CN102327333A - 一种治疗外感风邪所致眼疾的中药及其制备方法 - Google Patents
一种治疗外感风邪所致眼疾的中药及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗外感风邪所致眼疾的中药及其制备方法，它是由以下重量配比的药材组成：制川乌20-40份、川芎20-40份、荆芥20-40份、羌活100-200份、防风100-200份、薄荷100-200份、党参20-40份、黄芪20-40份。制备方法：称取所述重量份的药材；粉碎，过100目筛，混合均匀，得药粉；每10重量份药粉加入10-15重量份炼蜜，混合均匀，分成6克每份，团制成丸，即得大蜜丸。临床试验证实，本发明组方能够安全有效的治疗外感风邪所致的眼疾；容易看出，本发明药物的制备方法简便易行、绿色环保，适合生产和临床应用。
Description
技术领域
本发明涉及一种治疗外感风邪所致眼疾的中药及其制备方法。
背景技术
中医认为风邪外袭郁滞睑肤肌腠之间，而发为目痒。表现为：眼部奇痒，眼睑内微红或少许红色颗粒，舌苔薄白，脉浮。该症属于现代医学所指的结膜炎范畴。结膜炎根据其病因分为细菌性、病毒性、衣原体性、霉菌性、变态反应性等。
现有治疗药物大都为抗生素。抗生素有耐药性，为限制用药，不宜常服；且对于病毒性、非微生物感染性眼疾几乎没有疗效。
本发明所涉及药材的研究现状如下：
制川乌：【来源】本品为毛茛科植物乌头Aconitum carmichaelii Debx.的母根的炮制加工品。【功能主治】祛风除湿，温经止痛。用于风寒湿痹，关节疼痛，心腹冷痛，寒疝作痛及麻醉止痛。
川芎：【来源】本品为伞形科植物川芎Ligusticum chuam．iong Hort.的干燥根茎。【功能主治】活血行气，祛风止痛。用于胸痹心痛，胸胁刺痛，跌扑肿痛，月经不调，经闭痛经，瘾瘕腹痛，头痛，风湿痹痛。
荆芥：【来源】本品为唇形科植物荆芥Schizonepeta tenuifolia Briq．的干燥地上部分。【功能主治】解表散风，透疹，消疮。用于感冒，头痛，麻疹，风疹，疮疡初起。
羌活：【来源】本品为伞形科植物羌活Notopterygium incisum Ting ex H.T．Chang或宽叶羌活Notopterygiumfranchetii H. de Boiss.的干燥根茎和根。【功能主治】解表散寒，祛风除湿，止痛。用于风寒感冒，头痛项强，风湿痹痛，肩背酸痛。
防风：【来源】本品为伞形科植物防风Saposhnikovia divaricata( Turcz.) Schischk.的干燥根。【功能主治】祛风解表，胜湿止痛，止痉。用于感冒头痛，风湿痹痛，风疹瘙痒，破伤风。
薄荷：【来源】本品为唇形科植物薄荷 MenthahaplocalyxBriq.的干燥地上部分。【功能主治】宣散风热。清头目，透疹。用于风热感冒，风温初起，头痛，目赤，喉痹，口疮，风疹，麻疹，胸胁胀闷。
党参：【来源】本品为桔梗科植物党参Codonopsis pilosula(Franch.)Nannf.、素花党参Codonopsis pilosula Nannf.var.modesta(Nannf.)L.T.Shen或川党参Codonopsis tangshen 01iv.的干燥根。【功能主治】健脾益肺，养血生津。用于脾肺气虚，食少倦怠，咳嗽虚喘，气血不足，面色萎黄，心悸气短，津伤口渴，内热消渴。
黄芪：【来源】本品为豆科植物蒙古黄芪Astragalus membranaceus (Fisch)Bge.var.mongholicus(Bge)Hsiao或膜荚黄芪Astragalus membranaceus (Fisch)Bge.的干燥根。【功能主治】补气升阳，固表止汗，利水消肿，生津养血，行滞通痹，托毒排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，内热消渴，血虚萎黄，半身不遂，痹痛麻木，痈疽难溃，久溃不敛。
发明内容
本发明旨在提供一种治疗外感风邪所致眼疾的中药及其制备方法，通过选择合适的药物及其配比并制定其成药的制备方法，达到安全有效治疗外感风邪所致眼疾并使其适于在临床上推广应用的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗外感风邪所致眼疾的中药，其特征在于，它是由以下重量配比的药材组成：制川乌20-40份、川芎20-40份、荆芥20-40份、羌活100-200份、防风100-200份、薄荷100-200份、党参20-40份、黄芪20-40份。其中各药材的最佳重量配比为：制川乌30份、川芎30份、荆芥30份、羌活150份、防风150份、薄荷150份、党参30份、黄芪30份。
本发明最佳重量配比中药的制备方法为：称取所述重量份的药材；粉碎，过100目筛，混合均匀，得药粉；每10重量份药粉加入10-15重量份炼蜜，混合均匀，分成6克每份，团制成丸，即得大蜜丸。
大蜜丸用法用量：口服，正常成人一日2次，一次1丸。
本方明的有益效果：
本发明方中制川乌、川芎、荆芥、羌活、防风、薄荷祛风力强，可辛温发散；党参、黄芪辅助正气。诸药合用，共奏祛风散邪益气强体明目的功效。对于体弱不胜祛风重剂者有奇效。
