-04-03
DK2385954T3 (da) 2013-06-17
AU2010204178B2 (en) 2015-10-29
US8796218B2 (en) 2014-08-05
JP5679992B2 (ja) 2015-03-04
JP2012514466A (ja) 2012-06-28
AU2010204178A1 (en) 2011-09-01
EP2385954A1 (en) 2011-11-16
CA2752490A1 (en) 2010-07-15
US20120028883A1 (en) 2012-02-02
WO2010079362A1 (en) 2010-07-15
CA2752490C (en) 2020-03-10

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20120208