CN102327246A - Film coating for traditional Chinese medicine buccal tablets and preparation method thereof - Google Patents
Film coating for traditional Chinese medicine buccal tablets and preparation method thereof Download PDFInfo
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- CN102327246A CN102327246A CN201110211623A CN201110211623A CN102327246A CN 102327246 A CN102327246 A CN 102327246A CN 201110211623 A CN201110211623 A CN 201110211623A CN 201110211623 A CN201110211623 A CN 201110211623A CN 102327246 A CN102327246 A CN 102327246A
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Abstract
The invention discloses a film coating for traditional Chinese medicine buccal tablets and a preparation method thereof, belonging to the technical field of pharmaceutical auxiliary material production. The formula of the film coating for traditional Chinese medicine buccal tablets comprises polyvinyl alcohol, pectin and polyethylene glycol 4000. The preparation method of the film coating comprises the following steps: adding polyvinyl alcohol (PVA), pectin and polyethylene glycol 4000 to a high-speed shearing machine of a reaction tank in a weight ratio of 1:0.4:0.6, and stirring and shearing at a high speed for 15 minutes to obtain a premixed agent; then, weighing the premixed agent according to the amount of the coating being 4% the weight of the coated product, calculating the weight of process water based on 10% aqueous solution, and adding the process water to the premixed agent during the stirring process to obtain 10% aqueous solution; uniformly mixing, and taking out to obtain coating liquid for later use; and finally, coating by adopting the currently universal high-efficiency coating machine to form a film coating with a 100-400 mu m-thick film coated on the surface.
Description
Technical field
The invention relates to tablet film coating and manufacturing approach thereof, more particularly, especially relate to a kind of Chinese medicine buccal tablet with coating and preparation method thereof.
Background technology
The Chinese medicine buccal tablet refers to be contained in slow dissolved Chinese medicine compressed tablet in the oral cavity, can be used for partial antiinflammatory, sterilization etc. to oral cavity and the persistent drug effect of pharyngeal generation.The Chinese medicine buccal tablet often uses the adjuvant that is prone to moisture absorption such as sorbitol, cane sugar powder, mannitol etc.; The also moisture absorption very easily of Chinese medicine ingredients in addition; Therefore commercially available Chinese medicine buccal tablet tends to cause the variation of outward appearance even the decline of drug content because of moisture absorption; Though each manufacturer has taked aluminum-plastic packaged or good sealing performance packing method such as aluminum bag packing, but still can not solve root problem, and packing cost significantly improves.Now a lot of Chinese medicine buccal tablets generally all are that the HPMC that passes through carries out coating as filmogen; The coating membrane of HPMC mainly is to play effect attractive in appearance, has moisture-proof function seldom, and the film behind the coating is because bulge, sliver occur after the label moisture absorption easily; The film bad plasticity that forms of HPMC in addition; In the coating process and the coating caudacoria fracture appears easily, the viscosity of HPMC is generally higher in addition, occurs easily stifled spray gun, unilateral phenomenon such as coarse in the coating process.
Summary of the invention
The present invention is directed to existing Chinese medicine buccal tablet with the shortcoming that film coating exists, a kind of efficient protection against the tide, the smooth free from extraneous odour of mouthfeel, film coating product that light is attractive in appearance are provided, a kind of this film-coated method for preparing is provided simultaneously.
The present invention realizes through following technical scheme: a kind of Chinese medicine buccal tablet is used film coating, it is characterized in that: comprise polyvinyl alcohol, pectin and Macrogol 4000 in the prescription.
Said polyvinyl alcohol and pectin are as the film forming framework material; Said pectin in prescription as stabilizing agent, suspending agent, O/W type emulsifying agent, flavouring synergist and the side's of adhering to reinforcing agent.
A kind of Chinese medicine buccal tablet is used film-coated method for preparing; It may further comprise the steps: (1) adds polyvinyl alcohol (PVA), pectin and Macrogol 4000 in the retort high-speed shearing machine; Three's weight ratio is 1: 0.4: 0.6, and high-speed stirred is sheared after 15 minutes and processed pre-mixing agent; (2) be that 4% of institute's coated product weight takes by weighing above-mentioned pre-mixing agent by the coating consumption, the aqueous solution by 10% calculates the weight of used process water, and blunging with technology adds pre-mixing agent in the process and be made into 10% aqueous solution; Take out behind the mix homogeneously and process coating liquid, for use; (3) adopt the high-efficiency coating machine that generally uses at present to carry out coating, should adjust in the coating process discharge rate, degree of atomization, spray gun and unilateral distance, add the parameters such as temperature of hot blast, covering one deck thickness on the surface of Chinese medicine buccal tablet is 100--400 μ m coating membrane.