临床试验证实，本发明药物能够安全有效地治疗外感风邪所致的眼疾；容易看出，本发明丸剂的制备方法简便易行、绿色环保，适合生产和临床应用。
下面结合临床试验数据来说明本发明的有益效果：
自2008年1月至2011年2月，发明人在烟台市中医医院应用本发明最佳药物配比制得的大蜜丸治疗外感风邪眼疾患者75例，并与同期应用4%色甘酸二钠滴眼液治疗风邪眼症30例进行对照观察，收到较好效果。
1、临床资料
一般资料观察病例共105例，随机分为2组。治疗组75例，男30例，女45例；年龄(39.5±15.27)岁；病程(2±1)年；对照组30例，男20例，女10例；年龄(39.5±15.27)岁；病程(2±1)年。2组一般资料经统计学处理，差异均无显著性意义(P＞0.05)具有可比性。
2、治疗方法
2.1对照组外用4%色甘酸二钠滴眼液，每日4次，疗程4周。
2.2治疗组口服本发明最佳药物配比制得的大蜜丸，每天2次，每次1丸，疗程4周。
2.3观察项目包括治疗前后如下诸情况变化：痒，灼热感，畏光，流泪，分泌物，红肿，磨感，上睑结膜瘢痕，乳头增生或滤泡，体质虚弱症状。
2.4统计学方法采用SPSS统计软件进行分析。
3、疗效标准与治疗结果
3.1疗效标准参照《中医病症判断疗效标准》中有关疗效标准。
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗结果
两组临床疗效比较见表1。
表1 两组临床疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) |
| 治疗组 | 75 | 62(82.7%) | 12(16%) | 1(1.3%) | 98.7% |
| 对照组 | 30 | 12(40%) | 11(36.6%) | 7(23.4%) | 76.6% |
与治疗前比较※P＜0.01；与对照组治疗后比较，△P＜0.01
总有效率治疗组为98.7%，对照组为76.6%，两组比较，差异有显著性意义(P＜0.05) ，两组治疗过程均未发现明显不良反应。可见，本发明最佳配比制得的药物用于治疗外感风邪所致的眼疾用药安全、治愈率高。
根据上述临床实验数据，结合本发明组方机理和本领域公知常识，本领域技术人员容易推知，运用本发明中的药材，取其最佳重量配比附近值，即制川乌20-40份、川芎20-40份、荆芥20-40份、羌活100-200份、防风100-200份、薄荷100-200份、党参20-40份、黄芪20-40份，亦可取得与本发明最佳重量配制得的药物类似的技术效果。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取制川乌30份、川芎30份、荆芥30份、羌活150份、防风150份、薄荷150份、党参30份、黄芪30份；粉碎，过100目筛，混合均匀，得药粉；每10重量份药粉加入10-15重量份炼蜜，混合均匀，分成6克每份，团制成丸，即得大蜜丸。
用于治疗外感风邪所致的眼疾，口服，每日2次，一次1丸。
具体实施例2
称取制川乌20份、川芎20份、荆芥20份、羌活100份、防风100份、薄荷100份、党参20份、黄芪20份；粉碎，过100目筛，混合均匀，得药粉；每10重量份药粉加入10-15重量份炼蜜，混合均匀，分成4克每份，团制成丸，即得大蜜丸。
用于治疗外感风邪所致的眼疾，口服，每日2次，一次1丸。
具体实施例3
称取制川乌40份、川芎40份、荆芥40份、羌活200份、防风200份、薄荷200份、党参40份、黄芪40份；粉碎，过100目筛，混合均匀，得药粉；每10重量份药粉加入10-15重量份炼蜜，混合均匀，分成8克每份，团制成丸，即得大蜜丸。
用于治疗外感风邪所致的眼疾，口服，每日2次，一次1丸。
Claims (3)
1.一种治疗外感风邪所致眼疾的中药，其特征在于，它是由以下重量配比的药材组成：制川乌20-40份、川芎20-40份、荆芥20-40份、羌活100-200份、防风100-200份、薄荷100-200份、党参20-40份、黄芪20-40份。
2.按照权利要求1所述的治疗外感风邪所致眼疾的中药，其特征在于，它是由以下重量配比的药材组成：制川乌30份、川芎30份、荆芥30份、羌活150份、防风150份、薄荷150份、党参30份、黄芪30份。
3.按照权利要求2所述的治疗外感风邪所致眼疾的中药的制备方法，其特征在于，称取所述重量份的药材；粉碎，过100目筛，混合均匀，得药粉；每10重量份药粉加入10-15重量份炼蜜，混合均匀，分成6克每份，团制成丸，即得大蜜丸。
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| CN1596914A (zh) * | 2003-09-15 | 2005-03-23 | 徐万富 | 一种治疗由脏腑病所致眼病的药物 |
| CN101756568A (zh) * | 2010-03-16 | 2010-06-30 | 李忠凯 | 一种保健被褥 |
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