Compared with prior art, the invention has the beneficial effects as follows: have tangible moisture effect, the film brightness is high, the surface is fine and smooth, moisture effect significantly promotes, and sucking has natural pectin fragrance in the process, do not have the sensation of any demoulding.
The specific embodiment
Below in conjunction with embodiment the present invention is described further:
A kind of Chinese medicine buccal tablet is used film coating, comprises polyvinyl alcohol, pectin and Macrogol 4000 in the prescription.Said polyvinyl alcohol and pectin are as the film forming framework material, and polyvinyl alcohol is a kind of hydrophobic filmogen, has good film property, and the film moisture effect behind the coating is splendid, are highly suitable for the coating of traditional Chinese medicine mouth buccal tablet; Said pectin in prescription as stabilizing agent, suspending agent, O/W type emulsifying agent, flavouring synergist and the side's of adhering to reinforcing agent.
A kind of Chinese medicine buccal tablet is used film-coated method for preparing; It may further comprise the steps: (1) adds polyvinyl alcohol (PVA), pectin and Macrogol 4000 in the retort high-speed shearing machine; Three's weight ratio is 1: 0.4: 0.6, and high-speed stirred is sheared after 15 minutes and processed pre-mixing agent; (2) be that 4% of institute's coated product weight takes by weighing above-mentioned pre-mixing agent by the coating consumption, the aqueous solution by 10% calculates the weight of used process water, and blunging with technology adds pre-mixing agent in the process and be made into 10% aqueous solution; Take out behind the mix homogeneously and process coating liquid, for use; (3) adopt the high-efficiency coating machine that generally uses at present to carry out coating, should adjust in the coating process discharge rate, degree of atomization, spray gun and unilateral distance, add the parameters such as temperature of hot blast, covering one deck thickness on the surface of Chinese medicine buccal tablet is 100--400 μ m coating membrane.
Be to make the Chinese medicine buccal tablet to use the film coating method below:
Think that 2 kilograms of average sheets heavily are that 0.45 gram Herba Pileae Scriptae Tabellae is an example, carry out coating, and carry out outward appearance and accelerated tests contrast with commercially available coated tablet, common uncoated tablets respectively.
The film coating of Chinese medicine buccal tablet of the present invention is to be covered with one deck coating membrane on the surface of Chinese medicine buccal tablet, and the thickness of coating is 100--400 μ m.
The raw material of this coating comprises polyvinyl alcohol (PVA), pectin and Macrogol 4000, and three's weight ratio is: polyvinyl alcohol (PVA): pectin: Macrogol 4000=1: 0.4: 0.6
Can prepare coating according to the following steps:
1. in the retort high-speed shearing machine, add 100 kilograms of polyvinyl alcohol, add 40 kilograms of pectin, add 60 kilograms of high-speed stirred shearings of Macrogol 4000 and process the coating pre-mixing agent after 15 minutes.The coating pre-mixing agent should reach the described quality standard of following table:
2. take by weighing 90 kilograms of process waters and pour homogenizer into.Take by weighing 10 kilograms of coating pre-mixing agents, the startup homogenizer stirs whirlpool to be formed and slowly adds, and uniform mixing is processed coating liquid after 30 minutes, take out for use.
3. in the ratio of per 1 kilogram of Chinese medicine buccal tablet, take by weighing used coating liquid with coating liquid 400 grams of above-mentioned preparation.Adopt the coating machine that generally uses at present to carry out coating; Should adjust in the coating process discharge rate, degree of atomization, spray gun and unilateral distance, add the parameters such as temperature of hot blast; Make spray gun ejection coating liquid mist good uniformity, be fan-like pattern, arrives unilateral coating drop exquisiteness, be evenly distributed; Hot air drying is timely, wind speed is reasonable.
With the Herba Pileae Scriptae Tabellae of Herba Pileae Scriptae Tabellae of producing as stated above and commercially available back and not the Herba Pileae Scriptae Tabellae of coating compare, comparing aspect outward appearance, the hot and humid accelerated tests stability:
1, appearance test: buccal tablet and not buccal tablet any surface finish, the exquisiteness of coating of carrying out the commercially available coating of Herba Pileae Scriptae Tabellae surface ratio of coating by this patent.The Herba Pileae Scriptae Tabellae inlet of commercially available coating has demoulding sense, the Herba Pileae Scriptae Tabellae of this patent coating not to have any demoulding sense.
2, stability test: three kinds of samples of Herba Pileae Scriptae Tabellae of coating Herba Pileae Scriptae Tabellae, commercially available coating Herba Pileae Scriptae Tabellae, this patent coating are not got 5 respectively; Carry out hot and humid accelerated tests in the plastic sheeting sealed bag of inclosure similarity condition, whether the high spot reviews tablet appearance surperficial pit, color and luster variation, phenomenons such as color and luster is irregular, coating peels off, cracking, elephant skin, bubble, piebaldism occur; Whether sheet is heavy because changing appears in the moisture absorption; The condition of hot and humid accelerated tests is: constant temperature and humidity: 45 ℃ of temperature, relative humidity 75%.(additional speed experiment contrast table and conclusion)
Herba Pileae Scriptae Tabellae accelerated test contrast table (temperature: 45 ℃, temperature: 75%)
Conclusion: quicken to find after the contrast test through doing; The Herba Pileae Scriptae Tabellae moisture effect of this patent coating obviously is superior to the not Herba Pileae Scriptae Tabellae of coating and commercially available coating Herba Pileae Scriptae Tabellae; The coating prescription of this patent has good humidity resistance and superiority, is fit to very much the coating of Chinese medicine buccal tablet.
Claims (4)
1. a Chinese medicine buccal tablet is used film coating, it is characterized in that: comprise polyvinyl alcohol, pectin and Macrogol 4000 in the prescription.
2. use film coating according to right 1 described Chinese medicine buccal tablet, it is characterized in that: said polyvinyl alcohol and pectin are as the film forming framework material.
3. Chinese medicine buccal tablet according to claim 2 is used film coating, it is characterized in that: pectin in prescription as stabilizing agent, suspending agent, O/W type emulsifying agent, flavouring synergist and the side's of adhering to reinforcing agent.
4. a Chinese medicine buccal tablet is with film coating and preparation method thereof; It is characterized in that: it may further comprise the steps: (1) adds polyvinyl alcohol (PVA), pectin and Macrogol 4000 in the retort high-speed shearing machine; Three's weight ratio is 1: 0.4: 0.6, and high-speed stirred is sheared after 15 minutes and processed pre-mixing agent; (2) be that 4% of institute's coated product weight takes by weighing above-mentioned pre-mixing agent by the coating consumption, the aqueous solution by 10% calculates the weight of used process water, and blunging with technology adds pre-mixing agent in the process and be made into 10% aqueous solution; Take out behind the mix homogeneously and process coating liquid, for use; (3) adopt the high-efficiency coating machine that generally uses at present to carry out coating, should adjust in the coating process discharge rate, degree of atomization, spray gun and unilateral distance, add the parameters such as temperature of hot blast, covering one deck thickness on the surface of Chinese medicine buccal tablet is 100--400 μ m coating membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110211623A CN102327246A (en) | 2011-07-27 | 2011-07-27 | Film coating for traditional Chinese medicine buccal tablets and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110211623A CN102327246A (en) | 2011-07-27 | 2011-07-27 | Film coating for traditional Chinese medicine buccal tablets and preparation method thereof |
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| CN102327246A true CN102327246A (en) | 2012-01-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110211623A Pending CN102327246A (en) | 2011-07-27 | 2011-07-27 | Film coating for traditional Chinese medicine buccal tablets and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017065597A3 (en) * | 2015-10-15 | 2017-08-24 | Centro De Investigación Y Asistencia En Tecnología Y Diseño Del Estado De Jalisco A.C. | Polymer composition |
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2011
- 2011-07-27 CN CN201110211623A patent/CN102327246A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017065597A3 (en) * | 2015-10-15 | 2017-08-24 | Centro De Investigación Y Asistencia En Tecnología Y Diseño Del Estado De Jalisco A.C. | Polymer composition |
| CN108431127A (en) * | 2015-10-15 | 2018-08-21 | 哈利斯科州技术研究和援助中心 | Polymer composition |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20120125 |